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Catherine M. Amlie-Lefond, MD

Catherine M. Amlie-Lefond, MD


On staff since August 2011

Children's Title: Director, Pediatric Vascular Neurology Program

Academic Title: Associate Professor

Research Center: Center for Integrative Brain Research


ShayneGladstone, Michigan06.11.14
Dr Lefond took care of my son Andrew at Children's Hospital of Wisconsin, Milwaukee. Andrew had a brain pseudoaneurym rupture and suffered 3 strokes at 5 weeks of age. We traveled from Green Bay to see her and she was a great neurologist. (We have since moved to Michigan but continue care in Milwaukee.) We were sad to see her leave. Andrew is now 5 years old and has done remarkable for all he went thru- she would also be amazed. I agree with another parent, Seattle is very lucky to have her. Thank you Dr. Lefond for being so wonderful.
ChristinaSeattle, WA08.20.13
Dr. Le-Fond has been working with us over the past year regarding our son, who had a stroke at just over one years of age. I can't say enough positive things about her working demeanor and continued care of our son. I think it is not only her extensive knowledge of the subject matter, but also her approach to care that make her such a wonderful doctor. She carefully explains issues and is not afraid to consult with other specialists when necessary. I would not hesitate to recommend her to anyone facing these issues.
ColeBelgrade, Montana04.22.13
Our daughter had just turned 3 when she suffered her stroke and so began our journey that led us to meeting with Dr. Lefond. We spent a week in the hospital at Seattle Children's, and although she had many patients, we truly felt like our little girl was Dr. Lefonds only patient. We could tell it was a personal mission for her to find a cause to our daughters stroke. She was very attentive to our questions and was very diligent in finding answers. We do not live close to Seattle and have had to travel there many times; she has really helped in coordinating our appointments and making our stressful visits quite pleasant. We have been seeing her for almost a year now and she has gone so far beyond our expectations as a healthcare professional. She truly cares about Colbies health and well-being. It will be a bittersweet day when we no longer need her expertise.
JamieSheboygan Falls, WI04.22.13
Dr Lefond was beyond amazing!!! My son, Leroy, had a stroke while still in utero and was having seizures that lasted 12-15 minutes long right after birth. He was shipped from our hosp in Sheboygan to Children's Hospital in Milwaukee and got the amazing fortune to have Dr Lefond as his doctor! She was so attentive to him and got him on the right medications. Leroy gained weight so fast that he outgrew his medication faster than expected, so he ended up having a couple extra trips to Milwaukee to see her, but each time she was such a pleasure to work with! She never got impatient with us, she always answered all of our questions, and she ALWAYS made sure Leroy was on the proper dosage of the right medications. For each check-up trip that we had to make to see Dr Lefond, even if she was over-booked by accident (which only happened once) she still made certain she herself came to see Leroy and see how he was doing...and she ALWAYS came into the room with a smile on her face! I don't think anyone could ask for a better neurologist for their child! My only disappointment is that she had to leave Wisconsin and we no longer have her for ourselves! ;) I recommend that anyone needing a child neurologist go to her, because there truly is no better than her! We miss her greatly here in Wisconsin, and I hope Seattle's Children's Hospital knows how blessed they are to have her!
CeciliaMilwaukee, Wi05.21.12
Dr. Lefond was absolutely delightful to work with at Children's Hospital of Wisconsin. She is wonderful with children and she worked hard with our family to get answers regarding my son Levi having a stroke being only 10 years old. He was totally health and it turned our lives upside for a short while. Dr. Lefond has an incredible background in pediatric strokes. She did a very good job in making sure not only did we as Levi's parents understand his condition but that he also understood what was going on wig his body. We will dearly miss working with Dr. Lefond and her team. Wishing you all the best in life and your career <3 Sincerely, Cecilia and Family
Recommend Dr. Catherine Amlie-Lefond


Board Certification(s)
Neurology with Special Qualifications in Child Neu
Medical/Professional School
UCLA School of Medicine, Los Angeles
Pediatrics, University of Colorado - The Children's Hosp, Aurora
Child Neurology, University of Colorado - The Children's Hosp, Aurora
University of Colorado, Aurora
Clinical Interests

Pediatric stroke and cerebrovasculopathy, critical care neurology, general child neurology

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Fellow, American Heart Association conferred by the Stroke Council 2013
Fellow, American Neurological Association 2010


Cystathionine Beta-synthase Deficiency Heralded by Cerebral Sinus Venous Thrombosis and Stroke.
Pediatric neurology , Oct. 2013
Amlie-Lefond C. Stroke on Pediatric Wards. , 2013
The Stroke Book, 2nd ed (Torbey and Selim, ed); Cambridge University Press , 2013
Clinical trial design for endovascular ischemic stroke intervention.
Neurology , Sept. 2012: 79(13 Suppl 1)S221-33
Endovascular therapy in children with acute ischemic stroke: review and recommendations.
Neurology , Sept. 2012: 79(13 Suppl 1)S158-64
Optimizing the concentration and bolus of a drug delivered by continuous infusion.
Biometrics , Dec. 2011: 67(4)1638-46
Moyamoya disease in early infancy: case report and literature review.
Pediatric neurology , April 2011: 44(4)299-302
Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study.
Stroke; a journal of cerebral circulation , March 2011: 42(3)613-7
Childhood stroke: The devil is in the detail
Lancet Neurology , 2011: 10(7)606
Pharmacology in childhood arterial ischemic stroke.
Seminars in pediatric neurology , Dec. 2010: 17(4)237-44
Catheter angiogram in central nervous system vasculitis: still first among equals.
Developmental medicine and child neurology , Sept. 2010: 52(9)792
Diagnosis and management of pediatric arterial ischemic stroke.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association , May 2010: 19(3)175-83
Rashes, sniffles, and stroke: a role for infection in ischemic stroke of childhood.
Infectious disorders drug targets , April 2010: 10(2)67-75
Neurologic manifestations of varicella zoster virus infections.
Current neurology and neuroscience reports , Nov. 2009: 9(6)430-4
Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study.
Lancet neurology , June 2009: 8(6)530-6
Thrombolytics for hyperacute stroke in children.
Pediatric hematology and oncology , April 2009: 26(3)103-7
Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study.
Circulation , March 2009: 119(10)1417-23
Thrombolysis in acute childhood stroke: design and challenges of the thrombolysis in pediatric stroke clinical trial.
Neuroepidemiology , 2009: 32(4)279-86
Practical model-based dose finding in early-phase clinical trials: optimizing tissue plasminogen activator dose for treatment of ischemic stroke in children.
Stroke; a journal of cerebral circulation , Sept. 2008: 39(9)2627-36
Arterial ischemic stroke: experience in Chinese children.
Pediatric neurology , Aug. 2008: 39(2)142-3; author reply 143-4
Treatment of childhood arterial ischemic stroke.
Annals of neurology , June 2008: 63(6)679-96
Recent developments in childhood arterial ischaemic stroke.
Lancet neurology , May 2008: 7(5)425-35
Fatal neonatal stroke from a prenatal cardiac thrombus.
Pediatric neurology , Feb. 2008: 38(2)140-2
Cerebrospinal fluid analysis in the diagnosis and treatment of arterial ischemic stroke.
Pediatric neurology , Jan. 2008: 38(1)1-9
Localized purpura associated with lamotrigine.
Pediatric neurology , Sept. 2006: 35(3)227-8
Innate immunity for biodefense: a strategy whose time has come.
The Journal of allergy and clinical immunology , Dec. 2005: 116(6)1334-42


Presentations TitleEventLocationDate
Pediatric Stroke and tPA Study DesignHemostasis and Thrombosis Research SocietyApril 12, 2013
Pediatric Stroke: International Perspective2012 Canadian Stroke CongressOct. 1, 2012
Thrombolysis in Pediatric StrokeAmerican Academy of NeurologyApril 23, 2012
Thrombolysis in Pediatric Stroke-ongoing clinical trials posterInternational Stroke ConferenceNew Orleans, LAFeb. 2, 2012
Acute management of pediatric stroke: focus on tPA and other emergent treatmentsChild Neurology Society MeetingLouisville, KYOct. 17, 2009
tPA in children with arterial ischemic strokeXX1st Congress of the International Society on Thrombosis and HaemostasisGeneva, SwitzerlandJuly 7, 2007

Research Funding

Grant TitleGrantorAmountAward Date
Site PI: Vascular Effects of Infection in Pediatric Stroke 2008
Site PI: International Paediatric Stroke Study 2006

Primary Office

Seattle Children's
MB.7.420 - Neurology
4800 Sand Point Way NE
Seattle, WA 98105

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