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James M. Olson, MD, PhD

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James M. Olson, MD, PhD

Hematology-Oncology

On staff since July 1999

Academic Title: Professor

Research Center: Center for Clinical and Translational Research

Overview

Board Certification(s)
Pediatric Hematology-Oncology
Medical/Professional School
University of Michigan Medical School, Ann Arbor
Residency
Pediatrics, University of Washington School of Medicine, Seattle
Fellowship
Pediatric Hematology-Oncology, University of Washington School of Medicine, Seattle
Research Description

I am principal investigator on six projects that focus on developing effective new therapies for pediatric brain tumors, methods that allow surgeons to better visualize the border of brain cancer and normal brain, the molecular mechanisms of cerebellar development and genetic-based endpoints for neuro-degenerative diseases.

A study led by my team and I showed that tumor paint is 500 times better than a standard MRI at helping surgeons distinguish between cancer cells and normal tissue. Our team developed the paint, which is currently being studied in mice models, from a scorpion-derived peptide called chlorotoxin.

Research Focus Area

Cancer

Publications

DTI fiber tracking to differentiate demyelinating diseases from diffuse brain stem glioma.
NeuroImage , 2010 Aug 1: 217-23
Environmental enrichment reduces neuronal intranuclear inclusion load but has no effect on messenger RNA expression in a mouse model of Huntington disease.
Journal of neuropathology and experimental neurology , 2010 Aug: 817-27
Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.
Molecular and cellular neurosciences , 2010 Jun: 178-89
Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method.
PloS one , 2010 Mar 4: e9536
PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection.
Advanced functional materials , 2009 Jul 24: 2244-2251
E protein dosage influences brain development more than family member identity.
Journal of neuroscience research , 2008 May 15: 1472-81
Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).
Journal of neuro-oncology , 2008 Apr: 133-41
Self-esteem differences in the effects of hypocrisy induction on behavioral intentions in the health domain.
Journal of personality , 2008 Apr: 305-22
The Smo/Smo model: hedgehog-induced medulloblastoma with 90% incidence and leptomeningeal spread.
Cancer research , 2008 Mar 15: 1768-76
Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas.
Cancer genetics and cytogenetics , 2008 Jan 1: 47-50
Relative versus absolute measures of explicit attitudes: Implications for predicting diverse attitude-relevant criteria.
Journal of personality and social psychology , 2007 Dec: 907-26
Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2007 Oct 24: 11758-68
Assessing bias in experiment design for large scale mass spectrometry-based quantitative proteomics.
Molecular & cellular proteomics : MCP , 2007 Oct: 1741-8
Tumor paint: a chlorotoxin:Cy5.5 bioconjugate for intraoperative visualization of cancer foci.
Cancer research , 2007 Jul 15: 6882-8
Better, Stronger, Faster Self-Serving Judgment, Affect Regulation, and the Optimal Vigilance Hypothesis.
Perspectives on psychological science : a journal of the Association for Psychological Science , 2007 Jun: 124-141
Conservation of regional gene expression in mouse and human brain.
PLoS genetics , 2007 Apr 20: e59
Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma.
Journal of neuro-oncology , 2006 Sep: 259-70
N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth.
Cancer research , 2006 Sep 1: 8655-61
Congenital hypothyroidism (cretinism) in neuroD2-deficient mice.
Molecular and cellular biology , 2006 Jun: 4311-5
Assessment of the relationship between pre-chip and post-chip quality measures for Affymetrix GeneChip expression data.
BMC bioinformatics , 2006 Apr 19: 211
A statistical method for predicting splice variants between two groups of samples using GeneChip expression array data.
Theoretical biology & medical modelling , 2006 Apr 7: 19
Regional and cellular gene expression changes in human Huntington's disease brain.
Human molecular genetics , 2006 Mar 15: 965-77
Regulation of thalamocortical patterning and synaptic maturation by NeuroD2.
Neuron , 2006 Mar 2: 683-95
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.
Human molecular genetics , 2006 Jan 15: 273-85
Cisplatin-based chemotherapy followed by focal, reduced-dose irradiation for pediatric primary central nervous system germinomas.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology , 2006 Jan: 36-9
Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2005 Oct 26: 9932-9
Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
Human molecular genetics , 2005 Oct 15: 3065-78
The dosage of the neuroD2 transcription factor regulates amygdala development and emotional learning.
Proceedings of the National Academy of Sciences of the United States of America , 2005 Oct 11: 14877-82
Significance testing for small microarray experiments.
Statistics in medicine , 2005 Aug 15: 2281-98
Testing the generality of the name letter effect: name initials and everyday attitudes.
Personality and social psychology bulletin , 2005 Aug: 1099-111
Gene expression in Huntington's disease skeletal muscle: a potential biomarker.
Human molecular genetics , 2005 Jul 1: 1863-76
A class of models for analyzing GeneChip gene expression analysis array data.
BMC genomics , 2005 Feb 14: 16
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas.
Cancer research , 2004 Nov 1: 7794-800
p38 MAP kinase: a convergence point in cancer therapy.
Trends in molecular medicine , 2004 Mar: 125-9
Regulation of neuroD2 expression in mouse brain.
Developmental biology , 2004 Jan 1: 234-45
Genetic heterogeneity of stably transfected cell lines revealed by expression profiling with oligonucleotide microarrays.
Journal of cellular biochemistry , 2003 Dec 1: 1068-78
BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect.
Nature medicine , 2003 Aug: 1033-8
Framing social judgment: self-ingroup comparison and perceived discrimination.
Personality and social psychology bulletin , 2003 Feb: 228-36
An analysis of empirical research on the scope of justice.
Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc , 2003: 311-23
The vulnerability of values to attack: inoculation of values and value-relevant attitudes.
Personality and social psychology bulletin , 2003 Jan: 63-75
Estimating the statistical significance of gene expression changes observed with oligonucleotide arrays.
Human molecular genetics , 2002 Sep 15: 2207-21
Evaluating test statistics to select interesting genes in microarray experiments.
Human molecular genetics , 2002 Sep 15: 2223-32
Medulloblastoma growth inhibition by hedgehog pathway blockade.
Science (New York, N.Y.) , 2002 Aug 30: 1559-61
Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain.
Human molecular genetics , 2002 Aug 15: 1911-26
Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects.
Human molecular genetics , 2002 Aug 15: 1927-37
Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.
Human molecular genetics , 2002 Aug 15: 1939-51
Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses.
Human molecular genetics , 2002 Aug 15: 1953-65
Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor.
Human molecular genetics , 2002 Aug 15: 1967-76
A regression-based method to identify differentially expressed genes in microarray time course studies and its application in an inducible Huntington's disease transgenic model.
Human molecular genetics , 2002 Aug 15: 1977-85
Prediction of central nervous system embryonal tumour outcome based on gene expression.
Nature , 2002 Jan 24: 436-42

Primary Office

Seattle Children's
MB.8.501 - Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2106

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