Alison Paquette, PhD

Alison  Paquette, PhD

Academic Title: Assistant Professor

Research Center: Center for Developmental Biology and Regenerative Medicine

  • Biography

    Dr. Alison Paquette is an assistant professor in the Center for Developmental Biology and Regenerative Medicine (CDBRM) at Seattle Children’s Research Institute.

    Her primary research interest is to use 'omics data generated from the placenta to better understand the developmental origins of health and disease, with a particular focus on relationships between prenatal environmental exposures and spontaneous preterm birth. She has experience analyzing and integrating transcriptomic and epigenomic data in complex human datasets and in-vitro systems. Learn more about Dr. Paquette's research.

    • Related Pages

    • Paquette lab webpage

      Pregnancy is a transient but highly important time that shapes health throughout the lifespan. This concept is known as the Developmental Origins of Health and Disease (DOHAD) paradigm. The prenatal environment is influenced by a complex interplay of genetic, environmental and maternal factors. The

  • Publications

    Other Publications

    • Elkin ER, Campbell KA, Lapehn S, Harris SM, Padmanabhan V, Bakulski KM, Paquette AG
      Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology.
      37690473 Molecular and cellular endocrinology, 2023 Dec 1 : 578112066 PMCID:PMC10591899
    • Lapehn S, Houghtaling S, Ahuna K, Kadam L, MacDonald JW, Bammler TK, LeWinn KZ, Myatt L, Sathyanarayana S, Paquette AG
      Mono(2-ethylhexyl) phthalate induces transcriptomic changes in placental cells based on concentration, fetal sex, and trophoblast cell type.
      36695872 Archives of toxicology, 2023 March : 97(3)831-847 PMCID:PMC9968694
    • Paquette AG, Lapehn S, Freije S, MacDonald J, Bammler T, Day DB, Loftus CT, Kannan K, Alex Mason W, Bush NR, LeWinn KZ, Enquobahrie DA, Marsit C, Sathyanarayana S
      Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons.
      36689866 Environment international, 2023 Feb. : 172107763 PMCID:PMC10211546