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Christian L. Roth, MD

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Christian L. Roth, MD

Endocrinology, Disorders of Sex Development

On staff since October 2006

Research Center: Center for Integrative Brain Research

Overview

Board Certification(s)
General Pediatrics (Non-ABMS)
Neonatal-Perinatal (Non-ABMS)
Pediatric Endocrinology (Non-ABMS)
Medical/Professional School
Ruprechts-Karls-Universitat, Heidelberg
Residency
Pediatrics, University of Gottingen, Gottingen
Fellowship
Pediatric Endocrinology, University of Gottingen, Gottingen
Clinical Interests

Clinical Interests: Children with endocrine disorders and diabetes mellitus Research Interests: Obesity studies, including appetite-regulating peptides, factors of the metabolic syndrome, hypothalamic obesity and genetic and environmental factors involved in the onset of puberty

Research Description

My research is focused on childhood obesity, diabetes and puberty. It includes metabolic factors in body weight regulation and hypothalamic control of feeding circuits, genes involved in childhood obesity and diabetes, and post-craniopharyngioma obesity. On the field of puberty, I am working on treatment of precocious puberty and genes controllng the onset of puberty.

Research Focus Area

Biochemistry, Endocrinology / Metabolism, Diabetes

Publications

Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 May 31
Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children.
Metabolism: clinical and experimental , 2010 May 20
Appetite-Regulating Hormone Changes in Patients With Craniopharyngioma.
Obesity (Silver Spring, Md.) , 2010 Apr 8
Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity.
Metabolism: clinical and experimental , 2010 Feb: 186-94
Roles of gastrointestinal and adipose tissue peptides in childhood obesity and changes after weight loss due to lifestyle intervention.
Archives of pediatrics & adolescent medicine , 2010 Feb: 131-8
Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin sensitivity.
Journal of pediatric endocrinology & metabolism : JPEM , 2010 Jan-Feb: 101-8
A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity.
Endocrine , 2009 Aug: 52-9
Ghrelin and obestatin levels in severely obese women before and after weight loss after Roux-en-Y gastric bypass surgery.
Obesity surgery , 2009 Jan: 29-35
Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss.
The Journal of clinical endocrinology and metabolism , 2008 Nov: 4479-85
Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss.
The Journal of clinical endocrinology and metabolism , 2008 Jun: 2287-93
Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweight.
Clinical endocrinology , 2008 Feb: 304-10
Fetal adiponectin and resistin in correlation with birth weight difference in monozygotic twins with discordant growth.
Hormone research , 2008: 37-44
Type 2 diabetes in children and adolescents in a 2-year follow-up: insufficient adherence to diabetes centers.
Hormone research , 2008: 107-13
Adipocyte fatty acid-binding protein in obese children before and after weight loss.
Metabolism: clinical and experimental , 2007 Dec: 1735-41
Peptide YY and glucagon-like peptide-1 in morbidly obese patients before and after surgically induced weight loss.
Obesity surgery , 2007 Dec: 1571-7
Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty.
Endocrinology , 2007 Nov: 5147-61
Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis.
The Journal of clinical investigation , 2007 Aug: 2145-54
Amylin and its relation to insulin and lipids in obese children before and after weight loss.
Obesity (Silver Spring, Md.) , 2007 Aug: 2006-11
Fasting glucagon-like peptide-1 and its relation to insulin in obese children before and after weight loss.
Journal of pediatric gastroenterology and nutrition , 2007 May: 608-12
Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma.
Pediatric research , 2007 Apr: 496-501
Quantitative proteomics identifies a change in glial glutamate metabolism at the time of female puberty.
Molecular and cellular endocrinology , 2006 Jul 25: 51-9
Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins.
Journal of pediatric endocrinology & metabolism : JPEM , 2006 Jan: 3-9
Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss.
The Journal of clinical endocrinology and metabolism , 2005 Dec: 6386-91
Genes involved in the neuroendocrine control of normal puberty and abnormal puberty of central origin.
Pediatric endocrinology reviews : PER , 2005 Dec: 67-76
Rate of hypoglycaemia and insulin dosage in children during the initial therapy of type 1 diabetes mellitus.
European journal of pediatrics , 2005 Oct: 633-8
High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children.
Metabolism: clinical and experimental , 2005 Sep: 1155-61
Fetal insulin-like growth factor (IGF)-I, IGF-II, and ghrelin in association with birth weight and postnatal growth in monozygotic twins with discordant growth.
The Journal of clinical endocrinology and metabolism , 2005 Apr: 2270-4
Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity.
Pediatric diabetes , 2005 Mar: 5-12

Primary Office

Seattle Children's
OC.7.820 - Endocrinology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2640

Additional Offices

Seattle Children's Research Institute
C9S-913
1900 - 9th Ave
Seattle, WA 98101

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