Profile

Shaun W. Jackson, MB ChB, MD

Shaun W. Jackson, MB ChB, MD

Nephrology, Rheumatology, Nephrology Research

On staff since July 2012

Academic Title: Acting Assistant Professor

Research Center: Center for Immunity and Immunotherapies

Shaun Jackson, MD, PhD, is an attending physician in Pediatric Nephrology and Pediatric Rheumatology at Seattle Children's Hospital and an Acting Assistant Professor of Pediatrics at the University of Washington School of Medicine. After receiving his medical degree from the University of Cape Town in South Africa, he undertook post-doctoral studies in vascular biology at Harvard Medical School and completed pediatric residency training at Boston Children's Hospital. He completed dual pediatric nephrology and rheumatology fellowship training at Seattle Children's Hospital / University of Washington.

During his fellowship, Dr Jackson worked in the B cell immunology laboratory of Dr. David Rawlings at Seattle Children's Research Institute. His research in the laboratory is focused on two broad areas. First, he studies the mechanisms responsible for breaking B cell tolerance during the development of autoimmunity. Second, he has developed an interest in B cell-mediated acceleration of atherosclerosis in autoimmune disease.

Recommendations

  • will Yakima, Wa 08.29.12

    Dr. Jackson has been instrumental in our daughter recovey and maintenance of her illness. He is personable and does a thorough job on making sure our questions are answered and we understand all the medical jargon and research. Lastly, he is a friendly and compassionate person.

Overview

Board Certification(s)

Pediatrics

Medical/Professional School

University of Cape Town, Rodebosch, Cape Town
University of Cape Town, Rodebosch, Cape Town

Residency

Pediatrics, Boston Children's Hospital, Boston

Fellowship

Nephrology, University of Washington/Seattle Children's Hospital, Seattle
Rheumatology, University of Washington/Seattle Children's Hospital, Seattle

Clinical Interests

My clinical interests are in the diagnosis and management of infants, children and adolescents with renal and rheumatologic diseases. In particular, my focus is on those autoimmune conditions at the interface of nephrology and rheumatology, especially systemic lupus erythematosus (SLE) and systemic vasculitis.

Research Description

My research interests in the laboratory relate to basic cellular mechanisms that underlie B cell mediated autoimmunity. In particular, we study the why B cells break tolerance and develop reactivity to self in systemic autoimmune disease, for example in systemic lupus erythematosus (SLE). In addition, as accelerated cardiovascular disease is a major cause of morbidity in patients with autoimmune diseases, including SLE and rheumatoid arthritis, we are studying the B cells mechanisms responsible for accelerated atherosclerosis in autoimmune settings.

Awards and Honors

Award Name Award Description Awarded By Award Date
Outstanding Presentation Award Seattle Childrens Fellow and Resident Research Day April 2012
Fellow teaching award Seattle Children's Hospital June 2009
Best oral presentation, Young Investigator Award Session Asia Pacific Association for the Study of the Liver Feb. 2004
University Gold Medal For the most distinguished student in the graduating MBChB class University of Cape Town Dec. 2001

Publications

  • Rawlings DJ, Schwartz MA, Jackson SW, Meyer-Bahlburg A
    Integration of B cell responses through Toll-like receptors and antigen receptors.
    Nature reviews. Immunology , 2012 Mar. 16 : 12(4)282-94
  • Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL
    Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous.
    Journal of immunology (Baltimore, Md. : 1950) , 2012 Mar. 1 : 188(5)2065-9
  • Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ
    WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity.
    The Journal of experimental medicine , 2011 Sept. 26 : 208(10)2033-42
  • Shaun W. Jackson, MD
    Hypernatremia, Hyponatremia, Hyperkalemia, Hypokalemia, Renal Tubular Acidosis
    POCKET PEDIATRICS, 2nd edition , 2009
  • Jackson SW, Hoshi T, Wu Y, Sun X, Enjyoji K, Cszimadia E, Sundberg C, Robson SC
    Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice.
    The American journal of pathology , 2007 Oct. : 171(4)1395-404

Presentations

Presentations Title Event Location Date
Marginal zone defects in Wiskott-Aldrich syndrome are dependent on B cell intrinsic TLR signals. Federation of Clinical Immunology Societies meeting (FOCIS 2012) Vancouver, BC June 2012
Renal transplantation from a donor with undiagnosed Class V lupus nephritis demonstrates prolonged histopathologic features of lupus nephritis despite absence of SLE in recipients. Pediatric Rheumatology Symposium (PRSyM) Miami, FL June 2011
Decreased activity of endothelial V3 integrin in the Cd39-null mouse is associated with defective tumor angiogenesis. 4th International Symposium of Nucleosides and Nucleotides.Purines 2004 Chapel Hill, NC 2004
Disordered Liver Regeneration and Defective Angiogenesis in NTPDase1/Cd39-Null Mice. Young Investigator Award Session. Asia Pacific Association for the Study of the Liver Delhi, India 2004

Research Funding

Grant Title Grantor Amount Award Date
University of Washington Child Health Research Center (CHRC) NIH $85,000/year July 1, 2012 - June 30, 2014
ACR REF Rheumatology Scientist Development Award American College of Rheumatology $50,000-$75,000/year July 1, 2012 - June 30, 2014