Profile

David J. Rawlings, MD

David J. Rawlings, MD

Immunology

On staff since October 2001

Children's Title: Children's Guild Association Endowed Chair in Pediatric Immunology; Director, Center for Immunity and Immunotherapies, Seattle Children's Research Institute; Chief, Division of Immunology, Seattle Children?s Research Institute

Research Center: Center for Immunity and Immunotherapies

"As a parent and a physician, I am continually amazed by the capacity of our patients and their families to adapt to the challenges of living with a chronic immune-system disease. As a physician-scientist, I am driven by the challenge to make this battle less difficult by whatever means possible now and in the future. And as a graying athlete, I see medical care as the ultimate team sport. Each day, I do my best to build and lead stronger teams teams that more quickly identify a diagnosis and the impact of immune disease and, most importantly, teams that build better and safer treatments and cures for these conditions."

David J. Rawlings, MD, is chief in the Division of Immunology, overseeing the immunodeficiency clinic at Seattle Childrens Hospital. He is also director of the Center for Immunity and Immunotherapies leading the immunology research programs at Seattle Childrens Research Institute. Dr. Rawlings is professor of pediatrics and adjunct professor in the Department of Immunology at the University of Washington School of Medicine.

He earned his MD with honors from the University of North Carolina School of Medicine and completed a residency and chief residency in pediatrics at the University of California, San Francisco. He was an intramural research fellow at the NIH and a senior fellow at the Howard Hughes Medical Institute, UCLA. He completed specialty training in pediatric rheumatology and immunology at Childrens Hospital Los Angeles and directed the pediatric rheumatology program at UCLA. Dr. Rawlings has been the recipient of many awards including election to the American Society for Clinical Investigation, Association of American Physicians, and the Childrens Hospital Guild Association Endowed Chair in Pediatric Immunology Research. Dr. Rawlings also co-directs the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap for Medical Research and focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. His publications include more than 90 peer-reviewed papers and many invited reviews. His primary research interests include dysregulated B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. His laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders. He is also actively involved in collaborative studies with the bone marrow transplant team to design and test of new protocols for stem cell transplant in non-malignant disorders. Dr. Rawlings is a member of multiple regional and national organizations, an NIH study section member, and ad hoc reviewer for various grant programs and immunology journals.

Making A Difference

Overview

Board Certification(s)

Pediatric Rheumatology

Medical/Professional School

University of North Carolina at Chapel Hill School of Medicine, Chapel Hill

Residency

Pediatrics, University of California - San Francisco, San Francisco
Pediatrics, University of California - San Francisco, San Francisco

Fellowship

Pediatric Rheumatology, Children's Hospital of Los Angeles - Pediatric Residency, Los Angeles
Infectious Disease, National Institute of Health, Rockville
UCLA School of Medicine, Los Angeles

Research Description

My primary research interests include altered lymphoid B cell development and signaling leading to immunodeficiency, autoimmunity or lymphoid malignancies, and the development of gene therapy for primary immune deficiency diseases. My laboratory uses expertise in basic and clinical immunology, signal transduction and lymphocyte developmental biology to understand how altered signals can lead to immunologic disease, with the ultimate goal of developing translational therapies capable of specifically modulating these disorders.

I am a member of multiple regional and national organizations, an NIH study section member, chairman for the USIDNET XLA patient registry, and ad hoc reviewer for various grant programs and immunology journals. I also co-direct the Northwest Genome Engineering Consortium, a research program funded as part of the NIH Roadmap focused on developing enzymatic reagents and delivery methods for site specific gene repair in hematopoietic stem cells. Northwest Genome Engineering Consortium (NGEC), http://research.seattlechildrens.org/ngec.

The Immunology research laboratories carry out basic, pre-clinical and clinical research. Primary immunodeficiency disorders (PIDD) represent some of the best candidate disorders for treatment via hematopoietic stem cell gene therapy, and our translational research programs include modeling of novel gene and cellular therapies. Our clinical program also participates in novel clinical trials for non myeloablative hematopoietic stem cell transplant in PIDD.

Lab URL

http://depts.washington.edu/idimmweb/facultyMember.php?sort=21

Research Focus Area

Immunology

Awards and Honors

Award Name Award Description Awarded By Award Date
Member American Pediatric Society 2009
Children's Guild Association Endowed Chair in Pediatric Immunology 2008
Member Association of American Physicians 2007
Member American Society for Clinical Investigation 2007
Scholar Award The Leukemia & Lymphoma Society 1999 - 2004
Joan J. Drake Seed Grant for Excellence in Cancer Research 1998
James S. McDonnell Scholar 1997 - 2000
CHRC, HHMI, and Pennington Pediatric Faculty Research Awards 1996 - 1998
Physician's Scientist Award NIDDK, NIH 1993 - 1998
Beatrice S. Kolliner Fellow Jonsson Comprehensive Cancer Center 1993
Ellis Dresner Reserach Award Southern California Rheumatology Society 1993
Merle Carson Research Award Southwestern Pediatric Society 1992

Publications

  • Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC, on behalf of the workshop participants
    Primary Immune Deficiency Treatment Consortium (PIDTC) report.
    The Journal of allergy and clinical immunology , 2013 Oct. 15
  • Kuhar R, Gwiazda KS, Humbert O, Mandt T, Pangallo J, Brault M, Khan I, Maizels N, Rawlings DJ, Scharenberg AM, Certo MT
    Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks.
    Nucleic acids research , 2013 Oct. 10
  • Chen Y, Aardema J, Kale S, Whichard ZL, Awomolo A, Blanchard E, Chang B, Myers DR, Ju L, Tran R, Reece D, Christensen H, Boukour S, Debili N, Strom TS, Rawlings D, Vázquez FX, Voth GA, Zhu C, Kahr WH, Lam WA, Corey SJ
    Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
    Blood , 2013 Sept. 5 : 122(10)1695-706
  • Bermejo DA, Jackson SW, Gorosito-Serran M, Acosta-Rodriguez EV, Amezcua-Vesely MC, Sather BD, Singh AK, Khim S, Mucci J, Liggitt D, Campetella O, Oukka M, Gruppi A, Rawlings DJ
    Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORt and Ahr that leads to IL-17 production by activated B cells.
    Nature immunology , 2013 May : 14(5)514-22
  • Dai X, James RG, Habib T, Singh S, Jackson S, Khim S, Moon RT, Liggitt D, Wolf-Yadlin A, Buckner JH, Rawlings DJ
    A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.
    The Journal of clinical investigation , 2013 May 1 : 123(5)2024-36
  • Ferron M, Settembre C, Shimazu J, Lacombe J, Kato S, Rawlings DJ, Ballabio A, Karsenty G
    A RANKL-PKC-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
    Genes & development , 2013 Apr, 15 : 27(8)955-69
  • Moreno-García ME, Sommer K, Rincon-Arano H, Brault M, Ninomiya-Tsuji J, Matesic LE, Rawlings DJ
    Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-B activation.
    Molecular and cellular biology , 2013 Mar. : 33(6)1149-63
  • Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM
    Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
    Nature methods , 2012 Oct. : 9(10)973-5
  • Amezcua Vesely MC, Schwartz M, Bermejo DA, Montes CL, Cautivo KM, Kalergis AM, Rawlings DJ, Acosta-Rodríguez EV, Gruppi A
    FcRIIb and BAFF differentially regulate peritoneal B1 cell survival.
    Journal of immunology (Baltimore, Md. : 1950) , 2012 May 15 : 188(10)4792-800
  • Astrakhan A, Sather BD, Ryu BY, Khim S, Singh S, Humblet-Baron S, Ochs HD, Miao CH, Rawlings DJ
    Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.
    Blood , 2012 May 10 : 119(19)4395-407
  • Andrews SF, Dai X, Ryu BY, Gulick T, Ramachandran B, Rawlings DJ
    Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells.
    European journal of immunology , 2012 May : 42(5)1327-36
  • Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S, Belmont JW, Cooper MD, Conley ME, Witte ON
    Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. 1993.
    Journal of immunology (Baltimore, Md. : 1950) , 2012 Apr, 1 : 188(7)2936-47
  • Rawlings DJ, Schwartz MA, Jackson SW, Meyer-Bahlburg A
    Integration of B cell responses through Toll-like receptors and antigen receptors.
    Nature reviews. Immunology , 2012 Mar. 16 : 12(4)282-94
  • Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL
    Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
    Journal of immunology (Baltimore, Md. : 1950) , 2012 Mar. 1 : 188(5)2065-9
  • Iseki M, Omori-Miyake M, Xu W, Sun X, Takaki S, Rawlings DJ, Ziegler SF
    Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.
    International immunology , 2012 Mar. : 24(3)183-95
  • Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD
    Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
    The Journal of allergy and clinical immunology , 2012 Feb. : 129(2)559-62, 562.e1-2
  • Muñoz NM, Beard BC, Ryu BY, Luche RM, Trobridge GD, Rawlings DJ, Scharenberg AM, Kiem HP
    Novel reporter systems for facile evaluation of I-SceI-mediated genome editing.
    Nucleic acids research , 2012 Jan. : 40(2)e14
  • Habib T, Funk A, Rieck M, Brahmandam A, Dai X, Panigrahi AK, Luning Prak ET, Meyer-Bahlburg A, Sanda S, Greenbaum C, Rawlings DJ, Buckner JH
    Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.
    Journal of immunology (Baltimore, Md. : 1950) , 2012 Jan. 1 : 188(1)487-96
  • Meyer-Bahlburg A, Rawlings DJ
    Differential impact of Toll-like receptor signaling on distinct B cell subpopulations.
    Frontiers in bioscience (Landmark edition) , 2012 Jan. 1 : 171499-516
  • Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ
    Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
    Nucleic acids research , 2011 Nov. : 39(21)e143
  • Meyer-Bahlburg A, Renner ED, Rylaarsdam S, Reichenbach J, Schimke LF, Marks A, Tcheurekdjian H, Hostoffer R, Brahmandam A, Torgerson TR, Belohradsky BH, Rawlings DJ, Ochs HD
    Heterozygous signal transducer and activator of transcription 3 mutations in hyper-IgE syndrome result in altered B-cell maturation.
    The Journal of allergy and clinical immunology , 2011 Oct. 24
  • Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ
    WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
    The Journal of experimental medicine , 2011 Sept. 26 : 2033-42
  • Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ
    WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
    The Journal of experimental medicine , 2011 Sept. 26 : 208(10)2033-42
  • Bandaranayake AD, Correnti C, Ryu BY, Brault M, Strong RK, Rawlings DJ
    Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors.
    Nucleic acids research , 2011 Sept. 12
  • Thornton J, Pye SR, O'Neill TW, Rawlings D, Francis RM, Symmons DP, Ashcroft DM, Foster HE
    Bone health in adult men and women with a history of juvenile idiopathic arthritis.
    The Journal of rheumatology , 2011 Aug. : 38(8)1689-93
  • Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM
    Tracking genome engineering outcome at individual DNA breakpoints.
    Nature methods , 2011 July 10 : 671-6
  • Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM
    Tracking genome engineering outcome at individual DNA breakpoints.
    Nature methods , 2011 July 10 : 8(8)671-6
  • Sather BD, Ryu BY, Stirling BV, Garibov M, Kerns HM, Humblet-Baron S, Astrakhan A, Rawlings DJ
    Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.
    Molecular therapy : the journal of the American Society of Gene Therapy , 2011 Mar. : 515-25
  • Sather BD, Ryu BY, Stirling BV, Garibov M, Kerns HM, Humblet-Baron S, Astrakhan A, Rawlings DJ
    Development of B-lineage predominant lentiviral vectors for use in genetic therapies for B cell disorders.
    Molecular therapy : the journal of the American Society of Gene Therapy , 2011 Mar. : 19(3)515-25
  • Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR
    Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.
    PloS one , 2011 Feb. 9 : e16825
  • Aubert M, Ryu BY, Banks L, Rawlings DJ, Scharenberg AM, Jerome KR
    Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.
    PloS one , 2011 Feb. 9 : 6(2)e16825
  • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
    Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
    The Journal of allergy and clinical immunology , 2010 Nov. : 1000-5
  • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
    Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
    The Journal of allergy and clinical immunology , 2010 Nov. : 126(5)1000-5
  • Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
    G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
    The Journal of experimental medicine , 2010 Aug. 2 : 1775-89
  • Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
    G alpha q-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
    The Journal of experimental medicine , 2010 Aug. 2 : 207(8)1775-89
  • Misra RS, Shi G, Moreno-Garcia ME, Thankappan A, Tighe M, Mousseau B, Kusser K, Becker-Herman S, Hudkins KL, Dunn R, Kehry MR, Migone TS, Marshak-Rothstein A, Simon M, Randall TD, Alpers CE, Liggitt D, Rawlings DJ, Lund FE
    Galphaq-containing G proteins regulate B cell selection and survival and are required to prevent B cell-dependent autoimmunity.
    The Journal of experimental medicine , 2010 Aug. 2 : 1775-89
  • Burroughs LM, Torgerson TR, Storb R, Carpenter PA, Rawlings DJ, Sanders J, Scharenberg AM, Skoda-Smith S, Englund J, Ochs HD, Woolfrey AE
    Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.
    The Journal of allergy and clinical immunology , 2010 July 17
  • Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ
    B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
    Blood , 2010 Mar. 18 : 2146-55
  • Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ
    B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
    Blood , 2010 Mar. 18 : 115(11)2146-55
  • Kerns HM, Ryu BY, Stirling BV, Sather BD, Astrakhan A, Humblet-Baron S, Liggitt D, Rawlings DJ
    B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.
    Blood , 2010 Mar. 18 : 2146-55
  • Lingard EA, Mitchell SY, Francis RM, Rawlings D, Peaston R, Birrell FN, McCaskie AW
    The prevalence of osteoporosis in patients with severe hip and knee osteoarthritis awaiting joint arthroplasty.
    Age and ageing , 2010 Mar. : 39(2)234-9
  • Moreno-García ME, Sommer K, Shinohara H, Bandaranayake AD, Kurosaki T, Rawlings DJ
    MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
    Molecular and cellular biology , 2010 Feb. : 922-34
  • Moreno-García ME, Sommer K, Shinohara H, Bandaranayake AD, Kurosaki T, Rawlings DJ
    MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
    Molecular and cellular biology , 2010 Feb. : 30(4)922-34
  • Moreno-García ME, Sommer K, Shinohara H, Bandaranayake AD, Kurosaki T, Rawlings DJ
    MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.
    Molecular and cellular biology , 2010 Feb. : 922-34
  • Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C
    CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
    Immunity , 2010 Jan. 29 : 129-40
  • Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C
    CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
    Immunity , 2010 Jan. 29 : 32(1)129-40
  • Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C
    CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients.
    Immunity , 2010 Jan. 29 : 129-40
  • Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ
    Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec. 1 : 7362-70
  • Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT, Workshop Participants
    Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
    The Journal of allergy and clinical immunology , 2009 Dec. : 1152-60.e12
  • Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ
    Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec. 1 : 183(11)7362-70
  • Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT, Workshop Participants
    Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
    The Journal of allergy and clinical immunology , 2009 Dec. : 124(6)1152-60.e12
  • Cooke NJ, Rodgers L, Rawlings D, McCaskie AW, Holland JP
    Bone density of the femoral neck following Birmingham hip resurfacing.
    Acta orthopaedica , 2009 Dec. : 80(6)660-5
  • Moreno-García ME, Sommer K, Haftmann C, Sontheimer C, Andrews SF, Rawlings DJ
    Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Dec. 1 : 7362-70
  • Griffith LM, Cowan MJ, Notarangelo LD, Puck JM, Buckley RH, Candotti F, Conley ME, Fleisher TA, Gaspar HB, Kohn DB, Ochs HD, O'Reilly RJ, Rizzo JD, Roifman CM, Small TN, Shearer WT
    Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
    The Journal of allergy and clinical immunology , 2009 Dec. : 1152-60.e12
  • Peng B, Ye P, Rawlings DJ, Ochs HD, Miao CH
    Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
    Blood , 2009 Nov. 12 : 4373-82
  • Peng B, Ye P, Rawlings DJ, Ochs HD, Miao CH
    Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
    Blood , 2009 Nov. 12 : 114(20)4373-82
  • Peng B, Ye P, Rawlings DJ, Ochs HD, Miao CH
    Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy.
    Blood , 2009 Nov. 12 : 4373-82
  • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
    CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
    Blood , 2009 Nov. 5 : 4034-44
  • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
    CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
    Blood , 2009 Nov. 5 : 114(19)4034-44
  • Miao CH, Harmeling BR, Ziegler SF, Yen BC, Torgerson T, Chen L, Yau RJ, Peng B, Thompson AR, Ochs HD, Rawlings DJ
    CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice.
    Blood , 2009 Nov. 5 : 4034-44
  • Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS
    Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
    Experimental hematology , 2009 Nov. : 1353-63
  • Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS
    Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
    Experimental hematology , 2009 Nov. : 37(11)1353-63
  • Marathe BM, Prislovsky A, Astrakhan A, Rawlings DJ, Wan JY, Strom TS
    Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption.
    Experimental hematology , 2009 Nov. : 1353-63
  • Astrakhan A, Ochs HD, Rawlings DJ
    Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 June 15 : 7370-80
  • Astrakhan A, Ochs HD, Rawlings DJ
    Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 June 15 : 182(12)7370-80
  • Astrakhan A, Ochs HD, Rawlings DJ
    Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 June 15 : 7370-80
  • James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT
    Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
    Science signaling , 2009 May 26 : ra25
  • James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT
    Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
    Science signaling , 2009 May 26 : 2(72)ra25
  • James RG, Biechele TL, Conrad WH, Camp ND, Fass DM, Major MB, Sommer K, Yi X, Roberts BS, Cleary MA, Arthur WT, MacCoss M, Rawlings DJ, Haggarty SJ, Moon RT
    Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling.
    Science signaling , 2009 May 26 : ra25
  • Meyer-Bahlburg A, Bandaranayake AD, Andrews SF, Rawlings DJ
    Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Apr, 1 : 4065-75
  • Meyer-Bahlburg A, Bandaranayake AD, Andrews SF, Rawlings DJ
    Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Apr, 1 : 182(7)4065-75
  • Meyer-Bahlburg A, Bandaranayake AD, Andrews SF, Rawlings DJ
    Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Apr, 1 : 4065-75
  • Andrews SF, Rawlings DJ
    Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Mar. 1 : 2868-78
  • Andrews SF, Rawlings DJ
    Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Mar. 1 : 182(5)2868-78
  • Andrews SF, Rawlings DJ
    Transitional B cells exhibit a B cell receptor-specific nuclear defect in gene transcription.
    Journal of immunology (Baltimore, Md. : 1950) , 2009 Mar. 1 : 2868-78
  • Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
    Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
    Clinical immunology (Orlando, Fla.) , 2009 Feb. : 162-74
  • Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
    Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
    Clinical immunology (Orlando, Fla.) , 2009 Feb. : 130(2)162-74
  • Liu P, Santisteban I, Burroughs LM, Ochs HD, Torgerson TR, Hershfield MS, Rawlings DJ, Scharenberg AM
    Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient.
    Clinical immunology (Orlando, Fla.) , 2009 Feb. : 162-74
  • Iyoda M, Hudkins KL, Becker-Herman S, Wietecha TA, Banas MC, Guo S, Meyer-Bahlburg A, Kowalewska J, Liu G, Ziegler SF, Rawlings DJ, Alpers CE
    Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
    Journal of the American Society of Nephrology : JASN , 2009 Jan. : 68-77
  • Iyoda M, Hudkins KL, Becker-Herman S, Wietecha TA, Banas MC, Guo S, Meyer-Bahlburg A, Kowalewska J, Liu G, Ziegler SF, Rawlings DJ, Alpers CE
    Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
    Journal of the American Society of Nephrology : JASN , 2009 Jan. : 20(1)68-77
  • Iyoda M, Hudkins KL, Becker-Herman S, Wietecha TA, Banas MC, Guo S, Meyer-Bahlburg A, Kowalewska J, Liu G, Ziegler SF, Rawlings DJ, Alpers CE
    Imatinib suppresses cryoglobulinemia and secondary membranoproliferative glomerulonephritis.
    Journal of the American Society of Nephrology : JASN , 2009 Jan. : 68-77
  • Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
    Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
    European journal of immunology , 2008 Dec. : 3411-25
  • Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
    Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
    European journal of immunology , 2008 Dec. : 38(12)3411-25
  • Wei B, Su TT, Dalwadi H, Stephan RP, Fujiwara D, Huang TT, Brewer S, Chen L, Arditi M, Borneman J, Rawlings DJ, Braun J
    Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells.
    European journal of immunology , 2008 Dec. : 3411-25
  • Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ
    Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
    Blood , 2008 Nov. 15 : 4158-69
  • Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ
    Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
    Blood , 2008 Nov. 15 : 112(10)4158-69
  • Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S, Weber M, Bouma G, Thrasher AJ, Batista FD, Rawlings DJ
    Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
    Blood , 2008 Nov. 15 : 4158-69
  • Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
    Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
    Blood , 2008 Sept. 1 : 1662-72
  • Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
    Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
    Blood , 2008 Sept. 1 : 112(5)1662-72
  • Peng B, Ye P, Blazar BR, Freeman GJ, Rawlings DJ, Ochs HD, Miao CH
    Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.
    Blood , 2008 Sept. 1 : 1662-72
  • Chanen AM, Jovev M, Djaja D, McDougall E, Yuen HP, Rawlings D, Jackson HJ
    Screening for borderline personality disorder in outpatient youth.
    Journal of personality disorders , 2008 Aug. : 22(4)353-64
  • Notarangelo LD, Rawlings DJ, Sullivan KE
    An exemplum of XLA.
    Clinical immunology (Orlando, Fla.) , 2008 Feb. : 137-9
  • Meyer-Bahlburg A, Rawlings DJ
    B cell autonomous TLR signaling and autoimmunity.
    Autoimmunity reviews , 2008 Feb. : 313-6
  • Notarangelo LD, Rawlings DJ, Sullivan KE
    An exemplum of XLA.
    Clinical immunology (Orlando, Fla.) , 2008 Feb. : 126(2)137-9
  • Meyer-Bahlburg A, Rawlings DJ
    B cell autonomous TLR signaling and autoimmunity.
    Autoimmunity reviews , 2008 Feb. : 7(4)313-6
  • Notarangelo LD, Rawlings DJ, Sullivan KE
    An exemplum of XLA.
    Clinical immunology (Orlando, Fla.) , 2008 Feb. : 137-9
  • Meyer-Bahlburg A, Rawlings DJ
    B cell autonomous TLR signaling and autoimmunity.
    Autoimmunity reviews , 2008 Feb. : 313-6
  • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ
    Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
    The Journal of experimental medicine , 2008 Jan. 21 : 155-68
  • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ
    Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
    The Journal of experimental medicine , 2008 Jan. 21 : 205(1)155-68
  • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli SA, Rawlings DJ
    Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation.
    The Journal of experimental medicine , 2008 Jan. 21 : 155-68
  • Meyer-Bahlburg A, Khim S, Rawlings DJ
    B cell intrinsic TLR signals amplify but are not required for humoral immunity.
    The Journal of experimental medicine , 2007 Dec. 24 : 3095-101
  • Meyer-Bahlburg A, Khim S, Rawlings DJ
    B cell intrinsic TLR signals amplify but are not required for humoral immunity.
    The Journal of experimental medicine , 2007 Dec. 24 : 204(13)3095-101
  • Meyer-Bahlburg A, Khim S, Rawlings DJ
    B cell intrinsic TLR signals amplify but are not required for humoral immunity.
    The Journal of experimental medicine , 2007 Dec. 24 : 3095-101
  • Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM
    Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
    The Journal of cell biology , 2007 Nov. 19 : 717-31
  • Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM
    Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
    The Journal of cell biology , 2007 Nov. 19 : 179(4)717-31
  • Habib T, Park H, Tsang M, de Alborán IM, Nicks A, Wilson L, Knoepfler PS, Andrews S, Rawlings DJ, Eisenman RN, Iritani BM
    Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.
    The Journal of cell biology , 2007 Nov. 19 : 717-31
  • Scharenberg AM, Humphries LA, Rawlings DJ
    Calcium signalling and cell-fate choice in B cells.
    Nature reviews. Immunology , 2007 Oct. : 778-89
  • Scharenberg AM, Humphries LA, Rawlings DJ
    Calcium signalling and cell-fate choice in B cells.
    Nature reviews. Immunology , 2007 Oct. : 7(10)778-89
  • Scharenberg AM, Humphries LA, Rawlings DJ
    Calcium signalling and cell-fate choice in B cells.
    Nature reviews. Immunology , 2007 Oct. : 778-89
  • Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
    Novel suppressive function of transitional 2 B cells in experimental arthritis.
    Journal of immunology (Baltimore, Md. : 1950) , 2007 June 15 : 7868-78
  • Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
    Novel suppressive function of transitional 2 B cells in experimental arthritis.
    Journal of immunology (Baltimore, Md. : 1950) , 2007 June 15 : 178(12)7868-78
  • Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, Mauri C
    Novel suppressive function of transitional 2 B cells in experimental arthritis.
    Journal of immunology (Baltimore, Md. : 1950) , 2007 June 15 : 7868-78
  • Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ
    Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
    Nature immunology , 2007 May : 522-31
  • Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ
    Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
    Nature immunology , 2007 May : 8(5)522-31
  • Astrakhan A, Omori M, Nguyen T, Becker-Herman S, Iseki M, Aye T, Hudkins K, Dooley J, Farr A, Alpers CE, Ziegler SF, Rawlings DJ
    Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.
    Nature immunology , 2007 May : 522-31
  • Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
    Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
    The Journal of clinical investigation , 2007 Feb. : 407-18
  • Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
    Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
    The Journal of clinical investigation , 2007 Feb. : 117(2)407-18
  • Humblet-Baron S, Sather B, Anover S, Becker-Herman S, Kasprowicz DJ, Khim S, Nguyen T, Hudkins-Loya K, Alpers CE, Ziegler SF, Ochs H, Torgerson T, Campbell DJ, Rawlings DJ
    Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
    The Journal of clinical investigation , 2007 Feb. : 407-18
  • Rawlings DJ, Sommer K, Moreno-García ME
    The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
    Nature reviews. Immunology , 2006 Nov. : 6(11)799-812
  • Rawlings DJ, Sommer K, Moreno-García ME
    The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
    Nature reviews. Immunology , 2006 Nov. : 799-812
  • Rawlings DJ, Sommer K, Moreno-García ME
    The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes.
    Nature reviews. Immunology , 2006 Nov. : 799-812
  • Bartram SA, Peaston RT, Rawlings DJ, Walshaw D, Francis RM, Thompson NP
    Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease.
    World journal of gastroenterology : WJG , 2006 Sept. 21 : 12(35)5680-6
  • Bartram SA, Peaston RT, Rawlings DJ, Walshaw D, Francis RM, Thompson NP
    Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn's disease.
    World journal of gastroenterology : WJG , 2006 Sept. 21 : 5680-6
  • Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
    Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
    Blood , 2006 July 1 : 108(1)19-27
  • Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
    Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
    Blood , 2006 July 1 : 19-27
  • Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD
    Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia A mice.
    Blood , 2006 July 1 : 19-27
  • Poreh AM, Rawlings D, Claridge G, Freeman JL, Faulkner C, Shelton C
    The BPQ: a scale for the assessment of borderline personality based on DSM-IV criteria.
    Journal of personality disorders , 2006 June : 20(3)247-60
  • Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK
    HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
    Immunity , 2006 June : 24(6)741-52
  • Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK
    HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
    Immunity , 2006 June : 741-52
  • Gomez TS, McCarney SD, Carrizosa E, Labno CM, Comiskey EO, Nolz JC, Zhu P, Freedman BD, Clark MR, Rawlings DJ, Billadeau DD, Burkhardt JK
    HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
    Immunity , 2006 June : 741-52
  • Rawlings DJ
    The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
    EMBO reports , 2006 Jan. : 7(1)25-30
  • Aspray TJ, Stevenson P, Abdy SE, Rawlings DJ, Holland T, Francis RM
    Low bone mineral density measurements in care home residents--a treatable cause of fractures.
    Age and ageing , 2006 Jan. : 35(1)37-41
  • Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
    Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
    Advances in experimental medicine and biology , 2006 : 58489-106
  • Aspray TJ, Stevenson P, Abdy SE, Rawlings DJ, Holland T, Francis RM
    Low bone mineral density measurements in care home residents--a treatable cause of fractures.
    Age and ageing , 2006 Jan. : 37-41
  • Rawlings DJ
    The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
    EMBO reports , 2006 Jan. : 25-30
  • Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
    Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
    Advances in experimental medicine and biology , 2006 : : 89-106
  • Rawlings DJ
    The biology and biochemistry of inflammatory signalosomes. Meeting on signaling networks in immunity and inflammation.
    EMBO reports , 2006 Jan. : 25-30
  • Moreno-García ME, Sommer KM, Bandaranayake AD, Rawlings DJ
    Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-kappaB activation.
    Advances in experimental medicine and biology , 2006 : 89-106
  • Gleeson JF, Rawlings D, Jackson HJ, McGorry PD
    Early warning signs of relapse following a first episode of psychosis.
    Schizophrenia research , 2005 Dec. 1 : 80(1)107-11
  • Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
    Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
    Immunity , 2005 Dec. : 23(6)561-74
  • Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
    Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
    Immunity , 2005 Dec. : 561-74
  • Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ
    Phosphorylation of the CARMA1 linker controls NF-kappaB activation.
    Immunity , 2005 Dec. : 561-74
  • Pearce MS, Birrell FN, Francis RM, Rawlings DJ, Tuck SP, Parker L
    Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study.
    Journal of epidemiology and community health , 2005 June : 59(6)475-80
  • Pearce MS, Birrell FN, Francis RM, Rawlings DJ, Tuck SP, Parker L
    Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study.
    Journal of epidemiology and community health , 2005 June : 475-80
  • Murray JR, Cooke NJ, Rawlings D, Holland JP, McCaskie AW
    A reliable DEXA measurement technique for metal-on-metal hip resurfacing.
    Acta orthopaedica , 2005 Apr, : 76(2)177-81
  • Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
    Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
    Molecular and cellular biology , 2005 Mar. : 25(6)2073-84
  • Gleeson JF, Rawlings D, Jackson HJ, McGorry PD
    Agreeableness and neuroticism as predictors of relapse after first-episode psychosis: a prospective follow-up study.
    The Journal of nervous and mental disease , 2005 Mar. : 193(3)160-9
  • Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
    CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
    Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar. 1 : 174(5)2687-95
  • Rawlings D
    The IVF experience--a patient perspective.
    Australian family physician , 2005 Mar. : 34(3)173
  • Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
    CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
    Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar. 1 : 2687-95
  • Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
    Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
    Molecular and cellular biology , 2005 Mar. : 2073-84
  • Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF
    Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.
    Molecular and cellular biology , 2005 Mar. : 2073-84
  • Moreno-García ME, López-Bojórques LN, Zentella A, Humphries LA, Rawlings DJ, Santos-Argumedo L
    CD38 signaling regulates B lymphocyte activation via a phospholipase C (PLC)-gamma 2-independent, protein kinase C, phosphatidylcholine-PLC, and phospholipase D-dependent signaling cascade.
    Journal of immunology (Baltimore, Md. : 1950) , 2005 Mar. 1 : 2687-95
  • Schaller JL, Rawlings DB
    Escitalopram in adolescent major depression.
    MedGenMed : Medscape general medicine , 2005 Jan. 31 : 7(1)6
  • Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R
    Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
    Genome biology , 2005 : 6(1)R9
  • David J. Rawlings, MD
    TSLP (Thymic stromal lymphopoietin)
    Enclyclopedia of Hormones , 2005
  • David J. Rawlings, MD
    B-Cell Development
    Hematology: Basic Principles and Practice , 2005 : 119-133
  • Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R
    Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
    Genome biology , 2005 : R9
  • Desiere F, Deutsch EW, Nesvizhskii AI, Mallick P, King NL, Eng JK, Aderem A, Boyle R, Brunner E, Donohoe S, Fausto N, Hafen E, Hood L, Katze MG, Kennedy KA, Kregenow F, Lee H, Lin B, Martin D, Ranish JA, Rawlings DJ, Samelson LE, Shiio Y, Watts JD, Wollscheid B, Wright ME, Yan W, Yang L, Yi EC, Zhang H, Aebersold R
    Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry.
    Genome biology , 2005 : R9
  • Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
    Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
    The Journal of biological chemistry , 2004 Nov. 12 : 279(46)47720-5
  • Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
    Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
    The Journal of biological chemistry , 2004 Nov. 12 : 47720-5
  • Kawakami Y, Nishimoto H, Kitaura J, Maeda-Yamamoto M, Kato RM, Littman DR, Leitges M, Rawlings DJ, Kawakami T
    Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.
    The Journal of biological chemistry , 2004 Nov. 12 : 47720-5
  • Schaller JL, Thomas J, Rawlings D
    Low-dose tiagabine effectiveness in anxiety disorders.
    MedGenMed : Medscape general medicine , 2004 Sept. 17 : 6(3)8
  • Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA
    ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
    Biochemical and biophysical research communications , 2004 Sept. 10 : 322(1)74-81
  • Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA
    ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
    Biochemical and biophysical research communications , 2004 Sept. 10 : 74-81
  • Chun HH, Cary RB, Lansigan F, Whitelegge J, Rawlings DJ, Gatti RA
    ATM protein purified from vaccinia virus expression system: DNA binding requirements for kinase activation.
    Biochemical and biophysical research communications , 2004 Sept. 10 : 74-81
  • Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
    Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
    The Journal of biological chemistry , 2004 Sept. 3 : 279(36)37651-61
  • Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
    Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
    The Journal of biological chemistry , 2004 Sept. 3 : 37651-61
  • Humphries LA, Dangelmaier C, Sommer K, Kipp K, Kato RM, Griffith N, Bakman I, Turk CW, Daniel JL, Rawlings DJ
    Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker.
    The Journal of biological chemistry , 2004 Sept. 3 : 37651-61
  • Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ
    Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
    Blood , 2004 Sept. 1 : 104(5)1281-90
  • Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ
    Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
    Blood , 2004 Sept. 1 : 1281-90
  • Yu PW, Tabuchi RS, Kato RM, Astrakhan A, Humblet-Baron S, Kipp K, Chae K, Ellmeier W, Witte ON, Rawlings DJ
    Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer.
    Blood , 2004 Sept. 1 : 1281-90
  • Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
    Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
    Molecular therapy : the journal of the American Society of Gene Therapy , 2004 July : 10(1)117-26
  • Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
    Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
    Molecular therapy : the journal of the American Society of Gene Therapy , 2004 July : 117-26
  • Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH
    Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice.
    Molecular therapy : the journal of the American Society of Gene Therapy , 2004 July : 117-26
  • Boyce SH, Corfield AR, McGuffie AC, Stevenson J, Rawlings D
    Spontaneous tension pneumopericardium.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine , 2004 June : 11(3)181-4
  • Guo B, Su TT, Rawlings DJ
    Protein kinase C family functions in B-cell activation.
    Current opinion in immunology , 2004 June : 16(3)367-73
  • Guo B, Su TT, Rawlings DJ
    Protein kinase C family functions in B-cell activation.
    Current opinion in immunology , 2004 June : 367-73
  • Guo B, Su TT, Rawlings DJ
    Protein kinase C family functions in B-cell activation.
    Current opinion in immunology , 2004 June : 367-73
  • Su TT, Guo B, Wei B, Braun J, Rawlings DJ
    Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
    Immunological reviews , 2004 Feb. : 197161-78
  • Su TT, Guo B, Wei B, Braun J, Rawlings DJ
    Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
    Immunological reviews , 2004 Feb. : 161-78
  • Su TT, Guo B, Wei B, Braun J, Rawlings DJ
    Signaling in transitional type 2 B cells is critical for peripheral B-cell development.
    Immunological reviews , 2004 Feb. : 161-78
  • David J. Rawlings, MD
    Predominant Antibody Deficiencies: X-linked Agammaglobulinemia
    Immunologic Disorders of Infants and Children , 2004 : 357-373
  • Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL
    BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
    Immunity , 2003 Nov. : 669-78
  • Saito K, Tolias KF, Saci A, Koon HB, Humphries LA, Scharenberg A, Rawlings DJ, Kinet JP, Carpenter CL
    BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.
    Immunity , 2003 Nov. : 669-78
  • Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
    A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
    Proceedings of the National Academy of Sciences of the United States of America , 2003 Aug. 5 : 100(16)9470-5
  • Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
    A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
    Proceedings of the National Academy of Sciences of the United States of America , 2003 Aug. 5 : 9470-5
  • Kawakami Y, Kitaura J, Yao L, McHenry RW, Kawakami Y, Newton AC, Kang S, Kato RM, Leitges M, Rawlings DJ, Kawakami T
    A Ras activation pathway dependent on Syk phosphorylation of protein kinase C.
    Proceedings of the National Academy of Sciences of the United States of America , 2003 Aug. 5 : 9470-5
  • Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J
    B cell developmental requirement for the G alpha i2 gene.
    Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb. 15 : 170(4)1707-15
  • Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J
    B cell developmental requirement for the G alpha i2 gene.
    Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb. 15 : 1707-15
  • Dalwadi H, Wei B, Schrage M, Spicher K, Su TT, Birnbaumer L, Rawlings DJ, Braun J
    B cell developmental requirement for the G alpha i2 gene.
    Journal of immunology (Baltimore, Md. : 1950) , 2003 Feb. 15 : 1707-15
  • Clement WA, Graham I, Ablett M, Rawlings D, Dempster JH
    Intramuscular hemangioma of the posterior belly of the digastric muscle failing to highlight on magnetic resonance imaging.
    The Annals of otology, rhinology, and laryngology , 2002 Nov. : 111(11)1050-3
  • Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA
    Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
    Proceedings of the National Academy of Sciences of the United States of America , 2002 Oct. 29 : 99(22)14392-7
  • Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA
    Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
    Proceedings of the National Academy of Sciences of the United States of America , 2002 Oct. 29 : 14392-7
  • Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC 3rd, Teitell MA
    Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.
    Proceedings of the National Academy of Sciences of the United States of America , 2002 Oct. 29 : 14392-7
  • Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M
    A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation.
    The Journal of experimental medicine , 2002 Sept. 16 : 196(6)753-63
  • Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
    SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
    Blood , 2002 Sept. 1 : 100(5)1852-9
  • Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
    SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
    Blood , 2002 Sept. : : 1852-9
  • Kant AM, De P, Peng X, Yi T, Rawlings DJ, Kim JS, Durden DL
    SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.
    Blood , 2002 Sept. 1 : 1852-9
  • Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ
    PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
    Nature immunology , 2002 Aug. : 3(8)780-6
  • Su TT, Guo B, Kawakami Y, Sommer K, Chae K, Humphries LA, Kato RM, Kang S, Patrone L, Wall R, Teitell M, Leitges M, Kawakami T, Rawlings DJ
    PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling.
    Nature immunology , 2002 Aug. : 780-6
  • Su TT, Guo B, Rawlings DJ
    Emerging roles for PKC isoforms in immune cell function.
    Molecular interventions , 2002 June : 2(3)141-4
  • Su TT, Guo B, Rawlings DJ
    Emerging roles for PKC isoforms in immune cell function.
    Molecular interventions , 2002 June : 141-4
  • Su TT, Rawlings DJ
    Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development.
    Journal of immunology (Baltimore, Md. : 1950) , 2002 Mar. 1 : 168(5)2101-10
  • Su TT, Rawlings DJ
    Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development.
    Journal of immunology (Baltimore, Md. : 1950) , 2002 Mar. 1 : 2101-10
  • Kang SW, Wahl MI, Chu J, Kitaura J, Kawakami Y, Kato RM, Tabuchi R, Tarakhovsky A, Kawakami T, Turck CW, Witte ON, Rawlings DJ
    PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
    The EMBO journal , 2001 Oct. 15 : 5692-702
  • Said JW, Hoyer KK, French SW, Rosenfelt L, Garcia-Lloret M, Koh PJ, Cheng TC, Sulur GG, Pinkus GS, Kuehl WM, Rawlings DJ, Wall R, Teitell MA
    TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma.
    Laboratory investigation; a journal of technical methods and pathology , 2001 Apr, : 555-64
  • Ziegner UH, Ochs HD, Schanen C, Feig SA, Seyama K, Futatani T, Gross T, Wakim M, Roberts RL, Rawlings DJ, Dovat S, Fraser JK, Stiehm ER
    Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies.
    The Journal of pediatrics , 2001 Apr, : 570-3
  • Gallagher KT, Shaham B, Reiff A, Tournay A, Villablanca JP, Curran J, Nelson MD Jr, Bernstein B, Rawlings DJ
    Primary angiitis of the central nervous system in children: 5 cases.
    The Journal of rheumatology , 2001 Mar. : 616-23
  • Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda-Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T
    Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation.
    Journal of immunology (Baltimore, Md. : 1950) , 2000 Aug. 1 : 1210-9
  • Guo B, Kato RM, Garcia-Lloret M, Wahl MI, Rawlings DJ
    Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex.
    Immunity , 2000 Aug. : 243-53
  • Goldman FD, Gilman AL, Hollenback C, Kato RM, Premack BA, Rawlings DJ
    Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties.
    Blood , 2000 June 1 : 3460-6
  • Gordon MS, Kato RM, Lansigan F, Thompson AA, Wall R, Rawlings DJ
    Aberrant B cell receptor signaling from B29 (Igbeta, CD79b) gene mutations of chronic lymphocytic leukemia B cells.
    Proceedings of the National Academy of Sciences of the United States of America , 2000 May 9 : 5504-9
  • Rawlings DJ
    Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.
    Clinical immunology (Orlando, Fla.) , 1999 June : 243-53
  • Nisitani S, Kato RM, Rawlings DJ, Witte ON, Wahl MI
    In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies.
    Proceedings of the National Academy of Sciences of the United States of America , 1999 Mar. 2 : 2221-6
  • Fluckiger AC, Sanz E, Garcia-Lloret M, Su T, Hao QL, Kato R, Quan S, de la Hera A, Crooks GM, Witte ON, Rawlings DJ
    In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells.
    Blood , 1998 Dec. 15 : 4509-20
  • Satterthwaite AB, Rawlings DJ, Witte ON
    DSHP: a "power bar" for sustained immune responses?
    Proceedings of the National Academy of Sciences of the United States of America , 1998 Nov. 10 : 13355-7
  • Fluckiger AC, Li Z, Kato RM, Wahl MI, Ochs HD, Longnecker R, Kinet JP, Witte ON, Scharenberg AM, Rawlings DJ
    Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation.
    The EMBO journal , 1998 Apr, 1 : 1973-85
  • Reiff A, Rawlings DJ, Shaham B, Franke E, Richardson L, Szer IS, Bernstein BH
    Preliminary evidence for cyclosporin A as an alternative in the treatment of recalcitrant juvenile rheumatoid arthritis and juvenile dermatomyositis.
    The Journal of rheumatology , 1997 Dec. : 2436-43
  • Wahl MI, Fluckiger AC, Kato RM, Park H, Witte ON, Rawlings DJ
    Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors.
    Proceedings of the National Academy of Sciences of the United States of America , 1997 Oct. 14 : 11526-33
  • Li T, Rawlings DJ, Park H, Kato RM, Witte ON, Satterthwaite AB
    Constitutive membrane association potentiates activation of Bruton tyrosine kinase.
    Oncogene , 1997 Sept. 18 : 1375-83
  • Rawlings DJ, Quan S, Hao QL, Thiemann FT, Smogorzewska M, Witte ON, Crooks GM
    Differentiation of human CD34+CD38- cord blood stem cells into B cell progenitors in vitro.
    Experimental hematology , 1997 Jan. : 66-72
  • Afar DE, Park H, Howell BW, Rawlings DJ, Cooper J, Witte ON
    Regulation of Btk by Src family tyrosine kinases.
    Molecular and cellular biology , 1996 July : 3465-71
  • Park H, Wahl MI, Afar DE, Turck CW, Rawlings DJ, Tam C, Scharenberg AM, Kinet JP, Witte ON
    Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
    Immunity , 1996 May : 515-25
  • Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP
    Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
    Science (New York, N.Y.) , 1996 Feb. 9 : 822-5
  • Kerner JD, Appleby MW, Mohr RN, Chien S, Rawlings DJ, Maliszewski CR, Witte ON, Perlmutter RM
    Impaired expansion of mouse B cell progenitors lacking Btk.
    Immunity , 1995 Sept. : 301-12
  • Rawlings DJ, Witte ON
    The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function.
    Seminars in immunology , 1995 Aug. : 237-46
  • Rawlings DJ, Quan SG, Kato RM, Witte ON
    Long-term culture system for selective growth of human B-cell progenitors.
    Proceedings of the National Academy of Sciences of the United States of America , 1995 Feb. 28 : 1570-4
  • Faust EA, Rawlings DJ, Saffran DC, Witte ON
    Development of btk transgenic mice.
    Current topics in microbiology and immunology , 1995 : 363-70
  • Shahabuddin M, Rawlings DJ, Kaslow DC
    A novel glucose-6-phosphate dehydrogenase in Plasmodium falciparum: cDNA and primary protein structure.
    Biochimica et biophysica acta , 1994 Sept. 13 : 191-4
  • Zhu Q, Zhang M, Rawlings DJ, Vihinen M, Hagemann T, Saffran DC, Kwan SP, Nilsson L, Smith CI, Witte ON, Chen SH, Ochs HD
    Deletion within the Src homology domain 3 of Bruton's tyrosine kinase resulting in X-linked agammaglobulinemia (XLA).
    The Journal of experimental medicine , 1994 Aug. 1 : 461-70
  • Tsukada S, Rawlings DJ, Witte ON
    Role of Bruton's tyrosine kinase in immunodeficiency.
    Current opinion in immunology , 1994 Aug. : 623-30
  • Saffran DC, Parolini O, Fitch-Hilgenberg ME, Rawlings DJ, Afar DE, Witte ON, Conley ME
    Brief report: a point mutation in the SH2 domain of Bruton's tyrosine kinase in atypical X-linked agammaglobulinemia.
    The New England journal of medicine , 1994 May 26 : 1488-91
  • Rawlings DJ, Witte ON
    Bruton's tyrosine kinase is a key regulator in B-cell development.
    Immunological reviews , 1994 Apr, : 105-19
  • Rawlings DJ, Bernstein B, Rowland JM, Shaham B, Szer IS
    Prolonged course of illness in a child with malignant lymphoma mimicking sarcoidosis.
    The Journal of rheumatology , 1993 Sept. : 1583-7
  • Rawlings DJ, Saffran DC, Tsukada S, Largaespada DA, Grimaldi JC, Cohen L, Mohr RN, Bazan JF, Howard M, Copeland NG
    Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.
    Science (New York, N.Y.) , 1993 July 16 : 358-61
  • Tsukada S, Saffran DC, Rawlings DJ, Parolini O, Allen RC, Klisak I, Sparkes RS, Kubagawa H, Mohandas T, Quan S
    Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
    Cell , 1993 Jan. 29 : 279-90
  • Kaslow DC, Rawlings DJ
    Introducing restriction sites into double-stranded plasmid DNA.
    Methods in enzymology , 1993 : 295-301
  • Scharenberg AM, Hannibal MC, Torgerson T, Ochs HD, Rawlings DJ, Pagon RA, Bird TD, Dolan CR, Stephens K
    Common Variable Immune Deficiency Overview
  • Rawlings DJ, Fujioka H, Fried M, Keister DB, Aikawa M, Kaslow DC
    Alpha-tubulin II is a male-specific protein in Plasmodium falciparum.
    Molecular and biochemical parasitology , 1992 Dec. : 239-50
  • Rawlings DJ, Kaslow DC
    Adjuvant-dependent immune response to malarial transmission-blocking vaccine candidate antigens.
    The Journal of experimental medicine , 1992 Nov. 1 : 1483-7
  • Rawlings DJ, Kaslow DC
    A novel 40-kDa membrane-associated EF-hand calcium-binding protein in Plasmodium falciparum.
    The Journal of biological chemistry , 1992 Feb. 25 : 3976-82
  • Kaslow DC, Rawlings DJ
    Rapid method for introducing restriction sites into double stranded plasmid DNA.
    Nucleic acids research , 1989 Dec. 11 : 10135
  • David J. Rawlings, MD
    Immunologic Basics of Hematology Part 2: B-Cell Immunity
    Hematology: Basic Principles and Practice. 5th Edition

Presentations

Presentations Title Event Location Date
Altered B Cell Signaling Orchestrates Loss of Tolerance and Systemic Autoimmunity University of Washington, Amgen Symposium Seattle, WA Nov. 7, 2013
New Insights into Normal and Dysregulated B Cell Function Jeffrey Modell Centers Summit Berlin, Germany July 17, 2013 - July 20, 2013
Updates in Gene Therapy for PID Clinical Immunology Society Annual Meeting Miami, FL April 25, 2013 - April 28, 2013
Seminaire dImmunologie, Hematologie et de Rhumatologie Pediatriques Pierre Royer Institut Paris, France Feb. 19, 2013 - Feb. 22, 2013
A Novel, B Cell Intrinsic, IL17 B Program helps to control Trypanosoma Cruzi Infection Seattle BioMedical Research Institute Research Seminar Seattle, WA Dec. 10, 2012
Clinical Insights Derived from B-Cell Immunodeficiency Disorders American Society of Hematology Meeting San Diego, CA Dec. 10, 2011 - Dec. 11, 2011
A Link between Innate and Adaptive Immunity Jeffrey Modell World Immunology Conference Rockefeller University; NY June 1, 2011 - June 5, 2011
Viral Vectors for Gene Targeting and Homologous Recombination in Gene Therapy ASGCT 14th Annual Meeting Seattle, WA May 18, 2011 - May 22, 2011
B Cells: New Insights into Normal versus Dysregulated Function 2011 Keystone Symposium Whistler, British Columbia, Canada April 12, 2011 - April 17, 2011
B Cell homeostatis and activiation IUIS Expert Meeting on Primary Immunodeficiencies Dublin, Ireland June 3, 2009
Improving Cellular Therapy for Primary Immune Deficiency Diseases - Recognition, Diagnosis and Management NIH Workshop Bethesda, MD May 20, 2009
Antigen receptor driven NFkB signals in B cells- distinct inputs modulate activation, tolerance, and lymphoma development 50. University of Cincinnati, Cancer and Cell Biology Seminar Series Cincinnati, OH April 23, 2008 - April 24, 2008
Role of PKC Signals in B Cell Activation, Survival and Malignancy Harvard Medical School Program in Immunology Seminar Series Boston, MA May 23, 2007
Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced Signals Keystone Symposia "Biology of B Cells in Health and Disease (B5)" Banff, Alberta, Canada Feb. 6, 2007 - Feb. 11, 2007
Gene Rx for WAS and XLA NIH Gene Therapy Conference, Gene Therapy for Inherited Immune Deficiencies: Advances and Safety Issues Bethesda, MD Sept. 18, 2006 - Sept. 19, 2006
Gene Therapy of Primary Immunodeficiency Disorders UW Cystic Fibrosis Research Seminar Series Seattle, WA Dec. 22, 2005
Distinct signaling responses of transitional B cell subsets and their developmental consequences 7th Latin American Congress of Immunology Cordoba, Argentina Oct. 2, 2005 - Oct. 6, 2005
Btk-dependent events controlling calcium and NF-kB signaling in B lymphocytes 3rd Lymphocyte Signal Transduction Workshop Crete, Greece May 27, 2005 - June 1, 2005
Regulation of CARMA1-mediated NF-B signaling via PKC isoforms in B and T lymphocytes Cantoblanco Workshops Madrid, Spain May 22, 2005 - May 24, 2005
Molecular Mechanism(s) Controlling PKC-Dependent, Immunoreceptor-Induced NF-kappaB Activation Keystone Symposia Steamboat Springs, Colorado March 28, 2005 - April 3, 2005
Preclinical Gene Therapy Studies in XLA and WAS NIH Conference on Wiskott-Aldrich Syndrome Gene Therapy for Wiskott-Aldrich Syndrome Bethesda, MD Sept. 22, 2004 - Sept. 23, 2004
Gene Therapy for Immunodeficiency Disease Progress, Challenges and Coming Trials Childrens Hospital and Regional Medical Center Seattle, Grand Aug. 8, 2004
The Role of BtK in B Cell Activation 12th International Congress of Immunology and 4th Annual Conference of FOCIS Montreal, Canada July 18, 2004 - July 23, 2004
Molecular Events Controlling B Cell Receptor Dependent NfkappaB Activation Amgen Inc. and the University of Washington Department of Immunology Eighth Annual Joint Immunology Symposium Seattle, WA May 21, 2004
Untangling the Pathways for Lymphocyte Activation American Association of Immunologists May 2003