Profile

Ghayda Mirzaa, MD

Ghayda Mirzaa, MD

Genetics, Vascular Anomalies

On staff since September 2012

Research Center: Center for Integrative Brain Research

    • Catherine Federal way WA 12.27.14

      She is a wonderful blend of knowledge, compasion, and bed side manor. She actually talks to and interacts With my son. She has also never down played my need For answers. Wonderful DR!

  • Award Name Award Description Awarded By Award Date
    Neurobiology of Disease in Children Young Investigator Award 2015
    Honorary Mention for significant contribution 34th David W. Smith Workshop on Malformations and Morphogenesis 2013
    2013 John M Opitz Young Investigator Award for best publication in 2013 by a young investigator American Journal of Medical Genetics 2013
    The Peter Duncan Fellow Award 33rd David W. Smith Workshop on Malformations and Morphogeneisis 2012
    • Di Donato N, Rump A, Mirzaa GM, Alcantara D, Oliver A, Schrock E, Dobyns WB, O'Driscoll M
      Identification and Characterization of a Novel Constitutional PIK3CA Mutation in a Child Lacking the Typical Segmental Overgrowth of "PIK3CA-Related Overgrowth Spectrum".
      26593112 Human mutation , 2016 Mar. - 2016 Mar. : 37(3)242-5 PMCID: PMC4752430
    • Di Donato N, Rump A, Mirzaa GM, Alcantara D, Oliver A, Schrock E, Dobyns WB, O'Driscoll M
      Identification and Characterization of a Novel Constitutional PIK3CA Mutation in a Child Lacking the Typical Segmental Overgrowth of "PIK3CA-Related Overgrowth Spectrum".
      26593112 Human mutation , 2016 Mar. - 2016 Mar. : 37(3)242-5 PMCID: PMC4752430
    • Jansen LA, Mirzaa GM, Ishak GE, O'Roak BJ, Hiatt JB, Roden WH, Gunter SA, Christian SL, Collins S, Adams C, Rivière JB, St-Onge J, Ojemann JG, Shendure J, Hevner RF, Dobyns WB
      PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia.
      25722288 Brain : a journal of neurology , 2015 June - 2015 June : 138(Pt 6)1613-28 PMCID: PMC4614119
    • Chen LP, Beck AE, Tsuchiya KD, Chow PM, Mirzaa GM, Wiester RT, Feldman KW
      Institutional Protocol to Manage Consanguinity Detected by Genetic Testing in Pregnancy in a Minor
      Pediatrics , 2015 PMCID: 25687148
    • Jansen LA, Mirzaa GM, Ishak GE, O'Roak BJ, Hiatt JB, Roden WH, Gunter S, Christian
      PI3K/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia
      Brain , 2015
    • Dubchak I, Balasubramanian S, Wang S, Meyden C, Sulakhe D, Poliakov A, Brnigen D
      An integrative computational approach for prioritization of genomic variants
      PLoS One , 2014 Dec. 15 : 9(12) PMCID: 25506935
    • Tokita MJ, Chow PM, Mirzaa GM, Dikow N, Maas B, Isidor B, Le Caignec C, Penney LS, Mazzotta G, Bernardini L, Filippi T, Battaglia A, Donti E, Earl D, Prontera P
      Five children with deletions of 1p34.3 encompassing AGO1 and AGO3
      Eur J Hum Genet. , 2014 Oct. PMCID: 25271087
    • AT, Clark RD, Curry CJ, Link N, Schulze KL, Boerwinkle E, Dobyns WB, Allikmets R, Gibbs RA, Chen R, Lupski JR, Wangler MF, Bellen HJ
      A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases
      Cell , 2014 Sept. 25 : 159(1)200-14 PMCID: 25259927
    • Mirzaa GM, Parry DA, Fry AE, Giamanco KA, Schwartzentruber J, Vanstone M, Logan CV, Roberts N, Johnson CA, Singh S, Kholmanskikh SS, Adams C, Hodge RD, Hevner RF, Bonthron DT, Braun KP, Faivre L, Rivière JB, St-Onge J, Gripp KW, Mancini GM, Pang K, Sweeney E, van Esch H, Verbeek N, Wieczorek D, Steinraths M, Majewski J, FORGE Canada Consortium, Boycott KM, Pilz DT, Ross ME, Dobyns WB, Sheridan EG
      De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome.
      24705253 Nature genetics , 2014 May - 2014 May : 46(5)510-5 PMCID: PMC4004933
    • Mirzaa GM, Kuzniecky R, Guerrini R.
      Malformations of cortical development and epilepsy
      Wyllies treatment of epilepsy: principles and practice (6th edition) , 2014
    • Dubchak I, Balasubramanian S, Wang S, Cem M, Sulakhe D, Poliakov A, Börnigen D, Xie B, Taylor A, Ma J, Paciorkowski AR, Mirzaa GM, Dave P, Agam G, Xu J, Al-Gazali L, Mason CE, Ross ME, Maltsev N, Gilliam TC
      An integrative computational approach for prioritization of genomic variants.
      25506935 PloS one , 2014 - 2014 : 9(12)e114903 PMCID: PMC4266634
    • Swarr DT, Khalek N, Treat J, Horton MA, Mirzaa GM, Riviere JB, Dobyns WB, Zackai EH
      Expanding the differential diagnosis of fetal hydrops: an unusual prenatal
      23754335 Prenatal Diagnosis. , 2013 Oct. : 33(10)1010-2
    • Mirzaa GM, Paciorkowski AR, Marsh ED, Berry-Kravis EM, Medne Livija, Grix A, Wirrell EC, Powell BR, Nickels KC, Burton B, Paras A, Kim K, Chung W, Dobyns WB, Das S
      CDKL5 and ARX mutations in males with early-onset epilepsy
      23583054 Pediatric Neurology , 2013 May : 48(5)367-77
    • McDonell LM, Mirzaa GM, Alcantara D, Schwartzentruber J, Carter MT, Clericuzio CL, Graham JM, Morris-Rosendahl DJ, Polster T, Acsadi G, Townshend S11, Williams S, Halbert A, Isidor B, Smyser CD, Paciorkowski AR, Willing M, Beaulieu CL, Marcadier J, Geraghty MT, FORGE Canada Consortium, Majewski J, Bulman DE, Dobyns WB, ODriscoll M, Boycott KM
      A RASopathy caused by mutations in the deubiquitinating enzyme STAMBP.
      23542699 Nature Genetics. , 2013 May : 45(5)556-62
    • Rivière JB, Mirzaa GM, O'Roak BJ, Beddaoui M, Alcantara D, Conway RL, St-Onge J, Schwartzentruber JA, Gripp KW, Nikkel SM, Worthylake T, Sullivan CT, Ward TR, Butler HE, Kramer NA, Albrecht B, Armour CM, Armstrong L, Caluseriu O, Cytrynbaum C, Drolet BA, Innes AM, Lauzon JL, Lin AE, Mancini GM, Meschino WS, Reggin JD, Saggar AK, Lerman-Sagie T, Uyanik G, Weksberg R, Zirn B, Beaulieu CL, Finding of Rare Disease Genes (FORGE) Canada Consortium, Majewski J, Bulman DE, O'Driscoll M, Shendure J, Graham JM Jr, Boycott KM, Dobyns WB
      De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
      22729224 Nature genetics , 2012 June 24 - 2012 June 24 : 44(8)934-40 PMCID: PMC3408813
    • Mirzaa G, Conway R, Graham JM Jr, Dobyns WB, Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Mefford HC, Smith RJH, Stephens K
      <i>PIK3CA</i>-Related Segmental Overgrowth
      23946963

  • Presentations Title Event Location Date
    Cardinal signs of selected syndrome: The microcephaly-chorioretinopathy-lymphedema syndrome The American College of Medical Genetics Meeting 2015
    Mutations of the phosphoinositide-3-kinase regulatory subunit PIK3R2 cause perisylvian polymicrogyria with or without megalencephaly: a paradigm for constitutional and mosaic mutations causing common malformations of cortical development 36th David W. Smith Workshops on Malformations and Morphogenesis 2015
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH): 3 genes, evidence for mosaicism, familial recurrence and genotype-phenotype analysis 35th David W. Smith Workshops on Malformations and Morphogenesis 2014
    Brain growth pathways and early life epilepsies Child Neurology Society symposium 2014
    Molecular insights into mosaic megalencephaly syndromes 34th David W. Smith Workshops on Malformations and Morphogenesis 2013
    The extremes of brain size: megalencephaly (MEG) -- new genes, new pathways, overlapping phenotypes The Pacific Northwest Neurology Exchange 2013

Overview

Board Certification(s)

Pediatrics
Clinical Genetics (MD)
Clinical Molecular Genetics

Medical/Professional School

Arabian Gulf University, Manama, Kingdom of Bahrain

Residency

Pediatrics, University of Illinois Chicago - Pediatric Dept., Chicago

Fellowship

Clinical Genetics, University of Chicago , Chicago
University of Washington, Seattle