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Carrie L. Heike, MD, MS

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Carrie L. Heike, MD, MS

Craniofacial

On staff since July 2006

Academic Title: Associate Professor

Research Center: Center for Clinical and Translational Research

Making a Difference

Overview

Board Certification(s)
Pediatrics
Medical/Professional School
University of Washington School of Medicine, Seattle
University of Washington School of Medicine, Seattle, Clinical Genetics
Residency
Pediatrics, University of Washington School of Medicine, Seattle
Fellowship
Craniofacial Medicine, University of Washington, Seattle
Clinical Interests

Research includes whether genetic variation contributes to the development of craniofacial anomalies in 22q11.2 deletion syndrome.

Research Description

My current clinical research focuses on the investigation of the relationship between the genotype and phenotype in children with the 22q11.2 deletion syndrome. My clinical and research training in the Children's Craniofacial Center has provided me the opportunity to work with a number of children with the 22q11.2 deletion and observe the wide variability in clinical phenotype. Within this collaborative environment, I have worked with our multi-disciplinary team to generate hypotheses to further our understanding of the phenotypic variability in this patient-population. Our current research is designed to expand scientific understanding regarding the role of specific genetic variations in the development of craniofacial anomalies within this specific population. To accomplish this goal, we are applying novel methods to quantify the subtle facial features which are affected in some individuals with this condition. We are also resequencing genes in the TBX1 pathway to determine sequence variations that may contribute to the phenotypic variability.

I also participate in research to use advanced technology further quantify the phenotypic features affected in other conditions that alter craniofacial features. Advances in the field of three-dimensional imaging combined with anthropometry now provide opportunities to obtain very objective and specific information in craniofacial features. Our ongoing work to characterize facial features in children with 22q11.2 deletion syndrome incorporates new methods that we hope will also be valuable in quantifying craniofacial variation in other conditions that affect craniofacial structures. We have enrolled over 200 participants in our Craniofacial Normative Database study, and we are developing novel techniques to quantify typical and atypical craniofacial variation.

I work with collaborators at Seattle Children's Hospital, as well as in the Departments of Genome Sciences, Computer Science and Engineering, and Epidemiology at the University of Washington on these projects.

Lab URL

http://www.seattlechildrens.org/research/clinical-and-translational-research/heike-lab/

Research Focus Area

Epidemiology, Genetics and Developmental Biology, Craniofacial

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
1st Place Journal Award, American Society of Plastic Surgical Nurses 2010
Elected to the Society for Pediatric Research 2010
Young Investigator Award, Childrens Hospital and Regional Medical Center 2006 - 2008
Young Investigator Research Grant, American Academy of Pediatrics, Section on Genetics and Birth Defects 2004 - 2005
Frederic C. Moll Prize in Pediatrics 2000
Scott Greenwood Memorial Scholarship 1998
University of Washington Womens Varsity Crew Scholarship Award 1994 - 1996

Publications

Reliability of nasolabial anthropometric measures using three-dimensional stereophotogrammetry in infants with unrepaired unilateral cleft lip.
Plastic and reconstructive surgery , 2014 Apr: 133(4)530e-42e
Comparison of two-dimensional and three-dimensional images for phenotypic assessment of craniofacial microsomia.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2013 May: 50(3)305-14
Development at age 36 months in children with deformational plagiocephaly.
Pediatrics , 2013 Jan: 131(1)e109-15
Making the diagnosis: metopic ridge versus metopic craniosynostosis.
The Journal of craniofacial surgery , 2013 Jan: 24(1)178-85
Development at age 36 months in children with deformational plagiocephaly.
Pediatrics , 2013 Jan: 131(1)e109-15
Shape-based classification of 3D facial data to support 22q11.2DS craniofacial research.
Journal of digital imaging : the official journal of the Society for Computer Applications in Radiology , 2012 Jun: 25(3)400-8
Longitudinal, three-dimensional analysis of head shape in children with and without deformational plagiocephaly or brachycephaly.
The Journal of pediatrics , 2012 Apr: 160(4)673-678.e1
Microtia: epidemiology and genetics.
American journal of medical genetics. Part A , 2012 Jan: 158A(1)124-39
Photographic protocol for image acquisition in craniofacial microsomia.
Head & face medicine , 2011 Dec 30: 725
Development in toddlers with and without deformational plagiocephaly.
Archives of pediatrics & adolescent medicine , 2011 Jul: 165(7)653-8
Increased risk of orofacial clefts associated with maternal obesity: case-control study and Monte Carlo-based bias analysis.
Paediatric and perinatal epidemiology , 2010 Sep: 502-12
3D digital stereophotogrammetry: a practical guide to facial image acquisition.
Head & face medicine , 2010 Jul 28: 18
Case-control study of neurodevelopment in deformational plagiocephaly.
Pediatrics , 2010 Mar: 125(3)e537-42
Craniofacial summer cAMP: an educational experience for campers, cAMP staff, and the craniofacial team.
Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses , 2010 Jan-Mar: 6-11; quiz 12-3
Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome.
Birth defects research. Part A, Clinical and molecular teratology , 2010 Jan: 54-63
Three patients with oculo-auriculo-vertebral spectrum and microdeletion 22q11.2.
American journal of medical genetics. Part A , 2009 Dec: 149A(12)2860-4
Picture perfect? Reliability of craniofacial anthropometry using three-dimensional digital stereophotogrammetry.
Plastic and reconstructive surgery , 2009 Oct: 1261-72
What the patients and parents do not tell you-recollections from families following external LeFort III midface distraction.
Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses , 2009 Apr-Jun: 29(2)78-85; quiz 86-7
Automatic analysis of local nasal features in 22q11.2DS affected individuals.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference , 2009: 20093597-600
Evaluation of the infant with an abnormal skull shape.
Current opinion in pediatrics , 2007 Dec: 645-51
Syndromic craniosynostosis: from history to hydrogen bonds.
Orthodontics & craniofacial research , 2007 May: 67-81
Sleep disturbances in 22q11.2 deletion syndrome: a case with obstructive and central sleep apnea.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2007 May: 340-6
Geographic and occupational risk factors for ventricular septal defects: Washington State, 1987-2003.
Archives of pediatrics & adolescent medicine , 2007 Jan: 89-95
Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis?
American journal of medical genetics. Part A , 2005 Dec 1: 67-77
Craniofacial defects of blastogenesis: duplication of pituitary with cleft palate and orophgaryngeal tumors.
American journal of medical genetics. Part A , 2005 May 15: 135(1)13-20
Craniofacial Microsomia Overview
, 1993

Research Funding

Grant TitleGrantorAmountAward Date
CFM: Longitudinal Outcomes in Children pre-Kindergarten (CLOCK)NIH NIDCR $2,730,156 2012 - 2017
Hemifacial Microsomia: Psychosocial and Other SequelaeNIH NIDCR $955,722 2010 - 2015

Primary Office

Seattle Children's
OB.9.520 - Craniofacial
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2208

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