As one of the nation’s top five pediatric research centers, Seattle Children’s Research Institute has pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies and has made other major contributions to pediatric medicine. With a workforce of over 1,100, our labs and research groups are working toward the next wave of discoveries for hundreds of diseases and disorders.

Alphabetical Listing of Research Labs

Name Research Center Disease or Condition Description
Beier Lab Center for Developmental Biology and Regenerative Medicine Genetic disorders The Beier Lab uses genetic analysis in model systems as a means to understand human biology and disease, and identifies genes that contribute to human disease and developmental abnormalities.
Burns Lab Center for Global Infectious Disease Research Cystic fibrosis The Burns lab studies the pathogenesis and treatment of cystic fibrosis (CF) lung infections.
Christakis Lab Center for Child Health, Behavior and Development Attention problems, behavioral disorders The Christakis lab investigates the impact that early experiences, including television exposure, have on children’s cognitive, social and behavioral development.
Cox Lab Center for Developmental Biology and Regenerative Medicine Cleft lip and palate, midface hypoplasia The Cox lab investigates the genetic and nutritional causes of clef lip and palate, midface hypoplasia and other common craniofacial disorders.
Crane Lab Ben Towne Center for Childhood Cancer Research Brain tumors, neuroblastoma The Crane lab is pursuing therapies that use the immune system to wipe out brain tumors, neuroblastoma and other solid tumors.
Craniofacial Outcomes Research and Epidemiology (CORE) Group Center for Clinical and Translational Research Craniofacial microsomia, 22q11.2 deletion syndrome and other craniofacial conditions The CORE group collaborates to understand the epidemiology of craniofacial conditions and to identify treatments to improve outcomes for those conditions.
Cunningham Lab Center for Developmental Biology and Regenerative Medicine Craniosynostosis and other craniofacial conditions The Cunningham lab investigates the fundamental mechanisms behind craniosynostosis and other malformations, pursuing discoveries that improve patient care.
Debley Lab Center for Immunity and Immunotherapies Asthma The Debley Lab is engaged in an array of translational research investigating the role of the airway epithelium in childhood asthma.
Evans Lab Center for Clinical and Translational Research Robin sequence and other craniofacial conditions The Evans lab investigates sleep and breathing in children born with craniofacial conditions, with the goal of improving outcomes.
Frenkel Lab Center for Global Infectious Disease Research HIV The Frenkel lab is working to prevent mother-infant HIV transmission by studying the mechanisms behind that transmission; developing practical, affordable ways to prevent it; and developing tests and treatments for drug-resistant HIV.
Hahn Lab Center for Developmental Therapeutics Mitochondrial diseases, Wilson disease The Hahn lab develops and validates assays that help screen, diagnose and monitor disease.
Heike Lab Center for Clinical and Translational Research Craniofacial microsomia, 22q11.2 deletion syndrome and other craniofacial conditions The Heike lab aims to improve care by unraveling the causes of craniofacial conditions, developing new evaluation tools and assessing treatment outcomes.
Hevner Lab Center for Integrative Brain Research Lissencephaly and other neurodevelopmental disorders The Hevner lab studies transcription factors and neurogenesis, the process by which neurons are formed in the developing brain. Neurogenesis holds great scientific and medical interest because of its significance for human brain development and disease.
Hing Studies Center for Developmental Biology and Regenerative Medicine Cleft lip and palate, midface hypoplasia, craniosynostosis and other craniofacial conditions Dr. Anne V. Hing investigates the genetic causes of craniofacial disorders and specializes in recruiting patients for studies.
James Lab Center for Immunity and Immunotherapies Lymphoma, autoimmune diseases The James lab investigates how genetic variation and pharmacological treatments alter cellular signaling.
Jensen Lab Ben Towne Center for Childhood Cancer Research Leukemia, lymphoma and neuroblastoma The Jensen lab is pursuing innovative treatments that reprogram a child’s defense system to eliminate cancer cells, without chemotherapy or radiation – or their debilitating side effects.
Kalume Laboratory Center for Integrative Brain Research Epilepsy, Dravet syndrome, sudden unexpected death in epilepsy The Kalume Laboratory investigates the mechanisms that drive epilepsy and related conditions, with the goal of making discoveries that lead to improved treatments for affected children and adults.
Katzenellenbogen Lab Center for Global Infectious Disease Research Human papillomavirus (HPV) The Katzenellenbogen lab studies the mechanism by which human papillomavirus (HPV) activates telomerase in order to understand how HPV drives cells to become malignant. Telomerase is an enzyme found normally in stem cells and is almost categorically activated in cancers.
Kean Lab Ben Towne Center for Childhood Cancer Research Cancer, graft-versus-host disease, autoimmune diseases The Kean lab is working to solve the mystery of immune recognition and immune tolerance. Its researchers are pursuing new techniques that overcome transplant rejection and prevent graft-versus-host disease.
Kolker Lab Center for Developmental Therapeutics Bioinformatics, health informatics The Kolker lab focuses on bioinformatics, health informatics and integrative analyses. It uses high-throughput technologies to examine and model molecular mechanisms of biological processes.
Luquetti Lab Center for Developmental Biology and Regenerative Medicine Microtia, craniofacial microsomia and other craniofacial conditions The Luquetti lab studies the genetics and epidemiology of craniofacial malformations, with the goal of identifying their causes and developing research methods that can apply to a variety of birth defects.
Maga Lab Center for Developmental Biology and Regenerative Medicine Fetal alcohol spectrum disorders, craniofacial malformations The Maga lab investigates the mechanisms responsible for human malformations, specifically craniofacial disorders, and normal phenotypic variation.
Majesky Lab Center for Developmental Biology and Regenerative Medicine Congenital heart defects and other cardiac abnormalities The Majesky lab is studying the embryonic development of the heart and vascular system, with the goal of developing cell-based therapies for congenital heart defects and other cardiac abnormalities.
Maves Lab Center for Developmental Biology and Regenerative Medicine Heart defects, muscular dystrophy The Maves lab is investigating heart and muscle cell development, and pursuing new treatments for muscular dystrophy and heart disorders.
McCarty Lab Center for Child Health, Behavior and Development Adolescent behavioral health The McCarty lab's mission is to improve the emotional and behavioral health of children and adolescents through enhanced scientific understanding, promoting social-emotional competencies and disseminating evidence-based treatments.
Mendoza Lab Center for Child Health, Behavior and Development Obesity and related health problems The Mendoza lab focuses on preventing childhood obesity and its long-term health effects, especially among minorities and low-income groups.
Millen Lab Center for Integrative Brain Research Dandy-Walker malformation and other cerebellar malformations The Millen lab studies the genetic and developmental basis of structural birth defects of the brain both in humans and mice.
Morgan Laboratory Center for Developmental Therapeutics Mitochondrial diseases The Morgan laboratory works closely with the Sedensky laboratory to study mitochondria's role in childhood diseases.
Myers Lab Center for Child Health, Behavior and Development Telemental health The Myers lab is focused on providing evidence-based mental healthcare services through telemental health to rectify current disparities in access to mental healthcare.
Neonatal Respiratory Support Technologies (NeoRest) Center for Developmental Therapeutics Infant respiratory distress The NeoRest team is developing simple, affordable technologies that provide respiratory care to infants in developing countries for a fraction of the cost of conventional ventilators.
Ojemann Lab Center for Integrative Brain Research Epilepsy The Ojemann lab is interested in using electrocorticography (ECoG), a technology for long-term clinical monitoring of epilepsy patients, to answer basic neuroscience questions as well as to develop tools for clinical and rehabilitative applications.
Olson Lab Center for Developmental Therapeutics Effect of cardiac energy production on heart function The Olson Lab is unraveling how changes in cardiac energy production affect heart function, leading to innovative treatments for heart disease.
Palermo Lab Center for Child Health, Behavior and Development Chronic pain The Palermo lab studies pain in children, particularly the interrelationships of pain, sleep and behavioral/psychological factors. The lab also studies psychological and family treatments for pediatric chronic pain management; technological and Internet-based innovations for pain assessment; and health risk factors and chronic pain.
Portman Research Group Center for Developmental Therapeutics Heart defects, Kawasaki disease The Portman Research Group discovers ways to protect children’s hearts from damage related to surgery and leads major research on Kawasaki disease.
Quintana Lab Center for Developmental Therapeutics Mitochondrial disease The Quintana lab works to identify novel targets that lead to improved treatments for mitochondrial disease.
Rajagopal Lab Center for Global Infectious Disease Research Streptococcus, Staphylococcus aureus The Rajagopal lab uses genetic, molecular, biochemical and proteomic approaches to study infectious diseases caused by bacteria. The human pathogens that we study are Group B Streptococcus and Staphylococcus aureus.
Ramirez Lab Center for Integrative Brain Research Epilepsy, sudden infant death syndrome (SIDS), sleep apnea and other neurological disorders The Ramirez lab is making fundamental advances in our understanding of the brain and building toward potential cures for sudden infant death syndrome (SIDS), epilepsy and other disorders. The lab is currently focusing on how periods of hypoxia, such as those experienced by sleep apnea patients, alter the neuronal network that controls respiration.
Rose Lab Center for Global Infectious Disease Research Kaposi’s sarcoma, human herpesvirus, HIV, AIDS-related malignancies The Rose lab focuses on the Kaposi's sarcoma–associated herpesvirus/human herpesvirus 8 and its transmission and role in AIDS-related malignancies.
Saelens Lab Center for Child Health, Behavior and Development Pediatric overweight The Saelens lab investigates how environmental factors influence physical activity, eating behaviors and the psychosocial factors that influence individual choice for weight-related behaviors.
Scharenberg Lab Center for Immunity and Immunotherapies Severe combined immunodeficiency and other immune disorders The Scharenberg Lab develops gene editing technologies and translational applications of these technologies in adoptive T-cell immunotherapies and hematopoietic stem cell gene therapy.
Sedensky Laboratory Center for Developmental Therapeutics Mitochondrial diseases The Sedensky laboratory works closely with the Morgan laboratory to study mitochondria's role in childhood diseases.
Speltz Lab Center for Child Health, Behavior and Development Cleft lip and palate, single-suture craniosynostosis, deformational plagiocephaly, hemifacial microsomia and other craniofacial disorders The Speltz lab focuses on the neurobehavioral development of children with craniofacial disorders, including cleft lip and palate, single-suture craniosynostosis, deformational plagiocephaly and hemifacial microsomia.
Stevens Lab Center for Immunity and Immunotherapies Lupus, scleroderma, juvenile idiopathic arthritis The Stevens lab is working to understand what causes autoimmune diseases, and is pursuing innovative treatments for scleroderma, lupus and juvenile idiopathic arthritis.
Webb Lab Center for Global Infectious Disease Research Autism, fragile X, developmental delay and other developmental disabilities The Webb lab studies how infants, children and adults learn about their environment, and how that learning is impacted by developmental disruptions.
Weissman Lab Center for Global Infectious Disease Research Antibiotic-resistant infections The Weissman lab studies how antibiotic-resistant bacteria emerge and develops innovative ways to identify and monitor them.