Revolutionizing Treatment for Graft-Versus-Host Disease

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Dr. Leslie Kean broke new ground when she discovered that a rheumatoid arthritis drug could potentially eliminate GVHD. Now she is leading a Phase II clinical trial to evaluate whether the drug works in children - the nation's only multicenter pediatric clinical trial aimed at preventing the disease. 
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Bringing Balance to the Face

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Our Craniofacial Center is the first to offer children with Apert syndrome a revolutionary procedure to normalize their facial proportions.
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Cancer Immunotherapy: Early Gains

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Our work to cure cancer using reprogrammed T cells transitioned from treating mice to helping people in 2013.
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Seizure-Free with Minimal Risk

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When children with epilepsy run out of treatment options, MRI-guided laser ablation surgery offers hope for a seizure-free life.
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Pioneering Care for Pelvic Anomalies

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A new bowel management program and quality-of-life database help the Reconstructive Pelvic Medicine Clinic improve long-term outcomes.
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Teens and Tech: Promise and Risk

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Our researchers develop an iPad app to address key teen health issues and provide guidance for using social media safely.
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Advancing Ventricular Assist Devices

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We are in the vanguard of using mechanical circulatory support to give kids and teens with advanced heart failure the best quality of life.
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Cure Factory

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Our new cell production facility helps turn laboratory discoveries into lifesaving therapies - starting with cancer immunotherapy.
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New Approach to Curing Crohn's

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Our researchers are using fecal transplant to find cures for inflammatory bowel disease in children.
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Lifelong Learning for Adults with ASD

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We are meeting a critical community need, offering services for adults with autism spectrum disorder and other developmental disabilities.
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Stellar Recruits of 2013

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From curing graft-versus-host disease to using Facebook to prevent drunk driving, Seattle Children's Research Institute's newest researchers are pursuing innovative solutions to seemingly intractable problems.
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Identifying Best Practices for CFM

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Dr. Carrie Heike continues her quest to give families better guidance and identify therapies for craniofacial microsomia that work best.
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Nailing Difficult Diagnoses

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Our Immunology Diagnostic Laboratory develops tests - and makes difficult diagnoses - that help children with immune disorders lead longer, healthier lives.
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The Gift of a Life Without a Shunt

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Seattle Children's is among the first to offer a surgical treatment that gives children with hydrocephalus the hope of a life free from the burden of a shunt.
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New Hope for Neuroblastoma

Best of Nueroblastoma MIBG Julie Park 70x70

Seattle Children's adds smart radiation to its arsenal of tools to fight a deadly childhood cancer.
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Clues to Brain Growth Found

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The discovery of mutations in genes that help regulate brain growth could lead to better treatments for brain disorders and other conditions, including cancer, autism and epilepsy.
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Why Pain Meds Make Some Kids Sick

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A genetic variation in a regulatory protein may predispose children to side effects from opioids - a finding that may change how pain meds are prescribed.
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Making the Smartphone Smarter

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A novel mobile phone app being developed at Seattle Children's and the University of Washington may transform care for patients with chronic lung diseases.
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Spearheading New Cancer Therapy

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Seattle Children's takes a step toward revolutionizing the way cancer is treated with the hospital's first reprogrammed T cell immunotherapy trial for relapsed leukemia.
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Improving Tools for Gene Repair

Improving Tools for Gene Repair

Innovations in enzyme development made by the Scharenberg and Rawlings labs and their partners at the University of Washington and Fred Hutchinson Cancer Research Center move researchers closer to making precision gene manipulation a therapeutic reality.
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Benefits of New CF Drug Confirmed

Benefits of New CF Drug Confirmed

Results from international clinical trials led by Dr. Bonnie Ramsay signal a breakthrough in treatment for cystic fibrosis.
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New Treatment for Hemangiomas

New Treatment for Hemangiomas

Dr. Jonathan Perkins' use of a blood-pressure medicine to treat hemangiomas has reduced the need for surgery by 75%. Now he's working to understand why the drug works.
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Improving Quality of Life After Cancer

Improving Quality of Life After Cancer

Drs. Scott Baker and Eric Chow are on a mission to help survivors of childhood cancer live the healthiest possible lives.
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Progress in Cord Blood Transplants

Progress in Cord Blood Transplants

Dr. Colleen Delaney's pioneering approach to accelerating white blood cell recovery moves to Phase II trials.
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Developing a Modern Shunt

Developing a Modern Shunt

A new kind of hydrocephalus shunt being developed by Dr. Sam Browd incorporates the latest technologies and promises to dramatically reduce failure rates.
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Seattle Children's Lands a Major Grant to Study Kaposi's Sarcoma

Seattle Children's Lands a Major Grant to Study Kaposi's Sarcoma

Seattle Children's lands a major NIH grant to take a multipronged look at how the virus that causes Kaposi's sarcoma spreads and turns cancerous.
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Healthy Media Use

Healthy Media Use

Dr. Dimitri Christakis has devoted his career to investigating how media exposure impacts children and helping parents take control of their family's media habits.
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Rapid Response to H1N1

Rapid Response to H1N1

Dr. Janet Englund played a dual role in the nation's response to the H1N1 pandemic. She helped determine priority groups who would get the vaccine earliest and also helped test the vaccine's safety and potential effectiveness in children.
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Are New Meds Safer?

Are New Meds Safer?

One thrust of Dr. Jack McClellan's research - studying the safety and usefulness of current antipsychotic medications - points to the need for better therapies. The other - searching for genetic causes of schizophrenia - could someday lead to more effective diagnostic and treatment strategies for that disease.
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Hope for Juvenile Arthritis

Hope for juvenile arthritis

Dr. Carol Wallace is investigating whether aggressive treatment within a year of onset will result in better outcomes for patients with juvenile idiopathic arthritis (JIA) by halting progression of the disease.
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How Neurons Regenerate

How neurons regenerate

Dr. Robert Hevner focuses on contributing important discoveries to the essential stockpile of knowledge he hopes will further the ultimate goal of neuroregeneration - regrowth and repair of neurons.
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Improving Virus Detection

Improving virus detection

Recent outbreaks of respiratory viruses highlight the need for quick diagnosis to prevent the spread of disease. However, laboratories are still only able to detect virus in about 50% of samples. Tim Rose, PhD, wants to increase that detection rate.
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Obesity: Causes/Solutions

Obesity causes and solutions

Today, with more than 15% of American children considered obese, it's feared that weight-related diseases will reach epidemic levels as these youth reach adulthood. Two Seattle Children's researchers are working to reverse this trend.
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What Causes Lupus?

What causes lupus?

Dr. Anne Stevens, a physician-scientist at Seattle Children's, believes maternal cells - which are transported to a fetus during pregnancy and persist through a child's lifetime - might play a role in pediatric lupus.
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Dr. Daniel Rubens: Listening to a Hunch

Dr. Daniel Rubens, SIDS researcher

Dr. Daniel Rubens follows his intuition and opens a new door that may reveal a secret to SIDS.
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Craniosynostosis Collaboration with Dr. Matt Speltz

Dr. Matt Speltz, craniosynostosis researcher

There appears to be some relationship between craniosynostosis and neurodevelopment, but the nature of that relationship is currently unknown. Dr. Matt Speltz hopes to find the answer to that relationship.
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Repairing Defective Genes

Dr. Andrew Scharenbert, gene repair research

Dr. Andrew Scharenberg is working on an innovative approach to gene therapy called gene repair, in which proteins will cut defective sequences of DNA within a gene and cause them to be replaced with corrected sequences.
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Which Behaviors Hurt Us, Which Help

Dr. Dimitri Chistakis

On the road to a healthy future, information can be the best medicine. That's the premise behind health outcomes research and the work of Dr. Dimitri Christakis.
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Correcting Genetic Defects Through Gene Therapy

Dr. David Rawlings, primary immune deficiency disease researcher

Dr. Dave Rawlings is looking for ways to correct primary immune deficiency diseases (PIDD).
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Combating Viral Infection After Bone Marrow Transplant

Dr. Danielle Zerr

Dr. Danielle Zerr visits Jordan Keen four days after his stem cell transplant to fight acute lymphocytic leukemia.
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Research Seeks Cure for Primary Immune Deficiency Diseases

Dr. Hans Ochs, primary immune deficiency disease researcher

Dr. Hans Ochs is looking at the connection between immune deficiencies and genes.
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