Erin E Crotty, MD

Erin E Crotty, MD

Specialties

  • Children's Title: Attending Physician, Pediatric Hematology, Oncology, Bone Marrow Transplant, and Cellular Therapy
  • Academic Title: Assistant Professor, Department of Pediatrics, University of Washington School of Medicine
  • Research Center: Ben Towne Center for Childhood Cancer Research
  • On Staff Since: July 2020
"“Caring for young patients with challenging diagnoses is a privilege and I’m committed to treating not only the tumor but supporting the whole child or young adult and the community of family and friends routing for them. I’m lucky to work with a multidisciplinary team of clinical scientists and research leaders who work to bring innovative therapies from the lab directly to the patient.”"

  • Biography

    Erin Crotty, M.D. is an attending physician and pediatric oncologist in the Brain Tumor Program at Seattle Children's Hospital and Assistant Professor at the University of Washington School of Medicine. She cares for children and young adults with brain and spinal cord tumors, and is the clinical oncology lead for the Retinoblastoma Program. She is involved locally and internationally in early phase clinical trials for children with brain tumors and serves as site Principal Investigator for the Pacific Pediatric Neuro-oncology Consortium (PNOC). Her clinical research focus is dedicated to bringing new therapies, including immunotherapies, and precision medicine approaches, to young patients with difficult-to-treat central nervous system tumors. She is a member of the Collaborative Network for Neuro-oncology Clinical Trials (CONNECT) Immunotherapy Working Group and the Consortium for Pediatric Cellular Immunotherapy (CPCI) Pediatric CNS Working Group.

     

    Dr. Crotty completed her pediatric residency training at Children's National Medical Center in Washington, D.C. and returned home to the west coast for her hematology/oncology fellowship at Seattle Children's Hospital/University of Washington, where she completed additional translational research training in the laboratory of James Olson, M.D.,Ph.D. at the Fred Hutchinson Cancer Research Center, studying novel protein therapeutics.

    Dr. Crotty moderates Seattle Children’s weekly Brain Tumor Board, a platform for multidisciplinary review of patient cases offering tailored advice to providers and families on personalized treatment options and innovative clinical trials.

    Board Certification(s)

    Pediatric Hematology-Oncology
    Pediatrics

    Education

    George Washington University School of Medicine & Health Sciences, Washington, DC

    Residency

    Children's National Medical Center, Washington, DC

    Fellowship

    University of Washington School of Medicine, Seattle, WA

    Clinical Interests

    Brain and spinal cord tumors of childhood; high-grade glioma (HGG), diffuse intrinsic pontine glioma (DIPG); diffuse midline glioma (DMG); medulloblastoma, ependymoma, atypical teratoid rhabdoid tumor (ATRT); CAR T cell immunotherapy; early phase clinical trials; retinoblastoma

    Research Description

    Dr. Crotty's research interests include immuno-oncology and precision medicine approaches for children with brain and spinal cord tumors. Dr. Crotty is particularly interested in the translation of promising therapies from the lab bench into innovative clinical trials for patients. She collaborates with international cancer consortium members in the design and implementation of clinical trials. 

    Dr. Crotty's prior work in the Olson Laboratory at the Fred Hutchinson Cancer Center (now located at Seattle Children's Research Institute) studying immunotherapy approaches for medulloblastoma provided the preclinical foundation for an upcoming international CONNECT Phase I clinical trial, which she will lead as co-Principal Investigator.

    In 2022, she was awarded the Children's Cancer Research Fund Emerging Scientist Award to study a liquid biopsy platform using cell-free DNA from children with brain tumors. This new test is designed to detect disease left over after treatment in the cerebrospinal fluid (CSF). For children with central nervous system tumors, this platform has the potential to transform clinical care by improving outcomes and reducing toxicity. 

    Research Focus Area

    Cancer biology, Immunotherapy, CAR-T cells, cell-free DNA, liquid biopsy, CSF biomarkers, DIPG, DMG, ATRT, CAR T cell therapy, epigenetics, early phase clinical trials

  • Related Resources

    • The Olson Lab

      The Olson lab identifies, prioritizes, and advances therapeutics into clinical trials for children with brain cancer, with increasing focus on types of brain tumors that are uncommon and have the greatest need for translational research.

    • Retinoblastoma Program

      Learn about treatment options for retinoblastoma, cancer in the lining of the eye. At Seattle Children’s, your child will get care from a team of specialists experienced in treating retinoblastoma. We provide the most advanced treatments in our region, including intra-arterial chemotherapy.

  • Patient Testimonials

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  • Awards and Honors

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  • Publications

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  • Clinical Trials and Research Studies

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