Profile

Brandon K. Hadland, MD, PhD

Brandon K. Hadland, MD, PhD

Hematology-Oncology

On staff since July 2012

Children's Title: Attending Physician, Pediatric Hematology/Oncology and Bone Marrow Transplant

Academic Title: Acting Instructor

"I am amazed and humbled every day by the strength and resilience of our patients and their families; they are an inspiration for us to continue the pursuit of researching novel therapies and improving clinical care. My long-term research goal is to generate new sources of blood stem cells that could one day be used to correct inherited, blood-based diseases."

  • The goal of my research is to use lessons from embryonic development to re-engineer in the lab the environmental signals that are involved in creating new blood stem cells. Such efforts may lead to ways to create new sources of blood stem cells for patients and expand them outside of the body, in order to harvest the full potential of these cells to treat cancers and inherited blood diseases.

  • Award Name Award Description Awarded By Award Date
    Hyundai Hope Scholar Hyundai Hope on Wheels Foundation 2015
    Alex's Lemonade Stand Young Investigator Award Alex's Lemonade Stand Foundation 2014
    Alpha Omega Alpha Honor Medical Society 2006
    Phi Lambda Upsilon Honorary Chemical Society 1998
    • Palpant NJ, Pabon L, Roberts M, Hadland B, Jones D, Jones C, Moon RT, Ruzzo WL, Bernstein I, Zheng Y, Murry CE
      Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes.
      26153229 Development (Cambridge, England) , 2015 Sept. 15 - 2015 Sept. 15 : 142(18)3198-209 PMCID: PMC4582173
    • Hadland BK, Varnum-Finney B, Poulos MG, Moon RT, Butler JM, Rafii S, Bernstein ID
      Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
      25866967 The Journal of clinical investigation , 2015 May - 2015 May : 125(5)2032-45 PMCID: PMC4463208
    • Doulatov S, Vo LT, Chou SS, Kim PG, Arora N, Li H, Hadland BK, Bernstein ID, Collins JJ, Zon LI, Daley GQ
      Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
      24094326 Cell stem cell , 2013 Oct. : 13(4)459-70
    • Palpant NJ, Pabon L, Rabinowitz JS, Hadland BK, Stoick-Cooper CL, Paige SL, Bernstein ID, Moon RT, Murry CE
      Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development.
      23924634 Development (Cambridge, England) , 2013 Sept. : 140(18)3799-808 PMCID: PMC3754478
    • Hadland BK, Bernstein ID
      Visualizing human ESC-derived hematopoiesis.
      23372149 Blood , 2013 Jan. : 121(5)717-8
    • Hadland BK, Longmore GD
      Erythroid-stimulating agents in cancer therapy: potential dangers and biologic mechanisms.
      19636005 Journal of clinical oncology : official journal of the American Society of Clinical Oncology , 2009 Sept. : 27(25)4217-26
    • Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R
      Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.
      17215306 Development (Cambridge, England) , 2007 Feb. : 134(3)535-44 PMCID: PMC2583343
    • Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD
      A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.
      15251982 Blood , 2004 Nov. : 104(10)3097-105
    • Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS
      Notch pathway is dispensable for adipocyte specification.
      15354292 Genesis (New York, N.Y. : 2000) , 2004 Sept. : 40(1)40-4
    • Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, Wolfe MS, Schroeter EH, Kopan R
      Gamma -secretase inhibitors repress thymocyte development.
      11416218 Proceedings of the National Academy of Sciences of the United States of America , 2001 June : 98(13)7487-91 PMCID: PMC34695
    • McFadden, C.S., R. Donahue, B.K. Hadland, R. Weston
      A molecular phylogenetic analysis of reproductive trait evolution in the soft coral genus Alcyonium
      Evolution Int J Org Evolution , 2001 : 5554-67

  • Presentations Title Event Location Date
    Differential expression profiling of hematopoietic niche endothelial cells to identify signal pathways regulating HSC genesis Progenitor Cell Biology Consortium Annual Meeting Houston, TX Oct. 2015
    Embryonic pathways to HSC development PCBC Second Annual Focused Workshop on HSC Genesis Boston, MA July 2015
    Vascular niche and Notch-mediated generation of hematopoietic stem cells from pluripotent stem cells Hyundai Hope on Wheels Thought Leaders Summit Washington, D.C. Sept. 2014
    Vascular niche specification and notch-dependent expansion of AGM-derived HSC populations in vitro International Society for Stem Cell Research Vancouver, Canada June 2014
    Tools to support and explore HSC development ex vivo PCBC First Annual Focused Workshop on HSC Genesis Boston, MA June 2014
    AGM-Derived endothelial cells and Notch ligands provide embryonic hematopoietic stem cell-supportive niches in vitro American Society of Hematology New Orleans, LA Dec. 2013
    Recreating an embryonic hematopoietic stem cell-supporting niche in vitro Progenitor Cell Biology Consortium Annual Meeting Minneapolis, MN Oct. 2013
    Activation of Notch signaling mediates ex vivo expansion of multilineage, engrafting murine hematopoietic progenitors from embryonic sources American Society of Hematology Atlanta, GA Dec. 2012
  • Grant Title Grantor Amount Award Date
    Hyundai Hope Scholar Grant Hyundai Hope on Wheels Foundation $ 2015 - 2016
    Alexs Lemonade Stand Young Investigator Award Alex's Lemonade Stand Foundation 2014 - 2016
    K12 Career Development in Pediatric and Medical Oncology NIH 2012 - 2014
    T32 CA009351 NCI: Pediatric Oncology Training Program NCI 2010 - 2012

Overview

Board Certification(s)

Pediatrics
Pediatric Hematology-Oncology

Medical/Professional School

Washington University School of Medicine, St Louis

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Hematology, University of Washington, Seattle
Hematology, University of Washington, Seattle

Clinical Interests

Stem cell transplant

Research Description

Signal pathways regulating hematopoietic stem cell development