Center for Respiratory Biology and Therapeutics
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Projects

Altered hyaluronan deposition by bronchial epithelial cells contributes to inflammation during respiratory syncytial virus infection

In this project, we use primary differentiated human bronchial epithelial cells (BECs) to investigate the role of heavy chain hyaluronan (HC-HA) and tumor necrosis factor stimulated gene 6 (TSG-6) in establishing a proinflammatory extracellular matrix that promotes airway inflammation during RSV.

Developing an ex-vivo organotypic co-culture system to model airway epithelial cell-chondrocyte interactions during tracheal development

We are collaborating with the Eldredge Lab to establish a novel model of ex vivo tracheal development using primary organotypic human airway epithelial cells grown in co-culture with chondrocyte organoids established from primary mesenchymal stem cells.

Seattle Children’s complies with applicable federal and other civil rights laws and does not discriminate, exclude people or treat them differently based on race, color, religion (creed), sex, gender identity or expression, sexual orientation, national origin (ancestry), age, disability, or any other status protected by applicable federal, state or local law. Financial assistance for medically necessary services is based on family income and hospital resources and is provided to children under age 21 whose primary residence is in Washington, Alaska, Montana or Idaho.