Profile

Margaret Rosenfeld, MD, MPH

Pulmonary and Sleep Medicine

On staff since May 1995

Children's Title: Assoc Director, Center for Clinical and Translational Research; Co-Director, Fellows' College

Academic Title: Associate Professor, Department of Pediatrics

Research Center: Center for Clinical and Translational Research

Margaret Rosenfeld, MD, MPH, is attending physician at Seattle Children’s Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. Her clinical interests focus on the diagnosis and management of respiratory illnesses in children of all ages. Her research program focuses on the assessment and treatment of early cystic fibrosis (CF) lung disease, including infant and preschool lung function tests, determining risk factors for early acquisition of Pseudomonas aeruginosa and clinical trials in infants with CF.

She is also an investigator in a national network investigating rare disorders of mucociliary clearance, including primary ciliary dyskinesia. She is associate director of the Center for Clinical and Translational Research, co–director of the Seattle Children’s Fellows College and medical director of the Pulmonary Function Laboratory. She serves as CF consultant to the Washington State Newborn Screening Program.

Recommendations

EllisaChehalis, WA03.21.11

We first saw Dr. Rosenfeld when our child was very young, around 4 months old. We were seeing her to determine if our child had PCD. She was very caring, thourough, and was willing to sit and answer all our questions as long as we needed. She has continued caring for our child, who is now 2. We are so greatful to have such a knowledgable Doctor taking care of our child and helping us prevent future health problems and research this rare pulmonary disorder. We highly recommend her. Ellisa Alderson

Recommend Dr. Margaret Rosenfeld

Overview
Publications
Presentations
Research Funding

Overview

Board Certification(s): Pediatric Pulmonology
Medical/Professional School: Harvard Medical School, Boston
University of Washington, Seattle
Clinical Interests: Early lung disease in cystic fibrosis, Cystic fibrosis epidemiology
Research Description: Clinical and epidemiologic research in cystic fibrosis (CF), emphasizing early CF lung disease. Development of outcome measures for clinical trials in young CF patients, including infant and preschool lung function tests.
Research Focus Area: Therapeutic Trials

Publications

Association of intraventricular hemorrhage secondary to prematurity with cerebrospinal fluid shunt surgery in the first year following initial shunt placement
J Neurosurg Pediatr. , Jan. 2012: 54-63

Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
Thorax , 2011 Dec 18

Lung function distinguishes preschool children with CF from healthy controls in a multi-center setting.
Pediatric pulmonology , 2011 Nov 11

Analysis of the associations between lung function and clinical features in preschool children with cystic fibrosis.
Pediatric pulmonology , 2011 Nov 11

Treatment and microbiology of repeated cerebrospinal fluid shunt infections in children.
The Pediatric infectious disease journal , 2011 Sep: 731-5

Comparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis.
Archives of pediatrics & adolescent medicine , 2011 Sep: 847-56

Initial Pseudomonas aeruginosa treatment failure is associated with exacerbations in cystic fibrosis.
Pediatric pulmonology , 2011 Aug 9

Emergence of oseltamivir-resistant pandemic H1N1 in an immunocompetent child with severe status asthmaticus.
The Journal of asthma : official journal of the Association for the Care of Asthma , 2011 Aug: 572-5

Inhaled hypertonic saline in infants and toddlers with cystic fibrosis: short-term tolerability, adherence, and safety.
Pediatric pulmonology , 2011 Jul: 666-71

Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosis.
Chest , 2011 Jul: 178-85

Pulmonary exacerbations are associated with subsequent FEV1 decline in both adults and children with cystic fibrosis.
Pediatric pulmonology , 2011 Apr: 393-400

Diagnostic yield of nasal scrape biopsies in primary ciliary dyskinesia: A multicenter experience.
Pediatric pulmonology , 2011 Jan 31

Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpoints.
American journal of respiratory and critical care medicine , 2010 Dec 1: 1387-97

Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohort.
Pediatric pulmonology , Sept. 2010: 934-44

Failure to recover to baseline pulmonary function after cystic fibrosis pulmonary exacerbation.
American journal of respiratory and critical care medicine , 2010 Sep 1: 627-32

Multicenter Evaluation of Infant Lung Function Tests as Cystic Fibrosis Clinical Trial Endpoints.
American journal of respiratory and critical care medicine , July 2010

Therapeutic bilateral lung lavage in a child with pulmonary alveolar proteinosis.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 May: e28-31

Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively?
Pediatric pulmonology , Feb. 2010: 107-17

Return of FEV1 after pulmonary exacerbation in children with cystic fibrosis.
Pediatric pulmonology , 2010 Feb: 127-34

Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis.
The Journal of pediatrics , 2009 Dec: S73-93

Early anti-pseudomonal acquisition in young patients with cystic fibrosis: rationale and design of the EPIC clinical trial and observational study'.
Contemporary clinical trials , 2009 May: 256-68

Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosis.
The Journal of pediatrics , 2009 Feb: 183-8

Reproducibility of spirometry during cystic fibrosis pulmonary exacerbations.
Pediatric pulmonology , 2008 Nov: 1142-6

Pharmacogenomic testing to prevent aminoglycoside-induced hearing loss in cystic fibrosis patients: potential impact on clinical, patient, and economic outcomes.
Genetics in medicine : official journal of the American College of Medical Genetics , 2007 Oct: 695-704

Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis.
Pediatric pulmonology , 2007 Sep: 751-6

An overview of endpoints for cystic fibrosis clinical trials: one size does not fit all.
Proceedings of the American Thoracic Society , 2007 Aug 1: 299-301

Endpoints for clinical trials in young children with cystic fibrosis.
Proceedings of the American Thoracic Society , 2007 Aug 1: 418-30

Guidelines for implementation of cystic fibrosis newborn screening programs: Cystic Fibrosis Foundation workshop report.
Pediatrics , 2007 Feb: e495-518

Potential impact of newborn screening for cystic fibrosis on child survival: a systematic review and analysis.
The Journal of pediatrics , 2006 Sep: 362-6

Cystic fibrosis pulmonary exacerbations.
The Journal of pediatrics , 2006 Feb: 259-64

Disease-specific reference equations for lung function in patients with cystic fibrosis.
American journal of respiratory and critical care medicine , 2005 Oct 1: 885-91

Overview of published evidence on outcomes with early diagnosis from large US observational studies.
The Journal of pediatrics , 2005 Sep: S11-4

The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study.
The Journal of pediatrics , 2005 Aug: 233-8

Update on cystic fibrosis epidemiology.
Current opinion in pulmonary medicine , 2004 Nov: 510-4

Newborn screening for cystic fibrosis: evaluation of benefits and risks and recommendations for state newborn screening programs.
MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control , 2004 Oct 15: 1-36

Pseudomonas acquisition in young patients with cystic fibrosis: pathophysiology, diagnosis, and management.
Current opinion in pulmonary medicine , 2003 Nov: 492-7

Improved survival among young patients with cystic fibrosis.
The Journal of pediatrics , 2003 Jun: 631-6

Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosis.
American journal of respiratory and critical care medicine , 2003 Mar 15: 841-9

Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system.
Chest , 2003 Jan: 28-36

Developing cystic fibrosis lung transplant referral criteria using predictors of 2-year mortality.
American journal of respiratory and critical care medicine , 2002 Dec 15: 1550-5

Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis.
Pediatric pulmonology , 2002 Aug: 91-100

Presentations

Presentations Title	Event	Location	Date
Writing Your First Grant	ITHS career development series, University of Washington	Seattle, WA	Oct. 30, 2009
Successful Transition to an Academic Career	half-day SCH Fellows’ College workshop	unknown	Oct. 28, 2009
Newborn screening	North American Cystic Fibrosis Conference	Minneapolis, MN	Oct. 17, 2009
Risk factors for early age at acquisition of Pseudomonas aeruginosa	North American Cystic Fibrosis Conference	Minneapolis, MN	Oct. 17, 2009
Pulmonary Exacerbations: How do we define them	Symposium presentation, North American Cystic Fibrosis Conference	Minneapolis, MN	Oct. 16, 2009
Comparison of published pulmonary exacerbation definitions	Cystic Fibrosis Foundation Workshop on Pulmonary Exacerbations	Bethesda, MD	Sept. 9, 2009
Guidelines for Care of theGuidelines for Care of the Infant with CF Infant with CF	Cystic Fibrosis annual Northwest regional conference, Center for Urban Horticulture	unknown	July 24, 2009
Risk factors for early Pseudomonas acquisition	Cystic Fibrosis Epidemiology/Biostatistics Working Group annual meeting, Center for Urban Horticulture	unknown	July 23, 2009
Optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia and recurrernt wheezing in children under 6 years of age	American Thoracic Society annual convention	San Diego, CA	May 12, 2009
unknown	33. ITHS Career Development Seminar- Career Development (K Award) Seminar	unknown	Jan. 29, 2009

Research Funding

Grant Title	Grantor	Amount	Award Date
CF-ePRO: Electronic Self-and Parent-Reported Patient Outcomes in Cystic Fibrosis	NIH/NHLBI	$$75,499	Sept. 1, 2011 - Aug. 31, 2013
Translational Research Center to Expedite Novel Therapies in Cystic Fibrosis	NIH/NIDDK	$, $$200,642	July 6, 2010 - May 31, 2015
PAS001	Cystic Fibrosis Foundation Therapeutics Inc	$$89,172.00	Feb. 1, 2010 - Jan. 31, 2012
Genetic Disorders of Mucociliary Clearance	NIH (NCRR)	$129,739.00	Sept. 1, 2009
EPIC Observational Study	Cystic Fibrosis Foundation Therapeutics Inc	$830,555.00	April 1, 2009
Parent Report of Signs of a Respiratory Exacerbation in Infants and Young Children with Cystic Fibrosis	NIH ITHS	$10,000.00	March 1, 2009
Infant Study of Inhaled Saline	NIH/NHLBI	$417,075.00	Sept. 15, 2008
Infant Study of Inhaled Saline	Cystic Fibrosis Foundation	$378,356.00	Oct. 1, 2007
Spirometry in Preschool CF Patients	Cystic Fibrosis Foundation	$180,663.00	Feb. 1, 2005

Primary Office

Seattle Children's

OC.7.720 - Pulmonary
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2174

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Margaret Rosenfeld, MD, MPH

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