Profile

Kasey Joanne Leger, MD

Kasey Joanne Leger, MD

Hematology-Oncology

On staff since August 2014

Academic Title: Assistant Professor

Research Center: Center for Clinical and Translational Research

"Its an honor to partner with my patients and their families in their life changing battle against cancer. I am inspired to help my patients and those who will face this disease in the future to not only overcome cancer, but to experience healthy and fulfilling lives after cancer."

  • Kasey Leger, MD, is an attending physician at Seattle Childrens Hospital and assistant professor of pediatrics at the University of Washington School of Medicine. Her clinical interests focus on leukemia, lymphoma, and cancer survivorship.

    Dr. Leger's research interests focus on the cardiovascular health of survivors of childhood cancer. She is currently working to identify early predictors of chemotherapy-induced heart injury. Early diagnosis and targeted treatment of cancer therapy-related cardiovascular disease could help preserve the cardiac health of childhood cancer survivors.

  • Award Name Award Description Awarded By Award Date
    Clinical Research Scholar Seattle Children's Center for Clinical and Translational Research May 2015
    American Society of Clinical Oncology (ASCO) Young Investigator Award American Society of Clinical Oncology 2012 - 2013
    Selected participant in AACR/ASCO Workshop: Methods in Clinical Cancer Research 2012
    Alpha Omega Alpha Honor Society 2005
    • Leger KJ, Cushing-Haugen K, Hansen JA, Fan W, Leisenring WM, Martin PJ, Zhao LP, Chow EJ
      Clinical and Genetic Determinants of Cardiomyopathy Risk among Hematopoietic Cell Transplantation Survivors.
      26968791 Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation , 2016 Mar. 8 - 2016 Mar. 8
    • Leger K, Singh S, Canseco D, Collins S, Karim-Ud-Din S, Mishkin JD, Patel PC, Markham DW, Drazner MH, Mammen PP
      Whole blood microRNA profiling reveals novel miRs in ischemic cardiomyopathy
    • Leger K, Leonard D, Nielson D, Cochran C, De Lemos JA, Mammen PP, Winick NJ
      microRNAs as novel markers of acute anthracycline-induced cardiotoxicity in children
      Journal of Clinical Oncology , 2016 Feb.
    • Schuh AM, Leger KJ, Summers C, Uspal N.
      Lactic acidosis in a critically ill patient: Not always sepsis
      Pediatric Emergency Care , 2016 Feb.
    • Leger K, Singh S, Canseco D, Collins S, Karim-Ud-Din S, Mishkin JD, Patel PC, Markham DW, Drazner MH, Mammen PP
      Whole blood microRNA profiling reveals novel miRs in ischemic cardiomyopathy
      Circulation Heart Failure , 2016 Feb.
    • Leger K, Slone T, Lemler M, Leonard D, Cochran C, Bowman WP, Bashore L, Winick N
      Subclinical cardiotoxicity in childhood cancer survivors exposed to very low dose anthracycline therapy.
      25176022 Pediatric blood and cancer , 2015 Jan. - 2015 Jan. : 62(1)123-7
    • Lipshultz SE, Diamond MB, Franco VI, Aggarwal S, Leger K, Santos MV, Sallan SE, Chow EJ
      Managing chemotherapy-related cardiotoxicity in survivors of childhood cancers.
      25134924 Paediatric drugs , 2014 Oct. - 2014 Oct. : 16(5)373-89 PMCID: PMC4417358
    • Leger K
      The Potential Role of Plasma MicroRNAs as Novel Markers of Hypertrophy and Fibrosis in Patients with HCM
      http:/Biomarkers.Cardiosource.org , 2014 June 23
      http://biomarkers.cardiosource.org/Article-of-the-Month/2014/06/The-Potential-Role-of-Plasma-MicroRNAs.aspx.
    • Leger K, Singh S1, Canseco D, Collins S, Karim-Ud-Din S, Drazner MH, Mammen PP
      Identification of novel circulating microRNAs in ischemic cardiomyopathy utilizing whole blood microRNA profiling
      American Heart Association 2013 Scientific Sessions , 2013 : Vol 128(Issue 22 Suppl.)
    • Leger K, Leonard D, Nielson D, de Lemos JA, Winick NJ, Mammen PP
      Evaluation of microRNAs as Novel Markers of Cardiotoxicity in Patients Treated With Anthracycline Therapy for Childhood Cancer
      American Heart Association 2013 Scientific Sessions : Vol 128(Issue 22 suppl)
    • Leonard D, Nielson D, de Lemos JA, Nielson D, Mammen PP, Winick NJ
      Plasma microRNAs: Novel markers of cardiotoxicity in children undergoing anthracycline chemotherapy
      J Clin Oncol : Vol 32(No 15_suppl)

  • Presentations Title Event Location Date
    Intrachromosomal amplification of chromosome 21 (iAMP21) in childhood preB ALL Seattle Childrens Hematopathology Conference 2015
    Treatment of childhood and adolescent T-cell Acute Lymphoblastic Leukemia Seattle Childrens Clinical Standard Practice 2015
    Cardiovascular Disease in Childhood Cancer Survivors: Case Presentations. Cardiovascular Disease in Survivors of Childhood Cancer: Novel Insights into Pathophysiology, Screening, and Prevention Workshop American Society of Pediatric Hematology/ Oncology Annual Meeting April 2013
    Prospective Evaluation of Early Markers of Cardiotoxicity in Children Undergoing Anthracycline Chemotherapy UT Southwestern Clinical Science Forum 2013
    Acute Alterations in Plasma microRNA Expression Following Anthracycline Therapy UT Southwestern Translational Science Forum Works in Progress 2013
    Evaluation of microRNAs as novel markers of cardiotoxicity in children treated with anthracycline chemotherapy UT Southwestern Pediatrics Department Fellows Core Curriculum Conference 2012
    Cardiotoxicity in Childhood Cancer Survivors Childrens Medical Center Nursing Education Curriculum Lecture Series 2012
    The use of Rituximab in Treatment of Burkitts Lymphoma Childrens Medical Center Tumor Board 2011
    Anthracycline Related Cardiotoxicity: An Evaluation of Doxorubicin Pharmacokinetics and Cardiac Troponins UT Southwestern Department of Pediatrics Research Conference 2011
    General Principals in Leukemia UT Southwestern Resident Board Review Conference 2011
    Local Control for Ewings Sarcoma Childrens Medical Center Tumor Board 2011
    Detection of Bone Marrow Involvement in Hodgkins Lymphoma Childrens Medical Center Tumor Board 2010
    Treatment Approaches in Atypical Neuroblastoma Childrens Medical Center Tumor Board 2010
    Coagulation basics Resident Supervisors Conference Childrens Hospital Colorado 2008
  • Grant Title Grantor Amount Award Date
    Clinical Research Scholar Program $90,000 2016 - 2018
    Hyundai Hope on Wheels Senior Research Award Hyundai Hope on Wheels $250,000 2015 - 2018
    T32HL007360-35 NIH Training in Cardiovascular Research Grant 2012 - 2014
    Childrens Cancer Fund Dallas $28,000 2012 - 2014

Overview

Board Certification(s)

Pediatrics

Medical/Professional School

University of Texas Health Science Center at Houston, Houston
UT Southwestern Medical School, Dallas

Residency

Pediatrics, University of Colorado, Aurora

Fellowship

Pediatric Hematology-Oncology, UT Southwestern Medical Center, Dallas

Clinical Interests

Leukemia, Lymphoma and cancer survivorship

Research Description

Early identification and prevention of cancer therapy-induced cardiovascular disease