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Heather B. Jaspan, MD, PhD

Heather B. Jaspan, MD, PhD

Infectious Disease

On staff since June 2013

Academic Title: Assistant Professor


Board Certification(s)
Pediatric Infectious Diseases
Medical/Professional School
Tulane University School of Medicine, New Orleans
Tulane University School of Medicine, New Orleans
Pediatrics, University of Washington/Seattle Children's Hospital, Seattle
Pediatric Infectious Disease, Seattle Children's Hospital, Seattle
Clinical Interests

Infant immunology, vaccines, HIV

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Octave Workshop for Young and Emerging InvestigatorsNew York 2011
Clinical Research Loan Repayment ProgramNIH 2011
Young Investigator AwardConference on Retroviruses and Opportunistic Infections 2009
AztraZeneca Highly Commended Clinical Research Young Investigator AwardMedical Research Day 2008, Cape Town 2008
International Scholarship AwardConference on Retroviruses and Opportunistic Infections 2008
Clinical Research Loan Repayment ProgramNIH 2004 - 2007
Outstanding Medical Student in PediatricsNew Orleans Pediatric Society 1999
Patrick Hanley ScholarshipTulane Medical School 1997
National Research Service AwardNIMH 1995 - 1999
Phi Beta Kappa 1993


In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.
AIDS (London, England) , 2014 Jun 19: 28(10)1421-30
Role of semen in altering the balance between inflammation and tolerance in the female genital tract: does it contribute to HIV risk?
Viral immunology , 2014 Jun: 27(5)200-6
The oral mucosa immune environment and oral transmission of HIV/SIV.
Immunological reviews , 2013 Jul: 254(1)34-53
Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa.
BMC infectious diseases , 2012 Jan 25: 1221
Utility of clinical parameters to identify HIV infection in infants below ten weeks of age in South Africa: a prospective cohort study.
BMC pediatrics , 2011 Nov 21: 11104
Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV shedding.
The Journal of infectious diseases , 2011 Nov 15: 204(10)1550-6
Effect of caregivers' depression and alcohol use on child antiretroviral adherence in South Africa.
AIDS patient care and STDs , 2011 Oct: 25(10)595-600
Sexual health, HIV risk, and retention in an adolescent HIV-prevention trial preparatory cohort.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2011 Jul: 49(1)42-6
Standard measures are inadequate to monitor pediatric adherence in a resource-limited setting.
AIDS and behavior , 2011 Feb: 15(2)422-31
Intra- and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials.
PloS one , 2011: 6(10)e26096
Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
The Pediatric infectious disease journal , 2010 Apr: 29(4)379-81
Virological suppression achieved with suboptimal adherence levels among South African children receiving boosted protease inhibitor-based antiretroviral therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2009 Jan 1: 48(1)e3-5
Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program.
The Pediatric infectious disease journal , 2008 Nov: 27(11)993-8
Community perspectives on the ethical issues surrounding adolescent HIV vaccine trials in South Africa.
Vaccine , 2008 Oct 23: 26(45)5679-83
The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: a retrospective cohort study.
BMC infectious diseases , 2008 Sep 24: 8127
Bacterial disease and antimicrobial susceptibility patterns in HIV-infected, hospitalized children: a retrospective cohort study.
PloS one , 2008 Sep 24: 3(9)e3260
Inclusion of adolescents in preventive HIV vaccine trials: public health policy and research design at a crossroads.
Journal of acquired immune deficiency syndromes (1999) , 2008 Jan 1: 47(1)86-92
Immunology of infants through adolescents: responses to emulate for HIV vaccines.
Current opinion in HIV and AIDS , 2007 Sep: 2(5)391-8
Brief report: methods for collecting sexual behaviour information from South African adolescents--a comparison of paper versus personal digital assistant questionnaires.
Journal of adolescence , 2007 Apr: 30(2)353-9
Adolescent HIV prevalence, sexual risk, and willingness to participate in HIV vaccine trials.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine , 2006 Nov: 39(5)642-8
The maturing immune system: implications for development and testing HIV-1 vaccines for children and adolescents.
AIDS (London, England) , 2006 Feb 28: 20(4)483-94
Adolescents and HIV vaccine trials: what are the clinical trial site issues?
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) , 2005 Dec: 4(4)93-7
Scientific justification for the participation of children and adolescents in HIV-1 vaccine trials in South Africa.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde , 2005 Sep: 95(9)685-7
Amniotic fluid has higher relative levels of lentivirus-specific antibodies than plasma and can contain neutralizing antibodies.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology , 2004 Nov: 31(3)190-7
Preventing neonatal HIV: a review.
Current HIV research , 2003 Jul: 1(3)321-7
Quantitative competitive reverse transcription polymerase chain reaction is not a useful method for quantification of CD4 and CD8 cell status during HIV infection.
Journal of negative results in biomedicine , 2003 Mar 12: 22
Expression of granzyme B mRNA is altered in human immunodeficiency virus infected patients.
Experimental and molecular pathology , 2003 Feb: 74(1)13-6


Presentations TitleEventLocationDate
Infant Feeding and HIVDurban AIDS Conference 2011
Adolescents in HIV Vaccine Trials. At Immunobiology: From Infection to Immune ControlKeystone, Colorado 2009
Can we eliminate Pediatric HIV? ARV Master Class, University of Cape Town 2008
HIV vaccine trials and adolescentsIRENSA Training, University of Cape Town 2006 - 2007
South African HIV Clinicians Society Skills Development ProgramDurban AIDS Conference 2005

Research Funding

Grant TitleGrantorAmountAward Date
"Intestinal microbiota, immune activation and vaccine responsiveness of the HIV-exposed infant" (Co-PI with Cameron)Canadian Institutes of Health Research $100,000 2014 - 2015
"Innate, Adaptive and Mucosal Immune Responses in HIV-1 Exposed Uninfected Infants: A Human Model to Understand Correlates of Immune Protection"Canadian HIV Vaccine Initiative/ Canadian Institutes for Health Research $577,406 for Jaspan 2012 - 2016
"Myeloid-derived Suppressor cells (MDSC) suppress infant immune responses" (PI: Horton) (Jaspan: South African PI)NICHHD/NIH $180,000 total subcontract 2012 - 2017
K08 "Assessing feeding practices, immune activation, and HIV risk in South African infants"NIH/NIAID $100,000 per year 2011 - 2016

Primary Office

Seattle Children's Research Institute
JMB - 8 - Infectious Disease
1900 - 9th Ave
Seattle, WA 98101

Additional Offices

Seattle Children's
MA.7.226 - Infectious Disease/Immunology
4800 Sand Point Way NE
Seattle, WA 98105

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