Selected Publications
Listed below is a selection of recent publications from the Kappe Lab.
Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. Mikolajczak SA, Vaughan AM, Kangwanrangsan N, …, Kappe SH. Cell Host Microbe. 2015 Apr 8;17(4):526-35.
A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion. Mikolajczak SA, Lakshmanan V, Fishbaugher M, Camargo N, Harupa A, Kaushansky A, Douglass AN, Baldwin M, Healer J, O'Neill M, Phuong T, Cowman A, Kappe SH. Mol Ther. 2014 Sep;22(9):1707-15.
Interferon-mediated innate immune responses against malaria parasite liver stages. Miller JL, Sack BK, Baldwin M, Vaughan AM, Kappe SH Cell Rep. 2014 Apr 24;7(2):436-47.
First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers. Spring M, Murphy J, Nielsen R, … Kappe SH Vaccine. 2013 Oct 9;31(43):4975-83.
Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility. Lindner SE, Mikolajczak SA, Vaughan AM, Moon W, Joyce BR, Sullivan WJ Jr, Kappe SH. Cell Microbiol. 2013 Jul;15(7):1266-83
Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. Vaughan AM, Mikolajczak SA, Wilson EM, Grompe M, Kaushansky A, Camargo N, Bial J, Ploss A, Kappe SH. J Clin Invest. 2012 Oct;122(10):3618-28.
Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. Cell Host Microbe. 2011 Jun 16;9(6):451-62
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM, Aly AS, Cowman AF, Kappe SH. Cell Microbiol. 2009 Mar;11(3):506-20
Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection. Aly AS, Mikolajczak SA, Rivera HS, Camargo N, Jacobs-Lorena V, Labaied M, Coppens I, Kappe SH. Mol Microbiol. 2008 Jul;69(1):152-63