Profile

Heather B. Jaspan, MD, PhD

Heather B. Jaspan, MD, PhD

Infectious Disease

On staff since June 2013

Academic Title: Assistant Professor

Overview

Board Certification(s)

Pediatrics
Pediatric Infectious Diseases

Medical/Professional School

Tulane University School of Medicine, New Orleans
Tulane University School of Medicine, New Orleans

Residency

Pediatrics, University of Washington, Seattle

Fellowship

Pediatric Infectious Disease, Seattle Children's Hospital, Seattle

Clinical Interests

Infant immunology, vaccines, HIV

Research Description

Heather Jaspan, MD, PhD is an investigator in the Center for Global Infectious Disease Research and an assistant professor of pediatric infectious diseases at the University of Washington. At this time, most of Dr. Jaspan's research is conducted in South Africa: In sub-Saharan Africa, there are 200,000 new infant HIV infections annually and adolescents are the fastest growing group of infected individuals. Our lab seeks to: identify correlates of HIV risk at mucosal surfaces, namely the infant gut and the adolescent genital tract; study the role of the commensal bacteria at these mucosal surfaces in modulating immunity; understand immunity of infants born to HIV-infected mothers, who are uninfected yet have high morbidity and mortality; identify vaccination strategies that reduce HIV infection and improve infectious morbidities in these vulnerable HIV-exposed infants. Our clinical site is primarily located in Cape Town, South Africa, where recruitment and sample processing occur.

Awards and Honors

Award Name Award Description Awarded By Award Date
Clinical Research Loan Repayment Program NIH 2011
Octave Workshop for Young and Emerging Investigators New York 2011
Young Investigator Award Conference on Retroviruses and Opportunistic Infections 2009
International Scholarship Award Conference on Retroviruses and Opportunistic Infections 2008
AztraZeneca Highly Commended Clinical Research Young Investigator Award Medical Research Day 2008, Cape Town 2008
Clinical Research Loan Repayment Program NIH 2004 - 2007
Outstanding Medical Student in Pediatrics New Orleans Pediatric Society 1999
Patrick Hanley Scholarship Tulane Medical School 1997
National Research Service Award NIMH 1995 - 1999
Phi Beta Kappa 1993

Publications

  • Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB
    Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants.
    25108027 The Journal of infectious diseases , 2015 Feb. 1 : 211(3)338-46 PMCID: PMC4318913
  • Kidzeru EB, Hesseling AC, Passmore JA, Myer L, Gamieldien H, Tchakoute CT, Gray CM, Sodora DL, Jaspan HB
    In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.
    24785950 AIDS (London, England) , 2014 June 19 : 28(10)1421-30
  • Rametse CL, Olivier AJ, Masson L, Barnabas S, McKinnon LR, Ngcapu S, Liebenberg LJ, Jaumdally SZ, Gray CM, Jaspan HB, Passmore JA
    Role of semen in altering the balance between inflammation and tolerance in the female genital tract: does it contribute to HIV risk?
    24821528 Viral immunology , 2014 June : 27(5)200-6
  • Gervassi A, Lejarcegui N, Dross S, Jacobson A, Itaya G, Kidzeru E, Gantt S, Jaspan H, Horton H
    Myeloid derived suppressor cells are present at high frequency in neonates and suppress in vitro T cell responses.
    25248150 PloS one , 2014 : 9(9)e107816 PMCID: PMC4172591
  • Wood LF, Chahroudi A, Chen HL, Jaspan HB, Sodora DL
    The oral mucosa immune environment and oral transmission of HIV/SIV.
    23772613 Immunological reviews , 2013 July : 254(1)34-53 PMCID: PMC3821196
  • Nglazi MD, Kranzer K, Holele P, Kaplan R, Mark D, Jaspan H, Lawn SD, Wood R, Bekker LG
    Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa.
    22273267 BMC infectious diseases , 2012 Jan. 25 : 1221 PMCID: PMC3295677
  • Jaspan HB, Myer L, Madhi SA, Violari A, Gibb DM, Stevens WS, Dobbels E, Cotton MF
    Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study.
    22103994 BMC pediatrics , 2011 Nov. 21 : 11104 PMCID: PMC3258191
  • Jaspan HB, Liebenberg L, Hanekom W, Burgers W, Coetzee D, Williamson AL, Little F, Myer L, Coombs RW, Sodora D, Passmore JA
    Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.
    21940422 The Journal of infectious diseases , 2011 Nov. 15 : 204(10)1550-6 PMCID: PMC3192190
  • Jaspan HB, Mueller AD, Myer L, Bekker LG, Orrell C
    Effect of caregivers' depression and alcohol use on child antiretroviral adherence in South Africa.
    21470047 AIDS patient care and STDs , 2011 Oct. : 25(10)595-600 PMCID: PMC3183652
  • Jaspan HB, Flisher AJ, Myer L, Mathews C, Middelkoop K, Mark D, Bekker LG
    Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort.
    21700155 The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2011 July : 49(1)42-6 PMCID: PMC3124666
  • Müller AD, Jaspan HB, Myer L, Hunter AL, Harling G, Bekker LG, Orrell C
    Standard measures are inadequate to monitor pediatric adherence in a resource-limited setting.
    20953692 AIDS and behavior , 2011 Feb. : 15(2)422-31 PMCID: PMC3032912
  • Zembe L, Burgers WA, Jaspan HB, Bekker LG, Bredell H, Stevens G, Gilmour J, Cox JH, Fast P, Hayes P, Vardas E, Williamson C, Gray CM
    Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials.
    22022524 PloS one , 2011 : 6(10)e26096 PMCID: PMC3192159
  • Jaspan HB, Brothers AW, Campbell AJ, McGuire JK, Browd SR, Manley TJ, Pak D, Weissman SJ
    Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
    20010311 The Pediatric infectious disease journal , 2010 Apr, : 29(4)379-81
  • Müller AD, Myer L, Jaspan H
    Virological suppression achieved with suboptimal adherence levels among South African children receiving boosted protease inhibitor-based antiretroviral therapy.
    19025495 Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2009 Jan. 1 : 48(1)e3-5
  • Jaspan HB, Berrisford AE, Boulle AM
    Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program.
    18818556 The Pediatric infectious disease journal , 2008 Nov. : 27(11)993-8
  • Jaspan HB, Soka NF, Strode AE, Mathews C, Mark D, Flisher AJ, Wood R, Bekker LG
    Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa.
    18782594 Vaccine , 2008 Oct. 23 : 26(45)5679-83 PMCID: PMC2590661
  • Jaspan HB, Huang LC, Cotton MF, Whitelaw A, Myer L
    Bacterial disease and antimicrobial susceptibility patterns in HIV-infected, hospitalized children: a retrospective cohort study.
    18813340 PloS one , 2008 Sept. 24 : 3(9)e3260 PMCID: PMC2533121
  • Huang LC, Myer L, Jaspan HB
    The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: a retrospective cohort study.
    18811982 BMC infectious diseases , 2008 Sept. 24 : 8127 PMCID: PMC2570677
  • Jaspan HB, Cunningham CK, Tucker TJ, Wright PF, Self SG, Sheets RL, Rogers AS, Bekker LG, Wilson CM, Duerr A, Wasserheit JN, HIV Vaccine Adolescent Trials Working Group
    Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads.
    17984759 Journal of acquired immune deficiency syndromes (1999) , 2008 Jan. 1 : 47(1)86-92
  • Jaspan HB, Hanekom WA
    Immunology of infants through adolescents: responses to emulate for HIV vaccines.
    19372917 Current opinion in HIV and AIDS , 2007 Sept. : 2(5)391-8
  • Jaspan HB, Flisher AJ, Myer L, Mathews C, Seebregts C, Berwick JR, Wood R, Bekker LG
    Brief report: methods for collecting sexual behaviour information from South African adolescents--a comparison of paper versus personal digital assistant questionnaires.
    17187853 Journal of adolescence , 2007 Apr, : 30(2)353-9
  • Jaspan HB, Berwick JR, Myer L, Mathews C, Flisher AJ, Wood R, Bekker LG
    Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials.
    17046499 The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2006 Nov. : 39(5)642-8
  • Jaspan HB, Lawn SD, Safrit JT, Bekker LG
    The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents.
    16470112 AIDS (London, England) , 2006 Feb. 28 : 20(4)483-94
  • Bekker LG, Jaspan H, McIntyre J, Wood R, Gray G
    Adolescents and HIV vaccine trials: what are the clinical trial site issues?
    16533798 Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) , 2005 Dec. : 4(4)93-7
  • Jaspan HB, Gray GE, Robinson AK, Coovadia HM, Bekker LG
    Scientific justification for the participation of children and adolescents in HIV-1 vaccine trials in South Africa.
    16327928 South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde , 2005 Sept. : 95(9)685-7
  • Jaspan HB, Robinson JE, Amedee AM, Van Dyke RB, Garry RF
    Amniotic fluid has higher relative levels of lentivirus-specific antibodies than plasma and can contain neutralizing antibodies.
    15465411 Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2004 Nov. : 31(3)190-7
  • Jaspan HB, Garry RF
    Preventing neonatal HIV: a review.
    15046256 Current HIV research , 2003 July : 1(3)321-7
  • Jaspan HB, Richard Gaumer H, Garry RF
    Quantitative competitive reverse transcription polymerase chain reaction is not a useful method for quantification of CD4 and CD8 cell status during HIV infection.
    12702212 Journal of negative results in biomedicine , 2003 Mar. 12 : 22 PMCID: PMC153544
  • Jaspan HB, Gaumer HR, Garry RF
    Expression of granzyme B mRNA is altered in human immunodeficiency virus infected patients.
    12645627 Experimental and molecular pathology , 2003 Feb. : 74(1)13-6

Presentations

Presentations Title Event Location Date
Infant Feeding and HIV Durban AIDS Conference 2011
Adolescents in HIV Vaccine Trials. At Immunobiology: From Infection to Immune Control Keystone, Colorado 2009
Can we eliminate Pediatric HIV? ARV Master Class, University of Cape Town 2008
HIV vaccine trials and adolescents IRENSA Training, University of Cape Town 2006 - 2007
South African HIV Clinicians Society Skills Development Program Durban AIDS Conference 2005

Research Funding

Grant Title Grantor Amount Award Date
"Intestinal microbiota, immune activation and vaccine responsiveness of the HIV-exposed infant" (Co-PI with Cameron) Canadian Institutes of Health Research $100,000 2014 - 2015
"Myeloid-derived Suppressor cells (MDSC) suppress infant immune responses" (PI: Horton) (Jaspan: South African PI) NICHHD/NIH $180,000 total subcontract 2012 - 2017
"Innate, Adaptive and Mucosal Immune Responses in HIV-1 Exposed Uninfected Infants: A Human Model to Understand Correlates of Immune Protection" Canadian HIV Vaccine Initiative/ Canadian Institutes for Health Research $577,406 for Jaspan 2012 - 2016
K08 "Assessing feeding practices, immune activation, and HIV risk in South African infants" NIH/NIAID $100,000 per year 2011 - 2016