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Janet A. Englund, MD

On staff since November 2002

Academic Title: Professor

Research Center: Center for Clinical and Translational Research

"I’ve always been interested in preventing disease. Finding ways to keep children healthy is what I love to do. I began focusing on vaccines because they are one of the best ways to stop children and adults from getting sick in the first place. By working to make vaccines safe and effective, I feel like I’m making a difference in the lives of millions of people around the world."

Janet A. Englund, MD: Professor of Pediatric Infectious Diseases. My research interests include the study of vaccine-preventable diseases and viral respiratory diseases in young children and immunocompromised hosts, including transplant recipients, as well as the evaluation of antiviral therapy for the prevention and treatment of viral diseases.

As a Clinical Associate at Fred Hutchinson Cancer Research Center, I am active in many transplant-related protocols in the prevention and treatment of disease in the immunocompromised host. As a member of the NIH-sponsored Seattle Vaccine Treatment and Evaluation Unit, I am involved in research with new vaccines and maternal immunization with Tdap and influenza vaccines. I am also involved in the evaluation of new respiratory virus vaccines including live-attenuated parainfluenza virus vaccines through collaboration with Johns Hopkins University and the NIH. My research group is active in studying influenza virus vaccines in diverse populations, including infants, school-age children in the schools, and pregnant women, as well as the development of antiviral resistance and novel methods of antiviral therapy.

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Overview
Publications
Presentations
Research Funding

Overview

Board Certification(s): Pediatrics
Pediatric Infectious Diseases
Medical/Professional School: University of Michigan Medical School, Ann Arbor
Residency: Pediatrics, Fairview University Medical Center, Minneapolis
Fellowship: Infectious Disease, University of Minnesota Medical School, Minneapolis
Infectious Disease, University of Minnesota Medical School, Minneapolis
Research Description: My research interests include the study of vaccine-preventable diseases and viral respiratory diseases in young children and immunocompromised hosts, including transplant recipients, as well as the evaluation of antiviral therapy for the prevention and treatment of viral diseases.

As a Clinical Associate of Fred Hutchinson Cancer Research Center, I am active in many transplant-related protocols in the prevention and treatment of disease in the immunocompromised host. As a member of the NIH-sponsored Seattle Vaccine Treatment and Evaluation Unit, I am involved in research with new vaccines and maternal immunization with Tdap and influenza vaccines.

My research group is active in studying influenza virus vaccines in diverse populations, including infants, school-age children in the schools, and pregnant women.
Research Focus Area: Immunocompromised Hosts, Virology, Infectious Disease

Publications

Development of a symptom score for clinical studies to identify children with a documented viral upper respiratory tract infection.
Pediatric research , 2010 Sep: 252-7

Epidemiology of viral respiratory tract infections in a prospective cohort of infants and toddlers attending daycare.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2010 Sep: 16-20

Viral respiratory infections in hospitalized and community control children in Alaska.
Journal of medical virology , 2010 Jul: 1282-90

Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: do children of all ages respond equally?
Vaccine , 2010 Jun 17: 4376-83

Frequent and prolonged shedding of bocavirus in young children attending daycare.
The Journal of infectious diseases , 2010 Jun 1: 1625-32

Respiratory failure caused by 2009 novel influenza A/H1N1 in a hematopoietic stem-cell transplant recipient: Detection of extrapulmonary H1N1 RNA and use of intravenous peramivir.
Annals of internal medicine , 2010 May 4: 619-20

Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients.
Blood , 2010 Mar 11: 2088-94

Safety and immunogenicity of trivalent inactivated influenza vaccine in infants: a randomized double-blind placebo-controlled study.
The Pediatric infectious disease journal , 2010 Feb: 105-10

Detection of bocavirus in saliva of children with and without respiratory illness.
Journal of clinical microbiology , 2009 Dec: 4131-2

Trivalent inactivated influenza virus vaccine given to two-month-old children: an off-season pilot study.
The Pediatric infectious disease journal , 2009 Dec: 1099-104

BK nephropathy in pediatric hematopoietic stem cell transplant recipients.
Pediatric transplantation , 2009 Nov: 913-8

Seasonal influenza in adults and children--diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2009 Apr 15: 1003-32

Multiple viral respiratory pathogens in children with bronchiolitis.
Acta paediatrica (Oslo, Norway : 1992) , 2009 Jan: 123-6

Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus.
Diagnostic microbiology and infectious disease , 2008 Dec: 382-8

Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
Antimicrobial agents and chemotherapy , 2008 Nov: 3909-14

Influenza-associated morbidity in children with cancer.
Pediatric blood & cancer , 2008 May: 983-7

Hospital-based influenza vaccination of children: an opportunity to prevent subsequent hospitalization.
Pediatrics , 2008 Feb: 345-8

Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection.
Blood , 2007 Sep 1: 1681-8

Coronavirus-associated pneumonia in previously healthy children.
The Pediatric infectious disease journal , 2007 Aug: 753-5

Safety and tolerability of oseltamivir prophylaxis in hematopoietic stem cell transplant recipients: a retrospective case-control study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2007 Jul 15: 187-93

Antimicrobial susceptibility of Bordetella pertussis isolates in the state of Washington.
International journal of antimicrobial agents , 2007 May: 609-11

Community respiratory virus infections in immunocompromised patients: hematopoietic stem cell and solid organ transplant recipients, and individuals with human immunodeficiency virus infection.
Seminars in respiratory and critical care medicine , 2007 Apr: 222-42

Multitarget PCR for diagnosis of pertussis and its clinical implications.
Journal of clinical microbiology , 2007 Feb: 506-11

Clinical disease in children associated with newly described coronavirus subtypes.
Pediatrics , 2007 Jan: e70-6

Effectiveness of school-based influenza vaccination.
The New England journal of medicine , 2006 Dec 14: 2523-32

Influenza vaccine for young children: two doses are better than one.
The Journal of pediatrics , 2006 Dec: 737-8

Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming?
Pediatrics , 2006 Sep: e570-8

Immunization with trivalent inactivated influenza vaccine in partially immunized toddlers.
Pediatrics , 2006 Sep: e579-85

Brief communication: fatal human metapneumovirus infection in stem-cell transplant recipients.
Annals of internal medicine , 2006 Mar 7: 344-9

Management of outbreaks of methicillin-resistant Staphylococcus aureus infection in the neonatal intensive care unit: a consensus statement.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America , 2006 Feb: 139-45

Duration of immunity against pertussis after natural infection or vaccination.
The Pediatric infectious disease journal , 2005 May: S58-61

Role of maternal pertussis antibodies in infants.
The Pediatric infectious disease journal , 2005 May: S62-5

Pertussis immunization in the global pertussis initiative North American region: recommended strategies and implementation considerations.
The Pediatric infectious disease journal , 2005 May: S83-6

A comparison of 2 influenza vaccine schedules in 6- to 23-month-old children.
Pediatrics , 2005 Apr: 1039-47

Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit.
The Pediatric infectious disease journal , 2004 Nov: 990-4

Influenza A pneumonia presenting as progressive focal infiltrates in a stem cell transplant recipient.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2004 Oct: 96-9

Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants.
The Journal of infectious diseases , 2004 Sep 1: 975-8

Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2004 Sep 1: 743-6

Pandoraea bacteremia in a cystic fibrosis patient with associated systemic illness.
The Pediatric infectious disease journal , 2004 Sep: 881-2

Influenza-like symptoms in the college dormitory environment: a survey taken during the 1999-2000 influenza season.
Journal of environmental health , 2004 Apr: 39-42, 44

Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection.
The Pediatric infectious disease journal , 2003 Dec: 1033-9

Maternal immunization with Haemophilus influenzae type b vaccines in different populations.
Vaccine , 2003 Jul 28: 3455-9

Maternal immunization with inactivated influenza vaccine: rationale and experience.
Vaccine , 2003 Jul 28: 3460-4

Tuberculous otitis media with mastoiditis and central nervous system involvement.
The Pediatric infectious disease journal , 2003 May: 453-6

Immunogenic protein contaminants in pneumococcal vaccines.
The Journal of infectious diseases , 2003 Mar 15: 1019-23

Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children.
Journal of clinical pharmacology , 2003 Feb: 133-40

Response to changes in antiretroviral therapy after genotyping in human immunodeficiency virus-infected children.
The Pediatric infectious disease journal , 2002 Jul: 647-53

Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions.
Vaccine , 2002 May 31: S44-7

Antiviral therapy of influenza.
Seminars in pediatric infectious diseases , 2002 Apr: 120-8

Presentations

Presentations Title	Event	Location	Date
Influenza	Panelist, Global Health 101, at Seattle Biomedical Research Institute Lecture Series	Seattle, WA	Nov. 5, 2009
Pandemic Influenza	Panelist, Infectious Diseases Society of Washington Fall Meeting	Unknown	Nov. 4, 2009
Congenital CMV: Risk Factor for Childhood Hearing Loss	Universal Newborn Hearing Screening Meeting	Spokane, WA	May 15, 2009
Antiviral Therapy of Influenza	Hot Topics Session, SPR/PAS 2009	Baltimore, MD	May 5, 2009
Update on Human Papillomavirus Vaccine	Snohomish Health District	Everett, WA	March 10, 2009
The Impact of Viruses Disease in Daycare Centers			April 1, 2008
New Molecular Approaches for the Diagnosis of Viral Diseases	State of the Art Plenary Session, PAS/SPR 2009	Baltimore, MD	May 3, 1909
Explaining vaccines to parents	Pediatric Associates	Bellevue, WA	03.04..09

Research Funding

Grant Title	Grantor	Amount	Award Date
NIH Operation of a Facility for the Study of Infectious Agents, Vaccines, and Antimicrobials	NIH contract	$382,463.00	April 7, 2009
Phase II randomized, placebo-controlled, blinded investigation of 6 weeks vs. 6 months of oral valganciclovir therapy in infants with symptomatic ocongenital cytomegalovirus infection	Collaborative Antiviral Study Group (NIH-NIAID)	$177,000.00	Aug. 1, 2008
NIH Vaccine and Treatment Evaluation Unit	NIH contract	$4,020,000	Jan. 1, 2008
Pharmacokinetic-pharmacodynamic and safety evaluation of oseltamivir for the treatment of children less than 24 months with influenza	Collaborative Antiviral Study Group (NIH-NIAID)	$48,000.00	Feb. 1, 2007
Respiratory Viruses and Airflow Obstruction after HCT	NIH NIAID	$70,712.00	Sept. 19, 2005
Role of Viruses in CF Airway Infections	Cystic Fibrosis Foundation	$240,000.00	July 1, 2005

Primary Office

Seattle Children's

MA.7.226 - Infectious Disease Clinic
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2073

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Janet A. Englund, MD

Making a Difference

Rapid Response to H1N1

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