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David J. Rawlings, MD

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David J. Rawlings, MD

Immunology

On staff since October 2001

Children's Title: Children's Guild Association Endowed Chair in Pediatric Immunology; Director, Center for Immunity and Immunotherapies, Seattle Children's Research Institute; Chief, Division of Immunology, Seattle Children?s Research Institute

Research Center: Center for Immunity and Immunotherapies

"As a parent and a physician, I am continually amazed by the capacity of our patients and their families to adapt to the challenges of living with a chronic immune-system disease. As a physician-scientist, I am driven by the challenge to make this battle less difficult by whatever means possible now and in the future. And as a graying athlete, I see medical care as the ultimate team sport. Each day, I do my best to build and lead stronger teams teams that more quickly identify a diagnosis and the impact of immune disease and, most importantly, teams that build better and safer treatments and cures for these conditions."

Making a Difference

Overview

Board Certification(s)
Pediatric Rheumatology
Medical/Professional School
University of North Carolina at Chapel Hill School of Medicine, Chapel Hill
Residency
Pediatrics, University of California - San Francisco, San Francisco
Pediatrics, University of California - San Francisco, San Francisco
Fellowship
Pediatric Rheumatology, Children's Hospital of Los Angeles - Pediatric Residency, Los Angeles
Infectious Disease, National Institute of Health, Rockville
UCLA School of Medicine, Los Angeles
Research Description

My primary research interests include altered lymphoid B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. My laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders.

I am a member of multiple regional and national organizations, an NIH study section member, chairman for the USIDNET XLA patient registry, and ad hoc reviewer for various grant programs and immunology journals. I also co-direct the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. Northwest Genome Engineering Consortium (NGEC), http://research.seattlechildrens.org/ngec.

The Immunology research laboratories carry out basic, pre-clinical and clinical research. Primary immunodeficiency disorders (PIDD) represent some of the best candidate disorders for treatment via hematopoietic stem cell gene therapy, and our translational research programs include modeling of novel gene and cellular therapies. Our clinical program also participates in novel clinical trials for non myeloablative hematopoietic stem cell transplant in PIDD.

Lab URL

http://depts.washington.edu/idimmweb/facultyMember.php?sort=21

Research Focus Area

Immunology

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
MemberAmerican Pediatric Society 2009
Children's Guild Association Endowed Chair in Pediatric Immunology 2008
MemberAmerican Society for Clinical Investigation 2007
MemberAssociation of American Physicians 2007
Scholar AwardThe Leukemia & Lymphoma Society 1999 - 2004
Joan J. Drake Seed Grant for Excellence in Cancer Research 1998
James S. McDonnell Scholar 1997 - 2000
CHRC, HHMI, and Pennington Pediatric Faculty Research Awards 1996 - 1998
Ellis Dresner Reserach AwardSouthern California Rheumatology Society 1993
Beatrice S. Kolliner FellowJonsson Comprehensive Cancer Center 1993
Physician's Scientist AwardNIDDK, NIH 1993 - 1998
Merle Carson Research AwardSouthwestern Pediatric Society 1992

Publications

Primary Immune Deficiency Treatment Consortium (PIDTC) report.
The Journal of allergy and clinical immunology , 2013 Oct 15
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks.
Nucleic acids research , 2013 Oct 10
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
Blood , 2013 Sep 5: 122(10)1695-706
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
The Journal of clinical investigation , 2013 May 1: 123(5)2024-36
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORt and Ahr that leads to IL-17 production by activated B cells.
Nature immunology , 2013 May: 14(5)514-22
A RANKL-PKC-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
Genes & development , 2013 Apr 15: 27(8)955-69
Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-B activation.
Molecular and cellular biology , 2013 Mar: 33(6)1149-63
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Nature methods , 2012 Oct: 9(10)973-5
FcRIIb and BAFF differentially regulate peritoneal B1 cell survival.
Journal of immunology (Baltimore, Md. : 1950) , 2012 May 15: 188(10)4792-800
Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.
Blood , 2012 May 10: 119(19)4395-407
Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells.
European journal of immunology , 2012 May: 42(5)1327-36
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993.
Journal of immunology (Baltimore, Md. : 1950) , 2012 Apr 1: 188(7)2936-47
Integration of B cell responses through Toll-like receptors and antigen receptors.
Nature reviews. Immunology , 2012 Mar 16: 12(4)282-94
Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
International immunology , 2012 Mar: 24(3)183-95
Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
Journal of immunology (Baltimore, Md. : 1950) , 2012 Mar 1: 188(5)2065-9
Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
The Journal of allergy and clinical immunology , 2012 Feb: 129(2)559-62, 562.e1-2
Differential impact of Toll-like receptor signaling on distinct B cell subpopulations.
Frontiers in bioscience (Landmark edition) , 2012 Jan 1: 171499-516
Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.
Journal of immunology (Baltimore, Md. : 1950) , 2012 Jan 1: 188(1)487-96
Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.
Nucleic acids research , 2012 Jan: 40(2)e14
Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
Nucleic acids research , 2011 Nov: 39(21)e143
Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
The Journal of allergy and clinical immunology , 2011 Oct 24
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
The Journal of experimental medicine , 2011 Sep 26: 2033-42
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
The Journal of experimental medicine , 2011 Sep 26: 208(10)2033-42
Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
Nucleic acids research , 2011 Sep 12
Bone health in adult men and women with a history of juvenile idiopathic arthritis.
The Journal of rheumatology , 2011 Aug: 38(8)1689-93
Tracking genome engineering outcome at individual DNA breakpoints.
Nature methods , 2011 Jul 10: 671-6
Tracking genome engineering outcome at individual DNA breakpoints.
Nature methods , 2011 Jul 10: 8(8)671-6
Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.
Molecular therapy : the journal of the American Society of Gene Therapy , 2011 Mar: 515-25
Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.
Molecular therapy : the journal of the American Society of Gene Therapy , 2011 Mar: 19(3)515-25
Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.
PloS one , 2011 Feb 9: e16825
Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.
PloS one , 2011 Feb 9: 6(2)e16825
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , 2010 Nov: 1000-5
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , 2010 Nov: 126(5)1000-5
Galphaq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
The Journal of experimental medicine , 2010 Aug 2: 1775-89
G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
The Journal of experimental medicine , 2010 Aug 2: 1775-89
G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
The Journal of experimental medicine , 2010 Aug 2: 207(8)1775-89
Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
The Journal of allergy and clinical immunology , 2010 Jul 17
B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
Blood , 2010 Mar 18: 2146-55
B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
Blood , 2010 Mar 18: 2146-55
B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
Blood , 2010 Mar 18: 115(11)2146-55
The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty.
Age and ageing , 2010 Mar: 39(2)234-9
MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
Molecular and cellular biology , 2010 Feb: 922-34
MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
Molecular and cellular biology , 2010 Feb: 922-34
MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
Molecular and cellular biology , 2010 Feb: 30(4)922-34
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
Immunity , 2010 Jan 29: 129-40
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
Immunity , 2010 Jan 29: 129-40
CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
Immunity , 2010 Jan 29: 32(1)129-40
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology , 2009 Dec: 1152-60.e12
Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec 1: 7362-70
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology , 2009 Dec: 1152-60.e12
Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec 1: 7362-70
Bone density of the femoral neck following Birmingham hip resurfacing.
Acta orthopaedica , 2009 Dec: 80(6)660-5
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology , 2009 Dec: 124(6)1152-60.e12
Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec 1: 183(11)7362-70
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
Blood , 2009 Nov 12: 4373-82
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
Blood , 2009 Nov 12: 4373-82
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
Blood , 2009 Nov 12: 114(20)4373-82
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
Blood , 2009 Nov 5: 4034-44
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
Blood , 2009 Nov 5: 4034-44
CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
Blood , 2009 Nov 5: 114(19)4034-44
Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
Experimental hematology , 2009 Nov: 1353-63
Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
Experimental hematology , 2009 Nov: 1353-63
Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
Experimental hematology , 2009 Nov: 37(11)1353-63
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Jun 15: 7370-80
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Jun 15: 7370-80
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Jun 15: 182(12)7370-80
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
Science signaling , 2009 May 26: ra25
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
Science signaling , 2009 May 26: ra25
Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
Science signaling , 2009 May 26: 2(72)ra25
Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Apr 1: 4065-75
Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Apr 1: 4065-75
Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Apr 1: 182(7)4065-75
Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Mar 1: 2868-78
Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Mar 1: 2868-78
Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
Journal of immunology (Baltimore, Md. : 1950) , 2009 Mar 1: 182(5)2868-78
Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
Clinical immunology (Orlando, Fla.) , 2009 Feb: 162-74
Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
Clinical immunology (Orlando, Fla.) , 2009 Feb: 162-74
Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
Clinical immunology (Orlando, Fla.) , 2009 Feb: 130(2)162-74
Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
Journal of the American Society of Nephrology : JASN , 2009 Jan: 68-77
Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
Journal of the American Society of Nephrology : JASN , 2009 Jan: 68-77
Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
Journal of the American Society of Nephrology : JASN , 2009 Jan: 20(1)68-77
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
European journal of immunology , 2008 Dec: 3411-25
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
European journal of immunology , 2008 Dec: 3411-25
Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
European journal of immunology , 2008 Dec: 38(12)3411-25
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
Blood , 2008 Nov 15: 4158-69
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
Blood , 2008 Nov 15: 4158-69
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
Blood , 2008 Nov 15: 112(10)4158-69
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
Blood , 2008 Sep 1: 1662-72
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
Blood , 2008 Sep 1: 1662-72
Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
Blood , 2008 Sep 1: 112(5)1662-72
Screening for borderline personality disorder in outpatient youth.
Journal of personality disorders , 2008 Aug: 22(4)353-64
B cell autonomous TLR signaling and autoimmunity.
Autoimmunity reviews , 2008 Feb: 313-6
An exemplum of XLA.
Clinical immunology (Orlando, Fla.) , 2008 Feb: 137-9
B cell autonomous TLR signaling and autoimmunity.
Autoimmunity reviews , 2008 Feb: 313-6
An exemplum of XLA.
Clinical immunology (Orlando, Fla.) , 2008 Feb: 137-9
B cell autonomous TLR signaling and autoimmunity.
Autoimmunity reviews , 2008 Feb: 7(4)313-6
An exemplum of XLA.
Clinical immunology (Orlando, Fla.) , 2008 Feb: 126(2)137-9
Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
The Journal of experimental medicine , 2008 Jan 21: 155-68
Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
The Journal of experimental medicine , 2008 Jan 21: 155-68
Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
The Journal of experimental medicine , 2008 Jan 21: 205(1)155-68
B cell intrinsic TLR signals amplify but are not required for humoral immunity.
The Journal of experimental medicine , 2007 Dec 24: 3095-101
B cell intrinsic TLR signals amplify but are not required for humoral immunity.
The Journal of experimental medicine , 2007 Dec 24: 3095-101
B cell intrinsic TLR signals amplify but are not required for humoral immunity.
The Journal of experimental medicine , 2007 Dec 24: 204(13)3095-101
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
The Journal of cell biology , 2007 Nov 19: 717-31
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
The Journal of cell biology , 2007 Nov 19: 717-31
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
The Journal of cell biology , 2007 Nov 19: 179(4)717-31
Calcium signalling and cell-fate choice in B cells.
Nature reviews. Immunology , 2007 Oct: 778-89
Calcium signalling and cell-fate choice in B cells.
Nature reviews. Immunology , 2007 Oct: 778-89
Calcium signalling and cell-fate choice in B cells.
Nature reviews. Immunology , 2007 Oct: 7(10)778-89
Novel suppressive function of transitional 2 B cells in experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) , 2007 Jun 15: 7868-78
Novel suppressive function of transitional 2 B cells in experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) , 2007 Jun 15: 7868-78
Novel suppressive function of transitional 2 B cells in experimental arthritis.
Journal of immunology (Baltimore, Md. : 1950) , 2007 Jun 15: 178(12)7868-78
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
Nature immunology , 2007 May: 522-31
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
Nature immunology , 2007 May: 522-31
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
Nature immunology , 2007 May: 8(5)522-31
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation , 2007 Feb: 407-18
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation , 2007 Feb: 407-18
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation , 2007 Feb: 117(2)407-18
The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
Nature reviews. Immunology , 2006 Nov: 799-812
The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
Nature reviews. Immunology , 2006 Nov: 799-812
The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
Nature reviews. Immunology , 2006 Nov: 6(11)799-812
Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease.
World journal of gastroenterology : WJG , 2006 Sep 21: 5680-6
Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease.
World journal of gastroenterology : WJG , 2006 Sep 21: 12(35)5680-6
Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
Blood , 2006 Jul 1: 19-27
Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
Blood , 2006 Jul 1: 19-27
Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
Blood , 2006 Jul 1: 108(1)19-27
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
Immunity , 2006 Jun: 741-52
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
Immunity , 2006 Jun: 741-52
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
Immunity , 2006 Jun: 24(6)741-52
The BPQ: a scale for the assessment of borderline personality based on DSM-IV criteria.
Journal of personality disorders , 2006 Jun: 20(3)247-60
Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
Advances in experimental medicine and biology , 2006: : 89-106
The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
EMBO reports , 2006 Jan: 25-30
Low bone mineral density measurements in care home residents--a treatable cause of fractures.
Age and ageing , 2006 Jan: 37-41
Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
Advances in experimental medicine and biology , 2006: 89-106
The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
EMBO reports , 2006 Jan: 25-30
Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
Advances in experimental medicine and biology , 2006: 58489-106
Low bone mineral density measurements in care home residents--a treatable cause of fractures.
Age and ageing , 2006 Jan: 35(1)37-41
The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
EMBO reports , 2006 Jan: 7(1)25-30
Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
Immunity , 2005 Dec: 561-74
Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
Immunity , 2005 Dec: 561-74
Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
Immunity , 2005 Dec: 23(6)561-74
Early warning signs of relapse following a first episode of psychosis.
Schizophrenia research , 2005 Dec 1: 80(1)107-11
Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study.
Journal of epidemiology and community health , 2005 Jun: 475-80
Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study.
Journal of epidemiology and community health , 2005 Jun: 59(6)475-80
A reliable DEXA measurement technique for metal-on-metal hip resurfacing.
Acta orthopaedica , 2005 Apr: 76(2)177-81
Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
Molecular and cellular biology , 2005 Mar: 2073-84
CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar 1: 2687-95
CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar 1: 2687-95
Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
Molecular and cellular biology , 2005 Mar: 2073-84
The IVF experience--a patient perspective.
Australian family physician , 2005 Mar: 34(3)173
CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar 1: 174(5)2687-95
Agreeableness and neuroticism as predictors of relapse after first-episode psychosis: a prospective follow-up study.
The Journal of nervous and mental disease , 2005 Mar: 193(3)160-9
Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
Molecular and cellular biology , 2005 Mar: 25(6)2073-84
B-Cell Development
Hematology: Basic Principles and Practice , 2005: 119-133
TSLP (Thymic stromal lymphopoietin)
Enclyclopedia of Hormones , 2005
Escitalopram in adolescent major depression.
MedGenMed : Medscape general medicine , 2005 Jan 31: 7(1)6
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
Genome biology , 2005: R9
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
Genome biology , 2005: R9
Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
Genome biology , 2005: 6(1)R9
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
The Journal of biological chemistry , 2004 Nov 12: 47720-5
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
The Journal of biological chemistry , 2004 Nov 12: 47720-5
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
The Journal of biological chemistry , 2004 Nov 12: 279(46)47720-5
Low-dose tiagabine effectiveness in anxiety disorders.
MedGenMed : Medscape general medicine , 2004 Sep 17: 6(3)8
ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
Biochemical and biophysical research communications , 2004 Sep 10: 74-81
ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
Biochemical and biophysical research communications , 2004 Sep 10: 74-81
ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
Biochemical and biophysical research communications , 2004 Sep 10: 322(1)74-81
Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
The Journal of biological chemistry , 2004 Sep 3: 37651-61
Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
The Journal of biological chemistry , 2004 Sep 3: 37651-61
Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
The Journal of biological chemistry , 2004 Sep 3: 279(36)37651-61
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
Blood , 2004 Sep 1: 1281-90
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
Blood , 2004 Sep 1: 1281-90
Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
Blood , 2004 Sep 1: 104(5)1281-90
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
Molecular therapy : the journal of the American Society of Gene Therapy , 2004 Jul: 117-26
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
Molecular therapy : the journal of the American Society of Gene Therapy , 2004 Jul: 117-26
Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
Molecular therapy : the journal of the American Society of Gene Therapy , 2004 Jul: 10(1)117-26
Protein kinase C family functions in B-cell activation.
Current opinion in immunology , 2004 Jun: 367-73
Protein kinase C family functions in B-cell activation.
Current opinion in immunology , 2004 Jun: 367-73
Protein kinase C family functions in B-cell activation.
Current opinion in immunology , 2004 Jun: 16(3)367-73
Spontaneous tension pneumopericardium.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine , 2004 Jun: 11(3)181-4
Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
Immunological reviews , 2004 Feb: 161-78
Predominant Antibody Deficiencies: X-linked Agammaglobulinemia
Immunologic Disorders of Infants and Children , 2004: 357-373
Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
Immunological reviews , 2004 Feb: 161-78
Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
Immunological reviews , 2004 Feb: 197161-78
BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
Immunity , 2003 Nov: 669-78
BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
Immunity , 2003 Nov: 669-78
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America , 2003 Aug 5: 9470-5
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America , 2003 Aug 5: 9470-5
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America , 2003 Aug 5: 100(16)9470-5
B cell developmental requirement for the G alpha i2 gene.
Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb 15: 1707-15
B cell developmental requirement for the G alpha i2 gene.
Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb 15: 1707-15
B cell developmental requirement for the G alpha i2 gene.
Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb 15: 170(4)1707-15
Intramuscular hemangioma of the posterior belly of the digastric muscle failing to highlight on magnetic resonance imaging.
The Annals of otology, rhinology, and laryngology , 2002 Nov: 111(11)1050-3
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America , 2002 Oct 29: 14392-7
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America , 2002 Oct 29: 14392-7
Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
Proceedings of the National Academy of Sciences of the United States of America , 2002 Oct 29: 99(22)14392-7
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Blood , Sept. 2002: : 1852-9
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.
The Journal of experimental medicine , 2002 Sep 16: 196(6)753-63
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Blood , 2002 Sep 1: 1852-9
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
Blood , 2002 Sep 1: 100(5)1852-9
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
Nature immunology , 2002 Aug: 780-6
PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
Nature immunology , 2002 Aug: 3(8)780-6
Emerging roles for PKC isoforms in immune cell function.
Molecular interventions , 2002 Jun: 141-4
Emerging roles for PKC isoforms in immune cell function.
Molecular interventions , 2002 Jun: 2(3)141-4
Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development.
Journal of immunology (Baltimore, Md. : 1950) , 2002 Mar 1: 2101-10
Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development.
Journal of immunology (Baltimore, Md. : 1950) , 2002 Mar 1: 168(5)2101-10
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
The EMBO journal , 2001 Oct 15: 5692-702
Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies.
The Journal of pediatrics , 2001 Apr: 570-3
TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma.
Laboratory investigation; a journal of technical methods and pathology , 2001 Apr: 555-64
Primary angiitis of the central nervous system in children: 5 cases.
The Journal of rheumatology , 2001 Mar: 616-23
Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.
Immunity , 2000 Aug: 243-53
Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) , 2000 Aug 1: 1210-9
Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties.
Blood , 2000 Jun 1: 3460-6
Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.
Proceedings of the National Academy of Sciences of the United States of America , 2000 May 9: 5504-9
Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.
Clinical immunology (Orlando, Fla.) , 1999 Jun: 243-53
In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.
Proceedings of the National Academy of Sciences of the United States of America , 1999 Mar 2: 2221-6
In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells.
Blood , 1998 Dec 15: 4509-20
DSHP: a "power bar" for sustained immune responses?
Proceedings of the National Academy of Sciences of the United States of America , 1998 Nov 10: 13355-7
Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.
The EMBO journal , 1998 Apr 1: 1973-85
Preliminary evidence for cyclosporin A as an alternative in the treatment of recalcitrant juvenile rheumatoid arthritis and juvenile dermatomyositis.
The Journal of rheumatology , 1997 Dec: 2436-43
Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
Proceedings of the National Academy of Sciences of the United States of America , 1997 Oct 14: 11526-33
Constitutive membrane association potentiates activation of Bruton tyrosine kinase.
Oncogene , 1997 Sep 18: 1375-83
Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro.
Experimental hematology , 1997 Jan: 66-72
Regulation of Btk by Src family tyrosine kinases.
Molecular and cellular biology , 1996 Jul: 3465-71
Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
Immunity , 1996 May: 515-25
Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
Science (New York, N.Y.) , 1996 Feb 9: 822-5
Impaired expansion of mouse B cell progenitors lacking Btk.
Immunity , 1995 Sep: 301-12
The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function.
Seminars in immunology , 1995 Aug: 237-46
Long-term culture system for selective growth of human B-cell progenitors.
Proceedings of the National Academy of Sciences of the United States of America , 1995 Feb 28: 1570-4
Development of btk transgenic mice.
Current topics in microbiology and immunology , 1995: 363-70
A novel glucose-6-phosphate dehydrogenase in Plasmodium falciparum: cDNA and primary protein structure.
Biochimica et biophysica acta , 1994 Sep 13: 191-4
Role of Bruton's tyrosine kinase in immunodeficiency.
Current opinion in immunology , 1994 Aug: 623-30
Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).
The Journal of experimental medicine , 1994 Aug 1: 461-70
Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia.
The New England journal of medicine , 1994 May 26: 1488-91
Bruton's tyrosine kinase is a key regulator in B-cell development.
Immunological reviews , 1994 Apr: 105-19
Prolonged course of illness in a child with malignant lymphoma mimicking sarcoidosis.
The Journal of rheumatology , 1993 Sep: 1583-7
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.
Science (New York, N.Y.) , 1993 Jul 16: 358-61
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
Cell , 1993 Jan 29: 279-90
Common Variable Immune Deficiency Overview
, 1993
Introducing restriction sites into double-stranded plasmid DNA.
Methods in enzymology , 1993: 295-301
Alpha-tubulin II is a male-specific protein in Plasmodium falciparum.
Molecular and biochemical parasitology , 1992 Dec: 239-50
Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.
The Journal of experimental medicine , 1992 Nov 1: 1483-7
A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum.
The Journal of biological chemistry , 1992 Feb 25: 3976-82
Rapid method for introducing restriction sites into double stranded plasmid DNA.
Nucleic acids research , 1989 Dec 11: 10135
Immunologic Basics of Hematology Part 2: B-Cell Immunity
Hematology: Basic Principles and Practice. 5th Edition ,

Presentations

Presentations TitleEventLocationDate
Altered B Cell Signaling Orchestrates Loss of Tolerance and Systemic AutoimmunityUniversity of Washington, Amgen SymposiumSeattle, WANov. 7, 2013
New Insights into Normal and Dysregulated B Cell FunctionJeffrey Modell Centers SummitBerlin, GermanyJuly 17, 2013 - July 20, 2013
Updates in Gene Therapy for PIDClinical Immunology Society Annual MeetingMiami, FLApril 25, 2013 - April 28, 2013
Seminaire dImmunologie, Hematologie et de Rhumatologie PediatriquesPierre Royer InstitutParis, FranceFeb. 19, 2013 - Feb. 22, 2013
A Novel, B Cell Intrinsic, IL17 B Program helps to control Trypanosoma Cruzi InfectionSeattle BioMedical Research Institute Research SeminarSeattle, WADec. 10, 2012
Clinical Insights Derived from B-Cell Immunodeficiency DisordersAmerican Society of Hematology MeetingSan Diego, CADec. 10, 2011 - Dec. 11, 2011
A Link between Innate and Adaptive ImmunityJeffrey Modell World Immunology ConferenceRockefeller University; NYJune 1, 2011 - June 5, 2011
Viral Vectors for Gene Targeting and Homologous Recombination in Gene TherapyASGCT 14th Annual MeetingSeattle, WAMay 18, 2011 - May 22, 2011
B Cells: New Insights into Normal versus Dysregulated Function2011 Keystone Symposium Whistler, British Columbia, CanadaApril 12, 2011 - April 17, 2011
B Cell homeostatis and activiationIUIS Expert Meeting on Primary ImmunodeficienciesDublin, IrelandJune 3, 2009
Improving Cellular Therapy for Primary Immune Deficiency Diseases - Recognition, Diagnosis and ManagementNIH WorkshopBethesda, MDMay 20, 2009
Antigen receptor driven NFkB signals in B cells- distinct inputs modulate activation, tolerance, and lymphoma development50. University of Cincinnati, Cancer and Cell Biology Seminar SeriesCincinnati, OHApril 23, 2008 - April 24, 2008
Role of PKC Signals in B Cell Activation, Survival and MalignancyHarvard Medical School Program in Immunology Seminar SeriesBoston, MAMay 23, 2007
Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced SignalsKeystone Symposia "Biology of B Cells in Health and Disease (B5)"Banff, Alberta, CanadaFeb. 6, 2007 - Feb. 11, 2007
Gene Rx for WAS and XLANIH Gene Therapy Conference, Gene Therapy for Inherited Immune Deficiencies: Advances and Safety IssuesBethesda, MDSept. 18, 2006 - Sept. 19, 2006
Gene Therapy of Primary Immunodeficiency DisordersUW Cystic Fibrosis Research Seminar SeriesSeattle, WADec. 22, 2005
Distinct signaling responses of transitional B cell subsets and their developmental consequences7th Latin American Congress of ImmunologyCordoba, ArgentinaOct. 2, 2005 - Oct. 6, 2005
Btk-dependent events controlling calcium and NF-kB signaling in B lymphocytes3rd Lymphocyte Signal Transduction WorkshopCrete, GreeceMay 27, 2005 - June 1, 2005
Regulation of CARMA1-mediated NF-B signaling via PKC isoforms in B and T lymphocytesCantoblanco Workshops Madrid, SpainMay 22, 2005 - May 24, 2005
Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced NF-kappaB ActivationKeystone SymposiaSteamboat Springs, ColoradoMarch 28, 2005 - April 3, 2005
Preclinical Gene Therapy Studies in XLA and WASNIH Conference on Wiskott-Aldrich Syndrome Gene Therapy for Wiskott-Aldrich SyndromeBethesda, MDSept. 22, 2004 - Sept. 23, 2004
Gene Therapy for Immunodeficiency Disease Progress, Challenges and Coming TrialsChildrens Hospital and Regional Medical Center Seattle, Grand Aug. 8, 2004
The Role of BtK in B Cell Activation12th International Congress of Immunology and 4th Annual Conference of FOCISMontreal, CanadaJuly 18, 2004 - July 23, 2004
Molecular Events Controlling B Cell Receptor Dependent NfkappaB ActivationAmgen Inc. and the University of Washington Department of Immunology Eighth Annual Joint Immunology SymposiumSeattle, WAMay 21, 2004
Untangling the Pathways for Lymphocyte ActivationAmerican Association of ImmunologistsMay 2003

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Seattle , WA 98101
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