Shaun W Jackson, MD, PhD
Specialties
- Academic Title: Associate Professor
- Research Title: Principal Investigator
- Research Center: Center for Immunity and Immunotherapies
- On Staff Since: July 2012
"My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis."
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Biography
Shaun Jackson, MD, PhD, is an attending physician in Pediatric Nephrology and Pediatric Rheumatology at Seattle Children's Hospital and an Associate Professor of Pediatrics of Pediatrics at the University of Washington School of Medicine. After receiving his medical degree from the University of Cape Town in South Africa, he undertook post-doctoral studies in vascular biology at Harvard Medical School and completed pediatric residency training at Boston Children's Hospital. He completed dual pediatric nephrology and rheumatology fellowship training at Seattle Children's Hospital / University of Washington.
Dr. Jackson’s research aims to improve our understanding of the immune pathogenesis of human autoimmune diseases, in particular the role for B cells in Systemic Lupus Erythematosus (SLE). His research has resulted in a number of new insights into the B cell-intrinsic signals underlying lupus pathogenesis and has lent support to an emerging paradigm of humoral autoimmunity in which B cells orchestrate initial breaks in immune tolerance.
Board Certification(s)
Pediatric Rheumatology
Pediatric Nephrology
Education
University of Cape Town, Observatory, Cape Town
Fellowship
University of Washington School of Medicine, Seattle, WA
Clinical Interests
My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis.
Research Description
My research interests in the laboratory relate to basic cellular mechanisms that underlie B cell mediated autoimmunity. In particular, we study the why B cells break tolerance and develop reactivity to self in systemic autoimmune disease, for example in systemic lupus erythematosus (SLE). In addition, as accelerated cardiovascular disease is a major cause of morbidity in patients with autoimmune diseases, including SLE and rheumatoid arthritis, we are studying the B cells mechanisms responsible for accelerated atherosclerosis in autoimmune settings.
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Related Resources
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Shaun W Jackson, MD, PhD Researcher Profile
View the Seattle Children's Research Institute profile of Shaun W Jackson, MD, PhD including their publications and grants.
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The Jackson Lab studies the immune mechanisms underlying the development of systemic autoimmune diseases, focusing in particular on the role of B cells in systemic lupus erythematosus (SLE). The lab uses various chimeric and genetic knock-in murine strains to model the biology of human autoimmune diseases.
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Patient Testimonials
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Awards and Honors
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Publications
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Presentations
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Research Funding
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Clinical Trials and Research Studies
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