Profile

Kimberly J. Riehle, MD

Kimberly J. Riehle, MD

General Surgery

On staff since September 2010

Academic Title: Assistant Professor of Surgery and Pathology

"Liver failure can be devastating, often leading to severe illness, the need for transplantation, and in some cases even death. My efforts are aimed at improving the lives of children devastated by liver disease or injury and returning them to health. As a physician and a mom, I take particular care in explaining surgical diseases and operations to patients and families."

Kimberly Riehle, MD, is an attending surgeon at Seattle Children's Hospital. She was born in Jefferson, Iowa and went to high school in Cedar Falls, Iowa. Both of her parents were teachers. She attended Washington University in St. Louis, double majoring in Chemistry and French. She received her medical degree from Emory University School of Medicine. While clinically active, Dr. Riehle spends much of her time in the laboratory studying the liver biology, including how the liver responds to injury and what causes it to regenerate in some cases and not in others. She is also mom to son Jonah, who was born in 2004.

Recommendations

  • Carol Seattle 03.31.15

    Exceptional Surgeon With equal amounts of skill and compassion, Dr. Riehle transformed a scared, miserable emergency appendectomy patient back to my smiling 8 year-old son. She did this by covering his surgical incision with a specially cut star bandage—at 3 am after a very busy Friday night in the ER. I heard there were 5 other appendectomy cases that evening, but I feel our experience would not be the same if Dr. Riehle had not given my son such personalized care and attention. My son looks back at his first ever hospital visit/stay and only remembers the cute bandage, eating popsicles and the wonderful staff that helped him heal. Many thanks!

  • Tina West Richland, WA 03.05.11

    Dr. Riehle performed surgery on my 16 year old son for his Chrons disease. She removed part of his small and large intestine plus his appendix. She was very personal and professional both before and after the surgery, always keeping us informed and explaining every detail very clearly. I felt she truly wanted what was best for my son and my son trusted her completely. I highly recommend her and feel very secure with her as a doctor.

Overview

Board Certification(s)

Surgery - General
Pediatric Surgery

Medical/Professional School

Emory University School of Medicine, Atlanta

Residency

General Surgery, University of Washington, Seattle
Pediatric Surgery, Children's Hospital Boston, Boston

Clinical Interests

Neonatal surgery, pediatric general and thoracic surgery Liver regeneration, molecular studies of the relationship between inflammation and cancer

Research Focus Area

Research Liver Regeneration

Awards and Honors

Award Name Award Description Awarded By Award Date
New Investigator Award Fred Hutchinson Cancer Consortium Dec. 2014
American Surgical Association Foundation Fellowship Recipient American Surgical Association July 2013
American College of Surgeons Louis C. Argenta Award Recipient American College of Surgeons July 2012
Sydney Farber House Staff Award Children's Hospital Boston June 2010
David Tapper Resident Teaching Award University of Washington, Department of Surgery, Seattle WA June 2008
American College of Surgeons Forum on Fundamental Surgical Problems Resident/Fellow Excellence in Research Award American College of Surgeons Oct. 2006
First Prize, Schilling Resident Research Symposium Department of Surgery, University of Washington, Seattle, WA Jan. 2006
June 2004-July 2006: National Institutes of Health Loan Repayment Program Awardee in Pediatric Research National Institutes of Health June 2004 - July 2006
American College of Surgeons Resident Research Scholarship American College of Surgeons June 2004 - July 2006
Schilling Foundation Resident Research Scholarship University of Washington June 2004 - July 2006
Gate Pharmaceutical Outstanding Student Award (Faculty Award for top student, medical school class) Emory University School of Medicine, Atlanta, GA May 2001
Magna cum laude Emory University, Atlanta, GA May 2001
Alpha Omega Alpha Emory University School of Medicine, Atlanta, GA Aug. 2000
Solvay Pharmaceuticals Project Fund recipient Emory University School of Medicine, Atlanta, GA June 1998
James L. Campbell Scholar in Medicine Emory University School of Medicine, Atlanta, GA Aug. 1997 - May 2001
Summa cum laude Washington University, St. Louis, MO Dec. 1996
Phi Beta Kappa Washington University, St. Louis, MO Dec. 1996

Publications

  • Kimberly J. Riehle, MD Riehle KJ, Riggle KM, and Campbell JS
    The Priming and Progression Theory of Liver Regeneration
    1st edition of Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications , 2015
  • Riehle KJ, Yeh MM, Yu JJ, Kenerson HL, Harris WP, Park JO, Yeung RS
    mTORC1 and FGFR1 signaling in fibrolamellar hepatocellular carcinoma.
    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc , 2015 Jan. : 28(1)103-10
  • Bahrami AJ, Gunaje JJ, Hayes BJ, Riehle KJ, Kenerson HL, Yeung RS, Stempien-Otero AS, Campbell JS, Mahoney WM Jr
    Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury.
    PloS one , 2014 : 9(10)e108505
  • Kenerson HL, Yeh MM, Kazami M, Jiang X, Riehle KJ, McIntyre RL, Park JO, Kwon S, Campbell JS, Yeung RS
    Akt and mTORC1 have different roles during liver tumorigenesis in mice.
    Gastroenterology , 2013 May : 144(5)1055-65
  • Kimberly J. Riehle, MD Riehle KJ and Fausto N
    Mechanisms of Liver Injury
    1st edition of Clinical Pediatric Hepatology , 2013
  • Aarabi S, Sidhwa F, Riehle KJ, Chen Q, Mooney DP
    Pediatric appendicitis in New England: epidemiology and outcomes.
    Journal of pediatric surgery , 2011 June : 46(6)1106-14
  • Riehle KJ, Dan YY, Campbell JS, Fausto N
    New concepts in liver regeneration.
    Journal of gastroenterology and hepatology , 2011 Jan. : 203-12
  • Li J, Campbell JS, Mitchell C, McMahan RS, Yu X, Riehle KJ, Bumgarner RE, Fausto N
    Relationships between deficits in tissue mass and transcriptional programs after partial hepatectomy in mice.
    The American journal of pathology , 2009 Sept. : 947-57
  • Langdale LA, Hoagland V, Benz W, Riehle KJ, Campbell JS, Liggitt DH, Fausto N
    Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury.
    Journal of hepatology , 2008 Aug. : 198-206
  • Riehle KJ, Campbell JS, McMahan RS, Johnson MM, Beyer RP, Bammler TK, Fausto N
    Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3.
    The Journal of experimental medicine , 2008 Jan. 21 : 91-103
  • Cheung RS, Brooling JT, Johnson MM, Riehle KJ, Campbell JS, Fausto N
    Interactions between MYC and transforming growth factor alpha alter the growth and tumorigenicity of liver progenitor cells.
    Carcinogenesis , 2007 Dec. : 2624-31
  • Campbell JS, Johnson MM, Bauer RL, Hudkins KL, Gilbertson DG, Riehle KJ, Yeh MM, Alpers CE, Fausto N
    Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis.
    Differentiation; research in biological diversity , 2007 Nov. : 843-52
  • Riehle KJ, Magnuson DK, Waldhausen JH
    Low recurrence rate after Gore-Tex/Marlex composite patch repair for posterolateral congenital diaphragmatic hernia.
    Journal of pediatric surgery , 2007 Nov. : 1841-4
  • Stoick-Cooper CL, Weidinger G, Riehle KJ, Hubbert C, Major MB, Fausto N, Moon RT
    Distinct Wnt signaling pathways have opposing roles in appendage regeneration.
    Development (Cambridge, England) , 2007 Feb. : 479-89
  • Campbell JS, Riehle KJ, Brooling JT, Bauer RL, Mitchell C, Fausto N
    Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4.
    Journal of immunology (Baltimore, Md. : 1950) , 2006 Feb. 15 : 2522-8
  • Fausto N, Campbell JS, Riehle KJ
    Liver regeneration.
    Hepatology (Baltimore, Md.) , 2006 Feb. : S45-53
  • Fausto N, Riehle KJ
    Mechanisms of liver regeneration and their clinical implications.
    Journal of hepato-biliary-pancreatic surgery , 2005 : 181-9
  • Rozycki GS, Tchorz KM, Riehle KJ, Hattaway A, Naidu DK
    A prospective study of a focused, surgeon-performed ultrasound examination for the detection of occult common femoral vein thrombosis in critically ill patients.
    Archives of surgery (Chicago, Ill. : 1960) , 2004 Mar. : 275-80

Presentations

Presentations Title Event Location Date
Characterization of a novel mutation in fibrolamellar hepatocellular carcinoma (presentation: Riggle KM, Kenerson HL, Bauer R, Kazami M, Yeung RS, Riehle KJ) Academic Surgical Congress Las Vegas, NV 2015
Enhanced cyclic AMP induced protein kinase A activity in fibrolamellar hepatocellular carcinoma (presentation: Riggle KM, Kenerson HL, Bauer R, Kazami M, Yeung RS, Riehle KJ) American Society of Clinical Oncology GI Symposium San Francisco, CA 2015
Enhanced cyclic AMP induced protein kinase A activity in fibrolamellar hepatocellular carcinoma (presentation: Riggle KM, Kenerson HL, Bauer R, Kazamii M, Yeung RS, Riehle KJ) Schilling Foundation Research Symposium Seattle, WA 2015
Liver Regeneration: Past, Present, and Future. Center for Developmental Biology and Regenerative Medicine Lecture Series Seattle Childrens Research Institute Dec. 20, 2013
Long Gap Esophageal Atresia. Operative Staff Educational Series Seattle Childrens Hospital March 5, 2013
Fundamentals of Liver Regeneration Grand Rounds University of Washington Department of Surgery May 2, 2012
Regeneration in the Setting of Liver Fibrosis: Studies of 2/3 Partial Hepatectomy in Platelet-derived Growth Factor-C transgenic mice (poster presentation: Riehle KJ, Johansson F, Vaquero J, Bauer R, Fausto N, and Campbell JS) American Association for the Study of Liver Diseases Meeting San Francisco, CA 2011
Deletion of Suppressor of Cytokine Signaling 3 is Protective Against Liver Ischemia-Reperfusion Injury (poster presentation: Riehle KJ, Hoagland V, Campbell JS, and Langdale LA. American Association for the Study of Liver Diseases Meeting San Francisco, CA 2011
Low recurrence rate after Composite Patch Repair of Bochdalek Congenital Diaphragmatic Hernia (presentation: Riehle KJ, Magnuson D, Waldhausen JHT) Washington State Chapter of the American College of Surgeons Meeting Chelan, WA 2007
Regulation of Liver Regeneration by Suppressors of Cytokine Signaling 3 (presentation: Riehle KJ, Croker BA, Campbell JS, and Fausto N) 2006 Schilling Resident Research Symposium Seattle, WA 2006
SOCS3 Negatively Regulates Hepatocyte Proliferation (poster presentation: Riehle KJ, McMahan RS, Campbell JS, Croker BA, and Fausto N) University of Washington Department of Pathology Annual Retreat Leavenworth, WA 2006
Therapeutic Potential of Epithelial Progenitor Cells From Human Fetal Liver (presentation: Dan YY, Riehle KJ, Lazaro CA, Haque J, Campbell JS, and Fausto N) Gastroenterological Society of Singapore Annual Scientific Meeting Singapore 2006
Regulation of Liver Regeneration by Suppressors of Cytokine Signaling 3 (presentation: Riehle KJ, McMahan RS, Croker BA, Campbell JS, and Fausto N) American College of Surgeons Forum on Fundamental Surgical Problems Chicago, IL 2006
Distinct Wnt Signaling Pathways Have Opposing Roles in Appendage Regeneration (poster presentation: Stoick-Cooper C, Weidinger G, Riehle KJ, Hubbert C, Major MB, Nelson Fausto, and Randall T Moon) Keystone Symposium Snowbird, UT 2006
LPS Signaling in Liver Regeneration (presentation: Riehle KJ, Campbell JS, Brooling JT, Fausto N) 2005 Schilling Resident Research Symposium Seattle, WA 2005
Isolation and Characterization of Multipotent Human Fetal Liver Progenitor Cells. (poster presentation: Dan YY, Riehle KJ, Lazaro CA, Campbell JS, and Fausto N) 2005 University of Washington Department of Pathology Annual Retreat Leavenworth, WA 2005
Liver Regeneration is Enhanced in Hepatocyte-specific Socs3 KO mice (poster presentation: Riehle KJ, Croker BA, Campbell JS, Hilton DJ, and Fausto N) American Association for the Study of Liver Diseases Annual Meeting San Francisco, CA 2005
Isolation and Characterization of Multipotent Human Fetal Liver Progenitor Cells (presentation: Dan YY, Riehle KJ, Lazaro CA, Campbell JS, and Fausto N) American Association for the Study of Liver Diseases Annual Meeting San Francisco, CA 2005

Research Funding

Grant Title Grantor Amount Award Date
Fred Hutchinson/University of Washington Cancer Consortium New Investigator Award Fred Hutchinson/University of Washington Cancer Consortium $95,495.00 Dec. 2014
Improving Regeneration in the Fibrotic Liver American Surgical Association Foundation Fellowship $75,000/year July 2013 - June 2015
University of Washington Department of Surgery Research Reinvestment Fund University of Washington, Department of Surgery $50,000.00 Nov. 2012
Improving Regeneration in the Fibrotic Liver American College of Surgeons Louis C. Argenta Fellowship $40,000.00/year July 2012 - June 2013
Mechanisms of Liver Regeneration, from , 2012 Seattle Childrens Hospital Discovery Fund $15,000.00 one time gift 2012
Liver Regeneration 50,000.00 one time private gift from Dr. Ann Delancey 2012
Molecular Mechanisms of Liver Regeneration Herbert Coe Foundation and Department of Surgery $25,000.00/yr through June 2015