Profile

Ann J. Melvin, MD

Ann J. Melvin, MD

Infectious Disease, Pediatrics-Inpatient, Infectious Disease Research

On staff since November 1993

Academic Title: Associate Professor, Pediatrics

Research Center: Center for Clinical and Translational Research

Ann J. Melvin, MD, MPH: Associate Professor of Pediatric Infectious Diseases. She is Director of the Pediatric HIV program at SCH. Her primary research interests are in the antiretroviral management of HIV disease in children and prevention and management of complications of HIV treatment.

Dr. Melvin is principle investigator of the International Maternal Pediatric Adolescent AIDS Clinical Trials unit at Seattle Childrens Research Institute, sponsored by the NIH, through which she has been chair or co-chair of several national and international research trials. She is also the Senior Faculty Director of Clinical Resources for the Institute of Translational Health Sciences of the University of Washington. She collaborates with Drs. Frenkel, Wagner, Englund and Wald.

Overview

Board Certification(s)

Pediatric Infectious Diseases
Pediatrics

Medical/Professional School

Tulane University School of Medicine, New Orleans

Residency

Pediatrics, Children's Hospital and Regional Medical Center, Seattle

Clinical Interests

Prevention and treatment of pediatric HIV disease, research ethics

Research Focus Area

Translational Research

Awards and Honors

Award Name Award Description Awarded By Award Date
Family Choice Award Seattle Children's Hospital 2002

Publications

  • Yin DE, Warshaw MG, Miller WC, Castro H, Fiscus SA, Harper LM, Harrison LJ, Klein NJ, Lewis J, Melvin AJ, Tudor-Williams G, McKinney RE Jr, PENPACT-1 (PENTA 9/PACTG 390) Study Team
    Using CD4 percentage and age to optimize pediatric antiretroviral therapy initiation.
    Pediatrics , 2014 Oct. : 134(4)e1104-16
  • Langat A, Benki-Nugent S, Wamalwa D, Tapia K, Ngugi E, Diener L, Richardson BA, Melvin A, John-Stewart GC
    Lipid changes in Kenyan HIV-1-infected infants initiating highly active antiretroviral therapy by 1 year of age.
    The Pediatric infectious disease journal , 2013 July : 32(7)e298-304
  • Melvin AJ, Edwards K. Malone J, Hassell L, Wilfond BS.
    Role for CTSAs in Leveraging a Distributed Research Infrastructure to Engage Diverse Stakeholders in Emergent Research Policy Development
    Clinical and Translational Science , 2013 : 6(1)57-9
  • Healy S, Gupta S, Melvin A
    HIV/HBV Co-infection in Children and Antiviral Therapy
    Expert Review of Anti-Infective Therapy , 2013 : 11251-63
  • Englund JA, Karron RA, Cunningham CK, LaRussa P, Melvin A, Yogev R, Handelsman E, Siberry GK, Thumar B, Schappell E, Bull CV, Chu HY, Schaap-Nutt A, Buchholz U, Collins PL, Schmidt AC and the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) P1096 Study Group
    Safety and Infectivity of Two Doses of Live -Attenuated Recombinant Cold-Passaged Human Parainfluenza Type 3 Virus Vaccine rHPIV3cp45 in HPIV3-Seronegative Young Children
    Vaccine , 2013 : 31(48)5706-12
  • Siberry GK, Warshaw MG, Williams PL, Spector SA, Decker MD, Jean-Philippe P, Yogev R, Heckman BE, Manzella A, Roa J, Nachman S, Lujan-Zilbermann J, IMPAACT P1065 Protocol Team
    Safety and immunogenicity of quadrivalent meningococcal conjugate vaccine in 2- to 10-year-old human immunodeficiency virus-infected children.
    The Pediatric infectious disease journal , 2012 Jan. : 31(1)47-52
  • Healy SA, Mohan KM, Melvin AJ, Wald
    Primary maternal Herpes Simplex Virus- 1 gingivostomatitis during pregnancy and neonatal herpes: case series and literature review
    Journal of the Pediatric Infectious Disease Society , 2012 : 1299-305
  • Penpact 1 Study Team (Melvin AJ)
    First-line antiretroviral therapy with a protease inhibitor
    Thee Lancet-Infectious Diseases , 2011 : 11(4)273-83
  • Jacobson DL, Williams P, Tassiopoulos K, Melvin A, Hazra R, Farley J.
    Clinical management and follow-up of hypercholesterolemia among perinatally HIV-infected children enrolled in the PACTG 219C study
    Journal of Acquired Immune Deficency Syndromes , 2011 : 57(5)413-20
  • Levin MJ, Moscicki AB, Song LY, Fenton T, Meyer WA 3rd, Read JS, Handelsman EL, Nowak B, Sattler CA, Saah A, Radley DR, Esser MT, Weinberg A, IMPAACT P1047 Protocol Team
    Safety and immunogenicity of a quadrivalent human papillomavirus (types 6, 11, 16, and 18) vaccine in HIV-infected children 7 to 12 years old.
    Journal of acquired immune deficiency syndromes (1999) , 2010 Oct. : 197-204
  • Wagner TA, Tobin NH, McKernan JL, Xu M, Melvin AJ, Mohan KM, Learn GH, Mullins JI, Frenkel LM
    Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses.
    AIDS (London, England) , 2009 May 15 : 923-8
  • Williams PL, Van Dyke R, Eagle M, Smith D, Vincent C, Ciupak G, Oleske J, Seage GR 3rd
    Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study.
    American journal of epidemiology , 2008 June 1 : 1375-86
  • Patel K, Hernán MA, Williams PL, Seeger JD, McIntosh K, Dyke RB, Seage GR 3rd
    Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2008 June 1 : 1751-60
  • Tassiopoulos K, Williams PL, Seage GR 3rd, Crain M, Oleske J, Farley J
    Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children.
    Journal of acquired immune deficiency syndromes (1999) , 2008 Apr, 15 : 607-14
  • Melvin AJ, Kang M, Hitti J, Livingston E, Cohn SE, Stocker V, Ross AC, Watts H, McComsey GA
    Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy.
    Antiviral therapy , 2008 : 349-55
  • McComsey G, Kang M, Ross A, Lebrecht D, Livingston E, Melvin A, Hitti J, Cohn SE, and Walker UA for the AIDS Clinical Trials Group A5084
    Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV infected mothers on antiretroviral therapy
    HIV Clinical Trails , 2008 : 9(2)126-36
  • Gupta D, Lhewa D, Viswanath R, Jacob SM, Parameshwari S, Radhakrishnan R, Seidel K, Frenkel LM, Samuel NM, Melvin AJ
    Effectiveness of antenatal group HIV voluntary counseling and testing services in rural India.
    AIDS education and prevention : official publication of the International Society for AIDS Education , 2007 June : 187-97
  • Hitti J, Andersen J, McComsey G, Liu T, Melvin A, Smith L, Stek A, Aberg J, Hull A, Alston-Smith B, Watts DH, Livingston E, AIDS Clinical Trials Group 5084 Study Team
    Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084.
    American journal of obstetrics and gynecology , 2007 Apr, : 196(4)331.e1-7
  • Holte SE, Melvin AJ, Mullins JI, Tobin NH, Frenkel LM
    Density-dependent decay in HIV-1 dynamics.
    Journal of acquired immune deficiency syndromes (1999) , 2006 Mar. : 266-76
  • Johnson DC, McFarland EJ, Muresan P, Fenton T, McNamara J, Read JS, Hawkins E, Bouquin PL, Estep SG, Tomaras GD, Vincent CA, Rathore M, Melvin AJ, Gurunathan S, Lambert J
    Safety and immunogenicity of an HIV-1 recombinant canarypox vaccine in newborns and infants of HIV-1-infected women.
    The Journal of infectious diseases , 2005 Dec. 15 : 2129-33
  • Tobin NH, Learn GH, Holte SE, Wang Y, Melvin AJ, McKernan JL, Pawluk DM, Mohan KM, Lewis PF, Mullins JI, Frenkel LM
    Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus.
    Journal of virology , 2005 Aug. : 9625-34
  • Melvin AJ, Alarcon J, Velasquez C, Rodriguez C, Piscoya J, Giraldo A, Dinh P, Frenkel LM
    Rapid HIV type 1 testing of women presenting in late pregnancy with unknown HIV status in Lima, Peru.
    AIDS research and human retroviruses , 2004 Oct. : 1046-52
  • Melvin AJ, Alarcon J, Velasquez C, Rodriguez C, Piscoya J, Giraldo A, Dinh P, Frenkel LM
    Rapid HIV type 1 testing of women presenting in late pregnancy with unknown HIV status in Lima, Peru.
    AIDS research and human retroviruses , 2004 Oct. : 1046-52
  • Frenkel LM, Wang Y, Learn GH, McKernan JL, Ellis GM, Mohan KM, Holte SE, De Vange SM, Pawluk DM, Melvin AJ, Lewis PF, Heath LM, Beck IA, Mahalanabis M, Naugler WE, Tobin NH, Mullins JI
    Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy.
    Journal of virology , 2003 May : 5721-30
  • Melvin, A. J., and K. M. Mohan
    Response to immunization with measles, tetanus, and Haemophilus influenzae type b vaccines in children who have human immunodeficiency virus type 1 infection and are treated with highly active antiretroviral therapy
    Pediatrics , 2003 : 111(6 pt 1)e641-4
  • Melvin AJ, Lewis PF, Mohan KM, Naugler WS, Frenkel LM
    Efficacy and toxicity of antiretroviral therapy using 4 or more agents: application of a strategy for antiretroviral management in human immunodeficiency virus-infected children.
    Archives of pediatrics & adolescent medicine , 2002 June : 568-73
  • Beck, I. A., K. D. Drennan, A. J. Melvin, K. M. Mohan, A. M. Herz, J. Alarcon, J. Piscoya, C. Velazquez, and L. M. Frenkel
    Simple, sensitive, and specific detection of human immunodeficiency virus type 1 subtype B DNA in dried blood samples for diagnosis in infants in the field.
    Journal of Clinical Microbiology , 2001 : 39(1)29-33
  • Melvin, A. J., S. Lennon, K. M. Mohan, and J. Q. Purnell
    Metabolic abnormalities in HIV type 1-infected children treated and not treated with protease inhibitors
    AIDS Research and Human Retroviruses , 2001 : 17(12)1117-23
  • Frenkel, L. M., E. V. Capparelli, W. M. Dankner, J. Xu, I. L. Smith, A. Ballow, M. Culnane, J. S. Read, M. Thompson, K. M. Mohan, A. Shaver, C. A. Robinson, M. J. Stempien, S. K. Burchett, A. J. Melvin, W. Borkowsky, A. Petru, A. Kovacs, R. Yogev, J. Goldsmith, E. J. McFarland, and S. A. Spector
    Oral ganciclovir in children: pharmacokinetics, safety, tolerance, and antiviral effects. The Pediatric AIDS Clinical Trials Group
    Journal of Infectious Disease , 2000 : 182(6)1616-24
  • Melvin, A.J., Rodrigo, A. G, Mohan K.M., Lewis, P.A., Manns-Arcuino, L.A., Coombs R.W., Mullins J.I., Frenkel L.M
    HIV-1 dynamics in children
    Journal of Acquired Immune Defiency Syndromes and Human Retro Virology , 1999 : 20(5)468-73
  • Melvin, A.J., Rodrigo, A. G, Mohan K.M., Lewis, P.A., Manns-Arcuino, L.A., Coombs R.W., Mullins J.I., Frenkel L.M
    HIV-1 dynamics in children
    Journal of Acquired Immune Deficency Syndromes and Human Retrovirology , 1999 : 20(5)468-73
  • Melvin, A. J
    Anti-retroviral therapy for HIV-infected children--toward maximal effectiveness
    The Pediatric Infectious Disease Journal , 1999 : 18(8)723-4
  • Melvin, A.J., Rodrigo, A. G, Mohan K.M., Lewis, P.A., Manns-Arcuino, L.A., Coombs R.W., Mullins J.I., Frenkel L.M
    HIV-1 dynamics in children, 1999
    Journal of Acquired Immune Deficency Syndromes and Human Retrovirology , 1999 : 20(5)468-73
  • Melvin, A. J., G. S. Tamura, J. K. House, A. C. Hobson, R. W. Cone, L. M. Frenkel, and S. Burchett
    Lack of detection of human immunodeficiency virus type 1 in the saliva of infected children and adolescents.
    Archives of Pediatric and Adolescent Medicine , 1997 : 151(3)228-32
  • Frenkel, L. M., M. K. Cowles, D. E. Shapiro, A. J. Melvin, D. H. Watts, C. McLellan, K. Mohan, B. Murante, S. Burchett, Y. J. Bryson, M. J. O'Sullivan, C. Mitchell, and D. Landers
    Analysis of the maternal components of the AIDS clinical trial group 076 zidovudine regimen in the prevention of mother-to-infant transmission of human immunodeficiency virus type 1
    The Journal of Infectious Disease , 1997 : 175(4)971-4
  • Melvin, A. J., S. K. Burchett, D. H. Watts, J. Hitti, J. P. Hughes, C. L. McLellan, P. D. King, E. J. Johnson, B. L. Williams, L. M. Frenkel, and R. W. Coom
    Effect of pregnancy and zidovudine therapy on viral load in HIV-1-infected women
    Journal of Acquired Immune Deficency Syndromes and Human Retrovirology , 1997 : 14(3)232-6
  • Melvin, A. J., and L. M. Frenkel.
    Prevention of mother-to-infant transmission of HIV-1
    Molecular Medicine Today , 1997 : 3(6)242-5
  • Melvin, A. J., K. M. Mohan, L. A. Arcuino, R. E. Edelstein, and L. M. Frenkel
    Clinical, virologic and immunologic responses of children with advanced human immunodeficiency virus type 1 disease treated with protease inhibitors
    The Pediatric Infectious Disease Journal , 1997 : 16(10)968-74
  • Edelstein, R. E., L. A. Arcuino, J. P. Hughes, A. J. Melvin, K. M. Mohan, P. D. King, C. L. McLellan, B. L. Murante, B. P. Kassman, and L. M. Frenkel
    Risk of mother-to-infant transmission of HIV-1 is not reduced in 32ccr5/CCR5 heterozygotes
    Journal of Acquired Immune Syndromes and Human Retrovirology , 1997 : 16(4)243-6
  • Melvin, A. J., M. E. McGurn, S. J. Bort, C. Gibson, and D. B. Lewis
    Hypomethylation of the interferon- gene correlates with its expression by primary T-lineage cells.
    European Journal of Immunology , 1995 : 25(2)426-30
  • Melvin, A. J., K. Mohan, and J. Dragavon
    ICD p24 antigen in HIV-infected children with low HIV-specific antibody
    Pediatric AIDS and HIV Infection , 1995 : 6(6)356-7
  • Young, H. A., P. Ghosh, J. Ye, J. Lederer, A. Lichtman, J. R. Gerard, L. Penix, C. B. Wilson, A. J. Melvin, M. E. McGurn, and et al.
    Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene
    Journal of Immunology , 1994 : 153(8)3603-10
  • Wilson, C. B., L. Penix, A. Melvin, and D. B. Lewis
    Lymphokine regulation and the role of abnormal regulation in immunodeficiency
    Clinical Immunology and Immunopathy , 1993 : 67(3 pt. 2)S25-32
  • Wilson, C. B., L. Penix, W. M. Weaver, A. Melvin, and D. B. Lewis.
    Ontogeny of T lymphocyte function in the neonate
    American Journal of Reproductive Immunology , 1992 : 28(3-4)132-5

Research Funding

Grant Title Grantor Amount Award Date
International and Domestic Pediatric and Maternal HIV Studies Coordinating Center NIH $220,081 June 1, 2014 - May 31, 2015
Bone mineral density in tenofovir-exposed infants and young children Gilead Sciences Phase4 program $47,943.00 June 23, 2008 - May 30, 2011
International and Domestic Pediatric and Maternal HIV Studies Coordinating Center NIH $659,107.00 Dec. 16, 2007 - May 31, 2014
Supplement 3 R01 NIH Sept. 26, 2007 - May 30, 2011
NIH Cooperative Agreement NIH Sept. 1, 2007 - May 31, 1917
Reservoirs of Drug-Resistant HIV-1 US-India Collaborative Research Supplement NIH $58,907.00 March 1, 2005 - Feb. 28, 2012