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Heather C. Mefford, MD, PhD

Heather C. Mefford, MD, PhD

Genetics

On staff since August 2008

Academic Title: Acting Assistant Professor

Research Center: Center for Integrative Brain Research

"Geneticists are driven to understand the genetic basis of disease because we believe this information will lead us to better treatments and cures. I am so fortunate to be able to interact with a great group of researchers in Seattle who are using technology to understand disease. The scientists and the physicians I work with are very innovative and collaborative, which creates an inspiring, fun and successful working environment."

Making a Difference

  • Mentoring Talented Junior Faculty

    An academic medical center and research institute, Seattle Children’s is dedicated to helping junior faculty establish research careers. Recently, several of our emerging genetics researchers have made significant contributions to their field.... cont.

Overview

Board Certification(s)
Pediatrics
Clinical Genetics (MD)
Medical/Professional School
University of Washington, Seattle
University of Washington, Seattle, Medical Genetics
Residency
Seattle Children's Hospital, Seattle, Pediatrics
Fellowship
University of Washington, Seattle, Medical Genetics
Clinical Interests

Microdeletion syndromes; chromosome rearrangements and copy number changes as a cause of birth defects, mental retardation or autism.

Publications

Copy number variation analysis in single-suture craniosynostosis: multiple rare variants including RUNX2 duplication in two cousins with metopic craniosynostosis.
American journal of medical genetics. Part A , 2010 Sep: 2203-10
Recurrent 200-kb deletions of 16p11.2 that include the SH2B1 gene are associated with developmental delay and obesity.
Genetics in medicine : official journal of the American College of Medical Genetics , 2010 Aug 30:
Genome-wide copy number variation in epilepsy: novel susceptibility loci in idiopathic generalized and focal epilepsies.
PLoS genetics , 2010 May 20: e1000962
A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay.
Nature genetics , 2010 Mar: 203-9
Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies.
Brain : a journal of neurology , 2010 Jan: 23-32
Genotype to phenotype-discovery and characterization of novel genomic disorders in a "genotype-first" era.
Genetics in medicine : official journal of the American College of Medical Genetics , 2009 Dec: 836-42
Familial and sporadic 15q13.3 microdeletions in idiopathic generalized epilepsy: precedent for disorders with complex inheritance.
Human molecular genetics , 2009 Oct 1: 3626-31
A method for rapid, targeted CNV genotyping identifies rare variants associated with neurocognitive disease.
Genome research , 2009 Sep: 1579-85
Duplication hotspots, rare genomic disorders, and common disease.
Current opinion in genetics & development , 2009 Jun: 196-204
Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy.
Human molecular genetics , 2009 Apr 1: 1200-8
Interstitial deletion of 11q in a mother and fetus: implications of directly transmitted chromosomal imbalances for prenatal genetic counseling.
Prenatal diagnosis , 2009 Mar: 283-6
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Nature genetics , 2009 Feb: 160-2
Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes.
The New England journal of medicine , 2008 Oct 16: 1685-99
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures.
Nature genetics , 2008 Mar: 322-8
Recurrent reciprocal genomic rearrangements of 17q12 are associated with renal disease, diabetes, and epilepsy.
American journal of human genetics , 2007 Nov: 1057-69
Use of fluorescent sequence-specific polyamides to discriminate human chromosomes by microscopy and flow cytometry.
Nucleic acids research , 2002 Jul 1: 2790-9
The complex structure and dynamic evolution of human subtelomeres.
Nature reviews. Genetics , 2002 Feb: 91-102

Primary Office

Seattle Children's
A-7937 - Medical Genetics
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2056

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