Profile

Russell P. Saneto, DO, PhD

Russell P. Saneto, DO, PhD

Neurology, Epilepsy, Mitochondrial Medicine

On staff since November 2001

Children's Title: Attending Physician, Neurology

Academic Title: Professor, Neurology; Adjunct Professor, Pediatrics

Research Center: Center for Clinical and Translational Research

Recommendations

  • Suzie Kennewick, WA 03.25.13

    Dr. Saneto was our neurologist for our son's brain surgery, and we are ever so grateful to him for his part in a surgery which forever changed our son's life. We had no guarantees that our baby's functioning would improve from the surgery, but 2 days after surgery, he was looking around, smiling, and sitting up with support. Soon after that, our child who had been profoundly delayed, began to achieve developmental milestone after milestone, and now, at age 2 1/2 (just 18 months after surgery) is within normal limits in his language skills and close to normal in his gross motor skills. He still has some difficulties w/ some fine motor tasks, but has made amazing gains in every single area of development. Our son had Infantile Spasms, and his surgery was for focal cortical dysplasia, and the surgery was termed a focal cortical resection of the occipital lobe. When people look at our son today, they assume that he is a normal 2 year old, and they are completely amazed at how delayed he was, even at almost a year old. Our son can speak in 4 word utterances, saying things like, "Shut the door, Mommy", and can walk up and down stairs, go down the slide, open doors, eat with a fork and spoon, and drink from an open cup without spilling. He can also climb a ladder and go down the slide, and can put large knob puzzle pieces in a puzzle and stack 2 blocks. This is a child who could not sit up with support at 11 months, was floppy, and had poor head/neck control, and was hypotonic (low muscle tone). We praise God for doctors Saneto, Ojemann (neurosurgeon) and Novotny, and we thank God for the miracle of our baby's healing. These doctors were a complete answer to our prayer, and they were a wonderful, caring team with whom to work. They took on our son's case even though they said it might be too late (to effect a change), and that the area of seizure activity had beyond its original site. When you are facing brain surgery for your child, you feel very scared and desperate, but rest assured that Dr. Saneto and his excellent team will provide the very best outcome for your child, and will take good care of your child during surgery.

  • Clarissa Battle Ground, WA 05.23.12

    Dr. Saneto was an answer to our prayers in 2008, after searching over a year for a doctor to listen to us and to help us diagnose our daughter. She has been Dr. Saneto's patient since April 2008 and was diagnosed in October 2008 with a mitochondrial disease at the age of 22 month old. We have been very thankful for him every since! He listens and cares about what you have to say, explains things wonderfully, and really gets that we as parents should play a leading role in our child's health care.

  • Brandi Nampa, Idaho 03.20.11

    I truly believe the Dr. Saneto was a God Send!!! We are dealing with Dravet Syndrome in our family, and Dr. Saneto and Seattle Children's have been wonderful every step of the way since we found them. Dr. Saneto is rare among his peers. You get the sense when you are with him that he is truly interested in what you have to say, and that he truly cares. His ability to impart information so we can truly understand is amazing... I really can not put completely into words how he has made our lives with this truly devastating disorder so much easier... Brandi

Overview

Board Certification(s)

Pediatrics
Neurology with Special Qualifications in Child Neu

Medical/Professional School

University of Osteopathic Medicine and Health Sciences, Des Moines

Residency

Pediatrics, Cleveland Clinic Foundation, Cleveland

Fellowship

Child Neurology, Cleveland Clinic Foundation, Cleveland
Child Neurology, Cleveland Clinic Foundation, Cleveland

Clinical Interests

Diagnosis and treatment of mitochondrial disease, intractable seizures, epilepsy surgery candidates, neurometabolic and neurogenetic disorders

Research Focus Area

Translational Research

Awards and Honors

Award Name Award Description Awarded By Award Date
Seattle's Top Doc Seattle Met Magazine 2013
Best Doctors' Best Doctors is a nomination and electoral process that selects 5% of the physicians nationwide for inclusion on the Best Doctors list. Best Doctors 2009 - 2014

Publications

  • Buckley RT, Morgan T, Saneto RP, Barber J, Ellenbogen RG, Ojemann JG
    Dysphagia after pediatric functional hemispherectomy.
    Journal of neurosurgery. Pediatrics , 2013 Nov. 8
  • Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R, Mitochondrial Medicine Society Clinical Directors Working Group, Clinical Director's Work Group
    Practice patterns of mitochondrial disease physicians in North America. Part 2: treatment, care and management.
    Mitochondrion , 2013 Nov. : 13(6)681-7
  • Wirrell EC, Laux L, Franz DN, Sullivan J, Saneto RP, Morse RP, Devinsky O, Chugani H, Hernandez A, Hamiwka L, Mikati MA, Valencia I, Le Guern ME, Chancharme L, de Menezes MS
    Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
    Epilepsia , 2013 Sept. : 54(9)1595-604
  • Parikh S, Goldstein A, Koenig MK, Scaglia F, Enns GM, Saneto R, for the Mitochondrial Medicine Society Clinical Directors Working Group, Clinical Director's Work Group
    Practice patterns of mitochondrial disease physicians in North America. Part 1: Diagnostic and clinical challenges.
    Mitochondrion , 2013 July 26
  • Poliachik SL, Poliakov AV, Jansen LA, McDaniel SS, Wray CD, Kuratani J, Saneto RP, Ojemann JG, Novotny EJ Jr
    Tissue localization during resective epilepsy surgery.
    Neurosurgical focus , 2013 June : 34(6)E8
  • Saneto RP, Sedensky MM
    Mitochondrial disease in childhood: mtDNA encoded.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics , 2013 Apr, : 10(2)199-211
  • Stumpf JD, Saneto RP, Copeland WC
    Clinical and molecular features of POLG-related mitochondrial disease.
    Cold Spring Harbor perspectives in biology , 2013 Apr, 1 : 5(4)a011395
  • Saneto RP, Cohen BH, Copeland WC, Naviaux RK
    Alpers-Huttenlocher syndrome.
    Pediatric neurology , 2013 Mar. : 48(3)167-78
  • Lew SM, Matthews AE, Hartman AL, Haranhalli N, Post-Hemispherectomy Hydrocephalus Workgroup
    Posthemispherectomy hydrocephalus: results of a comprehensive, multiinstitutional review.
    Epilepsia , 2013 Feb. : 54(2)383-9
  • Ojemann JG, Hersonskey TY, Abeshaus S, Geyer JR, Saneto RP, Novotny EJ, Kollros P, Leary S, Holmes MD
    Epilepsy surgery after treatment of pediatric malignant brain tumors.
    Seizure : the journal of the British Epilepsy Association , 2012 Oct. : 21(8)624-30
  • Vasta V, Merritt JL 2nd, Saneto RP, Hahn SH
    Next-generation sequencing for mitochondrial diseases: a wide diagnostic spectrum.
    Pediatrics international : official journal of the Japan Pediatric Society , 2012 Oct. : 54(5)585-601
  • Cohen BH, Saneto RP
    Mitochondrial translational inhibitors in the pharmacopeia.
    Biochimica et biophysica acta , 2012 Sept. : 1819(9-10)1067-74
  • Carr RB, Khanna PC, Saneto RP
    Childhood subdural hemorrhage, macrocephaly, and coagulopathy associated with Prader-Willi syndrome: case report and review of the literature.
    Pediatric neurology , 2012 July : 47(1)59-61
  • Anderson GD, Saneto RP
    Current oral and non-oral routes of antiepileptic drug delivery.
    Advanced drug delivery reviews , 2012 July : 64(10)911-8
  • Golden AS, Law YM, Shurtleff H, Warner M, Saneto RP
    Mitochondrial electron transport chain deficiency, cardiomyopathy, and long-term cardiac transplant outcome.
    Pediatric transplantation , 2012 May : 16(3)265-8
  • Wray CD, McDaniel SS, Saneto RP, Novotny EJ Jr, Ojemann JG
    Is postresective intraoperative electrocorticography predictive of seizure outcomes in children?
    Journal of neurosurgery. Pediatrics , 2012 May : 9(5)546-51
  • Russell P. Saneto, DO, PhD
    Craig AK, Sotero de Menezes M, Saneto RP
    Seizure , 2012 : 17-21
  • Russell P. Saneto, DO, PhD
    Preserved interhemispheric functional connectivity in a case of corpus callosum agenesis.
    Neuroradiology , 2011 : (Epub ahead of print)
  • Russell P. Saneto, DO, PhD
    Mutations in Pickle orthologs cause seizures in flies, mice, and humans.
    Am J Med Genetics , 2011 : 138-146
  • Saneto RP, Singh KK
    Illness-induced exacerbation of Leigh syndrome in a patient with the MTATP6 mutation, m. 9185 T>C.
    Mitochondrion , 2010 Aug. : 567-72
  • Weiss MD, Saneto RP
    Sensory ataxic neuropathy with dysarthria and ophthalmoparesis (SANDO) in late life due to compound heterozygous POLG mutations.
    Muscle & nerve , 2010 June : 882-5
  • Friedman SD, Shaw DW, Ishak G, Gropman AL, Saneto RP
    The use of neuroimaging in the diagnosis of mitochondrial disease.
    Developmental disabilities research reviews , 2010 June : 129-35
  • Saneto RP, Naviaux RK
    Polymerase gamma disease through the ages.
    Developmental disabilities research reviews , 2010 June : 163-74
  • Saneto RP, Lee IC, Koenig MK, Bao X, Weng SW, Naviaux RK, Wong LJ
    POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.
    Seizure : the journal of the British Epilepsy Association , 2010 Apr, : 140-6
  • Saneto RP, Anderson GD
    Onset of action and seizure control in Lennox-Gaustaut syndrome: focus on rufinamide.
    Therapeutics and clinical risk management , 2009 Apr, : 271-80
  • Pearl PL, Vezina LG, Saneto RP, McCarter R, Molloy-Wells E, Heffron A, Trzcinski S, McClintock WM, Conry JA, Elling NJ, Goodkin HP, de Menezes MS, Ferri R, Gilles E, Kadom N, Gaillard WD
    Cerebral MRI abnormalities associated with vigabatrin therapy.
    Epilepsia , 2009 Feb. : 184-94
  • Saneto RP, Friedman SD, Shaw DW
    Neuroimaging of mitochondrial disease.
    Mitochondrion , 2008 Dec. : 396-413
  • Wong LJ, Naviaux RK, Brunetti-Pierri N, Zhang Q, Schmitt ES, Truong C, Milone M, Cohen BH, Wical B, Ganesh J, Basinger AA, Burton BK, Swoboda K, Gilbert DL, Vanderver A, Saneto RP, Maranda B, Arnold G, Abdenur JE, Waters PJ, Copeland WC
    Molecular and clinical genetics of mitochondrial diseases due to POLG mutations.
    Human mutation , 2008 Sept. : E150-72
  • Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darin N, Wong LJ, Cohen BH, Naviaux RK
    The in-depth evaluation of suspected mitochondrial disease.
    Molecular genetics and metabolism , 2008 May : 16-37
  • Holmes MD, Brown M, Tucker DM, Saneto RP, Miller KJ, Wig GS, Ojemann JG
    Localization of extratemporal seizure with noninvasive dense-array EEG. Comparison with intracranial recordings.
    Pediatric neurosurgery , 2008 : 474-9
  • Haas RH, Parikh S, Falk MJ, Saneto RP, Wolf NI, Darin N, Cohen BH
    Mitochondrial disease: a practical approach for primary care physicians.
    Pediatrics , 2007 Dec. : 1326-33
  • Miyagawa T, Sotero M, Avellino AM, Kuratani J, Saneto RP, Ellenbogen RG, Ojemann JG
    Apnea caused by mesial temporal lobe mass lesions in infants: report of 3 cases.
    Journal of child neurology , 2007 Sept. : 1079-83
  • Arthur TM, Saneto RP, de Menezes MS, Devinsky O, Lajoie J, Murphy PJ, Cook WB, Ojemann JG
    Vagus nerve stimulation in children with mitochondrial electron transport chain deficiencies.
    Mitochondrion , 2007 July : 279-83
  • Saneto RP, Sotero de Menezes M
    Persistence of suppression-bursts in a patient with Ohtahara syndrome.
    Journal of child neurology , 2007 May : 631-4
  • Smyth MD, Limbrick DD Jr, Ojemann JG, Zempel J, Robinson S, O'Brien DF, Saneto RP, Goyal M, Appleton RE, Mangano FT, Park TS
    Outcome following surgery for temporal lobe epilepsy with hippocampal involvement in preadolescent children: emphasis on mesial temporal sclerosis.
    Journal of neurosurgery , 2007 Mar. : 205-10
  • Saneto RP, Sotero de Menezes MA, Ojemann JG, Bournival BD, Murphy PJ, Cook WB, Avellino AM, Ellenbogen RG
    Vagus nerve stimulation for intractable seizures in children.
    Pediatric neurology , 2006 Nov. : 323-6
  • Everett LL, van Rooyen IF, Warner MH, Shurtleff HA, Saneto RP, Ojemann JG
    Use of dexmedetomidine in awake craniotomy in adolescents: report of two cases.
    Paediatric anaesthesia , 2006 Mar. : 338-42
  • Saneto RP, Bouldin A
    A boy with muscle weakness, hypercarbia, and the mitochondrial DNA A3243G mutation.
    Journal of child neurology , 2006 Jan. : 77-9
  • Russell P. Saneto, DO, PhD
    Clinical Director's Work Group: Practice patterns of mitochondrial disease physicians in North America. Part 2: Treatment, care, and management.
    Mitochondrion : 13(6)681-687

Research Funding

Grant Title Grantor Amount Award Date
Ultragenyx trial UX007G-CL201-A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Adaptive Study to Ass ess the Safety and Efficacy of UX007 in Patients with Glucoe Transporter Type 1 Deficiency Syndrome. Ultragenyx Pharmaceuticals 2014 - 2015
A Phase 2B Randomized placebo controlled, double-blind clinical trial of EPI-743 in children with genetically confirmed Leigh syndrome. Edison Pharmaceuticals 2013 - 2015
Emergency use protocol for EPI-743 in acutely ill patients with congenital mitochondrial respiratory chain disease within 90 days of end-of-life care. Edison Pharmaceuticals 2011 - 2014
North American Mitochondrial Disease Consortium (NAMDC): Subaward: Natural History Study of Alpers-Huttenlocher Syndrome The National Instutue of Neurological Disorders and Stroke 2011 - 2014
Developing a North American Mitochondrial Disease Consortium. The National Institute of Neurological Disorders and Stroke. $ 2009 - 2014
Childhood Absence Epilepsy RX, PK-PD-Pharmacogenetics The National Institute of Neurological Disorders and Stroke $ 2007 - 2014