Jason Scott Debley, MD, MPH

Jason Scott Debley, MD, MPH


  • Academic Title: Professor, Pediatrics, Pulmonary and Sleep Medicine
  • Research Title: Interim Director, Center for Respiratory Biology and Therapeutics
  • Research Center: Center for Respiratory Biology and Therapeutics
  • On Staff Since: July 2000
  • Biography

    Jason S. Debley, MD, MPH, is attending physician in the Pulmonary and Sleep Medicine Division at Seattle Children's Hospital and Professor in the Department of Pediatrics at the University of Washington School of Medicine. He received his MD from Northwestern University Medical School and completed his pediatrics internship and residency at Children’s Memorial Hospital in Chicago, Illinois. He completed his pediatric pulmonary fellowship at Seattle Children’s and earned an MPH from the University of Washington. He has clinical expertise in severe asthma, recurrent wheezing of early childhood, bronchopulmonary dysplasia, restrictive lung diseases of childhood and the management of chronic respiratory failure.

    As a physician-scientist Dr. Debley's research has spanned clinical, epidemiologic, basic and mechanistic patient-oriented translational asthma research. His work over the past two decades has concentrated on investigation of the role of the airway epithelium in asthma pathobiology, with focus areas including study of innate immune responses of airway epithelial cells to respiratory viruses and aberrant epithelial regulation of airway remodeling responses. He built a translational research program wherein primary bronchial airway epithelial cells are obtained from children with asthma and healthy children undergoing elective surgical procedures at Seattle Children’s Hospital. This infrastructure is a unique resource in the United States, providing a steady source of primary bronchial airway epithelial cells from carefully characterized children with asthma that are used to conduct mechanistic research to advance our understanding of the role of airway epithelial responses in asthma and to identify novel therapeutic targets.

    Board Certification(s)

    Pediatric Pulmonology


    Northwestern University, Chicago, IL
    University of Washington School of Public Health, Seattle, WA


    Children's Memorial Hospital, Chicago, IL
    Legacy Emanuel Hospital and Health Center, Portland, OR


    Seattle Children's Hospital, Seattle, WA

    Clinical Interests

    Recurrent wheezing of early childhood, Non-invasive measures of airway inflammation, Asthma epidemiology

    Research Focus Area

    Therapeutic Trials, Translational research, observational studies, investigator-initiated interventional studies

  • Related Resources

    • Debley Lab

      The Debley Lab is engaged in an array of translational research investigating the role of the airway epithelium in childhood asthma.

  • Patient Testimonials

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  • Awards and Honors

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  • Publications

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  • Clinical Trials and Research Studies

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