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Russell P. Saneto, DO, PhD

Russell P. Saneto, DO, PhD

Neurology, Epilepsy, Mitochondrial Medicine

On staff since November 2001

Children's Title: Attending Physician, Neurology

Academic Title: Professor, Neurology; Adjunct Professor, Pediatrics

Research Center: Center for Clinical and Translational Research


SuzieKennewick, WA03.25.13
Dr. Saneto was our neurologist for our son's brain surgery, and we are ever so grateful to him for his part in a surgery which forever changed our son's life. We had no guarantees that our baby's functioning would improve from the surgery, but 2 days after surgery, he was looking around, smiling, and sitting up with support. Soon after that, our child who had been profoundly delayed, began to achieve developmental milestone after milestone, and now, at age 2 1/2 (just 18 months after surgery) is within normal limits in his language skills and close to normal in his gross motor skills. He still has some difficulties w/ some fine motor tasks, but has made amazing gains in every single area of development. Our son had Infantile Spasms, and his surgery was for focal cortical dysplasia, and the surgery was termed a focal cortical resection of the occipital lobe. When people look at our son today, they assume that he is a normal 2 year old, and they are completely amazed at how delayed he was, even at almost a year old. Our son can speak in 4 word utterances, saying things like, "Shut the door, Mommy", and can walk up and down stairs, go down the slide, open doors, eat with a fork and spoon, and drink from an open cup without spilling. He can also climb a ladder and go down the slide, and can put large knob puzzle pieces in a puzzle and stack 2 blocks. This is a child who could not sit up with support at 11 months, was floppy, and had poor head/neck control, and was hypotonic (low muscle tone). We praise God for doctors Saneto, Ojemann (neurosurgeon) and Novotny, and we thank God for the miracle of our baby's healing. These doctors were a complete answer to our prayer, and they were a wonderful, caring team with whom to work. They took on our son's case even though they said it might be too late (to effect a change), and that the area of seizure activity had beyond its original site. When you are facing brain surgery for your child, you feel very scared and desperate, but rest assured that Dr. Saneto and his excellent team will provide the very best outcome for your child, and will take good care of your child during surgery.
ClarissaBattle Ground, WA05.23.12
Dr. Saneto was an answer to our prayers in 2008, after searching over a year for a doctor to listen to us and to help us diagnose our daughter. She has been Dr. Saneto's patient since April 2008 and was diagnosed in October 2008 with a mitochondrial disease at the age of 22 month old. We have been very thankful for him every since! He listens and cares about what you have to say, explains things wonderfully, and really gets that we as parents should play a leading role in our child's health care.
BrandiNampa, Idaho03.20.11
I truly believe the Dr. Saneto was a God Send!!! We are dealing with Dravet Syndrome in our family, and Dr. Saneto and Seattle Children's have been wonderful every step of the way since we found them. Dr. Saneto is rare among his peers. You get the sense when you are with him that he is truly interested in what you have to say, and that he truly cares. His ability to impart information so we can truly understand is amazing... I really can not put completely into words how he has made our lives with this truly devastating disorder so much easier... Brandi
Recommend Dr. Russell Saneto


Board Certification(s)
Neurology with Special Qualifications in Child Neu
Medical/Professional School
University of Osteopathic Medicine and Health Sciences, Des Moines
Pediatrics, Cleveland Clinic Foundation, Cleveland
Child Neurology, Cleveland Clinic Foundation, Cleveland
Child Neurology, Cleveland Clinic Foundation, Cleveland
Clinical Interests

Diagnosis and treatment of mitochondrial disease, intractable seizures, epilepsy surgery candidates, neurometabolic and neurogenetic disorders

Research Focus Area

Translational Research

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Seattle's Top DocSeattle Met Magazine 2013
Best Doctors'Best Doctors is a nomination and electoral process that selects 5% of the physicians nationwide for inclusion on the Best Doctors list.Best Doctors 2009 - 2014


Dysphagia after pediatric functional hemispherectomy.
Journal of neurosurgery. Pediatrics , 2013 Nov 8
Practice patterns of mitochondrial disease physicians in North America. Part 2: treatment, care and management.
Mitochondrion , 2013 Nov: 13(6)681-7
Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
Epilepsia , 2013 Sep: 54(9)1595-604
Practice patterns of mitochondrial disease physicians in North America. Part 1: Diagnostic and clinical challenges.
Mitochondrion , 2013 Jul 26
Tissue localization during resective epilepsy surgery.
Neurosurgical focus , 2013 Jun: 34(6)E8
Clinical and molecular features of POLG-related mitochondrial disease.
Cold Spring Harbor perspectives in biology , 2013 Apr 1: 5(4)a011395
Mitochondrial disease in childhood: mtDNA encoded.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics , 2013 Apr: 10(2)199-211
Alpers-Huttenlocher syndrome.
Pediatric neurology , 2013 Mar: 48(3)167-78
Posthemispherectomy hydrocephalus: results of a comprehensive, multiinstitutional review.
Epilepsia , 2013 Feb: 54(2)383-9
Next-generation sequencing for mitochondrial diseases: a wide diagnostic spectrum.
Pediatrics international : official journal of the Japan Pediatric Society , 2012 Oct: 54(5)585-601
Epilepsy surgery after treatment of pediatric malignant brain tumors.
Seizure : the journal of the British Epilepsy Association , 2012 Oct: 21(8)624-30
Mitochondrial translational inhibitors in the pharmacopeia.
Biochimica et biophysica acta , 2012 Sep-Oct: 1819(9-10)1067-74
Current oral and non-oral routes of antiepileptic drug delivery.
Advanced drug delivery reviews , 2012 Jul: 64(10)911-8
Childhood subdural hemorrhage, macrocephaly, and coagulopathy associated with Prader-Willi syndrome: case report and review of the literature.
Pediatric neurology , 2012 Jul: 47(1)59-61
Is postresective intraoperative electrocorticography predictive of seizure outcomes in children?
Journal of neurosurgery. Pediatrics , 2012 May: 9(5)546-51
Mitochondrial electron transport chain deficiency, cardiomyopathy, and long-term cardiac transplant outcome.
Pediatric transplantation , 2012 May: 16(3)265-8
Craig AK, Sotero de Menezes M, Saneto RP
Seizure , 2012: 17-21
Mutations in Pickle orthologs cause seizures in flies, mice, and humans.
Am J Med Genetics , 2011: 138-146
Preserved interhemispheric functional connectivity in a case of corpus callosum agenesis.
Neuroradiology , 2011: (Epub ahead of print)
Illness-induced exacerbation of Leigh syndrome in a patient with the MTATP6 mutation, m. 9185 T>C.
Mitochondrion , 2010 Aug: 567-72
Polymerase gamma disease through the ages.
Developmental disabilities research reviews , 2010 Jun: 163-74
The use of neuroimaging in the diagnosis of mitochondrial disease.
Developmental disabilities research reviews , 2010 Jun: 129-35
Sensory ataxic neuropathy with dysarthria and ophthalmoparesis (SANDO) in late life due to compound heterozygous POLG mutations.
Muscle & nerve , 2010 Jun: 882-5
POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.
Seizure : the journal of the British Epilepsy Association , 2010 Apr: 140-6
Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide.
Therapeutics and clinical risk management , 2009 Apr: 271-80
Cerebral MRI abnormalities associated with vigabatrin therapy.
Epilepsia , 2009 Feb: 184-94
Neuroimaging of mitochondrial disease.
Mitochondrion , 2008 Dec: 396-413
Molecular and clinical genetics of mitochondrial diseases due to POLG mutations.
Human mutation , 2008 Sep: E150-72
The in-depth evaluation of suspected mitochondrial disease.
Molecular genetics and metabolism , 2008 May: 16-37
Localization of extratemporal seizure with noninvasive dense-array EEG. Comparison with intracranial recordings.
Pediatric neurosurgery , 2008: 474-9
Mitochondrial disease: a practical approach for primary care physicians.
Pediatrics , 2007 Dec: 1326-33
Apnea caused by mesial temporal lobe mass lesions in infants: report of 3 cases.
Journal of child neurology , 2007 Sep: 1079-83
Vagus nerve stimulation in children with mitochondrial electron transport chain deficiencies.
Mitochondrion , 2007 Jul: 279-83
Persistence of suppression-bursts in a patient with Ohtahara syndrome.
Journal of child neurology , 2007 May: 631-4
Outcome following surgery for temporal lobe epilepsy with hippocampal involvement in preadolescent children: emphasis on mesial temporal sclerosis.
Journal of neurosurgery , 2007 Mar: 205-10
Vagus nerve stimulation for intractable seizures in children.
Pediatric neurology , 2006 Nov: 323-6
Use of dexmedetomidine in awake craniotomy in adolescents: report of two cases.
Paediatric anaesthesia , 2006 Mar: 338-42
A boy with muscle weakness, hypercarbia, and the mitochondrial DNA A3243G mutation.
Journal of child neurology , 2006 Jan: 77-9
Clinical Director's Work Group: Practice patterns of mitochondrial disease physicians in North America. Part 2: Treatment, care, and management.
Mitochondrion , : 13(6)681-687

Research Funding

Grant TitleGrantorAmountAward Date
Ultragenyx trial UX007G-CL201-A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Adaptive Study to Ass ess the Safety and Efficacy of UX007 in Patients with Glucoe Transporter Type 1 Deficiency Syndrome.Ultragenyx Pharmaceuticals 2014 - 2015
A Phase 2B Randomized placebo controlled, double-blind clinical trial of EPI-743 in children with genetically confirmed Leigh syndrome.Edison Pharmaceuticals 2013 - 2015
North American Mitochondrial Disease Consortium (NAMDC): Subaward: Natural History Study of Alpers-Huttenlocher SyndromeThe National Instutue of Neurological Disorders and Stroke 2011 - 2014
Emergency use protocol for EPI-743 in acutely ill patients with congenital mitochondrial respiratory chain disease within 90 days of end-of-life care.Edison Pharmaceuticals 2011 - 2014
Developing a North American Mitochondrial Disease Consortium.The National Institute of Neurological Disorders and Stroke. $, $ 2009 - 2014
Childhood Absence Epilepsy RX, PK-PD-PharmacogeneticsThe National Institute of Neurological Disorders and Stroke $, $ 2007 - 2014

Primary Office

Seattle Children's
MB.7.420 - Neurology
4800 Sand Point Way NE
Seattle, WA 98105

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