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Marie Bleakley, MD, PhD

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Marie Bleakley, MD, PhD

Hematology-Oncology

On staff since November 2005

Academic Title: Assistant Professor

Research Center: Center for Clinical and Translational Research

Overview

Medical/Professional School
Flinders University of South Australia, South Australia
University of Newcastle, Newcastle, NSW, Epidemiology
University of Sydney, Lidcombe NSW
Residency
Pediatrics, The Children's Hospital at Westmead, Westmead
Fellowship
Pediatric Oncology, The Children's Hospital at Westmead, Westmead
Pediatric Hematology-Oncology, Fred Hutchinson Cancer Research Center, Seattle
Research Focus Area

Cancer

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Poster Prize for Best Poster in Transplant CategoryInternational Society of Paediatric Oncology 2001
Young Investigators AwardThe New Children's Hospital Westmead 1997
Boots Prize in PsychiatryBoots 1993

Publications

Cytomegalovirus-specific T cells are primed early after cord blood transplant but fail to control virus in vivo.
Blood , 2013 Apr 4: 121(14)2796-803
Depletion of Naive T cells from Peripheral Blood Stem Cell Grafts for GVHD prevention
ASBMT meeting abstracts 2013 , 2013
NY-ESO-1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma.
Cancer , 2012 Sep 15: 118(18)4564-70
Augmentation of anti-tumor immunity by adoptive T-cell transfer after allogeneic hematopoietic stem cell transplantation.
Expert review of hematology , 2012 Aug: 5(4)409-25
HapMap SNP Scanner: an online program to mine SNPs responsible for cell phenotype.
Tissue antigens , 2012 Aug: 80(2)119-25
Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen.
Blood , 2012 Jun 7: 119(23)5492-501
Galactomannan Antigen Testing for Diagnosis of Invasive Aspergillosis in Pediatric Hematology Patients.
Journal of the Pediatric Infectious Diseases Society , 2012 Jun: 1(2)103-111
Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia.
Immunology and cell biology , 2011 Mar: 89(3)396-407
The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.
Blood , 2010 Nov 25: 116(22)4532-41
Leukemia-associated minor histocompatibility antigen discovery using T-cell clones isolated by in vitro stimulation of naive CD8+ T cells.
Blood , 2010 Jun 10: 115(23)4923-33
Development of tumor-reactive T cells after nonmyeloablative allogeneic hematopoietic stem cell transplant for chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research , 2009 Jul 15: 4759-68
Discovery of Leukemia Associated Minor Histocompatibilty Antigens Using CD8+ T cell clones Isolated By Primary In Vitro Stimulation of Nave T cells
Biology of Blood and Marrow Transplantation , 2008: 24(2)10-11
Activation-induced expression of CD137 permits detection, isolation, and expansion of the full repertoire of CD8+ T cells responding to antigen without requiring knowledge of epitope specificities.
Blood , 2007 Jul 1: 201-10
Role of prospective screening of blood for invasive aspergillosis by polymerase chain reaction in febrile neutropenic recipients of haematopoietic stem cell transplants and patients with acute leukaemia.
British journal of haematology , 2006 Feb: 132(4)478-86
Adoptive transfer of allogeneic antigen-specific T cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2006 Jan: 9-12
IL-21 influences the frequency, phenotype, and affinity of the antigen-specific CD8 T cell response.
Journal of immunology (Baltimore, Md. : 1950) , 2005 Aug 15: 2261-9
Unrelated cord blood transplant as salvage following non-engraftment of unrelated marrow transplant?
Bone marrow transplantation , 2004 Aug: 34(3)275-6
Molecules and mechanisms of the graft-versus-leukaemia effect.
Nature reviews. Cancer , 2004 May: 371-80
CD34 selection for bone marrow transplants for children with genetic diseases.
Bone marrow transplantation , 2004 Feb: 33(3)351; author reply 353
Growth and development of the pediatric recipient
Clinical Bone Marrow and Blood Stem Cell Transplantation , 2004: 3rd ed.1357-73
Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation.
Bone marrow transplantation , 2003 Mar: 31(6)481-6
Allogeneic bone marrow transplantation for childhood relapsed acute lymphoblastic leukemia: comparison of outcome in patients with and without a matched family donor.
Bone marrow transplantation , 2002 Jul: 30(1)1-7
Safety of early immunization against measles/mumps/rubella after bone marrow transplantation.
Blood , 2002 May 1: 3486
Bone marrow transplantation for paediatric AML in first remission: a systematic review and meta-analysis.
Bone marrow transplantation , 2002 May: 29(10)843-52
Searching for a cord blood unit for transplantation based on the unit's cell count.
Bone marrow transplantation , 2000 Sep: 26(5)585-6
Systemic inflammatory response syndrome associated with amifostine.
Medical and pediatric oncology , 2000 Apr: 34(4)309-10

Research Funding

Grant TitleGrantorAmountAward Date
Hope GrantHyundaiSept. 2012 - Dec. 2014
Damon Runyon Clinical Investigator AwardJuly 2011 - June 2014
Career Development Award Paul Calabresi (NCI K12 CA079630)July 2010 - July 2011
Special Fellow in Clinical Research Award Leukemia and Lymphoma SocietyJuly 2008 - June 2010
Millennium New Investigator Award American Society of Bone Marrow Transplant 2008 - 2010
FellowshipLeukemia and Lymphoma Society of AmericaJuly 2005 - June 2008

Primary Office

Fred Hutchinson Cancer Research Center
FHCRC Box 358080 - MS D3-100
PO Box 19024
Seattle, WA 98109-1024
206-667-6770

Additional Offices

Seattle Children's
MB.8.501 - Hematology-Oncology
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2106

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