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David L. Horn, MD

David L. Horn, MD


On staff since August 2010

Academic Title: Assistant Professor


DeniseMount Vernon, WA04.01.11
Our 11-year-old daughter Olivia came to Dr. Horn after receiving a diagnosis of a tumor in her parotid salivary gland. When he reviewed her case, he spent a lot of time explaining our options and even told us what he would do if Olivia were his own daughter. We went ahead with his recommendation to remove the tumor as soon as possible. He spent time with us right before the surgery - answering our questions and helping to put our minds at ease. We are so thankful that we went with his recommendation, because five days later we learned that her tumor was cancer. Because of his knowledge and expertise, our daughter's cancer was caught early and did not have a chance to spread throughout her body. He has given us a future filled with HOPE and we are grateful. Thank you!
My son who was 2 1/2 at the time of his surgery needed to have his adenoids removed. Dr. Horn is very knowledgeable, compassionate and gave me a very clear understanding of what my son's issues were. I was overwhelmed by the decision to either have the surgery to remove the adenoids or wait and see if things got better. He helped me make the right choice by providing me with the best medical information/advise and presenting it to me in "English" and not a lot of medical terminology. My son's surgery was very successful. Dr. Horn has a great personality, and really cares about his patience. I felt like my son was in excellent care before and during the surgery. Everything was well explained and lots of supportive materials were provided to me. I highly recommend Dr. Horn because of his charismatic personality his passion for his career, and ability to work well with children. Thank you!
Recommend Dr. David  Horn


Board Certification(s)
Medical/Professional School
Medical College of Wisconsin, Milwaukee
Otolaryngology, Indiana University School of Medicine, Indianapolis
Pediatric Otolaryngology, Children's Hospital of Pittsburgh, Pittsburgh
Clinical Interests

Congenital and pre-lingual hearing loss, cochlear implantation, chronic ear disease, pediatric airway management, congenital head and neck anomalies, obstructive sleep apnea


Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004-2008.
Diagnostic microbiology and infectious disease , 2012 Dec: 74(4)323-31
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry.
The Journal of infection , 2012 Nov: 65(5)453-64
Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.
Nucleic acids research , 2012 Nov 1: 40(20)10150-60
Telomeres, tethers and trypanosomes.
Nucleus (Austin, Tex.) , 2012 Nov-Dec: 3(6)478-86
The PATH (Prospective Antifungal Therapy) Alliance® registry and invasive fungal infections: update 2012.
Diagnostic microbiology and infectious disease , 2012 Aug: 73(4)293-300
Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America , 2012 Jul 3: 109(27)10996-1001
Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes.
Expert reviews in molecular medicine , 2012 May 29: 14e13
Two hundred and eleven cases of Candida osteomyelitis: 17 case reports and a review of the literature.
Diagnostic microbiology and infectious disease , 2012 May: 73(1)89-93
Trypanosomal histone H2A and the DNA damage response.
Molecular and biochemical parasitology , 2012 May: 183(1)78-83
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
Bioorganic & medicinal chemistry letters , 2012 Mar 1: 22(5)1886-90
Peptide markers of aminoacyl tRNA synthetases facilitate taxa counting in metagenomic data.
BMC genomics , 2012 Feb 10: 1365
Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam Principles).
Journal of proteome research , 2012 Feb 3: 11(2)1412-9
High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Nature , 2012 Jan 25: 482(7384)232-6
Treatment of candidemia with echinocandins: data on hospital resource use from a real world setting.
Journal of medical economics , 2012: 15(6)1130-8
Endoscopic anterior cricoid split with balloon dilation in infants with failed extubation.
The Laryngoscope , 2012 Jan: 122(1)216-9
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions.
PLoS biology , 2012: 10(3)e1001287
Aleuria Aurantia Lectin (AAL)-reactive immunoglobulin G rapidly appears in sera of animals following antigen exposure.
PloS one , 2012: 7(9)e44422
Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles).
Proteomics , 2012 Jan: 12(1)11-20
The treatment of low-energy femoral shaft fractures: a prospective study comparing the "walking spica" with the traditional spica cast.
The Journal of bone and joint surgery. American volume , 2011 Dec 7: 93(23)2196-202
Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam Principles).
Molecular & cellular proteomics : MCP , 2011 Dec: 10(12)O111.015446
Recommendations for mass spectrometry data quality metrics for open access data (corollary to the Amsterdam principles).
Proteomics. Clinical applications , 2011 Dec: 5(11-12)580-9
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment.
Journal of proteome research , 2011 Sep 2: 10(9)4088-104
High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.
Genome research , 2011 Jun: 21(6)915-24
Elongator protein 3b negatively regulates ribosomal DNA transcription in african trypanosomes.
Molecular and cellular biology , 2011 May: 31(9)1822-32
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.
Molecular and biochemical parasitology , 2011 Mar: 176(1)55-7
Microhomology-mediated deletion and gene conversion in African trypanosomes.
Nucleic acids research , 2011 Mar: 39(4)1372-80
Spontaneous formation of radially aligned microchannels.
Chemical communications (Cambridge, England) , 2011 Feb 21: 47(7)2047-9
Common peptides study of aminoacyl-tRNA synthetases.
PloS one , 2011: 6(5)e20361
The malondialdehyde-derived fluorophore DHP-lysine is a potent sensitizer of UVA-induced photooxidative stress in human skin cells.
Journal of photochemistry and photobiology. B, Biology , 2010 Dec 2: 101(3)251-64
Molecular mechanisms underlying the control of antigenic variation in African trypanosomes.
Current opinion in microbiology , 2010 Dec: 13(6)700-5
Ecoenzymatic stoichiometry in relation to productivity for freshwater biofilm and plankton communities.
Microbial ecology , 2010 Nov: 60(4)885-93
RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease.
Molecular and biochemical parasitology , 2010 Nov: 174(1)70-3
Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts.
Photochemistry and photobiology , 2010 Nov-Dec: 86(6)1307-17
Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.
Molecular microbiology , 2010 Sep: 77(5)1237-45
Deriving enzymatic and taxonomic signatures of metagenomes from short read data.
BMC bioinformatics , 2010 Jul 22: 11390
Pathologic lower extremity fractures in children with Alagille syndrome.
Journal of pediatric gastroenterology and nutrition , 2010 Jul: 51(1)66-70
UFFizi: a generic platform for ranking informative features.
BMC bioinformatics , 2010 Jun 3: 11300
Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program.
Diagnostic microbiology and infectious disease , 2010 Jun: 67(2)162-71
Current treatment of clubfoot in infancy and childhood.
Foot and ankle clinics , 2010 Jun: 15(2)235-43
Data mining of enzymes using specific peptides.
BMC bioinformatics , 2009 Dec 24: 10446
Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities.
Applied and environmental microbiology , 2009 Dec: 75(23)7537-41
Multi-axial correction system in the treatment of radial club hand.
Journal of children's orthopaedics , 2009 Dec: 3(6)493-8
Dynamic quantum clustering: a method for visual exploration of structures in data.
Physical review. E, Statistical, nonlinear, and soft matter physics , 2009 Dec: 80(6 Pt 2)066117
Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance Program.
Diagnostic microbiology and infectious disease , 2009 Sep: 65(1)27-34
Correction of Blount's disease by a multi-axial external fixation system.
Journal of children's orthopaedics , 2009 Aug: 3(4)291-9
Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei.
Molecular and biochemical parasitology , 2009 Aug: 166(2)194-7
What has DNA sequencing revealed about the VSG expression sites of African trypanosomes?
Trends in parasitology , 2009 Aug: 25(8)359-63
Epidemiology and outcome of multiple-species candidemia at a tertiary care center between 2004 and 2007.
Diagnostic microbiology and infectious disease , 2009 Jul: 64(3)289-94
Antigenic variation: extending the reach of telomeric silencing.
Current biology : CB , 2009 Jun 23: 19(12)R496-8
Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America , 2009 Jun 15: 48(12)1695-703
Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection.
Diagnostic microbiology and infectious disease , 2009 Jun: 64(2)152-7
Common peptides shed light on evolution of Olfactory Receptors.
BMC evolutionary biology , 2009 May 5: 991
Aspergillus osteomyelitis: review of 12 cases identified by the Prospective Antifungal Therapy Alliance registry.
Diagnostic microbiology and infectious disease , 2009 Apr: 63(4)384-7
Genomic DNA k-mer spectra: models and modalities.
Genome biology , 2009: 10(10)R108
DNA breaks as triggers for antigenic variation in African trypanosomes.
Genome biology , 2009: 10(6)223
Solution interactions between the uranyl cation [UO2(2+)] and histidine, N-acetyl-histidine, tyrosine, and N-acetyl-tyrosine.
Journal of inorganic biochemistry , 2009 Jan: 103(1)58-63
Effect of ant attendance by Monomorium minimum (Buckley) (Hymenoptera: Formicidae) on predation and parasitism of the soybean aphid Aphis glycines Matsumura (Hemiptera: Aphididae).
Environmental entomology , 2008 Oct: 37(5)1258-63
Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei.
Molecular and biochemical parasitology , 2008 Sep: 161(1)76-9
Syntactic structures in languages and biology.
Cognitive processing , 2008 Aug: 9(3)153-8
Candidemia in the 21st century.
Future microbiology , 2008 Aug: 3(4)463-72
Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes.
Molecular microbiology , 2008 Aug: 69(4)1054-68
Guidelines for reporting the use of mass spectrometry informatics in proteomics.
Nature biotechnology , 2008 Aug: 26(8)862
Guidelines for reporting the use of mass spectrometry in proteomics.
Nature biotechnology , 2008 Aug: 26(8)860-1
Biological roles of specific peptides in enzymes.
Proteins , 2008 Aug: 72(2)606-12
Oil pipeline corridor through an intact forest alters ground beetle (Coleoptera: Carabidae) assemblages in southeastern Ohio.
Environmental entomology , 2008 Jun: 37(3)725-33
Brain abscess and hereditary hemorrhagic telangiectasia.
Southern medical journal , 2008 Jun: 101(6)618-25
Global considerations in hierarchical clustering reveal meaningful patterns in data.
PloS one , 2008 May 21: 3(5)e2247
Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes.
Nucleic acids research , 2008 May: 36(8)2608-18
A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes.
Proceedings of the National Academy of Sciences of the United States of America , 2008 Apr 1: 105(13)5022-7
Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei.
Molecular microbiology , 2008 Feb: 67(4)762-71
Human Proteinpedia enables sharing of human protein data.
Nature biotechnology , 2008 Feb: 26(2)164-7
Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids.
BMC genomics , 2008 Jan 3: 92
Histone deacetylases.
Advances in experimental medicine and biology , 2008: 62581-6
Analysis of small GTPase function in trypanosomes.
Methods in enzymology , 2008: 43857-76
Unsupervised feature selection under perturbations: meeting the challenges of biological data.
Bioinformatics (Oxford, England) , 2007 Dec 15: 23(24)3343-9
Presentation of the PATH Alliance registry for prospective data collection and analysis of the epidemiology, therapy, and outcomes of invasive fungal infections.
Diagnostic microbiology and infectious disease , 2007 Dec: 59(4)407-14
Visual-motor integration skills of prelingually deaf children: implications for pediatric cochlear implantation.
The Laryngoscope , 2007 Nov: 2017-25
Neuropsychological correlates of vocabulary, reading, and working memory in deaf children with cochlear implants.
Journal of deaf studies and deaf education , 2007 Fall: 461-71
Divergence of fine and gross motor skills in prelingually deaf children: implications for cochlear implantation.
The Laryngoscope , 2006 Aug: 1500-6
Behavioral assessment of prelingually deaf children before cochlear implantation.
The Laryngoscope , 2005 Sep: 1603-11


Presentations TitleEventLocationDate
Update in Pediatric Hearing LossUniversity of Washington School of Medicine Otolaryngology Update for Primary Care Seattle, WA 2012
Update in Pediatric Sensorineural Hearing LossNorthwest Academy of Otolaryngology Winter ConferenceSeattle, WA 2011

Primary Office

Seattle Children's
OA.9.220 - Otolaryngology-ENT
4800 Sand Point Way NE
Seattle, WA 98105

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