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Richard G. James, PhD

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Richard G. James, PhD

Children's Title: Principal Investigator, Seattle Children's Research Institute, Center for Immunity and Immunotherapies

Academic Title: Assistant Professor, Dept. of Pediatrics, University of Washington

Research Center: Center for Immunity and Immunotherapies

Overview

Medical/Professional School
Harvard University, Cambridge
University of Michigan, Ann Arbor
Lab URL

http://www.seattlechildrens.org/research/immunity-and-immunotherapies/james-lab/

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
K99NHLBI 2010 - 2012
Pre-doctoral FellowshipHoward Hughes Medical Institute 1999 - 2004
Undergraduate Training GrantNational Science Foundation 1997 - 1998

Publications

Protein Kinase PKN1 Represses Wnt/-Catenin Signaling in Human Melanoma Cells.
The Journal of biological chemistry , 2013 Nov 29: 288(48)34658-70
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.
Molecular cell , 2013 May 9: 50(3)444-56
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
The Journal of clinical investigation , 2013 May 1: 123(5)2024-36
A role for Vg1/Nodal signaling in specification of the intermediate mesoderm.
Development (Cambridge, England) , 2013 Apr: 140(8)1819-29
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
The Journal of biological chemistry , 2012 Feb 24: 287(9)6539-50
Wnt/-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.
Science signaling , 2012 Jan 10: 5(206)ra3
WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling.
PloS one , 2012: 7(12)e50457
Promotion of avian endothelial cell differentiation by GATA transcription factors.
Developmental biology , 2011 May 1: 353(1)29-37
Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of -catenin signaling.
Lab on a chip , 2010 Dec 7: 10(23)3277-83
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
Science signaling , 2009 May 26: 2(72)ra25
Beta-catenin-independent Wnt pathways: signals, core proteins, and effectors.
Methods in molecular biology (Clifton, N.J.) , 2008: 468131-44
Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells.
Development (Cambridge, England) , 2006 Aug: 133(15)2995-3004
Bmp signaling promotes intermediate mesoderm gene expression in a dose-dependent, cell-autonomous and translation-dependent manner.
Developmental biology , 2005 Dec 1: 288(1)113-25
The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
Developmental biology , 2004 Jul 1: 271(1)176-89
Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2.
Arteriosclerosis, thrombosis, and vascular biology , 2003 Nov 1: 23(11)2083-9
Patterning of the avian intermediate mesoderm by lateral plate and axial tissues.
Developmental biology , 2003 Jan 1: 253(1)109-24

Presentations

Presentations TitleEventLocationDate
Integration of phosphoproteomic and siRNA screens of the Wnt/beta-catenin pathway unearth novel drug targets in melanomaAnnual Converence - American Society for Mass SpectrometryVancouver, BCMay 20, 2012
PKN1 inhibits Wnt-b-catenin signaling and is required for growth in melanomaAmerican Society for Mass Spectrometry National ConferenceVancouver, BC CanadaMay 20, 2012

Research Funding

Grant TitleGrantorAmountAward Date
In vivo role of Btk-mediated inhibition of Wnt/beta-catenin signaling during hematopoiesisNIH - NHLBIAug. 15, 2010 - May 30, 2015

Primary Office

Seattle Children's Research Institute
JMB - 7 - Immunology
1900 - 9th Ave
Seattle, WA 98101
206-987-7450

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