Profile

Danielle M. Zerr, MD, MPH

Danielle M. Zerr, MD, MPH

Infectious Disease, Infectious Disease Research

On staff since July 1999

Children's Title: Division Chief; Children's Hospital Guild Association Endowed Chair in Pediatric Infectious Disease Research

Academic Title: Professor, Pediatrics

Research Center: Center for Clinical and Translational Research

"The best part of my work is helping patients with serious infections (and their families) understand their infection and the treatment options."

Danielle M. Zerr, MD, MPH; Division Chief of Pediatric Infectious Disease, Affiliate Investigator at the Fred Hutchinson Cancer Research Center, and the Medical Director of Infection Prevention at Seattle Childrens Hospital.. Dr. Zerrs research has focused on two main areas.

(1) defining the epidemiology of viral pathogens in healthy children and immunocompromised hosts and (2) describing the epidemiology and defining prevention strategies for healthcare-associated infections. Recent work includes studies aimed at defining the epidemiology of human herpesvirus 6 (HHV-6) in hematopoietic stem cell transplant recipients. In addition, Dr. Zerr collaborates with Dr. Weissman and Dr. Qin in investigating the molecular epidemiology of broad-spectrum beta-lactam resistance in pediatric Enterobacteriaceae infections. Currently, they lead a multi-center surveillance study that will result in integrative analyses of patient characteristics, bacterial phylogenetics, and molecular resistance mechanisms in order to better target prevention strategies. Dr. Zerr also leads a multicenter trial aimed at reducing healthcare-associated infections in children with cancer. She collaborates with Drs. Corey, Boeckh, Englund, and Weissman.

Overview

Board Certification(s)

Pediatrics
Pediatric Infectious Diseases

Medical/Professional School

Temple University School of Medicine, Philadelphia
University of Washington School of Public Health , Seattle

Fellowship

Pediatric Infectious Disease, University of Washington, Seattle

Clinical Interests

Viral infections in healthy children and immunocompromised hosts and healthcare associated infections

Research Description

My research focuses on the epidemiology of infectious diseases in healthy and immunocompromised hosts. A particular focus areas include human herpesvirus 6 (HHV-6) infections in immunocompromised populations. I am also interested in studying the epidemiology and prevention of healthcare-associated infections in pediatrics.

Research Focus Area

Epidemiology, Host: Pathogen Interaction

Awards and Honors

Award Name Award Description Awarded By Award Date
SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014
SEATTLE MAGAZINE TOP DOCTOR - 2014 Seattle Magazine 2014
Society of Healthcare Epidemiology of America (SHEA) Pediatric Investigator Award Society of Healthcare Epidemiology of America 2014
Richard A. Molteni Award Medical Staff Award for Professionalism and Quality Seatle Children's Hospital 2013
Seattle's Top Doc Seattle Met Magazine 2013
Seattle Magazine Top Doctor - 2013 Seattle Magazine 2013
U.S. News Top Doctor U.S. News and World Report 2012

Publications

  • Payne DC, Baggs J, Zerr DM, Klein NP, Yih K, Glanz J, Curns AT, Weintraub E, Parashar UD
    Protective Association Between Rotavirus Vaccination and Childhood Seizures in the Year Following Vaccination in US Children.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2013 Nov. 20 : 58(2)173-7
  • Weissman SJ, Adler A, Qin X, Zerr DM
    Emergence of extended-spectrum -lactam resistance among Escherichia coli at a US academic children's hospital is clonal at the sequence type level for CTX-M-15, but not for CMY-2.
    International journal of antimicrobial agents , 2013 May : ;41(5)414-20
  • Milstone AM, Elward A, Song X, Zerr DM, Orscheln R, Speck K, Obeng D, Reich NG, Coffin SE, Perl TM, Pediatric SCRUB Trial Study Group
    Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomised, crossover trial.
    Lancet , 2013 Mar. 30 : ;381(9872)1099-106
  • Zerr DM, Boeckh M, Delaney C, Martin PJ, Xie H, Adler AL, Huang ML, Corey L, Leisenring WM
    HHV-6 reactivation and associated sequelae after hematopoietic cell transplantation.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2012 Nov. : ;18(11)1700-8
  • Zerr DM
    Human herpesvirus 6 (HHV-6) disease in the setting of transplantation.
    Current opinion in infectious diseases , 2012 Aug. : ;25(4)438-44
  • Lundgren IS, Zhou C, Malone FR, McAfee NG, Gantt S, Zerr DM
    Central venous catheter repair is associated with an increased risk of bacteremia and central line-associated bloodstream infection in pediatric patients.
    The Pediatric infectious disease journal , 2012 Apr, : ;31(4)337-40
  • Soma VL, Qin X, Zhou C, Adler A, Berry JE, Zerr DM
    The effects of daily chlorhexidine bathing on cutaneous bacterial isolates: a pilot study.
    Infection and drug resistance , 2012 : 575-8
  • Zerr DM, Fann JR, Breiger D, Boeckh M, Adler AL, Xie H, Delaney C, Huang ML, Corey L, Leisenring WM
    HHV-6 reactivation and its effect on delirium and cognitive functioning in hematopoietic cell transplantation recipients.
    Blood , 2011 May 12 : ;117(19)5243-9
  • Martin ET, Kerin T, Christakis DA, Blume HK, Gospe SM Jr, Vinje J, Bowen MD, Gentsch J, Zerr DM
    Redefining outcome of first seizures by acute illness.
    Pediatrics , 2010 Dec. : ;126(6)e1477-84
  • Martin ET, Fairchok MP, Kuypers J, Magaret A, Zerr DM, Wald A, Englund JA
    Frequent and prolonged shedding of bocavirus in young children attending daycare.
    The Journal of infectious diseases , 2010 June 1 : 1625-32
  • Stempel HE, Martin ET, Kuypers J, Englund JA, Zerr DM
    Multiple viral respiratory pathogens in children with bronchiolitis.
    Acta paediatrica (Oslo, Norway : 1992) , 2009 Jan. : 123-6
  • Qin X, Zerr DM, Weissman SJ, Englund JA, Denno DM, Klein EJ, Tarr PI, Kwong J, Stapp JR, Tulloch LG, Galanakis E
    Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
    Antimicrobial agents and chemotherapy , 2008 Nov. : 3909-14
  • Adler AL, Casper C, Boeckh M, Heath J, Zerr DM
    An outbreak of varicella with likely breakthrough disease in a population of pediatric cancer patients.
    Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America , 2008 Sept. : 866-70
  • Zerr DM, Englund JA, Robertson AS, Marcuse EK, Garrison MM, Christakis DA
    Hospital-based influenza vaccination of children: an opportunity to prevent subsequent hospitalization.
    Pediatrics , 2008 Feb. : 345-8
  • Posfay-Barbe KM, Zerr DM, Pittet D
    Infection control in paediatrics.
    The Lancet infectious diseases , 2008 Jan. : 19-31
  • Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD
    Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004-2006.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2007 Nov. 1 : 1120-31
  • Rhoads MP, Magaret AS, Zerr DM
    Family saliva sharing behaviors and age of human herpesvirus-6B infection.
    The Journal of infection , 2007 June : 623-6
  • Kronman MP, Baden HP, Jeffries HE, Heath J, Cohen GA, Zerr DM
    An investigation of Aspergillus cardiac surgical site infections in 3 pediatric patients.
    American journal of infection control , 2007 June : 332-7
  • Baggett HC, Duchin JS, Shelton W, Zerr DM, Heath J, Ortega-Sanchez IR, Tiwari T
    Two nosocomial pertussis outbreaks and their associated costs - King County, Washington, 2004.
    Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America , 2007 May : 537-43
  • Goldin AB, Sawin RS, Garrison MM, Zerr DM, Christakis DA
    Aminoglycoside-based triple-antibiotic therapy versus monotherapy for children with ruptured appendicitis.
    Pediatrics , 2007 May : 905-11
  • Zerr DM
    Human herpesvirus 6 and central nervous system disease in hematopoietic cell transplantation.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2006 Dec. : S52-6
  • Zerr DM, Frenkel LM, Huang ML, Rhoads M, Nguy L, Del Beccaro MA, Corey L
    Polymerase chain reaction diagnosis of primary human herpesvirus-6 infection in the acute care setting.
    The Journal of pediatrics , 2006 Oct. : 480-5
  • Zerr DM
    Human herpesvirus 6: a clinical update.
    Herpes : the journal of the IHMF , 2006 May : 20-4
  • Zerr DM, Blume HK, Berg AT, Del Beccaro MA, Gospe SM Jr, Allpress AL, Christakis DA
    Nonfebrile illness seizures: a unique seizure category?
    Epilepsia , 2005 June : 952-5
  • Zerr DM
    Alcohol hand rub: a simple solution in search of champions.
    Archives of pediatrics & adolescent medicine , 2005 May : 502-3
  • Zerr DM, Allpress AL, Heath J, Bornemann R, Bennett E
    Decreasing hospital-associated rotavirus infection: a multidisciplinary hand hygiene campaign in a children's hospital.
    The Pediatric infectious disease journal , 2005 May : 397-403
  • Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM
    Surgical site infections after pediatric intracranial surgery for craniofacial malformations: frequency and risk factors.
    Neurosurgery , 2005 Apr, : 733-9; discussion 733-9
  • Zerr DM, Garrison MM, Allpress AL, Heath J, Christakis DA
    Infection control policies and hospital-associated infections among surgical patients: variability and associations in a multicenter pediatric setting.
    Pediatrics , 2005 Apr, : e387-92
  • Christakis DA, Cowan CA, Garrison MM, Molteni R, Marcuse E, Zerr DM
    Variation in inpatient diagnostic testing and management of bronchiolitis.
    Pediatrics , 2005 Apr, : 878-84
  • Zerr DM, Corey L, Kim HW, Huang ML, Nguy L, Boeckh M
    Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2005 Apr, 1 : 932-40
  • Benson C, Gantt S, Zerr DM, Qin X, Abe P
    Use of 16S ribosomal DNA polymerase chain reaction to identify Haemophilus influenzae type b as the etiology of pericarditis in an infant.
    The Pediatric infectious disease journal , 2005 Mar. : 287-8
  • Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads MP, Nguy L, Bornemann R, Morrow RA, Corey L
    A population-based study of primary human herpesvirus 6 infection.
    The New England journal of medicine , 2005 Feb. 24 : 768-76
  • Allpress AL, Rosenthal GL, Goodrich KM, Lupinetti FM, Zerr DM
    Risk factors for surgical site infections after pediatric cardiovascular surgery.
    The Pediatric infectious disease journal , 2004 Mar. : 231-4
  • Byington CL, Zerr DM, Taggart EW, Nguy L, Hillyard DR, Carroll KC, Corey L
    Human herpesvirus 6 infection in febrile infants ninety days of age and younger.
    The Pediatric infectious disease journal , 2002 Nov. : 996-9
  • Bornemann R, Zerr DM, Heath J, Koehler J, Grandjean M, Pallipamu R, Duchin J
    An outbreak of Salmonella serotype Saintpaul in a children's hospital.
    Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America , 2002 Nov. : 671-6
  • Zerr DM, Yeung LC, Obrigewitch RM, Huang ML, Frenkel LM, Corey L
    Case report: primary human herpesvirus-6 associated with an afebrile seizure in a 3-week-old infant.
    Journal of medical virology , 2002 Mar. : ;66(3)384-7
  • Zerr DM, Gupta D, Huang ML, Carter R, Corey L
    Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2002 Feb. 1 : ;34(3)309-17
  • Danielle M. Zerr, MD, MPH
    Providers perceptions of a state-wide immunization registry.
    American Journal of Preventative Medication , 1999 Aug. : ;17(2)147-50
  • Danielle M. Zerr, MD, MPH
    Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila.
    Journal of Neuroscience , 1990 Aug. : ;10(8)2749-2762

Presentations

Presentations Title Event Location Date
Improving Outcomes in Hospitalized Children IDWeek San Diego, CA Oct. 2015
Implementing Infection Prevention Practices in Diverse Settings IDWeek San Diego, CA Oct. 2015
Roseoloviruses in Immune Compromised Patients: Impacts and Prospects for Clinical Trials NIAID (NIH) Grand Rounds NIH Nov. 14, 2014
Thorny Issues in Infection Prevention IDWeek Philadelphia, PA Oct. 2014
Prevention and Management of Cardiovascular Device Infections IDWeek Symposium title: Surgical Device Infections in Children Philadelphia, PA Oct. 2014
Prevention and Treatment of Cardiovascular Device Infections Ron Lemire Symposium on Sepsis Seattle, WA Oct. 2014
Roseoloviruses in Immune Compromised Patients NIH Roseolovirus Workshop NIH June 2014
HHV6 encephalitis in immunocompetent and in immunocompromised hosts Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 2012 San Francisco, CA Sept. 2012
HHV-6 Disease in Transplantation: Viral Integration, Disease Manifestations and Management 49th Annual Meeting of Infectious Disease Society of America (IDSA) Boston, MA Oct. 2011
Viral Respiratory Infections Fifth Decennial International Conference on Healthcare-Associated Infections Atlanta, GA March 2010
Evidence-Based Monitoring for Viral Infections in Transplant Recipients: Who, When, What Specimen, What Assay?: HHV-6 Joint meeting of ICAAC/IDSA Washington DC Oct. 2008
Protecting children from healthcare-associated infection: How are we doing? Grand Rounds, Department of Pediatrics, Childrens Hospital Seattle, WA Nov. 2007
Human Herpesvirus 6 Infection: A System to Identify Primary Infection Institute of Translational Health Sciences Symposia: Utilizing Saliva in Translational Research University of Washington Sept. 11, 2007
HHV-6: What Does a Positive PCR Mean? Stem Cell Transplantation in Children: Current Results and Controversies San Diego, CA Jan. 2007
Human herpesvirus 6: Cradle to Transplant Recipient General Clinical Research Center: Second Annual Symposium University of Washington Sept. 2006
The clinical impact of HHV-6: beyond roseola 31st International Herpesvirus Workshop Seattle, WA July 2006
Human Herpesvirus 6 Infection in Infancy and Childhood Not All Roseola and Febrile Seizures 44th Annual Meeting of Infectious Disease Society of America (IDSA) Toronto, Ontario, Canada 2006
HHV-6, 7, and 8: From Cradle to Transplant Recipient 45th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Washington DC Dec. 2005
HHV-6 Associated CNS Dysfunction Following HSCT Grand Rounds, Department of Neurology University of Washington March 2005
HHV-6, the HCT Recipient, and Protocol 1831 Grand Rounds, Seattle Cancer Care Alliance FHCRC Dec. 2004
HHV-6 Infections in Immunocompromised Patients Pediatric Academic Societies annual national meeting San Francisco, CA 2004
HHV-6 and Central Nervous System Dysfunction in the HSCT Recipient Grand Rounds, Seattle Cancer Care Alliance FHCRC Nov. 2003
Improving Patient Safety: The Infection Control Perspective Grand Rounds, Department of Pediatrics, Childrens Hospital Seattle, WA Nov. 2002
HHV-6 Reactivation and Disease in BMT Recipients Grand Rounds, Seattle Cancer Care Alliance FHCRC Dec. 2000
Human Herpesvirus 6 and Human Herpesvirus 7 Grand Rounds, Department of Laboratory Medicine University of Washington Nov. 1999

Research Funding

Grant Title Grantor Amount Award Date
Frequency and Duration of Intestinal Carriage and Bacterial Evolution Over Time in Pediatric Patients with Resistant Enterobacteriaceae Infections Children's Research Institute/Translational Research Ignition Projects Program $50,000 Dec. 12, 2012 - Sept. 30, 2013
Impact of chlorhexidine bathing on reducing infections in children with cancer NIH/NCI $$410,000 Aug. 1, 2012 - May 31, 2017
National surveillance of emerging MDR in pediatric Enterobacteriaceae infections NIH/NIAID $437,668 July 1, 2010 - June 30, 2014
Impact of Daily Bathing with Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit Sage Products, Inc. $100,000.00 Sept. 1, 2009 - July 31, 2012
HHV-6 and CNS disease following stem cell transplant NIH/NIAID $278,321.00 Sept. 1, 2009 - June 30, 2010
National surveillance of emerging MDR in pediatric Enterobacteriaceae infections NIH/NIAID $378,005.00
Infection Control of Keyboards (ICK) Study: A Randomized, Blinded, Multi-Center Study of Ultraviolet Light Decontamination Vioguard LLC $114,000.00 June 1, 2009 - Jan. 31, 2011
Emerging MDR in pediatric Enterobacteriaceae infections CCTR Pediatric Pilot Award $20,000.00 Dec. 1, 2008 - Nov. 30, 2009
HHV-6 and CNS disease following stem cell transplant NIH/NIAID $250,000.00 July 1, 2004 - June 30, 2011
Viral Pathogens and First Time Seizures in the Setting of Illness Private Donation $60,000.00 June 30, 2003 - July 1, 2010