Margaret M. Sedensky, MD

Margaret M. Sedensky, MD

Research Center: Center for Developmental Therapeutics

Making a Difference

  • Families Fuel Discovery

    Many rare and devastating diseases lack effective treatments or cures. The faith, funds and passion of families of our patients jump-start the search for answers that will help seriously ill children lead healthier lives. ... cont.


Board Certification(s)


Medical/Professional School

University of Colorado Health Sciences Center, Aurora
University of Colorado at Boulder, Boulder


Surgery - General, University Hosptials Case medical Center, Cleveland
Anesthesiology, University Hospitals Case Medical Center, Clevelenad


Anesthesiology, University of Washington, Seattle

Research Description

Our laboratory has a long-standing interest in the mechanism of action of volatile anesthetics. We have exploited the animal model C.elegans to examine this problem, primarily to use the powerful genetic tools available in this organism. This work has led us to appreciate the role of mitochondria in determining different aspects of behavior, including sensitivity to anesthetics.

Our current research includes translational studies to understand mitochondrial disease. We are exploring whether children with mitochondrial dysfunction are more sensitive to a gaseous anesthetic. In addition, we plan to study whether particular intravenous anesthetics are safe in children with mitochondrial disease.

About My Work

Research Focus Area

Genetics and Developmental Biology