Profile

Michael A. Portman, MD

Michael A. Portman, MD

Cardiology

On staff since October 1992

Children's Title: Director, Pediatric Cardiovascular Research

Academic Title: Professor, Pediatrics

Research Center: Center for Developmental Therapeutics

"Unlocking the secrets of heart disease in children both at the bench and at the bedside, and then developing new diagnostic and treatment approaches is most rewarding. In that way, my work extends not only to the children I personally treat but also to those cared for by other physicians."

Michael A. Portman, MD, is director of research in the Division of Cardiology at Seattle Children’s Hospital and professor in the Department of Pediatrics at the University of Washington School of Medicine. He is attending physician at Seattle Children’s Heart Center and the Cardiology Clinic at Providence Everett Medical Center.

Portman’s research activities include pharmacological clinical trials, basic science research projects focused on cardiac metabolism in animal models and mentoring future clinical researchers. He is an editorial board member of the American Journal of Physiology — Heart and Circulatory Physiology and co-investigator for a grant on cardiovascular research training.

Recommendations

  • Desiree New Port Richey,FL 12.17.14

    Dr. Portman is an amazing doctor. He has a Heart of gold. When my brother, Brandon, was 15, He was diagnosed with Hypertrophic Cardiomyopathy also known ad HCM. When I was younger I didn't realize the difference Dr. Portman had made to all our lives.Now That I am older I have realized he gave us all a reason to smile and laugh, no matter how hard the times. My brother has had had 2 open heart surgeries and has a pacemaker. He is okay now. But still has trouble from time to time. His most recent check up. They had told him the left side of his heart is only working at 80%. So this was a set back for us all. I really want to thank Dr. Portman for always explaining things to us in a manner I even knew what was going on back then. And for giving me a chance to grow up beside my brother. I am so happy he was there for the whole family for years. I really owe him my childhood. I don't know what I would have done with out my big brother. So thank you Dr. Portman. I wish you nothing but happiness. Thank you for being such a caring and understanding man!

  • kATHY Lacey 06.01.14

    DR. Portman is literally the smartest man I have met in real life. I met him when my daughter was 7 days old and he diagnosed her with transposition of the heart. I was 23 years old and my baby was broken. I was devastated . He treated her with kindness and caring. He was very good at explaining every detail of her treatment and what exactly was going on with her. He was there through Surgery and always goes above and beyond. His decisions saved her life. My daughter will be 19 in October and is still going strong thanks to his knowledge and expertise . She is going to college in the Fall and chose a college in Seattle so we could have his knowledge and care right down the road in case anything happens. He is an honorary member of my family and we all love him for what he has done for us.

Overview

Board Certification(s)

Pediatric Cardiology
Pediatrics

Medical/Professional School

University of Cincinnati College of Medicine, Cincinnati

Fellowship

Pediatric Cardiology, Case Western Reserve University, Cleveland

Clinical Interests

Cell metabolism, biomedicine, MRI

Research Description

We also perform research in Kawasaki Disease, which is an inflammatory syndrome attacking coronary arteries in children. Our work includes drug studies in animal models, and pharmacogenomic studies in patients. We are also performing clincial trials in patients.

We study cardiac metabolism and the impact of changing substrate utilization on the heart during development and during pathological states such as heart failure and cardiopulmonary bypass. Thyroid regulation of metabolism is a primary interest. Work is translational and progresses from basic benchtop studies to mice to large animals to the bedside.

Lab URL

http://www.seattlechildrens.org/research/developmental-therapeutics/labs-programs/portman-research-group/

Research Focus Area

Cardiology

Publications

  • Kajimoto M, O'Kelly Priddy CM, Ledee DR, Xu C, Isern N, Olson AK, Portman MA
    Extracorporeal membrane oxygenation promotes long chain fatty acid oxidation in the immature swine heart in vivo.
    Journal of molecular and cellular cardiology , 2013 Sept. : 62144-52
  • Portman MA
    Kawasaki disease and soy: potential role for isoflavone interaction with Fc receptors.
    Pediatric research , 2013 Feb. : 73(2)130-4
  • Olson AK, Ledee D, Iwamoto K, Kajimoto M, O'Kelly Priddy C, Isern N, Portman MA
    C-Myc induced compensated cardiac hypertrophy increases free fatty acid utilization for the citric acid cycle.
    Journal of molecular and cellular cardiology , 2013 Feb. : 55156-64
  • Priddy CM, Kajimoto M, Ledee DR, Bouchard B, Isern N, Olson AK, Des Rosiers C, Portman MA
    Myocardial oxidative metabolism and protein synthesis during mechanical circulatory support by extracorporeal membrane oxygenation.
    American journal of physiology. Heart and circulatory physiology , 2013 Feb. 1 : 304(3)H406-14
  • Priest JR, Slee A, Olson AK, Ledee D, Morrish F, Portman MA
    Triiodothyronine supplementation and cytokines during cardiopulmonary bypass in infants and children.
    The Journal of thoracic and cardiovascular surgery , 2012 Oct. : 144(4)938-943.e2
  • Shrestha S, Wiener H, Shendre A, Kaslow RA, Wu J, Olson A, Bowles NE, Patel H, Edberg JC, Portman MA
    Role of activating FcR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.
    Circulation. Cardiovascular genetics , 2012 June : 5(3)309-16
  • Priest JR, Girirajan S, Vu TH, Olson A, Eichler EE, Portman MA
    Rare copy number variants in isolated sporadic and syndromic atrioventricular septal defects.
    American journal of medical genetics. Part A , 2012 June : 158A(6)1279-84
  • Olson AK, Bouchard B, Ning XH, Isern N, Rosiers CD, Portman MA
    Triiodothyronine increases myocardial function and pyruvate entry into the citric acid cycle after reperfusion in a model of infant cardiopulmonary bypass.
    American journal of physiology. Heart and circulatory physiology , 2012 Mar. 1 : 302(5)H1086-93
  • Buroker NE, Huang JY, Barboza J, Ledee DR, Eastman RJ Jr, Reinecke H, Ning XH, Bassuk JA, Portman MA
    The adaptor-related protein complex 2, alpha 2 subunit (AP22) gene is a peroxisome proliferator-activated receptor cardiac target gene.
    The protein journal , 2012 Jan. : 31(1)75-83
  • Shrestha S, Wiener HW, Olson AK, Edberg JC, Bowles NE, Patel H, Portman MA
    Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease.
    The Journal of allergy and clinical immunology , 2011 Sept. : 128(3)677-80
  • Choueiter NF, Olson AK, Shen DD, Portman MA
    Prospective open-label trial of etanercept as adjunctive therapy for kawasaki disease.
    The Journal of pediatrics , 2010 Dec. : 157(6)960-966.e1
  • Buroker NE, Ning XH, Zhou ZN, Li K, Cen WJ, Wu XF, Ge M, Fan LP, Zhu WZ, Portman MA, Chen SH
    Genetic associations with mountain sickness in Han and Tibetan residents at the Qinghai-Tibetan Plateau.
    Clinica chimica acta; international journal of clinical chemistry , 2010 Oct. 9 : 1466-73
  • Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM
    Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.
    Pharmacogenetics and genomics , 2010 Sept. 18
  • Portman MA, Slee A, Olson AK, Cohen G, Karl T, Tong E, Hastings L, Patel H, Reinhartz O, Mott AR, Mainwaring R, Linam J, Danzi S
    Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis.
    Circulation , 2010 Sept. 14 : S224-33
  • Hyyti OM, Ledee D, Ning XH, Ge M, Portman MA
    Aging impairs myocardial fatty acid and ketone oxidation and modifies cardiac functional and metabolic responses to insulin in mice.
    American journal of physiology. Heart and circulatory physiology , 2010 Sept. : H868-75
  • Choueiter NF, Olson AK, Shen DD, Portman MA
    Prospective Open-Label Trial of Etanercept as Adjunctive Therapy for Kawasaki Disease.
    The Journal of pediatrics , 2010 July 26
  • Olson AK, Hyyti OM, Cohen GA, Ning XH, Sadilek M, Isern N, Portman MA
    Superior cardiac function via anaplerotic pyruvate in the immature swine heart after cardiopulmonary bypass and reperfusion.
    American journal of physiology. Heart and circulatory physiology , 2008 Dec. : H2315-20
  • Portman MA
    Thyroid hormone regulation of perinatal cardiovascular function.
    Seminars in perinatology , 2008 Dec. : 419-22
  • Hyyti OM, Olson AK, Ge M, Ning XH, Buroker NE, Chung Y, Jue T, Portman MA
    Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency.
    American journal of physiology. Endocrinology and metabolism , 2008 Aug. : E420-7
  • Ning XH, Hyyti O, Ge M, Anderson DL, Portman MA
    Rapid progressive central cooling to 29 degrees C by extracorporeal circuit preserves cardiac function and hemodynamics in immature swine.
    Resuscitation , 2008 Mar. : 443-8
  • Portman MA
    Thyroid hormone regulation of heart metabolism.
    Thyroid : official journal of the American Thyroid Association , 2008 Feb. : 217-25
  • Ning XH, Chi EY, Buroker NE, Chen SH, Xu CS, Tien YT, Hyyti OM, Ge M, Portman MA
    Moderate hypothermia (30 degrees C) maintains myocardial integrity and modifies response of cell survival proteins after reperfusion.
    American journal of physiology. Heart and circulatory physiology , 2007 Oct. : H2119-28
  • Buroker NE, Young ME, Wei C, Serikawa K, Ge M, Ning XH, Portman MA
    The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart.
    American journal of physiology. Endocrinology and metabolism , 2007 Feb. : E453-60
  • Ning XH, Chen SH, Buroker NE, Xu CS, Li FR, Li SP, Song DS, Ge M, Hyyti OM, Zhang M, Portman MA
    Short-cycle hypoxia in the intact heart: hypoxia-inducible factor 1alpha signaling and the relationship to injury threshold.
    American journal of physiology. Heart and circulatory physiology , 2007 Jan. : H333-41
  • Hyyti OM, Portman MA
    Molecular mechanisms of cross-talk between thyroid hormone and peroxisome proliferator activated receptors: focus on the heart.
    Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy , 2006 Dec. : 463-9
  • Morrish F, Buroker NE, Ge M, Ning XH, Lopez-Guisa J, Hockenbery D, Portman MA
    Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA.
    Mitochondrion , 2006 June : 143-8
  • Hyyti OM, Ning XH, Buroker NE, Ge M, Portman MA
    Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms.
    American journal of physiology. Endocrinology and metabolism , 2006 Feb. : E372-9
  • McClure TD, Young ME, Taegtmeyer H, Ning XH, Buroker NE, López-Guisa J, Portman MA
    Thyroid hormone interacts with PPARalpha and PGC-1 during mitochondrial maturation in sheep heart.
    American journal of physiology. Heart and circulatory physiology , 2005 Nov. : H2258-64
  • Portman MA, Qian K, Krueger J, Ning XH
    Direct action of T3 on phosphorylation potential in the sheep heart in vivo.
    American journal of physiology. Heart and circulatory physiology , 2005 May : H2484-90
  • Danzi S, Klein I, Portman MA
    Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect.
    The American journal of cardiology , 2005 Mar. 15 : 787-9
  • Portman MA, Fearneyhough C, Karl TR, Tong E, Seidel K, Mott A, Cohen G, Tacy T, Lewin M, Permut L, Schlater M, Azakie A
    The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale.
    American heart journal , 2004 Sept. : 393-8
  • Ning XH, Chen SH, Xu CS, Hyyti OM, Qian K, Krueger JJ, Portman MA
    Hypothermia preserves myocardial function and mitochondrial protein gene expression during hypoxia.
    American journal of physiology. Heart and circulatory physiology , 2003 July : H212-9
  • Ning XH, Chen SH, Xu CS, Li L, Yao LY, Qian K, Krueger JJ, Hyyti OM, Portman MA
    Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis.
    Journal of applied physiology (Bethesda, Md. : 1985) , 2002 May : 2200-7
  • Portman MA
    The adenine nucleotide translocator: regulation and function during myocardial development and hypertrophy.
    Clinical and experimental pharmacology & physiology , 2002 Apr, : 334-8

Presentations

Presentations Title Event Location Date
Cardiology Grand Rounds University of Illinois Chicago, IL Jan. 1, 2009
Etanercept for Kawasaki Disease Annual Meeting of the Western Society of Pediatric Cardiology Yosemite CA Jan. 1, 2009

Research Funding

Grant Title Grantor Amount Award Date
Thyroid Control of Myocardial Metabolism in Aging NIH/NIA $439,000.00 April 1, 2010
Metabolism During Mechanical Circulatory Support in the Developing Heart NIH/NHLBI $1,559,000.00 July 1, 2009
Triostat in Children during Cardiopulmonary Bypass: Orphan Products Development Grant FDA April 1, 2009
Etanercept for Acute Kawasaki Disease FDA $1,600,000.00 Feb. 15, 2009
Role of Fc-gamma Receptor Polymorphisms in Determining IVIG Response in Kawasaki Disease Thrasher Foundation $388,000.00 Jan. 1, 2008
Fcr Mutations in Kawasaki Disease NIH/NHLBI $439,000.00 June 1, 2007
Cell Metabolism & Myc Induced Growth, Death, & Neoplasia NIH/NCI April 1, 2005
UW Stipends for Training Aspiring Researchers NIH/NHLBI April 1, 2004