Profile

Jason Scott Debley, MD, MPH

Jason Scott Debley, MD, MPH

Pulmonary and Sleep Medicine

On staff since July 2000

Children's Title: Medical director, Pulmonary Diagnostic Lab; Director, Bronchoscopy Services

Academic Title: Associate Professor

Research Center: Center for Immunity and Immunotherapies

Jason S. Debley, MD, MPH, is attending physician and director of the Flexible Bronchoscopy Service at Seattle Childrens Hospital and associate professor in the Department of Pediatrics at the University of Washington School of Medicine. He received his MD from Northwestern University Medical School and completed his pediatrics internship and residency at Childrens Memorial Hospital in Chicago. He completed his pediatric pulmonary fellowship at Seattle Childrens and earned an MPH from the University of Washington.

He has clinical expertise in asthma, cystic fibrosis, bronchopulmonary dysplasia, restrictive lung diseases of childhood and the management of acute and chronic respiratory failure.His research is focused on the evaluation of noninvasive measures of airway inflammation in exhaled breath, in particular exhaled nitric oxide, to assist in the diagnosis and management of asthma, with a particular interest in the diagnosis asthma in wheezy infants and toddlers and a better understanding the origins of asthma in young children.Dr. Debley is also investigating the role of the airway epithelium in the development of airway remodeling and augmentation of airway inflammation in asthma, using bronchial and nasal epithelial cells from children with and without asthma to conduct in vitro research using an air-liquid interface model system.

Recommendations

  • Heather Granite Falls, WA 01.30.11

    We have been working with Dr. Debly and his staff for 7 years now, and I could not be happier. He is a wonderful, caring person who is always putting the needs of your child first. He is very easy to get along with and listens well. I would recommend this wonderful doctor to anyone I met that needed a pulmonary doc for the child. Thank you Dr. Debly for all you have done for us! As my son would say Thanks Dr. D!! Love Always The Family of Kaden Grimsby-Collins

  • Shatoya Kent, WA 02.02.11

    My daughter ( now almost 5) has been seeing Dr. Debley close to all her life. As a parent, I look for someone that I can trust and feel confident in. Dr. Debley has gone above and beyond with the care that he has given. He takes his time to explain things, and he is very knowledgeable in his field. Dr. Debley takes the time to listen to you, and he doesnt make you feel rushed or "just another person". He is very "in touch" with his patients and I could not be happier. He even takes the time out of his day to at least say hello if we are at the hospital for other appointments. He is a wonderful doctor.

Overview

Board Certification(s)

Pediatrics
Pediatric Pulmonology

Medical/Professional School

Northwestern University School of Medicine, Chicago
University of Washington School of Public Health , Seattle, Public Health-Preventative Med

Residency

Pediatrics, Emanuel Hospital and Health Center, Portland
Pediatrics, Children's Memorial Hospital, Chicago

Fellowship

Pulmonary Disease, Seattle Children's Hospital, Seattle

Clinical Interests

Recurrent wheezing of early childhood, Non-invasive measures of airway inflammation, Asthma epidemiology

Lab URL

http://www.seattlechildrens.org/research/immunity-and-immunotherapies/members/debley-lab/

Research Focus Area

Therapeutic Trials

Awards and Honors

Award Name Award Description Awarded By Award Date
Elected member Society for Pediatric Research 2010
Young Investigator of the Year award. University of Washington General Clinical Research Center 2007
Pediatric Research Loan Repayment Award NIH 2004 - 2008
Fellow Teaching Award University of Washington Pediatric Housestaff 2003
Research Training Grant American Lung Association of Washington 2001 - 2003
Sarah Baskin Award for Excellence in Research Rehabilitation Institute of Chicago 1995

Publications

  • Elliott M, Heltshe SL, Stamey DC, Cochrane ES, Redding GJ, Debley JS
    Exhaled nitric oxide predicts persistence of wheezing, exacerbations, and decline in lung function in wheezy infants and toddlers.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology , 2013 Dec. : 43(12)1351-61
  • Iwanaga K, Elliott MS, Vedal S, Debley JS
    Urban particulate matter induces pro-remodeling factors by airway epithelial cells from healthy and asthmatic children.
    Inhalation toxicology , 2013 Oct. : 25(12)653-60
  • Miazgowicz MM, Elliott MS, Debley JS, Ziegler SF
    Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells.
    Journal of inflammation research , 2013 : 653-61
  • Lee HC, Headley MB, Loo YM, Berlin A, Gale M Jr, Debley JS, Lukacs NW, Ziegler SF
    Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection.
    The Journal of allergy and clinical immunology , 2012 Nov. : 130(5)1187-1196.e5
  • Debley JS, Cochrane ES, Redding GJ, Carter ER
    Lung function and biomarkers of airway inflammation during and after hospitalization for acute exacerbations of childhood asthma associated with viral respiratory symptoms.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology , 2012 Aug. : 109(2)114-20
  • Debley J, Stanojevic S, Filbrun AG, Subbarao P
    Bronchodilator responsiveness in wheezy infants and toddlers is not associated with asthma risk factors.
    Pediatric pulmonology , 2012 May : 47(5)421-8
  • Lopez-Guisa JM, Powers C, File D, Cochrane E, Jimenez N, Debley JS
    Airway epithelial cells from asthmatic children differentially express proremodeling factors.
    The Journal of allergy and clinical immunology , 2012 Apr, : 129(4)990-7.e6
  • Debley JS, Ohanian AS, Spiekerman CF, Aitken ML, Hallstrand TS
    Effects of bronchoconstriction, minute ventilation, and deep inspiration on the composition of exhaled breath condensate.
    Chest , 2011 Jan. : 139(1)16-22
  • Ohanian AS, Zimmerman J, Debley JS
    Effects of sample processing, time and storage condition on cysteinyl leukotrienes in exhaled breath condensate.
    Journal of breath research , 2010 Dec. : 4(4)046002
  • Debley JS, Stamey DC, Cochrane ES, Gama KL, Redding GJ
    Exhaled nitric oxide, lung function, and exacerbations in wheezy infants and toddlers.
    The Journal of allergy and clinical immunology , 2010 June : 125(6)1228-1234.e13
  • Hsia D, DiBlasi RM, Richardson P, Crotwell D, Debley J, Carter E
    The effects of flexible bronchoscopy on mechanical ventilation in a pediatric lung model.
    Chest , 2009 Jan. : 135(1)33-40
  • Debley JS, Hallstrand TS, Monge T, Ohanian A, Redding GJ, Zimmerman J
    Methods to improve measurement of cysteinyl leukotrienes in exhaled breath condensate from subjects with asthma and healthy controls.
    The Journal of allergy and clinical immunology , 2007 Nov. : 120(5)1216-7
  • Hallstrand TS, Debley JS, Farin FM, Henderson WR Jr
    Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction.
    The Journal of allergy and clinical immunology , 2007 May : 119(5)1092-8
  • Carter ER, Debley JS, Redding GR
    Chronic productive cough in school children: prevalence and associations with asthma and environmental tobacco smoke exposure.
    Cough (London, England) , 2006 Dec. 27 : 211
  • Debley JS, Carter ER, Redding GJ
    Prevalence and impact of gastroesophageal reflux in adolescents with asthma: a population-based study.
    Pediatric pulmonology , 2006 May : 41(5)475-81
  • Debley JS, Carter ER, Gibson RL, Rosenfeld M, Redding GJ
    The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study.
    The Journal of pediatrics , 2005 Aug. : 147(2)233-8
  • Carter ER, Debley JS, Redding GJ
    Changes in asthma prevalence and impact on health and function in Seattle middle-school children: 1995 vs 2003.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology , 2005 June : 94(6)634-9
  • Debley JS, Smith JM, Redding GJ, Critchlow CW
    Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology , 2005 Feb. : 94(2)228-33
  • Jason Scott Debley, MD, MPH
    The Respiratory System
    Nelson Essential Pediatrics, 5th Edition , 2005 : 133-138
  • Debley JS, Redding GJ, Critchlow CW
    Impact of adolescence and gender on asthma hospitalization: a population-based birth cohort study.
    Pediatric pulmonology , 2004 Dec. : 38(6)443-50
  • Harding CO, Pillers DA, Steiner RD, Bottiglieri T, Rosenblatt DS, Debley J, Michael Gibson K
    Potential for misdiagnosis due to lack of metabolic derangement in combined methylmalonic aciduria/hyperhomocysteinemia (cblC) in the neonate.
    Journal of perinatology : official journal of the California Perinatal Association , 2003 July : 23(5)384-6

Presentations

Presentations Title Event Location Date
"Role of the Airway Epithelium in Asthma: from Inflammation to Innate Immunity to Remodeling Insights from work with Primary Human Cells" Asthma Research Conference Cincinnati Childrens Hospital Feb. 2013
The Airway Epithelium in Childhood Asthma: From Vitamin D to Airway Remodeling 4th Annual Northwest Epithelial Biology of Airways Disease Meeting University of British Columbia, Canada Dec. 2012
Pediatric Pulmonary Function Measurement and Techniques American Thoracic Society International Conference Denver, CO 2011
Co-Chair, Pediatric Chest Rounds American Thoracic Society International Conference Denver, CO 2011
Pro-remodeling and Immunoregulatory-associated Cytokine Production by the Airway Epithelium of Asthmatic Children Northwest Epithelial Biology of Airways Disease Meeting Nov. 2009
The Role of Exhaled Nitric Oxide in the Diagnosis and Management of Asthma in Children: FeNO as a Clinical and Research Tool University of Washington Allergy Division Nov. 2008
Analysis of Exhaled Breath to Assist in the Diagnosis and Management of Asthma North Pacific Pediatric Society Meeting March 2007
Asthma Update: Epidemiology, Diagnosis, and Management Pediatric Grand Rounds Emanuel Childrens Hospital Dec. 16, 2003

Research Funding

Grant Title Grantor Amount Award Date
Noninvasive Measures of Airway Inflammation and Airflow Obstruction in Wheezy Infants and Toddlers
Airway Epithelial Cell Cytokine Profiles of Children with and without Asthma NIH/NIAID, NIH/NHLBI, Benaroya Research Institute, Amgen, Firlands Foundation