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Shaun W. Jackson, MB ChB, MD

Shaun W. Jackson, MB ChB, MD

Nephrology, Rheumatology, Nephrology Research

On staff since July 2012

Academic Title: Acting Assistant Professor

Research Center: Center for Immunity and Immunotherapies


willYakima, Wa08.29.12
Dr. Jackson has been instrumental in our daughter recovey and maintenance of her illness. He is personable and does a thorough job on making sure our questions are answered and we understand all the medical jargon and research. Lastly, he is a friendly and compassionate person.
Recommend Dr. Shaun Jackson


Board Certification(s)
Medical/Professional School
University of Cape Town, Rodebosch, Cape Town
University of Cape Town, Rodebosch, Cape Town
Pediatrics, Boston Children's Hospital, Boston
Nephrology, University of Washington/Seattle Children's Hospital, Seattle
Rheumatology, University of Washington/Seattle Children's Hospital, Seattle
Clinical Interests

My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis.

Research Description

My research interests in the laboratory relate to basic cellular mechanisms that underlie B cell mediated autoimmunity. In particular, we study the why B cells break tolerance and develop reactivity to self in systemic autoimmune disease, for example in systemic lupus erythematosus (SLE). In addition, as accelerated cardiovascular disease is a major cause of morbidity in patients with autoimmune diseases, including SLE and rheumatoid arthritis, we are studying the B cells mechanisms responsible for accelerated atherosclerosis in autoimmune settings.

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Outstanding Presentation AwardSeattle Childrens Fellow and Resident Research DayApril 2012
Fellow teaching awardSeattle Children's HospitalJune 2009
Best oral presentation, Young Investigator Award SessionAsia Pacific Association for the Study of the LiverFeb. 2004
University Gold MedalFor the most distinguished student in the graduating MBChB classUniversity of Cape TownDec. 2001


Integration of B cell responses through Toll-like receptors and antigen receptors.
Nature reviews. Immunology , 2012 Mar 16: 12(4)282-94
Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
Journal of immunology (Baltimore, Md. : 1950) , 2012 Mar 1: 188(5)2065-9
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
The Journal of experimental medicine , 2011 Sep 26: 208(10)2033-42
Hypernatremia, Hyponatremia, Hyperkalemia, Hypokalemia, Renal Tubular Acidosis
POCKET PEDIATRICS, 2nd edition , 2009
Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice.
The American journal of pathology , 2007 Oct: 171(4)1395-404


Presentations TitleEventLocationDate
Marginal zone defects in Wiskott-Aldrich syndrome are dependent on B cell intrinsic TLR signals.Federation of Clinical Immunology Societies meeting (FOCIS 2012)Vancouver, BCJune 2012
Renal transplantation from a donor with undiagnosed Class V lupus nephritis demonstrates prolonged histopathologic features of lupus nephritis despite absence of SLE in recipients.Pediatric Rheumatology Symposium (PRSyM)Miami, FLJune 2011
Disordered Liver Regeneration and Defective Angiogenesis in NTPDase1/Cd39-Null Mice.Young Investigator Award Session. Asia Pacific Association for the Study of the LiverDelhi, India 2004
Decreased activity of endothelial V3 integrin in the Cd39-null mouse is associated with defective tumor angiogenesis. 4th International Symposium of Nucleosides and Nucleotides.Purines 2004Chapel Hill, NC 2004

Research Funding

Grant TitleGrantorAmountAward Date
ACR REF Rheumatology Scientist Development AwardAmerican College of Rheumatology $$50,000-$75,000/yearJuly 1, 2012 - June 30, 2014
University of Washington Child Health Research Center (CHRC) NIH $$85,000/yearJuly 1, 2012 - June 30, 2014

Primary Office

Seattle Children's
OC.9.820 - Nephrology
4800 Sand Point Way NE
Seattle, WA 98105

Additional Offices

Seattle Children's
MA.7.110 - Rheumatology
4800 Sand Point Way NE
Seattle, WA 98105

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