Profile

Thor A. Wagner, MD

On staff since July 2008

Academic Title: Assistant Professor

Research Center: Center for Childhood Infections and Prematurity Research

"My research is inspired by patients that I meet and directed at the problems that they face. There are exciting opportunities to adapt current biotechnology to help our patients' needs, and it's great motivation to know that the research we do has the potential to directly benefit our patients."

Thor Wagner, MD: Assistant Professor of Pediatric Infectious Diseases. Dr. Wagner’s research is focused on pediatric HIV infection, which accounts for 15% of all HIV deaths.

My primary interest is understanding chronic HIV infection during antiretroviral therapy. Specifically, why doesn't antiretroviral therapy eradicate HIV infection? Is there ongoing viral replication? Is there proliferation of cells with viable proviral HIV? Can we identify the remaining infected cells? Is immune tolerance to HIV a barrier to curing HIV? Answers to these questions should help design new treatment strategies more likely to cure HIV. My other research interest is improving infectious disease diagnostics in low resource settings. Specifically, I am working to develop a point-of-care diagnostic test for infant HIV. Currently there is no simple test to diagnose infants with HIV, and 50% of HIV-infected children die before they can be diagnosed. To accomplish this we are utilizing state-of-the-art monoclonal antibody screening technology to optimize the sensitivity of immunoassays to detect HIV antigens.

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Overview
Awards and Honors
Publications
Research Funding

Overview

Board Certification(s): Pediatrics
Pediatric Infectious Diseases
Medical/Professional School: Temple University School of Medicine, Philadelphia
Residency: Pediatrics, Children's Hospital of New York, CHN-517, New York
Fellowship: Infectious Disease, Children's Hospital and Regional Medical Center, Seattle
Clinical Interests: General pediatric infectious diseases, pediatric HIV Mechanism of persistent HIV infection despite effective treatment, improving HIV diagnostics for the low resource settings
Research Description: My research is focused on pediatric HIV infection, which accounts for 15percent of all HIV deaths.

My primary interest is understanding chronic HIV infection during antiretroviral therapy. Specifically, why doesn't antiretroviral therapy eradicate HIV infection? Is there ongoing viral replication? Is there proliferation of cells with viable proviral HIV? Can we identify the remaining infected cells? Is immune tolerance to HIV a barrier to curing HIV? Answers to these questions should help design new treatment strategies more likely to cure HIV.

My other research interest is improving infectious disease diagnostics in low resource settings. Specifically, I am working to develop a point-of-care diagnostic test for infant HIV. Currently there is no simple test to diagnose infants with HIV, and 50percent of HIV-infected children die before they can be diagnosed. To accomplish this we are utilizing state-of-the-art monoclonal antibody screening technology to optimize the sensitivity of immunoassays to detect HIV antigens.
Research Focus Area: Infectious Disease

Awards and Honors

Award Name	Award Description	Awarded By	Award Date
	Young Scientist Scholarship - XVIII HIV International Drug Resistance Workshop	XVIII HIV International Drug Resistance Workshop	Jan. 1, 2009
	Burroughs Wellcome Fund, American Society of Tropical Medicine and Hygiene: Postdoctoral Fellowship in Tropical Infectious Disease	Burroughs Wellcome Fund, American Society of Tropical Medicine and Hygiene	Jan. 1, 2009

Publications

Yet Another Reason to Treat HIV Infection.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2012 Apr: 54(7)1010-2

Monitoring of HIV Type 1 DNA Load and Drug Resistance in Peripheral Blood Mononuclear Cells During Suppressive Antiretroviral Therapy Does Not Predict Virologic Failure.
AIDS research and human retroviruses , 2012 Jan 27

Epidemiology and aetiology of maternal bacterial and viral infections in low and middle income countries
Journal of Global Health , 2011: 1(2)169-185

A global health opportunity: the potential of multiplexed diagnostics in low resource settings
Journal of Global Health , 2011: 1(2)136-139

Emerging Biomarkers for the Diagnosis of Severe Neonatal Infections Applicable to Low Resource Settings
Journal of Global Health , 2011: 1(2)208-221

Epidemiology and aetiology of parasitic maternal infections in low- and middleincome countries
Journal of Global Health , 2011: 1(2)187-198

Antiretroviral treatment for HIV-infected infants exposed to nevirapine.
JAMA : the journal of the American Medical Association , 2010 Dec 15: 304(23)2589; author reply 2589-90

Antiretroviral treatment for HIV-infected infants exposed to nevirapine.
JAMA : the journal of the American Medical Association , 2010 Dec 15: 2589; author reply 2589-90

Astrovirus encephalitis in boy with X-linked agammaglobulinemia.
Emerging infectious diseases , 2010 Jun: 16(6)918-25

Astrovirus encephalitis in boy with X-linked agammaglobulinemia.
Emerging infectious diseases , 2010 Jun: 918-25

Association between detection of HIV-1 DNA resistance mutations by a sensitive assay at initiation of antiretroviral therapy and virologic failure.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2010 May 15: 50(10)1397-404

Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay.
Journal of clinical microbiology , 2010 May: 48(5)1555-61

Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses.
AIDS (London, England) , 2009 May 15: 23(8)923-8

Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses.
AIDS (London, England) , 2009 May 15: 923-8

Assessment of mitochondrial toxicity by analysis of mitochondrial protein expression in mononuclear cells.
Cytometry. Part B, Clinical cytometry , 2009 May: 76(3)181-90

Assessment of mitochondrial toxicity by analysis of mitochondrial protein expression in mononuclear cells.
Cytometry. Part B, Clinical cytometry , 2009 May: 181-90

Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1.
AIDS (London, England) , 2008 Nov 12: 22(17)2393-5

Potential limitation of CCR5 antagonists: drug resistance more often linked to CXCR4-utilizing than to CCR5-utilizing HIV-1.
AIDS (London, England) , 2008 Nov 12: 2393-5

Anti-inflammatory properties of macrolides.
The Pediatric infectious disease journal , 2007 Jan: 26(1)75-6

Anti-inflammatory properties of macrolides.
The Pediatric infectious disease journal , 2007 Jan: 75-6

Clinical Significance of HIV-1 Drug Resistance Mutations
J. of Lab. Medicine , 2006: 37: 554-561

Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients.
Chest , 2005 Aug: 128(2)912-9

Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients.
Chest , 2005 Aug: 912-9

Ribozyme Engineering and Early Evolution
BioSciences , 1998: 48: 94-103

Research Funding

Grant Title	Grantor	Award Date
Systematic High-Throughput Screening of B-cell Repertoires to Identify Antibodies Specific for HIV-Infected Cells	Bill and Melinda Gates Foundation	Nov. 1, 2011 - April 30, 2013
Novel microcapillary immunoassay methodology to enable point-of-care infant HIV-1 diagnosis	Seattle Children’s Hospital	Jan. 1, 2009
Persistent HIV-1 Replication in the Respiratory Tract Despite Antiretroviral Treatment	NIH-NIAID	Sept. 1, 2008
Improving Pediatric HIV-1 Diagnostics in an Effort to Avoid Antiretroviral Treatment Failure in Tamilnadu, India	American Society of Tropical Medicine and Hygiene	July 1, 2008

Primary Office

Seattle Children's

MA.7.226 - Infectious Disease Clinic
4800 Sand Point Way NE

Seattle, WA 98105

206-884-3573

Seattle Children's Research Institute

C9S - 8 - Infectious Disease
1900 - 9th Ave

Seattle, WA 98101

206-987-2073

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Thor A. Wagner, MD

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