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Shaun W. Jackson, MB ChB, MD

On staff since July 2012

Academic Title: Acting Assistant Professor

Research Center: Center for Immunity and Immunotherapies

Shaun Jackson, MD, PhD, is an attending physician in Pediatric Nephrology and Pediatric Rheumatology at Seattle Childrens Hospital and an Acting Assistant Professor of Pediatrics at the University of Washington School of Medicine. After receiving his medical degree from the University of Cape Town in South Africa, he undertook post-doctoral studies in vascular biology at Harvard Medical School and completed pediatric residency training at Boston Children's Hospital. He completed dual pediatric nephrology and rheumatology fellowship training at Seattle Childrens Hospital / University of Washington.

During his fellowship, Dr Jackson worked in the B cell immunology laboratory of Dr. David Rawlings at Seattle Childrens Research Institute. His research in the laboratory is focused on two broad areas. First, he studies the mechanisms responsible for breaking B cell tolerance during the development of autoimmunity. Second, he has developed an interest in B cell-mediated acceleration of atherosclerosis in autoimmune disease.

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willYakima, Wa08.29.12

Dr. Jackson has been instrumental in our daughter recovey and maintenance of her illness. He is personable and does a thorough job on making sure our questions are answered and we understand all the medical jargon and research. Lastly, he is a friendly and compassionate person.

Recommend Dr. Shaun Jackson

Overview
Awards and Honors
Publications
Presentations
Research Funding

Overview

Board Certification(s): Pediatrics
Medical/Professional School: University of Cape Town, Rodebosch, Cape Town
University of Cape Town, Rodebosch, Cape Town
Residency: Pediatrics, Boston Children's Hospital, Boston
Fellowship: Nephrology, University of Washington/Seattle Children's Hospital, Seattle
Rheumatology, University of Washington/Seattle Children's Hospital, Seattle
Clinical Interests: My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis.
Research Description: My research interests in the laboratory relate to basic cellular mechanisms that underlie B cell mediated autoimmunity. In particular, we study the why B cells break tolerance and develop reactivity to self in systemic autoimmune disease, for example in systemic lupus erythematosus (SLE). In addition, as accelerated cardiovascular disease is a major cause of morbidity in patients with autoimmune diseases, including SLE and rheumatoid arthritis, we are studying the B cells mechanisms responsible for accelerated atherosclerosis in autoimmune settings.

Awards and Honors

Award Name	Award Description	Awarded By	Award Date
Outstanding Presentation Award		Seattle Childrens Fellow and Resident Research Day	April 2012
Fellow teaching award		Seattle Children's Hospital	June 2009
Best oral presentation, Young Investigator Award Session		Asia Pacific Association for the Study of the Liver	Feb. 2004
University Gold Medal	For the most distinguished student in the graduating MBChB class	University of Cape Town	Dec. 2001

Publications

Integration of B cell responses through Toll-like receptors and antigen receptors.
Nature reviews. Immunology , 2012 Mar 16: 12(4)282-94

Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
Journal of immunology (Baltimore, Md. : 1950) , 2012 Mar 1: 188(5)2065-9

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
The Journal of experimental medicine , 2011 Sep 26: 208(10)2033-42

Hypernatremia, Hyponatremia, Hyperkalemia, Hypokalemia, Renal Tubular Acidosis
POCKET PEDIATRICS, 2nd edition , 2009

Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice.
The American journal of pathology , 2007 Oct: 171(4)1395-404

Presentations

Presentations Title	Event	Location	Date
Marginal zone defects in Wiskott-Aldrich syndrome are dependent on B cell intrinsic TLR signals.	Federation of Clinical Immunology Societies meeting (FOCIS 2012)	Vancouver, BC	June 2012
Renal transplantation from a donor with undiagnosed Class V lupus nephritis demonstrates prolonged histopathologic features of lupus nephritis despite absence of SLE in recipients.	Pediatric Rheumatology Symposium (PRSyM)	Miami, FL	June 2011
Disordered Liver Regeneration and Defective Angiogenesis in NTPDase1/Cd39-Null Mice.	Young Investigator Award Session. Asia Pacific Association for the Study of the Liver	Delhi, India	2004
Decreased activity of endothelial V3 integrin in the Cd39-null mouse is associated with defective tumor angiogenesis.	4th International Symposium of Nucleosides and Nucleotides.Purines 2004	Chapel Hill, NC	2004

Research Funding

Grant Title	Grantor	Amount	Award Date
ACR REF Rheumatology Scientist Development Award	American College of Rheumatology	$$50,000-$75,000/year	July 1, 2012 - June 30, 2014
University of Washington Child Health Research Center (CHRC)	NIH	$$85,000/year	July 1, 2012 - June 30, 2014

Primary Office

Seattle Children's

OC.9.820 - Nephrology
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2524

Additional Offices

Seattle Children's

MA.7.110 - Rheumatology
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2057

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Shaun W. Jackson, MB ChB, MD

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