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Janet A. Englund, MD

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Janet A. Englund, MD

Infectious Disease, Infectious Disease Research

On staff since November 2002

Academic Title: Professor

Research Center: Center for Clinical and Translational Research

"Ive always been interested in preventing disease. Finding ways to keep children healthy is what I love to do. I began focusing on vaccines because they are one of the best ways to stop children and adults from getting sick in the first place. By working to make vaccines safe and effective, I feel like I'm making a difference in the lives of many people around the world."

Making a Difference

Overview

Board Certification(s)
Pediatrics
Pediatric Infectious Diseases
Medical/Professional School
University of Michigan Medical School, Ann Arbor
Residency
Pediatrics, Fairview University Medical Center, Minneapolis
Fellowship
Infectious Disease, University of Minnesota , Minneapolis
Infectious Disease, University of Minnesota , Minneapolis
Research Description

My research interests include the study of vaccine-preventable diseases and viral respiratory diseases in young children and immunocompromised hosts, including transplant recipients, as well as the evaluation of antiviral therapy for the prevention and treatment of viral diseases.

As a Clinical Associate of Fred Hutchinson Cancer Research Center, I am active in many transplant-related protocols in the prevention and treatment of disease in the immunocompromised host. As a member of the NIH-sponsored Seattle Vaccine Treatment and Evaluation Unit, I am involved in research with new vaccines and maternal immunization with Tdap and influenza vaccines.

My research group is active in studying influenza virus vaccines in diverse populations, including infants, school-age children in the schools, and pregnant women.

Research Focus Area

Immunocompromised Hosts, Virology, Infectious Disease

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
SEATTLE'S TOP DOCTOR - 2014Seattle Metropolitan Magazine 2014
Seattle's Top DocSeattle Met Magazine 2013

Publications

Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2013 Dec: 57(12)1731-41
Safety and infectivity of two doses of live-attenuated recombinant cold-passaged human parainfluenza type 3 virus vaccine rHPIV3cp45 in HPIV3-seronegative young children.
Vaccine , 2013 Nov 19: 31(48)5706-12
Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2013 Aug: 19(8)1220-6
Molecular epidemiology of respiratory syncytial virus transmission in childcare.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2013 Aug: 57(4)343-50
Outcome of respiratory syncytial virus lower respiratory tract disease in hematopoietic cell transplant recipients receiving aerosolized ribavirin: significance of stem cell source and oxygen requirement.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2013 Apr: 19(4)589-96
Epidemiology of multiple respiratory viruses in childcare attendees.
The Journal of infectious diseases , 2013 Mar 15: 207(6)982-9
Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza.
The Journal of infectious diseases , 2013 Mar 1: 207(5)709-20
Human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic stem cell transplant recipients have high mortality rates.
BBMT , 2013: 191220-6
Implementation of filmarray respiratory viral panel in a core laboratory improves testing turnaround time and patient care.
American journal of clinical pathology , 2013 Jan: 139(1)118-23
Combination therapy with amantadine, oseltamivir and ribavirin for influenza A infection: safety and pharmacokinetics.
Antiviral therapy , 2013: 18(3)377-86
Self-collection of foam nasal swabs for respiratory virus detection by PCR among immunocompetent subjects and hematopoietic cell transplant recipients.
Journal of clinical microbiology , 2013 Jan: 51(1)324-7
Influenza viral RNA detection in blood as a marker to predict disease severity in hematopoietic cell transplant recipients.
The Journal of infectious diseases , 2012 Dec 15: 206(12)1872-7
WU and KI polyomaviruses in respiratory samples from allogeneic hematopoietic cell transplant recipients.
Emerging infectious diseases , 2012 Oct: 18(10)1580-8
Respiratory viruses in children with cystic fibrosis: viral detection and clinical findings.
Influenza and other respiratory viruses , 2012 May: 6(3)218-23
Antiviral therapy of respiratory viruses in haematopoietic stem cell transplant recipients.
Antiviral therapy , 2012: 17(1 Pt B)175-91
Multiple versus single virus respiratory infections: viral load and clinical disease severity in hospitalized children.
Influenza and other respiratory viruses , 2012 Jan: 6(1)71-7
Infant pertussis: is cocooning the answer?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2011 Nov: 53(9)893-6
Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2011 Oct: 52(2)70-8
A prospective study of parainfluenza virus type 4 infections in children attending daycare.
The Pediatric infectious disease journal , 2011 Aug: 30(8)714-6
Impact of corticosteroid treatment and antiviral therapy on clinical outcomes in hematopoietic cell transplant patients infected with influenza virus.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2011 Jul: 17(7)979-86
Influenza vaccine for pregnant women in resource-constrained countries: a review of the evidence to inform policy decisions.
Vaccine , 2011 Jun 15: 29(27)4439-52
Safety of live attenuated influenza vaccine in mild to moderately immunocompromised children with cancer.
Vaccine , 2011 May 31: 29(24)4110-5
Introduction of a novel parechovirus RT-PCR clinical test in a regional medical center.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2011 May: 51(1)50-3
H275Y mutant pandemic (H1N1) 2009 virus in immunocompromised patients.
Emerging infectious diseases , 2011 Apr: 17(4)653-60; quiz 765
Shedding of pandemic (H1N1) 2009 virus among health care personnel, Seattle, Washington, USA.
Emerging infectious diseases , 2011 Apr: 17(4)639-44
Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2010 Sep: 16-20
Development of a symptom score for clinical studies to identify children with a documented viral upper respiratory tract infection.
Pediatric research , 2010 Sep: 252-7
Viral respiratory infections in hospitalized and community control children in Alaska.
Journal of medical virology , 2010 Jul: 1282-90
Viral respiratory infections in hospitalized and community control children in Alaska.
Journal of medical virology , 2010 Jul: 82(7)1282-90
Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally?
Vaccine , 2010 Jun 17: 4376-83
Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally?
Vaccine , 2010 Jun 17: 28(27)4376-83
Frequent and prolonged shedding of bocavirus in young children attending daycare.
The Journal of infectious diseases , 2010 Jun 1: 1625-32
Respiratory failure caused by 2009 novel influenza A/H1N1 in a hematopoietic stem-cell transplant recipient: Detection of extrapulmonary H1N1 RNA and use of intravenous peramivir.
Annals of internal medicine , 2010 May 4: 619-20
Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients.
Blood , 2010 Mar 11: 2088-94
How I treat influenza in patients with hematologic malignancies.
Blood , 2010 Feb 18: 115(7)1331-42
Safety and immunogenicity of trivalent inactivated influenza vaccine in infants: a randomized double-blind placebo-controlled study.
The Pediatric infectious disease journal , 2010 Feb: 105-10
Safety and immunogenicity of trivalent inactivated influenza vaccine in infants: a randomized double-blind placebo-controlled study.
The Pediatric infectious disease journal , 2010 Feb: 29(2)105-10
Recommended adult immunization schedule: United States, 2010.
Annals of internal medicine , 2010 Jan 5: 152(1)36-9
Trivalent inactivated influenza virus vaccine given to two-month-old children: an off-season pilot study.
The Pediatric infectious disease journal , 2009 Dec: 1099-104
Detection of bocavirus in saliva of children with and without respiratory illness.
Journal of clinical microbiology , 2009 Dec: 4131-2
Detection of bocavirus in saliva of children with and without respiratory illness.
Journal of clinical microbiology , 2009 Dec: 47(12)4131-2
BK nephropathy in pediatric hematopoietic stem cell transplant recipients.
Pediatric transplantation , 2009 Nov: 913-8
Seasonal influenza in adults and children--diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2009 Apr 15: 1003-32
Multiple viral respiratory pathogens in children with bronchiolitis.
Acta paediatrica (Oslo, Norway : 1992) , 2009 Jan: 123-6
Multiple viral respiratory pathogens in children with bronchiolitis.
Acta paediatrica (Oslo, Norway : 1992) , 2009 Jan: 98(1)123-6
Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus.
Diagnostic microbiology and infectious disease , 2008 Dec: 382-8
Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus.
Diagnostic microbiology and infectious disease , 2008 Dec: 62(4)382-8
Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
Antimicrobial agents and chemotherapy , 2008 Nov: 3909-14
Influenza-associated morbidity in children with cancer.
Pediatric blood & cancer , 2008 May: 983-7
Influenza-associated morbidity in children with cancer.
Pediatric blood & cancer , 2008 May: 50(5)983-7
Hospital-based influenza vaccination of children: an opportunity to prevent subsequent hospitalization.
Pediatrics , 2008 Feb: 345-8
Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection.
Blood , 2007 Sep 1: 1681-8
Coronavirus-associated pneumonia in previously healthy children.
The Pediatric infectious disease journal , 2007 Aug: 753-5
Safety and tolerability of oseltamivir prophylaxis in hematopoietic stem cell transplant recipients: a retrospective case-control study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2007 Jul 15: 187-93
Antimicrobial susceptibility of Bordetella pertussis isolates in the state of Washington.
International journal of antimicrobial agents , 2007 May: 609-11
Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection.
Seminars in respiratory and critical care medicine , 2007 Apr: 222-42
Multitarget PCR for diagnosis of pertussis and its clinical implications.
Journal of clinical microbiology , 2007 Feb: 506-11
Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2007 Jan 15: 44(2)245-9
Clinical disease in children associated with newly described coronavirus subtypes.
Pediatrics , 2007 Jan: e70-6
Clinical disease in children associated with newly described coronavirus subtypes.
Pediatrics , 2007 Jan: 119(1)e70-6
Effectiveness of school-based influenza vaccination.
The New England journal of medicine , 2006 Dec 14: 2523-32
Influenza vaccine for young children: two doses are better than one.
The Journal of pediatrics , 2006 Dec: 737-8
Immunization with trivalent inactivated influenza vaccine in partially immunized toddlers.
Pediatrics , 2006 Sep: e579-85
Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming?
Pediatrics , 2006 Sep: e570-8
Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients.
Annals of internal medicine , 2006 Mar 7: 344-9
Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients.
Annals of internal medicine , 2006 Mar 7: 144(5)344-9
Management of outbreaks of methicillin-resistant Staphylococcus aureus infection in the neonatal intensive care unit: a consensus statement.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America , 2006 Feb: 139-45
Emerging viral infections after hematopoietic cell transplantation.
Pediatric transplantation , 2005 Dec: 9 Suppl 748-54
Pertussis immunization in the global pertussis initiative North American region: recommended strategies and implementation considerations.
The Pediatric infectious disease journal , 2005 May: S83-6
Role of maternal pertussis antibodies in infants.
The Pediatric infectious disease journal , 2005 May: S62-5
Duration of immunity against pertussis after natural infection or vaccination.
The Pediatric infectious disease journal , 2005 May: S58-61
Role of maternal pertussis antibodies in infants.
The Pediatric infectious disease journal , 2005 May: 24(5 Suppl)S62-5
A comparison of 2 influenza vaccine schedules in 6- to 23-month-old children.
Pediatrics , 2005 Apr: 1039-47
A comparison of 2 influenza vaccine schedules in 6- to 23-month-old children.
Pediatrics , 2005 Apr: 115(4)1039-47
Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit.
The Pediatric infectious disease journal , 2004 Nov: 990-4
Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit.
The Pediatric infectious disease journal , 2004 Nov: 23(11)990-4
Influenza A pneumonia presenting as progressive focal infiltrates in a stem cell transplant recipient.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2004 Oct: 96-9
Pandoraea bacteremia in a cystic fibrosis patient with associated systemic illness.
The Pediatric infectious disease journal , 2004 Sep: 881-2
Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2004 Sep 1: 743-6
Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants.
The Journal of infectious diseases , 2004 Sep 1: 975-8
Influenza-like symptoms in the college dormitory environment: a survey taken during the 1999-2000 influenza season.
Journal of environmental health , 2004 Apr: 39-42, 44
Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection.
The Pediatric infectious disease journal , 2003 Dec: 1033-9
Maternal immunization with inactivated influenza vaccine: rationale and experience.
Vaccine , 2003 Jul 28: 3460-4
Maternal immunization with Haemophilus influenzae type b vaccines in different populations.
Vaccine , 2003 Jul 28: 3455-9
Maternal immunization with inactivated influenza vaccine: rationale and experience.
Vaccine , 2003 Jul 28: 21(24)3460-4
Tuberculous otitis media with mastoiditis and central nervous system involvement.
The Pediatric infectious disease journal , 2003 May: 453-6
Immunogenic protein contaminants in pneumococcal vaccines.
The Journal of infectious diseases , 2003 Mar 15: 1019-23
Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children.
Journal of clinical pharmacology , 2003 Feb: 133-40
Response to changes in antiretroviral therapy after genotyping in human immunodeficiency virus-infected children.
The Pediatric infectious disease journal , 2002 Jul: 647-53
Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions.
Vaccine , 2002 May 31: S44-7
Antiviral therapy of influenza.
Seminars in pediatric infectious diseases , 2002 Apr: 120-8

Presentations

Presentations TitleEventLocationDate
Prevention Strategies for Pertussis: Maternal immunization and CocooningWorld Society for Pediatric Infectious DiseasesCape Town, South AfricaNov. 19, 2013
Vaccines for special populationsINDVAC (Indian Vaccinology Course) 2013Vellore, IndiaSept. 18, 2013 - Sept. 21, 2013
New Respiratory Syncytial Virus VaccinesMaternal Immunization ConferenceAntalya, TurkeyMarch 14, 2013
Respiratory virus infections in the immunocompromised host; Argentina Pediatric Infectious Disease SocietyBueno Aires, ArgentinaMarch 13, 2013
Immunity to influenza following vaccination in childrenWorld Health Organization SAGE meetingGeneva SwitzerlandFeb. 14, 2012
Definition of ILI in Maternal Influenza Vaccine StudiesGates Foundation Maternal Immunization Study MeetingKathmandu, NepalMay 25, 2011 - May 27, 2011
New Molecular Approaches for the Diagnosis of Viral DiseasesState of the Art Plenary Session, PAS/SPR 2009Baltimore, MDMay 3, 1909

Research Funding

Grant TitleGrantorAmountAward Date
Clinical Significance of rhinovirusSeattle Children's Hospital Clinical Translational Research CenterDec. 20, 2012 - Sept. 30, 2013
RSV surveillance and antibody levels in Southeast Asia PATHMay 2012 - June 2014
New Vaccine Surveillance NetworkCDCAug. 1, 2011 - July 31, 2015
Operation of a Facility for the Study of Infectious Agents, Vaccines, and AntimicrobialsNIH/ Subsite of Johns HopkinsApril 7, 2009 - April 6, 2013
Maternal Immunization to protect the Mother and NeonateBill and Melinda Gates FndnJan. 2009 - Dec. 2014

Primary Office

Seattle Children's
MA.7.226 - Infectious Disease Clinic
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2073

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