Profile

Margaret Rosenfeld, MD, MPH

Margaret Rosenfeld, MD, MPH

Pulmonary and Sleep Medicine, Cystic Fibrosis Research

On staff since May 1995

Children's Title: Director, Clinical Research Scholars Program; Associate Director, Center for Clinical and Translational Research

Academic Title: Professor, Department of Pediatrics

Research Center: Center for Clinical and Translational Research

Margaret Rosenfeld, MD, MPH, is attending physician at Seattle Childrens Hospital and Professor in the Department of Pediatrics at the University of Washington School of Medicine. Her clinical interests focus on the diagnosis and management of respiratory illnesses in children of all ages. Her research program focuses on the assessment and treatment of early cystic fibrosis (CF) lung disease, including infant and preschool lung function tests, determining risk factors for early acquisition of Pseudomonas aeruginosa and clinical trials in infants with CF.

She is also an investigator in a national network investigating rare disorders of mucociliary clearance, including primary ciliary dyskinesia. She is director of the Clinical Research Scholars Program, codirector of the Seattle Childrens Fellows College. She serves as CF consultant to the Washington State Newborn Screening Program.

Making A Difference

  • Making the Smartphone Smarter

    A novel mobile phone app being developed at Seattle Children’s and the University of Washington may transform care for patients with chronic lung diseases. ... cont.

Recommendations

  • Ellisa Chehalis, WA 03.21.11

    We first saw Dr. Rosenfeld when our child was very young, around 4 months old. We were seeing her to determine if our child had PCD. She was very caring, thourough, and was willing to sit and answer all our questions as long as we needed. She has continued caring for our child, who is now 2. We are so greatful to have such a knowledgable Doctor taking care of our child and helping us prevent future health problems and research this rare pulmonary disorder. We highly recommend her. Ellisa Alderson

Overview

Board Certification(s)

Pediatric Pulmonology

Medical/Professional School

Harvard Medical School, Boston
University of Washington, Seattle

Clinical Interests

Early lung disease in cystic fibrosis, Cystic fibrosis epidemiology

Research Description

Clinical and epidemiologic research in cystic fibrosis (CF), emphasizing early CF lung disease. Development of outcome measures for clinical trials in young CF patients, including infant and preschool lung function tests.

Research Focus Area

Therapeutic Trials

Awards and Honors

Award Name Award Description Awarded By Award Date
Finalist, UW School of Medicine Mentoring Award 2013
Finalist, UW School of Medicine Mentoring Award 2010
Physician Scientist Fellowship Award Glaxo Corporation 1993
Leroy Matthews Physician Scientist Award Cystic Fibrosis Foundation 1992 - 1998

Publications

  • Stanojevic S, Stocks J, Bountziouka V, Aurora P, Kirkby J, Bourke S, Carr SB, Gunn E, Prasad A, Rosenfeld M, Bilton D
    The impact of switching to the new global lung function initiative equations on spirometry results in the UK CF Registry.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2013 Dec. 12
  • Rosenfeld M, Farrell PM, Kloster M, Swanson JO, Vu T, Brumback L, Acton JD, Castile RG, Colin AA, Conrad CK, Hart MA, Kerby GS, Hiatt PW, Mogayzel PJ, Johnson RC, Davis SD
    Association of lung function, chest radiographs and clinical features in infants with cystic fibrosis.
    The European respiratory journal , 2013 Dec. : 42(6)1545-52
  • Leigh MW, Hazucha MJ, Chawla KK, Baker BR, Shapiro AJ, Brown DE, Lavange LM, Horton BJ, Qaqish B, Carson JL, Davis SD, Dell SD, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Rosenfeld M, Milla C, Lee HS, Krischer J, Zariwala MA, Knowles MR
    Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia.
    Annals of the American Thoracic Society , 2013 Dec. : 10(6)574-81
  • Bakker EM, Borsboom GJ, van der Wiel-Kooij EC, Caudri D, Rosenfeld M, Tiddens HA
    Small airway involvement in cystic fibrosis lung disease: routine spirometry as an early and sensitive marker.
    Pediatric pulmonology , 2013 Nov. : 48(11)1081-8
  • Austin-Tse C, Halbritter J, Zariwala MA, Gilberti RM, Gee HY, Hellman N, Pathak N, Liu Y, Panizzi JR, Patel-King RS, Tritschler D, Bower R, O'Toole E, Porath JD, Hurd TW, Chaki M, Diaz KA, Kohl S, Lovric S, Hwang DY, Braun DA, Schueler M, Airik R, Otto EA, Leigh MW, Noone PG, Carson JL, Davis SD, Pittman JE, Ferkol TW, Atkinson JJ, Olivier KN, Sagel SD, Dell SD, Rosenfeld M, Milla CE, Loges NT, Omran H, Porter ME, King SM, Knowles MR, Drummond IA, Hildebrandt F
    Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.
    American journal of human genetics , 2013 Oct. 3 : 93(4)672-86
  • Mayer-Hamblett N, Rosenfeld M, Treggiari MM, Konstan MW, Retsch-Bogart G, Morgan W, Wagener J, Gibson RL, Khan U, Emerson J, Thompson V, Elkin EP, Ramsey BW, EPIC, ESCF Investigators
    Standard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis.
    Pediatric pulmonology , 2013 Oct. : 48(10)943-53
  • Ren CL, Konstan MW, Rosenfeld M, Pasta DJ, Millar SJ, Morgan WJ, for the Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis
    Early childhood wheezing is associated with lower lung function in cystic fibrosis.
    Pediatric pulmonology , 2013 Oct. 1
  • Morgan WJ, Wagener JS, Yegin A, Pasta DJ, Millar SJ, Konstan MW, Scientific Advisory Group, investigators, coordinators of the Epidemiologic Study of Cystic Fibrosis
    Probability of treatment following acute decline in lung function in children with cystic fibrosis is related to baseline pulmonary function.
    The Journal of pediatrics , 2013 Oct. : 163(4)1152-7.e2
  • Psoter KJ, Rosenfeld M
    Opportunities and pitfalls of registry data for clinical research.
    Paediatric respiratory reviews , 2013 Sept. : 14(3)141-5
  • Loeve M, Krestin GP, Rosenfeld M, de Bruijne M, Stick SM, Tiddens HA
    Chest computed tomography: a validated surrogate endpoint of cystic fibrosis lung disease?
    The European respiratory journal , 2013 Sept. : 42(3)844-57
  • Mayer-Hamblett N, Saiman L, Lands LC, Anstead M, Rosenfeld M, Kloster M, Fisher L, Ratjen F
    Impact of acute antibiotic therapy on the pulmonary exacerbation endpoint in cystic fibrosis clinical trials.
    Contemporary clinical trials , 2013 Sept. : 36(1)99-105
  • Subbarao P, Stanojevic S, Brown M, Jensen R, Rosenfeld M, Davis S, Brumback L, Gustafsson P, Ratjen F
    Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis. A pilot study using inhaled hypertonic saline.
    American journal of respiratory and critical care medicine , 2013 Aug. 15 : 188(4)456-60
  • Hjeij R, Lindstrand A, Francis R, Zariwala MA, Liu X, Li Y, Damerla R, Dougherty GW, Abouhamed M, Olbrich H, Loges NT, Pennekamp P, Davis EE, Carvalho CM, Pehlivan D, Werner C, Raidt J, Köhler G, Häffner K, Reyes-Mugica M, Lupski JR, Leigh MW, Rosenfeld M, Morgan LC, Knowles MR, Lo CW, Katsanis N, Omran H
    ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry.
    American journal of human genetics , 2013 Aug. 8 : 93(2)357-67
  • Zariwala MA, Gee HY, Kurkowiak M, Al-Mutairi DA, Leigh MW, Hurd TW, Hjeij R, Dell SD, Chaki M, Dougherty GW, Adan M, Spear PC, Esteve-Rudd J, Loges NT, Rosenfeld M, Diaz KA, Olbrich H, Wolf WE, Sheridan E, Batten TF, Halbritter J, Porath JD, Kohl S, Lovric S, Hwang DY, Pittman JE, Burns KA, Ferkol TW, Sagel SD, Olivier KN, Morgan LC, Werner C, Raidt J, Pennekamp P, Sun Z, Zhou W, Airik R, Natarajan S, Allen SJ, Amirav I, Wieczorek D, Landwehr K, Nielsen K, Schwerk N, Sertic J, Köhler G, Washburn J, Levy S, Fan S, Koerner-Rettberg C, Amselem S, Williams DS, Mitchell BJ, Drummond IA, Otto EA, Omran H, Knowles MR, Hildebrandt F
    ZMYND10 is mutated in primary ciliary dyskinesia and interacts with LRRC6.
    American journal of human genetics , 2013 Aug. 8 : 93(2)336-45
  • Stick S, Tiddens H, Aurora P, Gustafsson P, Ranganathan S, Robinson P, Rosenfeld M, Sly P, Ratjen F
    Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?
    The European respiratory journal , 2013 Aug. : 42(2)527-38
  • Byrnes CA, Vidmar S, Cheney JL, Carlin JB, Armstrong DS, Cooper PJ, Grimwood K, Moodie M, Robertson CF, Rosenfeld M, Tiddens HA, Wainwright CE, ACFBAL Study Investigators
    Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5 years of age.
    Thorax , 2013 July : 68(7)643-51
  • Byrnes CA, Vidmar S, Cheney JL, Carlin JB, Armstrong DS, Cooper PJ, Grimwood K, Moodie M, Robertson CF, Rosenfeld M, Tiddens HA, Wainwright CE, ACFBAL Study Investigators
    Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5 years of age.
    Thorax , 2013 July : 68(7)643-51
  • Mayer-Hamblett N, Rosenfeld M, Treggiari MM, Konstan MW, Retsch-Bogart G, Morgan W, Wagener J, Gibson RL, Khan U, Emerson J, Thompson V, Elkin EP, Ramsey BW, for the EPIC, ESCF Investigators
    Standard care versus protocol based therapy for new onset Pseudomonas aeruginosa in cystic fibrosis.
    Pediatric pulmonology , 2013 July
  • Peterson-Carmichael SL, Rosenfeld M, Ascher SB, Hornik CP, Arets HG, Davis SD, Hall GL
    Survey of clinical infant lung function testing practices.
    Pediatric pulmonology , 2013 June 13
  • Subbarao P, Stanojevic S, Brown M, Jensen R, Rosenfeld M, Davis S, Brumback L, Gustafsson P, Ratjen F
    Lung Clearance Index as an Outcome Measure for Clinical Trials in Young Children with Cystic Fibrosis: A Pilot Study using Inhaled Hypertonic Saline.
    American journal of respiratory and critical care medicine , 2013 June
  • Peterson-Carmichael SL, Rosenfeld M, Ascher SB, Hornik CP, Arets HG, Davis SD, Hall GL
    Survey of clinical infant lung function testing practices.
    Pediatric pulmonology , 2013 June
  • Mayer-Hamblett N, Saiman L, Lands LC, Anstead M, Rosenfeld M, Kloster M, Fisher L, Ratjen F
    Impact of acute antibiotic therapy on the pulmonary exacerbation endpoint in cystic fibrosis clinical trials.
    Contemporary clinical trials , 2013 June : 36(1)99-105
  • Psoter KJ, Rosenfeld M
    Opportunities and pitfalls of registry data for clinical research.
    Paediatric respiratory reviews , 2013 May
  • Rosenfeld M, Farrell PM, Kloster M, Swanson JO, Vu T, Brumback L, Acton JD, Castile RG, Colin AA, Conrad CK, Hart MA, Kerby GS, Hiatt PW, Mogayzel PJ, Johnson RC, Davis SD
    Association of lung function, Chest radiographs and clinical features in infants with cystic fibrosis.
    The European respiratory journal , 2013 May
  • Ruddy J, Emerson J, Moss R, Genatossio A, McNamara S, Burns JL, Anderson G, Rosenfeld M
    Sputum tobramycin concentrations in cystic fibrosis patients with repeated administration of inhaled tobramycin.
    Journal of aerosol medicine and pulmonary drug delivery , 2013 Apr, : 26(2)69-75
  • Rosenfeld M, Allen J, Arets BH, Aurora P, Beydon N, Calogero C, Castile RG, Davis SD, Fuchs S, Gappa M, Gustaffson PM, Hall GL, Jones MH, Kirkby JC, Kraemer R, Lombardi E, Lum S, Mayer OH, Merkus P, Nielsen KG, Oliver C, Oostveen E, Ranganathan S, Ren CL, Robinson PD, Seddon PC, Sly PD, Sockrider MM, Sonnappa S, Stocks J, Subbarao P, Tepper RS, Vilozni D, American Thoracic Society Assembly on Pediatrics Working Group on Infant and Preschool Lung Function Testing
    An official American Thoracic Society workshop report: optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia, and recurrent wheezing in children less than 6 years of age.
    Annals of the American Thoracic Society , 2013 Apr, : 10(2)S1-S11
  • Ruddy J, Emerson J, Moss R, Genatossio A, McNamara S, Burns JL, Anderson G, Rosenfeld M
    Sputum tobramycin concentrations in cystic fibrosis patients with repeated administration of inhaled tobramycin.
    Journal of aerosol medicine and pulmonary drug delivery , 2013 Apr, : 26(2)69-75
  • Rosenfeld M, Allen J, Arets BH, Aurora P, Beydon N, Calogero C, Castile RG, Davis SD, Fuchs S, Gappa M, Gustaffson PM, Hall GL, Jones MH, Kirkby JC, Kraemer R, Lombardi E, Lum S, Mayer OH, Merkus P, Nielsen KG, Oliver C, Oostveen E, Ranganathan S, Ren CL, Robinson PD, Seddon PC, Sly PD, Sockrider MM, Sonnappa S, Stocks J, Subbarao P, Tepper RS, Vilozni D, American Thoracic Society Assembly on Pediatrics Working Group on Infant and Preschool Lung Function Testing
    An official American Thoracic Society workshop report: optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia, and recurrent wheezing in children less than 6 years of age.
    Annals of the American Thoracic Society , 2013 Apr, : 10(2)S1-S11
  • Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE, Daniels ML, Noone PG, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A, Dixit A, O'Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD, Uk10k, Chung EM, Shoemark A, Knowles MR, Omran H, Mitchison HM
    Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
    Human mutation , 2013 Mar. : 34(3)462-72
  • Antony D, Becker-Heck A, Zariwala MA, Schmidts M, Onoufriadis A, Forouhan M, Wilson R, Taylor-Cox T, Dewar A, Jackson C, Goggin P, Loges NT, Olbrich H, Jaspers M, Jorissen M, Leigh MW, Wolf WE, Daniels ML, Noone PG, Ferkol TW, Sagel SD, Rosenfeld M, Rutman A, Dixit A, O'Callaghan C, Lucas JS, Hogg C, Scambler PJ, Emes RD, Uk10k, Chung EM, Shoemark A, Knowles MR, Omran H, Mitchison HM
    Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
    Human mutation , 2013 Mar. : 34(3)462-72
  • Stick S, Tiddens H, Aurora P, Gustafsson P, Ranganathan S, Robinson P, Rosenfeld M, Sly P, Ratjen F
    Early intervention studies in infants and preschool children with cystic fibrosis: are we ready?
    The European respiratory journal , 2013 Mar.
  • Bakker EM, Borsboom GJ, van der Wiel-Kooij EC, Caudri D, Rosenfeld M, Tiddens HA
    Small airway involvement in cystic fibrosis lung disease: Routine spirometry as an early and sensitive marker.
    Pediatric pulmonology , 2013 Feb.
  • Knowles MR, Leigh MW, Ostrowski LE, Huang L, Carson JL, Hazucha MJ, Yin W, Berg JS, Davis SD, Dell SD, Ferkol TW, Rosenfeld M, Sagel SD, Milla CE, Olivier KN, Turner EH, Lewis AP, Bamshad MJ, Nickerson DA, Shendure J, Zariwala MA, Genetic Disorders of Mucociliary Clearance Consortium
    Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia.
    American journal of human genetics , 2013 Jan. 10 : 92(1)99-106
  • Brumback LC, Davis SD, Kerby GS, Kloster M, Johnson R, Castile R, Hiatt PW, Hart M, Rosenfeld M
    Lung function from infancy to preschool in a cohort of children with cystic fibrosis.
    The European respiratory journal , 2013 Jan. : 41(1)60-6
  • Margaret Rosenfeld, MD, MPH
    Reference equations
    Diagnostic Techniques for the Pediatric Pulmonologist , 2013
  • Brumback LC, Davis SD, Kerby GS, Kloster M, Johnson R, Castile R, Hiatt PW, Hart M, Rosenfeld M
    Lung function from infancy to preschool in a cohort of children with cystic fibrosis.
    The European respiratory journal , 2013 Jan. : 41(1)60-6
  • Knowles MR, Leigh MW, Ostrowski LE, Huang L, Carson JL, Hazucha MJ, Yin W, Berg JS, Davis SD, Dell SD, Ferkol TW, Rosenfeld M, Sagel SD, Milla CE, Olivier KN, Turner EH, Lewis AP, Bamshad MJ, Nickerson DA, Shendure J, Zariwala MA, Genetic Disorders of Mucociliary Clearance Consortium
    Exome sequencing identifies mutations in CCDC114 as a cause of primary ciliary dyskinesia.
    American journal of human genetics , 2013 Jan. : 92(1)99-106
  • Loeve M, Krestin GP, Rosenfeld M, de Bruijne M, Stick SM, Tiddens HA
    Chest computed tomography; a validated surrogate endpoint of cystic fibrosis lung disease?
    The European respiratory journal , 2012 Dec.
  • Rosenfeld M, Emerson J, McNamara S, Thompson V, Ramsey BW, Morgan W, Gibson RL, EPIC Study Group
    Risk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohort.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2012 Sept. : 11(5)446-53
  • Rosenfeld M, Bernardo-Ocampo C, Emerson J, Genatossio A, Burns J, Gibson R
    Prevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis care.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2012 Sept. : 11(5)456-7
  • Rosenfeld M, Emerson J, McNamara S, Thompson V, Ramsey BW, Morgan W, Gibson RL, EPIC Study Group
    Risk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohort.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2012 Sept. : 11(5)446-53
  • Anstead M, Heltshe SL, Khan U, Barbieri JT, Langkamp M, Döring G, Dharia S, Gibson RL, Treggiari MM, Lymp J, Rosenfeld M, Ramsey B
    Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2012 Aug. 31
  • Anstead M, Heltshe SL, Khan U, Barbieri JT, Langkamp M, Döring G, Dharia S, Gibson RL, Treggiari MM, Lymp J, Rosenfeld M, Ramsey B
    Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial.
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2012 Aug.
  • Emond MJ, Louie T, Emerson J, Zhao W, Mathias RA, Knowles MR, Wright FA, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project, Lung GO, Gibson RL, Bamshad MJ
    Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis.
    Nature genetics , 2012 July : 44(8)886-9
  • Rosenfeld M, Ratjen F, Brumback L, Daniel S, Rowbotham R, McNamara S, Johnson R, Kronmal R, Davis SD, ISIS Study Group
    Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial.
    JAMA : the journal of the American Medical Association , 2012 June 6 : 307(21)2269-77
  • Kerby GS, Rosenfeld M, Ren CL, Mayer OH, Brumback L, Castile R, Hart MA, Hiatt P, Kloster M, Johnson R, Jones P, Davis SD
    Lung function distinguishes preschool children with CF from healthy controls in a multi-center setting.
    Pediatric pulmonology , 2012 June : 47(6)597-605
  • Ren CL, Rosenfeld M, Mayer OH, Davis SD, Kloster M, Castile RG, Hiatt PW, Hart M, Johnson R, Jones P, Brumback LC, Kerby GS
    Analysis of the associations between lung function and clinical features in preschool children with cystic fibrosis.
    Pediatric pulmonology , 2012 June : 47(6)574-81
  • Simon TD, Whitlock KB, Riva-Cambrin J, Kestle JR, Rosenfeld M, Dean JM, Holubkov R, Langley M, Hamblett NM
    Revision surgeries are associated with significant increased risk of subsequent cerebrospinal fluid shunt infection.
    The Pediatric infectious disease journal , 2012 June : 31(6)551-6
  • Simon TD, Whitlock KB, Riva-Cambrin J, Kestle JR, Rosenfeld M, Dean JM, Holubkov R, Langley M, Hamblett NM
    Revision surgeries are associated with significant increased risk of subsequent cerebrospinal fluid shunt infection.
    The Pediatric infectious disease journal , 2012 June : 31(6)551-6
  • Rosenfeld M, Ratjen F, Brumback L, Daniel S, Rowbotham R, McNamara S, Johnson R, Kronmal R, Davis SD, ISIS Study Group
    Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial.
    JAMA : the journal of the American Medical Association , 2012 June : 307(21)2269-77
  • Knowles MR, Leigh MW, Carson JL, Davis SD, Dell SD, Ferkol TW, Olivier KN, Sagel SD, Rosenfeld M, Burns KA, Minnix SL, Armstrong MC, Lori A, Hazucha MJ, Loges NT, Olbrich H, Becker-Heck A, Schmidts M, Werner C, Omran H, Zariwala MA, Genetic Disorders of Mucociliary Clearance Consortium
    Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
    Thorax , 2012 May : 67(5)433-41
  • Mayer-Hamblett N, Kronmal RA, Gibson RL, Rosenfeld M, Retsch-Bogart G, Treggiari MM, Burns JL, Khan U, Ramsey BW, EPIC Investigators
    Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis.
    Pediatric pulmonology , 2012 Feb. : 47(2)125-34
  • Mayer-Hamblett N, Kronmal RA, Gibson RL, Rosenfeld M, Retsch-Bogart G, Treggiari MM, Burns JL, Khan U, Ramsey BW, EPIC Investigators
    Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis.
    Pediatric pulmonology , 2012 Feb. : 47(2)125-34
  • Margaret Rosenfeld, MD, MPH
    Association of intraventricular hemorrhage secondary to prematurity with cerebrospinal fluid shunt surgery in the first year following initial shunt placement
    J Neurosurg Pediatr. , 2012 Jan. : 54-63
  • Knowles MR, Leigh MW, Carson JL, Davis SD, Dell SD, Ferkol TW, Olivier KN, Sagel SD, Rosenfeld M, Burns KA, Minnix SL, Armstrong MC, Lori A, Hazucha MJ, Loges NT, Olbrich H, Becker-Heck A, Schmidts M, Werner C, Omran H, Zariwala MA, for the Genetic Disorders of Mucociliary Clearance Consortium
    Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
    Thorax , 2011 Dec.
  • Kerby GS, Rosenfeld M, Ren CL, Mayer OH, Brumback L, Castile R, Hart MA, Hiatt P, Kloster M, Johnson R, Jones P, Davis SD
    Lung function distinguishes preschool children with CF from healthy controls in a multi-center setting.
    Pediatric pulmonology , 2011 Nov.
  • Ren CL, Rosenfeld M, Mayer OH, Davis SD, Kloster M, Castile RG, Hiatt PW, Hart M, Johnson R, Jones P, Brumback LC, Kerby GS
    Analysis of the associations between lung function and clinical features in preschool children with cystic fibrosis.
    Pediatric pulmonology , 2011 Nov.
  • Tuan TJ, Thorell EA, Hamblett NM, Kestle JR, Rosenfeld M, Simon TD
    Treatment and microbiology of repeated cerebrospinal fluid shunt infections in children.
    The Pediatric infectious disease journal , 2011 Sept. : 731-5
  • Treggiari MM, Retsch-Bogart G, Mayer-Hamblett N, Khan U, Kulich M, Kronmal R, Williams J, Hiatt P, Gibson RL, Spencer T, Orenstein D, Chatfield BA, Froh DK, Burns JL, Rosenfeld M, Ramsey BW, Early Pseudomonas Infection Control (EPIC) Investigators
    Comparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis.
    Archives of pediatrics & adolescent medicine , 2011 Sept. : 847-56
  • Renaud C, Kuypers J, Aspesberro F, Rosenfeld M, Englund JA
    Emergence of oseltamivir-resistant pandemic H1N1 in an immunocompetent child with severe status asthmaticus.
    The Journal of asthma : official journal of the Association for the Care of Asthma , 2011 Aug. : 572-5
  • Mayer-Hamblett N, Kronmal RA, Gibson RL, Rosenfeld M, Retsch-Bogart G, Treggiari MM, Burns JL, Khan U, Ramsey BW, for the EPIC Investigators
    Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis.
    Pediatric pulmonology , 2011 Aug.
  • Rosenfeld M, Davis S, Brumback L, Daniel S, Rowbotham R, Johnson R, McNamara S, Jensen R, Barlow C, Ratjen F
    Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: short-term tolerability, adherence, and safety.
    Pediatric pulmonology , 2011 July : 666-71
  • Loeve M, Gerbrands K, Hop WC, Rosenfeld M, Hartmann IC, Tiddens HA
    Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosis.
    Chest , 2011 July : 178-85
  • Sanders DB, Bittner RC, Rosenfeld M, Redding GJ, Goss CH
    Pulmonary exacerbations are associated with subsequent FEV1 decline in both adults and children with cystic fibrosis.
    Pediatric pulmonology , 2011 Apr, : 393-400
  • Olin JT, Burns K, Carson JL, Metjian H, Atkinson JJ, Davis SD, Dell SD, Ferkol TW, Milla CE, Olivier KN, Rosenfeld M, Baker B, Leigh MW, Knowles MR, Sagel SD, for the Genetic Disorders of Mucociliary Clearance Consortium
    Diagnostic yield of nasal scrape biopsies in primary ciliary dyskinesia: A multicenter experience.
    Pediatric pulmonology , 2011 Jan.
  • Davis SD, Rosenfeld M, Kerby GS, Brumback L, Kloster MH, Acton JD, Colin AA, Conrad CK, Hart MA, Hiatt PW, Mogayzel PJ, Johnson RC, Wilcox SL, Castile RG
    Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpoints.
    American journal of respiratory and critical care medicine , 2010 Dec. : 1387-97
  • Sanders DB, Bittner RC, Rosenfeld M, Hoffman LR, Redding GJ, Goss CH
    Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbation.
    American journal of respiratory and critical care medicine , 2010 Sept. : 627-32
  • Rosenfeld M, Emerson J, McNamara S, Joubran K, Retsch-Bogart G, Graff GR, Gutierrez HH, Kanga JF, Lahiri T, Noyes B, Ramsey B, Ren CL, Schechter M, Morgan W, Gibson RL
    Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort.
    Pediatric pulmonology , 2010 Sept. : 934-44
  • DiBlasi RM, Crotwell D, Geiduscheck JM, Richardson P, Smith A, Salyer JW, Rosenfeld M
    Therapeutic bilateral lung lavage in a child with pulmonary alveolar proteinosis.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 May : e28-31
  • Sanders DB, Hoffman LR, Emerson J, Gibson RL, Rosenfeld M, Redding GJ, Goss CH
    Return of FEV1 after pulmonary exacerbation in children with cystic fibrosis.
    Pediatric pulmonology , 2010 Feb. : 127-34
  • Tiddens HA, Donaldson SH, Rosenfeld M, Paré PD
    Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively?
    Pediatric pulmonology , 2010 Feb. : 107-17
  • Margaret Rosenfeld, MD, MPH
    Pulmonary Exacerbations
    Lung Biology in Health and Disease: Cystic Fibrosis , 2010
  • Margaret Rosenfeld, MD, MPH
    Cystic Fibrosis" and "Bronchiectasis
    The Netter Collection of Medical Illustrations, 2nd Edition: The Respiratory System , 2010
  • Borowitz D, Robinson KA, Rosenfeld M, Davis SD, Sabadosa KA, Spear SL, Michel SH, Parad RB, White TB, Farrell PM, Marshall BC, Accurso FJ
    Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis.
    The Journal of pediatrics , 2009 Dec. : S73-93
  • Treggiari MM, Rosenfeld M, Mayer-Hamblett N, Retsch-Bogart G, Gibson RL, Williams J, Emerson J, Kronmal RA, Ramsey BW
    Early anti-pseudomonal acquisition in young patients with cystic fibrosis: rationale and design of the EPIC clinical trial and observational study'.
    Contemporary clinical trials , 2009 May : 256-68
  • Sagel SD, Gibson RL, Emerson J, McNamara S, Burns JL, Wagener JS, Ramsey BW
    Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis.
    The Journal of pediatrics , 2009 Feb. : 183-8
  • Sanders DB, Rosenfeld M, Mayer-Hamblett N, Stamey D, Redding GJ
    Reproducibility of spirometry during cystic fibrosis pulmonary exacerbations.
    Pediatric pulmonology , 2008 Nov. : 1142-6
  • Margaret Rosenfeld, MD, MPH
    Cystic Fibrosis: Respiratory Manifestations
    In Pediatric Respiratory Diseases , 2008
  • Veenstra DL, Harris J, Gibson RL, Rosenfeld M, Burke W, Watts C
    Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomes.
    Genetics in medicine : official journal of the American College of Medical Genetics , 2007 Oct. : 695-704
  • Treggiari MM, Rosenfeld M, Retsch-Bogart G, Gibson R, Ramsey B
    Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis.
    Pediatric pulmonology , 2007 Sept. : 751-6
  • Rosenfeld M
    An overview of endpoints for cystic fibrosis clinical trials: one size does not fit all.
    Proceedings of the American Thoracic Society , 2007 Aug. : 299-301
  • Davis SD, Brody AS, Emond MJ, Brumback LC, Rosenfeld M
    Endpoints for clinical trials in young children with cystic fibrosis.
    Proceedings of the American Thoracic Society , 2007 Aug. : 418-30
  • Comeau AM, Accurso FJ, White TB, Campbell PW 3rd, Hoffman G, Parad RB, Wilfond BS, Rosenfeld M, Sontag MK, Massie J, Farrell PM, O'Sullivan BP
    Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop report.
    Pediatrics , 2007 Feb. : e495-518
  • Grosse SD, Rosenfeld M, Devine OJ, Lai HJ, Farrell PM
    Potential impact of newborn screening for cystic fibrosis on child survival: a systematic review and analysis.
    The Journal of pediatrics , 2006 Sept. : 362-6
  • Ferkol T, Rosenfeld M, Milla CE
    Cystic fibrosis pulmonary exacerbations.
    The Journal of pediatrics , 2006 Feb. : 259-64
  • Kulich M, Rosenfeld M, Campbell J, Kronmal R, Gibson RL, Goss CH, Ramsey B
    Disease-specific reference equations for lung function in patients with cystic fibrosis.
    American journal of respiratory and critical care medicine , 2005 Oct. : 885-91
  • Rosenfeld M
    Overview of published evidence on outcomes with early diagnosis from large US observational studies.
    The Journal of pediatrics , 2005 Sept. : S11-4
  • Debley JS, Carter ER, Gibson RL, Rosenfeld M, Redding GJ
    The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study.
    The Journal of pediatrics , 2005 Aug. : 233-8
  • Margaret Rosenfeld, MD, MPH
    Respiratory Mechanics
    Pediatric Pulmonary Function Testing , 2005 : 3320-33
  • Goss CH, Rosenfeld M
    Update on cystic fibrosis epidemiology.
    Current opinion in pulmonary medicine , 2004 Nov. : 510-4
  • Grosse SD, Boyle CA, Botkin JR, Comeau AM, Kharrazi M, Rosenfeld M, Wilfond BS
    Newborn screening for cystic fibrosis: evaluation of benefits and risks and recommendations for state newborn screening programs.
    MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control , 2004 Oct. : 1-36
  • Rosenfeld M, Ramsey BW, Gibson RL
    Pseudomonas acquisition in young patients with cystic fibrosis: pathophysiology, diagnosis, and management.
    Current opinion in pulmonary medicine , 2003 Nov. : 492-7
  • Kulich M, Rosenfeld M, Goss CH, Wilmott R
    Improved survival among young patients with cystic fibrosis.
    The Journal of pediatrics , 2003 June : 631-6
  • Gibson RL, Emerson J, McNamara S, Burns JL, Rosenfeld M, Yunker A, Hamblett N, Accurso F, Dovey M, Hiatt P, Konstan MW, Moss R, Retsch-Bogart G, Wagener J, Waltz D, Wilmott R, Zeitlin PL, Ramsey B
    Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosis.
    American journal of respiratory and critical care medicine , 2003 Mar. : 841-9
  • Geller DE, Rosenfeld M, Waltz DA, Wilmott RW
    Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system.
    Chest , 2003 Jan. : 28-36
  • Mayer-Hamblett N, Rosenfeld M, Emerson J, Goss CH, Aitken ML
    Developing cystic fibrosis lung transplant referral criteria using predictors of 2-year mortality.
    American journal of respiratory and critical care medicine , 2002 Dec. : 1550-5
  • Emerson J, Rosenfeld M, McNamara S, Ramsey B, Gibson RL
    Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis.
    Pediatric pulmonology , 2002 Aug. : 91-100
  • Margaret Rosenfeld, MD, MPH
    Respiratory Mechanics. In Pediatric Pulmonary Function Testing
    Respiratory System: Pediatrics. In Cystic Fibrosis , 2000 : . 204-218

Presentations

Presentations Title Event Location Date
Survey of clinical infant lung function testing practices. International Symposium on Respiratory Disease Shanghai, China Nov. 9, 2013
Early CF Lung Disease: Diagnosis, Treatment and Prevention Duke University School of Medicine Nov. 28, 2012
Pulmonary and Nutritional Consequences of CF in the First 6 Years of Life presentation in symposium "After the Newborn Screen: What to Do Next?" North American CF Conference Orlando, FL Oct. 2012
Designing Investigator Initiated Trials Presentation In symposium "Multidisciplinary Approach to Investigator-initiated Trials," North American CF Conference Orlando, FL Oct. 2012
Pulmonary Exacerbation as a Clinical Trial Endpoint: The Pros and Cons North American CF Conference Orlando, FL Oct. 2012
What lung function test is best for managing young children with CF talk in session "Is it time to bring pre-school lung function testing to the clinic? Update from the ATS/ERS Task Force" European Respiratory Society Congress Vienna, Austria Sept. 2012
Writing Your First Grant ITHS career development series, University of Washington Seattle, WA Oct. 30, 2009
Successful Transition to an Academic Career half-day SCH Fellows’ College workshop unknown Oct. 28, 2009
Newborn screening North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009
Risk factors for early age at acquisition of Pseudomonas aeruginosa North American Cystic Fibrosis Conference Minneapolis, MN Oct. 17, 2009
Pulmonary Exacerbations: How do we define them Symposium presentation, North American Cystic Fibrosis Conference Minneapolis, MN Oct. 16, 2009
Comparison of published pulmonary exacerbation definitions Cystic Fibrosis Foundation Workshop on Pulmonary Exacerbations Bethesda, MD Sept. 9, 2009
Guidelines for Care of theGuidelines for Care of the Infant with CF Infant with CF Cystic Fibrosis annual Northwest regional conference, Center for Urban Horticulture unknown July 24, 2009
Risk factors for early Pseudomonas acquisition Cystic Fibrosis Epidemiology/Biostatistics Working Group annual meeting, Center for Urban Horticulture unknown July 23, 2009
Optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia and recurrernt wheezing in children under 6 years of age American Thoracic Society annual convention San Diego, CA May 12, 2009
unknown 33. ITHS Career Development Seminar- Career Development (K Award) Seminar unknown Jan. 29, 2009

Research Funding

Grant Title Grantor Amount Award Date
Testing a Multifactorial Caries Model for Pediatric Patients with Cystic Fibrosis Sunstar and Cystic Fibrosis Foundation
Early Onset and Progression of Primary Ciliary Dyskinesia Lung Disease Prior to 10 Years of Age (RDN #5903) NIH
Longitudinal Study of Primary Ciliary Dyskinesia: Participants 5 -18 Years of Age (Protocol 5901) NIH
Study of Inhaled Saline in Preschool Children with CF (SHIP): Planning Grant Cystic Fibrosis Foundation
Development of an Observer Reported Outcome of Respiratory Signs for Young Children with Cystic Fibrosis CCTR
A Phase 1, Open-Label Study to evaluate the Pharmacokinetics and Safety of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation (VX12-809-011) Vertex
A Phase 3, 2 Arm, Roll-Over Study to Evaluate the Long Term Safety and Pharmacodynamics of Ivacaftor Treatment in Pediatric Subjects With Cystic Fibrosis and a CFTR Gating Mutation (VX11-770-109) Vertex
A Phase 3, 2-Part, Open-Label Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Ivacaftor in Subjects With Cystic Fibrosis and a CFTR Gating Mutation, Age 2to 5Years (VX11-770-108) Vertex
Infant Study of Inhaled Saline NIH and Cystic Fibrosis Foundation
Parent Report of Respiratory and Gastrointestinal Signs in Infants and Young Children with Cystic Fibrosis: A Feasibility study CCTR
The EPIC Observational Study: Longitudinal Assessment of Risk Factors and Impact of Pseudomonas aeruginosa Acquisition and Early Anti-Pseudomonal Treatment in Children with CF (Protocol # EPIC-002) Cystic Fibrosis Foundation
Novel Home Cough Monitor in Young Children with Cystic Fibrosis: A Pilot and Feasibility Study CCTR
Validation of a novel cell-phone spirometer in pediatric patients with respiratory diseases ITHS and Coulter Foundation