John K McGuire, MD

John K McGuire, MD

Critical Care, Pediatric Intensive Care Unit (PICU), Bronchopulmonary Dysplasia Program

On staff since November 2004

Children's Title: Chief, Division of Pediatrics Critical Care Medicine

Academic Title: Associate Professor

Research Center: Center for Respiratory Biology and Therapeutics

"Every day, I am reminded of the special privilege and honor that it is to participate in the care of the children and families in the Pediatric ICU at Seattle Children's Hospital. This inspires me to do my very best to provide outstanding patient care and education in pediatric critical care."

  • Biography

    John K. McGuire, MD, is the Chief of the Division of Pediatric Critical Care Medicine at Seattle Children's Hospital and Associate Professor of Pediatrics at the University of Washington School of Medicine. Dr. McGuire earned his MD from Northwestern University and trained in general pediatrics and pediatric critical care medicine at Childrens Memorial Hospital and Northwestern University in Chicago. Prior to joining the group in Seattle, he worked at Washington University in St. Louis.

    He is board certified in general pediatrics and pediatric critical care medicine and is a member of several academic societies including the American Thoracic Society, Society for Critical Care Medicine, and the American Society for Matrix Biology. Dr. McGuire is a member of the University of Washington Center for Lung Biology. His laboratory work is directed at understanding how epithelial responses to acute injury and infection regulate repair and resolution of inflammation. Related projects are focused on elucidating the role of matrix metalloproteinases in viral and bacterial lung infections. These studies receive funding from the National Institutes of Health and the Cystic Fibrosis Foundation. Dr. McGuire serves as a member of the Accreditation Council for Graduate Medical Education Board of Appeals Panel for Pediatrics and as a reviewer for the National Institutes of Health, the American Heart Association Research Program and several journals.

  • Patient Testimonials
  • Awards and Honors
    Award Name Award Description Awarded By Award Date
    SEATTLE TOP DOCTOR - 2022 Seattle Magazine 2022
    SEATTLE MAGAZINE TOP DOCTOR - 2016 Seattle Magazine 2016
    Seattles Top Doctor 2016 Seattle Met Magazine 2016
    SEATTLE MAGAZINE TOP DOCTOR - 2015 Seattle Magazine 2015
    Pediatric Critical Care Medicine Fellowship Outstanding Mentor Award Seattle Children's Hospital Jul 1, 2011
    Pediatric Critical Care Medicine Fellowship Outstanding Teacher Award Seattle Children's Hospital 2009
    Elected to membership Society for Pediatric Research 2008
    Outstanding Subspecialty Teacher Saint Louis Childrens Hospital 2003
    Resident Teaching Award Northwestern University Medical School 1995
    Outstanding PL-2 Resident Teacher 1995 Childrens Memorial Hospital 1995
    Outstanding PL-1 Resident Teacher Childrens Memorial Hospital 1994
    United States Public Health Service Citation 1990
  • Publications

    Manuscripts in Refereed Journals

    • 1. Schnaper HW, McGuire J, Runyan C, Hubchak SC.
      Sex steroids and the endothelium.
      Current Medicinal Chemistry, 2000 : 7(5):519-31.
    • Jaspan HB, Brothers AW, Campbell AJ, McGuire JK, Browd SR, Manley TJ, Pak D, Weissman SJ
      Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
      20010311 The Pediatric infectious disease journal, : 379-81

    Other Publications

    • Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P
      Syndecan-1 Attenuates Lung Injury During Influenza Infection By Potentiating c-Met Signaling to Suppress Epithelial Apoptosis.
      26959387 American journal of respiratory and critical care medicine, 2016 Mar 9
    • Lee V, McMahan RS, Hu X, Gao X, Faustman EM, Griffith WC, Kavanagh TJ, Eaton DL, McGuire JK, Parks WC
      Amphiphilic polymer-coated CdSe/ZnS quantum dots induce pro-inflammatory cytokine expression in mouse lung epithelial cells and macrophages.
      24983898 Nanotoxicology, 2014 Jul 1 : 1-8
    • Rims CR, McGuire JK
      Matrilysin (MMP-7) catalytic activity regulates -catenin localization and signaling activation in lung epithelial cells.
      24624896 Experimental lung research, 2014 April : 40(3)126-36
    • Gill SE, Gharib SA, Bench EM, Sussman SW, Wang RT, Rims C, Birkland TP, Wang Y, Manicone AM, McGuire JK, Parks WC
      Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.
      23742180 American journal of respiratory cell and molecular biology, 2013 Nov. : 49(5)768-77 PMCID:PMC3931094
    • Tanino Y, Chang MY, Wang X, Gill SE, Skerrett S, McGuire JK, Sato S, Nikaido T, Kojima T, Munakata M, Mongovin S, Parks WC, Martin TR, Wight TN, Frevert CW
      Syndecan-4 regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide.
      22427536 American journal of respiratory cell and molecular biology, 2012 Aug. : 47(2)196-202 PMCID:PMC3423465
    • John K. McGuire, MD, Deeter K, McGuire JK
      Submersion Injury in Children
      Perinatal and Pediatric Respiratory Care. 3rd Edition. Saint Louis: Saunders-Elsevier, 2010
    • Manicone AM, Huizar I, McGuire JK
      Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin).
      19893044 The American journal of pathology, 2009 Dec. : 2319-31
    • Swee M, Wilson CL, Wang Y, McGuire JK, Parks WC
      Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients.
      18334539 Journal of leukocyte biology, 2008 June : 1404-12
    • Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, Madtes DK
      Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.
      18385523 The American journal of pathology, 2008 May : 1256-70
    • Manicone AM, McGuire JK
      Matrix metalloproteinases as modulators of inflammation.
      17707664 Seminars in cell & developmental biology, 2008 Feb. : 34-41
    • Kassim SY, Gharib SA, Mecham BH, Birkland TP, Parks WC, McGuire JK
      Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
      17923522 Infection and immunity, 2007 Dec. : 5640-50
    • Thill PJ, McGuire JK, Baden HP, Green TP, Checchia PA
      Noninvasive positive-pressure ventilation in children with lower airway obstruction.
      15215002 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2004 July : 337-42
    • Surendran K, Simon TC, Liapis H, McGuire JK
      Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4.
      15149334 Kidney international, 2004 June : 2212-22
    • McGuire JK, Li Q, Parks WC
      Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.
      12759241 The American journal of pathology, 2003 June : 1831-43
  • Presentations
    Presentations Title Event Location Date
    Mechanisms of lung repairResolution biology as a pathway to new ARDS treatment 8th Annual Ron Lemire Northwest Pediatric Critical Care Symposium Seattle, WA 2015
    Resolution of Acute Lung Injury: Regulating the regulators. British Columbia Childrens Hospital Vancouver, B.C. 2013
    Epithelial-leukocyte interactions in acute lung injury 2012 University of Texas-Southwestern Dallas TX 2012
    Scientific Symposium: APCs in resolution of acute lung injury American Thoracic Society International Conference San Francisco, CA 2012
    ARDS in Children: Pathophysiology and Management Gertrudes Childrens Hospital Nairobi, Kenya 2012
    Dendritic cells promote resolution of lung injury. University of Colorado Denver, CO 2012
    ICU Infections/Viral Pneumonias in the PICU/Management of Acute Hypoxemic Respiratory Failure in the Pediatric Patient 2010 Ain-Shams Medical School International Pediatric Critical Care Conference Cairo, Egypt 2010
    ICU Infections/Viral Pneumonias in the PICU/Management of Acute Hypoxemic Respiratory Failure in the Pediatric Patient 2010 Ain-Shams Medical School International Pediatric Critical Care Conference Cairo, Egypt 2010
    Resolution of acute lung injury: Putting out the fire. Seattle Childrens Hospital, Pediatrics Grand Rounds Seattle, WA 2009
    Epithelial-leukocyte interactions in the resolution of acute lung injury 2008 University of Washington, Department of Anesthesia Grand Rounds Seattle, WA 2008
    Resolving acute lung injury: Getting the horse back in the barn 2008 First Annual Ron Lemire Northwest Pediatric Critical Care Symposium Seattle, WA 2008
    Shed E-cadherin controls influx of CD103+ dendritic cells American Society of Matrix Biology Nashville, TN 2006
    Matrix metalloproteinases in epithelial injury: A role for MMP-7 in inflammation and re-epithelialization European Tissue Repair Society Stuttgart, Germany 2005
    Proteinase function in epithelial repair and fibrosis Second World Union of Wound Healing Societies Paris, France 2004
  • Research Funding
    Grant Title Grantor Amount Award Date
    Cystic Fibrosis Research Center: Cell Culture Core Cystic Fibrosis Foundation $120,000 Oct. 2015 - Sept. 1919
    Regulatory T cell function in cystic fibrosis lung disease Cystic Fibrosis Foundation $180,000 April 2013 - March 2015
    E-cadherin shedding in chronic lung injury NIH-NHLBI $1,250,000 Jan. 2010 - Feb. 2015
    E-cadherin shedding in chronic lung injury NIH-NHLBI $1,250,000.00 Dec 1, 2009
    Epithelial-leukocyte interactions in regulation of pulmonary inflammation in cystic fibrosis Cystic Fibrosis Foundation-Research Development Program $36,000 Oct 1, 2009
    Mechanisms in the Remodeling of Lung Structure NIH-NHLBI $1,350,000 Sep 1, 2008
    Function in Pulmonary Fibrosis American Heart Association $120,000 Jul 1, 2008
    Cystic Fibrosis Research Center: Epithelial biology core Cystic Fibrosis Foundation $360,000 Oct. 2007 - Sept. 2015
    Arnold Lee Smith Endowed Professorship for Research Faculty Development Arnold Lee Smith Endowement $140,000.00 Sep 1, 2006


Board Certification(s)

Pediatric Critical Care Medicine

Medical/Professional School

Northwestern University, Chicago, IL


Children's Memorial Hospital, Chicago, IL


Children's Memorial Hospital, Chicago, IL