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Adrian M. Piliponsky, PhD

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Adrian M. Piliponsky, PhD

Immunology

Children's Title: Principal Investigator

Academic Title: Assistant Professor, Department of Pediatrics, University of Washington; Adjunct Professor, Department of Pathology, University of Washington

Research Center: Center for Immunity and Immunotherapies

"I am passionate to come to the lab because I love what I do. Every day in the lab presents itself with new challenges and an infinite number of questions for which we usually have few or no answers. As a consequence of this, there is always work to be done and progress that ought to be celebrated and shared with the rest of the scientific community. I strongly believe that this is what research is about, and I am lucky to enjoy doing it every day."

Overview

Medical/Professional School
The Hebrew University, Hadassah Medical School, Jerusalem, Immunology
Fellowship
Stanford University , Stanford

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Early Career Faculty Travel GrantHonor received to attend the American Association of Immunologists (AAI) 99th AAI Annual Meeting-IMMUNOLOGY 2012TMAmerican Association of Immunologists (AAI) 2012
Travel GrantHonor received to attend the American Academy of Allergy, Asthma and Immunology (AAAAI) 56th Annual Meeting in New Orleans, LA.American Academy of Allergy, Asthma and Immunology (AAAAI) 2001
Travel GrantHonor received to attend The Fourth International Workshop on Signal Transduction in the Activation and Development of Mast Cells and NIH, Basophils at the Bethesda, MDThe Aharon Katzir Center, Weizmann Institute of Science 2001
Travel GrantHonor received to attend the 8th Euroconference on Apoptosis, Davos, SwitzerlandEuropean Cell Death Organization (ECDO) 2000
Superpharm Scholarship for PhD students at the School of PharmacyThe Hebrew University of Jerusalem, Israel 2000
Golda Meir FellowshipThe Hebrew University of Jerusalem, Israel 1998 - 2001
Zuckerman FellowshipHebrew University of Jerusalem, Israel. National Institute of Drugs Fellowship, Ministry of Health, Buenos Aires, Argentina. 1995 - 1998
National Institute of Drugs FellowshipMinistry of Health, Buenos Aires, Argentina 1995

Publications

Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33.
The Journal of allergy and clinical immunology , 2013 Nov 9
Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33.
The Journal of allergy and clinical immunology , 2013 Nov 9
Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.
The Journal of allergy and clinical immunology , Feb. 2013: 131(2)541-8.e1-9
Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.
The Journal of allergy and clinical immunology , 2013 Feb: 131(2)541-8.e1-9
Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.
The Journal of allergy and clinical immunology , 2013 Feb: 131(2)541-8.e1-9
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
The American journal of pathology , Sept. 2012: 181(3)875-86
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
The American journal of pathology , 2012 Sep: 181(3)875-86
The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis.
The American journal of pathology , 2012 Sep: 181(3)875-86
Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.
Blood , Dec. 2011: 118(26)6930-8
Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.
Blood , 2011 Dec 22: 118(26)6930-8
Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice.
Blood , 2011 Dec 22: 118(26)6930-8
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.
The Journal of clinical investigation , Oct. 2011: 121(10)4180-91
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.
The Journal of clinical investigation , 2011 Oct: 121(10)4180-91
Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice.
The Journal of clinical investigation , 2011 Oct: 121(10)4180-91
Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.
The American journal of pathology , Feb. 2010: 176(2)926-38
Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.
The American journal of pathology , 2010 Feb: 176(2)926-38
Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice.
The American journal of pathology , 2010 Feb: 176(2)926-38
Rabaptin-5 regulates receptor expression and functional activation in mast cells.
Blood , Nov. 2008: 112(10)4148-57
Rabaptin-5 regulates receptor expression and functional activation in mast cells.
Blood , 2008 Nov 15: 112(10)4148-57
Rabaptin-5 regulates receptor expression and functional activation in mast cells.
Blood , 2008 Nov 15: 112(10)4148-57
The development of allergic inflammation.
Nature , July 2008: 454(7203)445-54
The development of allergic inflammation.
Nature , 2008 Jul 24: 454(7203)445-54
The development of allergic inflammation.
Nature , 2008 Jul 24: 454(7203)445-54
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.
Nature medicine , April 2008: 14(4)392-8
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.
Nature medicine , 2008 Apr: 14(4)392-8
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.
Nature medicine , 2008 Apr: 14(4)392-8
Mast cells in the promotion and limitation of chronic inflammation.
Immunological reviews , June 2007: 217304-28
Mast cells in the promotion and limitation of chronic inflammation.
Immunological reviews , 2007 Jun: 217304-28
Mast cells in the promotion and limitation of chronic inflammation.
Immunological reviews , 2007 Jun: 217304-28
Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.
Blood , March 2007: 109(5)1992-7
Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.
Blood , 2007 Mar 1: 109(5)1992-7
Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo.
Blood , 2007 Mar 1: 109(5)1992-7
Mast cells can enhance resistance to snake and honeybee venoms.
Science (New York, N.Y.) , July 2006: 313(5786)526-30
Mast cells can enhance resistance to snake and honeybee venoms.
Science (New York, N.Y.) , 2006 Jul 28: 313(5786)526-30
Mast cells can enhance resistance to snake and honeybee venoms.
Science (New York, N.Y.) , 2006 Jul 28: 313(5786)526-30
Human mast cells undergo TRAIL-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) , Feb. 2006: 176(4)2272-8
Human mast cells undergo TRAIL-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) , 2006 Feb 15: 176(4)2272-8
Human mast cells undergo TRAIL-induced apoptosis.
Journal of immunology (Baltimore, Md. : 1950) , 2006 Feb 15: 176(4)2272-8
The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts.
The Journal of allergy and clinical immunology , Jan. 2006: 117(1)103-10
Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response.
The Journal of allergy and clinical immunology , Dec. 2005: 116(6)1357-63
The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts.
The Journal of allergy and clinical immunology , 2006 Jan: 117(1)103-10
The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts.
The Journal of allergy and clinical immunology , 2006 Jan: 117(1)103-10
Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response.
The Journal of allergy and clinical immunology , 2005 Dec: 116(6)1357-63
Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response.
The Journal of allergy and clinical immunology , 2005 Dec: 116(6)1357-63
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
The American journal of pathology , Sept. 2005: 167(3)835-48
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
The American journal of pathology , 2005 Sep: 167(3)835-48
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
The American journal of pathology , 2005 Sep: 167(3)835-48
Human peripheral blood eosinophils induce angiogenesis.
The international journal of biochemistry & cell biology , March 2005: 37(3)628-36
Human peripheral blood eosinophils induce angiogenesis.
The international journal of biochemistry & cell biology , 2005 Mar: 37(3)628-36
Human peripheral blood eosinophils induce angiogenesis.
The international journal of biochemistry & cell biology , 2005 Mar: 37(3)628-36
Mast cells as "tunable" effector and immunoregulatory cells: recent advances.
Annual review of immunology , 2005: 23749-86
Mast cells as "tunable" effector and immunoregulatory cells: recent advances.
Annual review of immunology , 2005: 23749-86
Mast cells as "tunable" effector and immunoregulatory cells: recent advances.
Annual review of immunology , 2005: 23749-86
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.
Nature , Nov. 2004: 432(7016)512-6
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.
Nature , 2004 Nov 25: 432(7016)512-6
Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.
Nature , 2004 Nov 25: 432(7016)512-6
Tryptase, a novel link between allergic inflammation and fibrosis.
Trends in immunology , April 2003: 24(4)158-61
Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor.
Blood , March 2003: 101(5)1898-904
Tryptase, a novel link between allergic inflammation and fibrosis.
Trends in immunology , 2003 Apr: 24(4)158-61
Tryptase, a novel link between allergic inflammation and fibrosis.
Trends in immunology , 2003 Apr: 24(4)158-61
Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor.
Blood , 2003 Mar 1: 101(5)1898-904
Non-IgE-dependent activation of human lung- and cord blood-derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor.
Blood , 2003 Mar 1: 101(5)1898-904
Mast cells as initiators and effectors of allergic inflammation. In: New Trends in Allergy V
(Ring J, Behrendt H, Eds.), Springer-Verlag Berlin, Heidelberg 2003. , 2003
Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
Molecular immunology , Sept. 2002: 38(16-18)1369
Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
Molecular immunology , 2002 Sep: 38(16-18)1369
Effects of eosinophils on mast cells: a new pathway for the perpetuation of allergic inflammation.
Molecular immunology , 2002 Sep: 38(16-18)1369
Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus.
Investigative ophthalmology & visual science , June 2002: 43(6)1850-6
Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus.
Investigative ophthalmology & visual science , 2002 Jun: 43(6)1850-6
Nerve growth factor and eosinophils in inflamed juvenile conjunctival nevus.
Investigative ophthalmology & visual science , 2002 Jun: 43(6)1850-6

Presentations

Presentations TitleEventLocationDate
Role of mast cells and mast cell proteases in innate immunitySRI InternationalMenlo Park, CANov. 16, 2012
Mast cells and sepsisDepartment of Pathology, Sanford UniversityStanford, CANov. 15, 2012
Mast cells: from anaphylaxis to mastocytosis and beyondPediatric Grand RoundsMarch 15, 2012
Role of mast cells in innate immunityPulmonary Research Group, University of WashingtonUniversity of Washington, Seattle, WAJan. 23, 2012
TSLP promotes interleukin-3-independent basophil hematopoiesis and type 2 inflammation.Lung Division, University of WashingtonSouth Lake UnionSept. 29, 2011
Role of mast cells and mast cell proteases in innate immunity.Pediatric Inflammation Research Group, University of WashingtonSouth Lake UnionAug. 24, 2011
What good things do mast cells do and why do we need them?The Mastocytosis Society, Inc.17th Annual Conference, Boston 2011
Mast cell chymase degrades TNF, limits inflammation, and promotes survival in a mouse model of sepsis98th Annual Meeting of the American Association of ImmunologistsSan Francisco, CA 2011

Research Funding

Grant TitleGrantorAmountAward Date
1 R01 HL113351-01A1NIH/NHLBIJuly 15, 2012 - April 30, 2017
12GRNT9680021 WSA/American Heart Association Jan. 1, 2012 - Dec. 31, 2013

Primary Office

Seattle Children's Research Institute
JMB - 7 - Immunology
1900 - 9th Ave
Seattle, WA 98101
206-987-7450

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