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Christian L. Roth, MD

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Christian L. Roth, MD

Endocrinology, Disorders of Sex Development

On staff since October 2006

Research Center: Center for Integrative Brain Research

Overview

Board Certification(s)
General Pediatrics (Non-ABMS)
Neonatal-Perinatal (Non-ABMS)
Pediatric Endocrinology (Non-ABMS)
Medical/Professional School
Ruprechts-Karls-Universitat, Heidelberg
Residency
Pediatrics, University of Gottingen, Gottingen
Fellowship
Pediatric Endocrinology, University of Gottingen, Gottingen
Clinical Interests

Clinical Interests: Children with endocrine disorders and diabetes mellitus Research Interests: Obesity studies, including appetite-regulating peptides, factors of the metabolic syndrome, hypothalamic obesity and genetic and environmental factors involved in the onset of puberty

Research Description

My research is focused on childhood obesity, diabetes and puberty. It includes metabolic factors in body weight regulation and hypothalamic control of feeding circuits, genes involved in childhood obesity and diabetes, and post-craniopharyngioma obesity. On the field of puberty, I am working on treatment of precocious puberty and genes controllng the onset of puberty.

Research Focus Area

Biochemistry, Endocrinology / Metabolism, Diabetes

Publications

Hyperphagia: Current concepts and future directions proceedings of the 2nd international conference on hyperphagia.
Obesity (Silver Spring, Md.) , 2014 Feb: 22 Suppl 1S1-S17
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.
Nature genetics , 2014 Jan: 46(1)61-4
Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention.
BMC pediatrics , 2013 Nov 27: 13197
Glucocorticoids and insulin resistance in children with acute lymphoblastic leukemia.
Pediatric blood & cancer , 2013 Apr: 60(4)621-6
Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss.
Metabolism: clinical and experimental , 2013 Feb: 62(2)226-34
Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss.
Metabolism: clinical and experimental , 2013 Feb: 62(2)226-34
Mechanisms affecting neuroendocrine and epigenetic regulation of body weight and onset of puberty: potential implications in the child born small for gestational age (SGA).
Reviews in endocrine & metabolic disorders , 2012 Jun: 13(2)129-40
Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis.
The Journal of clinical endocrinology and metabolism , 2012 Jun: 97(6)2143-50
Functional Neuroimaging in Craniopharyngioma: A Useful Tool to Better Understand Hypothalamic Obesity?
Obesity facts , 2012 Apr 20: 5(2)243-253
Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation.
Hepatology (Baltimore, Md.) , 2012 Apr: 55(4)1103-11
Genotype-phenotype analysis in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency.
The Journal of clinical endocrinology and metabolism , 2012 Feb: 97(2)E257-67
Treatment with glucagon-like Peptide-1 agonist exendin-4 in a patient with hypothalamic obesity secondary to intracranial tumor.
Hormone research in paediatrics , 2012: 78(1)54-8
Glucagon-like peptide-1 agonist exendin-4 leads to reduction of weight and caloric intake in a rat model of hypothalamic obesity.
Hormone research in paediatrics , 2012: 78(1)47-53
Pregnancy-associated plasma protein A in obese children: relationship to markers and risk factors of atherosclerosis and members of the IGF system.
European journal of endocrinology / European Federation of Endocrine Societies , 2011 Oct: 165(4)613-22
Lack of association between apelin, insulin resistance, cardiovascular risk factors, and obesity in children: a longitudinal analysis.
Metabolism: clinical and experimental , 2011 Sep: 60(9)1349-54
Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss.
International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity , 2011 Aug: 6(3-4)236-43
Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents.
Pediatric diabetes , 2011 Jun: 12(4 Pt 2)435-41
A novel rodent model that mimics the metabolic sequelae of obese craniopharyngioma patients.
Pediatric research , 2011 Mar: 69(3)230-6
Hypothalamic obesity in patients with craniopharyngioma: profound changes of several weight regulatory circuits.
Frontiers in endocrinology , 2011: 249
Effects of methylphenidate on weight gain and food intake in hypothalamic obesity.
Frontiers in endocrinology , 2011: 278
Vitamin d deficiency in obese children and its relationship to insulin resistance and adipokines.
Journal of obesity , 2011: 2011495101
Studies of different female rat models of hypothalamic obesity.
Journal of pediatric endocrinology & metabolism : JPEM , 2011: 24(3-4)131-7
Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention.
Obesity facts , 2011: 4(1)67-75
Changes in dynamic insulin and gastrointestinal hormone secretion in obese children.
Journal of pediatric endocrinology & metabolism : JPEM , 2010 Dec: 23(12)1299-309
Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2010 May 31
Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children.
Metabolism: clinical and experimental , 2010 May 20
A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss.
International journal of obesity (2005) , 2010 May: 34(5)852-8
Appetite-Regulating Hormone Changes in Patients With Craniopharyngioma.
Obesity (Silver Spring, Md.) , 2010 Apr 8
Roles of gastrointestinal and adipose tissue peptides in childhood obesity and changes after weight loss due to lifestyle intervention.
Archives of pediatrics & adolescent medicine , 2010 Feb: 131-8
Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity.
Metabolism: clinical and experimental , 2010 Feb: 186-94
Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin sensitivity.
Journal of pediatric endocrinology & metabolism : JPEM , 2010 Jan-Feb: 101-8
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
Atherosclerosis , 2010 Jan: 208(1)183-9
Effect of moderate intake of sweeteners on metabolic health in the rat.
Physiology & behavior , 2009 Dec 7: 98(5)618-24
A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity.
Endocrine , 2009 Aug: 52-9
Ghrelin and obestatin levels in severely obese women before and after weight loss after Roux-en-Y gastric bypass surgery.
Obesity surgery , 2009 Jan: 29-35
Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss.
The Journal of clinical endocrinology and metabolism , 2008 Nov: 4479-85
TCF7L2 polymorphism rs7903146 and predisposition for type 2 diabetes mellitus in obese children.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme , 2008 Oct: 40(10)713-7
'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.
BMC medical genetics , 2008 Sep 17: 985
Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study.
PloS one , 2008 Aug 20: 3(8)e2986
Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss.
The Journal of clinical endocrinology and metabolism , 2008 Jun: 2287-93
Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweight.
Clinical endocrinology , 2008 Feb: 304-10
Type 2 diabetes in children and adolescents in a 2-year follow-up: insufficient adherence to diabetes centers.
Hormone research , 2008: 107-13
Fetal adiponectin and resistin in correlation with birth weight difference in monozygotic twins with discordant growth.
Hormone research , 2008: 37-44
Peptide YY and glucagon-like peptide-1 in morbidly obese patients before and after surgically induced weight loss.
Obesity surgery , 2007 Dec: 1571-7
Adipocyte fatty acid-binding protein in obese children before and after weight loss.
Metabolism: clinical and experimental , 2007 Dec: 1735-41
Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty.
Endocrinology , 2007 Nov: 5147-61
Amylin and its relation to insulin and lipids in obese children before and after weight loss.
Obesity (Silver Spring, Md.) , 2007 Aug: 2006-11
Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis.
The Journal of clinical investigation , 2007 Aug: 2145-54
Fasting glucagon-like peptide-1 and its relation to insulin in obese children before and after weight loss.
Journal of pediatric gastroenterology and nutrition , 2007 May: 608-12
Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma.
Pediatric research , 2007 Apr: 496-501
Shorter remission period in young versus older children with diabetes mellitus type 1.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association , 2007 Jan: 115(1)33-7
Modulation of circulating IGF-I and IGFBP-3 levels by hormonal regulators of energy homeostasis in obese children.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association , 2007 Jan: 115(1)17-23
Pancreatic polypeptide in obese children before and after weight loss.
International journal of obesity (2005) , 2006 Oct: 30(10)1476-81
Quantitative proteomics identifies a change in glial glutamate metabolism at the time of female puberty.
Molecular and cellular endocrinology , 2006 Jul 25: 51-9
Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach?
Endocrinology , 2006 Mar: 147(3)1166-74
Resistin concentrations before and after weight loss in obese children.
International journal of obesity (2005) , 2006 Feb: 30(2)297-301
Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts.
International journal of andrology , 2006 Feb: 29(1)256-63; discussion 286-90
Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins.
Journal of pediatric endocrinology & metabolism : JPEM , 2006 Jan: 3-9
Genes involved in the neuroendocrine control of normal puberty and abnormal puberty of central origin.
Pediatric endocrinology reviews : PER , 2005 Dec: 67-76
Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss.
The Journal of clinical endocrinology and metabolism , 2005 Dec: 6386-91
Rate of hypoglycaemia and insulin dosage in children during the initial therapy of type 1 diabetes mellitus.
European journal of pediatrics , 2005 Oct: 633-8
Androgens before and after weight loss in obese children.
The Journal of clinical endocrinology and metabolism , 2005 Oct: 90(10)5588-95
High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children.
Metabolism: clinical and experimental , 2005 Sep: 1155-61
Different effects of agonistic vs. antagonistic gnrh-analogues (triptorelin vs. cetrorelix) on bone modeling and remodeling in peripubertal female rats.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association , 2005 Sep: 113(8)451-6
Fetal insulin-like growth factor (IGF)-I, IGF-II, and ghrelin in association with birth weight and postnatal growth in monozygotic twins with discordant growth.
The Journal of clinical endocrinology and metabolism , 2005 Apr: 2270-4
Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents.
International journal of obesity (2005) , 2005 Apr: 29(4)362-8
Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity.
Pediatric diabetes , 2005 Mar: 5-12
Antagonistic and agonistic GnRH analogue treatment of precocious puberty: tracking gonadotropin concentrations in urine.
Hormone research , 2005: 63(5)257-62
Adiponectin before and after weight loss in obese children.
The Journal of clinical endocrinology and metabolism , 2004 Aug: 89(8)3790-4
Pituitary and gonadal effects of GnRH (gonadotropin releasing hormone) analogues in two peripubertal female rat models.
Pediatric research , 2004 Jan: 55(1)126-33
Obesity in patients with craniopharyngioma: assessment of food intake and movement counts indicating physical activity.
The Journal of clinical endocrinology and metabolism , 2003 Nov: 88(11)5227-31
Mutations in the PDS gene in German families with Pendred's syndrome: V138F is a founder mutation.
The Journal of clinical endocrinology and metabolism , 2003 Jun: 88(6)2916-21
Surfactant lavage demonstrates protein fibrils in a neonate with congenital surfactant protein b deficiency.
American journal of respiratory and critical care medicine , 2002 Nov 1: 166(9)1292-4
Therapeutic potential of GnRH antagonists in the treatment of precocious puberty.
Expert opinion on investigational drugs , 2002 Sep: 11(9)1253-9
Complete virilization in congenital adrenal hyperplasia: clinical course, medical management and disease-related complications.
Clinical endocrinology , 2002 Feb: 56(2)231-8

Primary Office

Seattle Children's
OC.7.820 - Endocrinology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2640

Additional Offices

Seattle Children's Research Institute
JMB-913
1900 - 9th Ave
Seattle, WA 98101

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