Ann J. Melvin, MD

Ann J. Melvin, MD

Infectious Disease, Pediatrics-Inpatient, Infectious Disease Research

On staff since November 1993

Academic Title: Associate Professor, Pediatrics

Research Center: Center for Clinical and Translational Research

Ann J. Melvin, MD, MPH: Associate Professor of Pediatric Infectious Diseases. She is co-director of the Pediatric HIV program at SCH. Her research interests are in the antiretroviral management of HIV disease in children and prevention and management of complications of HIV treatment.

Dr. Melvin is  co-principle investigator of the International Maternal Pediatric Adolescent Clinical Trials unit at the University of Washington, sponsored by the NIH, through which she is also chair or co-chair of several national and international research trials. She is also the co-director of the Regulatory Support and Bioethics Core of the Institute for Translational Health Sciences of the University of Washington. She collaborates with Drs. Englund, Frenkel, Corey, and Zerr.


Board Certification(s)

Pediatric Infectious Diseases

Medical/Professional School

Tulane University School of Medicine, New Orleans


Pediatrics, Children's Hospital and Regional Medical Center, Seattle

Clinical Interests

Prevention and treatment of pediatric HIV disease, research ethics

Research Focus Area

Translational Research


  • Patel K, Ming X, Williams PL, Robertson KR, Oleske JM, Seage GR 3rd
    Impact of HAART and CNS-penetrating antiretroviral regimens on HIV encephalopathy among perinatally infected children and adolescents.
    AIDS (London, England) , 2009 Sept. 10 : 1893-901
  • Weinberg A, Huang S, Fenton T, Patterson-Bartlett J, Gona P, Read JS, Dankner WM, Nachman S
    Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment.
    Journal of acquired immune deficiency syndromes (1999) , 2009 Sept. 1 : 17-24
  • Wagner TA, Tobin NH, McKernan JL, Xu M, Melvin AJ, Mohan KM, Learn GH, Mullins JI, Frenkel LM
    Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses.
    AIDS (London, England) , 2009 May 15 : 923-8
  • Nachman SA, Chernoff M, Gona P, Van Dyke RB, Dankner WM, Seage GR 3rd, Oleske J, Williams PL
    Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era.
    Archives of pediatrics & adolescent medicine , 2009 Feb. : 164-71
  • Williams PL, Van Dyke R, Eagle M, Smith D, Vincent C, Ciupak G, Oleske J, Seage GR 3rd
    Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study.
    American journal of epidemiology , 2008 June 1 : 1375-86
  • Patel K, Hernán MA, Williams PL, Seeger JD, McIntosh K, Dyke RB, Seage GR 3rd
    Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2008 June 1 : 1751-60
  • Tassiopoulos K, Williams PL, Seage GR 3rd, Crain M, Oleske J, Farley J
    Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children.
    Journal of acquired immune deficiency syndromes (1999) , 2008 Apr, 15 : 607-14
  • Melvin AJ, Kang M, Hitti J, Livingston E, Cohn SE, Stocker V, Ross AC, Watts H, McComsey GA
    Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy.
    Antiviral therapy , 2008 : 349-55
  • Gupta D, Lhewa D, Viswanath R, Jacob SM, Parameshwari S, Radhakrishnan R, Seidel K, Frenkel LM, Samuel NM, Melvin AJ
    Effectiveness of antenatal group HIV voluntary counseling and testing services in rural India.
    AIDS education and prevention : official publication of the International Society for AIDS Education , 2007 June : 187-97
  • Holte SE, Melvin AJ, Mullins JI, Tobin NH, Frenkel LM
    Density-dependent decay in HIV-1 dynamics.
    Journal of acquired immune deficiency syndromes (1999) , 2006 Mar. : 266-76
  • Johnson DC, McFarland EJ, Muresan P, Fenton T, McNamara J, Read JS, Hawkins E, Bouquin PL, Estep SG, Tomaras GD, Vincent CA, Rathore M, Melvin AJ, Gurunathan S, Lambert J
    Safety and immunogenicity of an HIV-1 recombinant canarypox vaccine in newborns and infants of HIV-1-infected women.
    The Journal of infectious diseases , 2005 Dec. 15 : 2129-33
  • Tobin NH, Learn GH, Holte SE, Wang Y, Melvin AJ, McKernan JL, Pawluk DM, Mohan KM, Lewis PF, Mullins JI, Frenkel LM
    Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus.
    Journal of virology , 2005 Aug. : 9625-34
  • Melvin AJ, Alarcon J, Velasquez C, Rodriguez C, Piscoya J, Giraldo A, Dinh P, Frenkel LM
    Rapid HIV type 1 testing of women presenting in late pregnancy with unknown HIV status in Lima, Peru.
    AIDS research and human retroviruses , 2004 Oct. : 1046-52
  • Frenkel LM, Wang Y, Learn GH, McKernan JL, Ellis GM, Mohan KM, Holte SE, De Vange SM, Pawluk DM, Melvin AJ, Lewis PF, Heath LM, Beck IA, Mahalanabis M, Naugler WE, Tobin NH, Mullins JI
    Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy.
    Journal of virology , 2003 May : 5721-30
  • Melvin AJ, Lewis PF, Mohan KM, Naugler WS, Frenkel LM
    Efficacy and toxicity of antiretroviral therapy using 4 or more agents: application of a strategy for antiretroviral management in human immunodeficiency virus-infected children.
    Archives of pediatrics & adolescent medicine , 2002 June : 568-73

Research Funding

Grant Title Grantor Amount Award Date
Bone mineral density in tenofovir-exposed infants and young children Gilead Sciences Phase4 program $47,943.00 June 23, 2008
Bioethics core NIH Cooperative Agreement $1,583,701.00 June 1, 2008
International and Domestic Pediatric and Maternal HIV Studies Coordinating Center NIH $659,107.00 Dec. 16, 2007
Reservoirs of Drug-Resistant HIV-1 – US-India Collaborative Research Supplement NIH $58,907.00 March 1, 2005