Jason Scott Debley, MD, MPH

Jason Scott Debley, MD, MPH

Pulmonary

On staff since July 2000

Academic Title: Professor, Pediatrics, Pulmonary and Sleep Medicine

Research Title: Interim Director, Center for Respiratory Biology and Therapeutics

Research Center: Center for Respiratory Biology and Therapeutics

  • Biography

    Jason S. Debley, MD, MPH, is attending physician in the Pulmonary and Sleep Medicine Division at Seattle Children's Hospital and Professor in the Department of Pediatrics at the University of Washington School of Medicine. He received his MD from Northwestern University Medical School and completed his pediatrics internship and residency at Children’s Memorial Hospital in Chicago, Illinois. He completed his pediatric pulmonary fellowship at Seattle Children’s and earned an MPH from the University of Washington. He has clinical expertise in severe asthma, recurrent wheezing of early childhood, bronchopulmonary dysplasia, restrictive lung diseases of childhood and the management of chronic respiratory failure.

    As a physician-scientist Dr. Debley's research has spanned clinical, epidemiologic, basic and mechanistic patient-oriented translational asthma research. His work over the past two decades has concentrated on investigation of the role of the airway epithelium in asthma pathobiology, with focus areas including study of innate immune responses of airway epithelial cells to respiratory viruses and aberrant epithelial regulation of airway remodeling responses. He built a translational research program wherein primary bronchial airway epithelial cells are obtained from children with asthma and healthy children undergoing elective surgical procedures at Seattle Children’s Hospital. This infrastructure is a unique resource in the United States, providing a steady source of primary bronchial airway epithelial cells from carefully characterized children with asthma that are used to conduct mechanistic research to advance our understanding of the role of airway epithelial responses in asthma and to identify novel therapeutic targets.

    • Related Pages

    • Debley Lab

      Debley Lab

      The Debley Lab is engaged in an array of translational research investigating the role of the airway epithelium in childhood asthma.

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  • Awards and Honors

    Award Name Award Description Awarded By Award Date
    Seattles Top Doctor 2016 Seattle Met Magazine 2016
    Elected member Society for Pediatric Research 2010
    Young Investigator of the Year award. University of Washington General Clinical Research Center 2007
    Pediatric Research Loan Repayment Award NIH 2004 - 2008
    Fellow Teaching Award University of Washington Pediatric Housestaff 2003
    Research Training Grant American Lung Association of Washington 2001 - 2003
    Sarah Baskin Award for Excellence in Research Rehabilitation Institute of Chicago 1995

  • Publications

    Other Publications

    • Elliott M, Heltshe SL, Stamey DC, Cochrane ES, Redding GJ, Debley JS
      Exhaled nitric oxide predicts persistence of wheezing, exacerbations, and decline in lung function in wheezy infants and toddlers.
      24261945 Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2013 Dec. : 43(12)1351-61 PMCID:PMC3839057
    • Iwanaga K, Elliott MS, Vedal S, Debley JS
      Urban particulate matter induces pro-remodeling factors by airway epithelial cells from healthy and asthmatic children.
      24102466 Inhalation toxicology, 2013 Oct. : 25(12)653-60
    • Miazgowicz MM, Elliott MS, Debley JS, Ziegler SF
      Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells.
      23576878 Journal of inflammation research, 2013 : 653-61 PMCID:PMC3617816
    • Lee HC, Headley MB, Loo YM, Berlin A, Gale M Jr, Debley JS, Lukacs NW, Ziegler SF
      Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection.
      22981788 The Journal of allergy and clinical immunology, 2012 Nov. : 130(5)1187-1196.e5
    • Debley JS, Cochrane ES, Redding GJ, Carter ER
      Lung function and biomarkers of airway inflammation during and after hospitalization for acute exacerbations of childhood asthma associated with viral respiratory symptoms.
      22840252 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2012 Aug. : 109(2)114-20 PMCID:PMC3430518
    • Debley J, Stanojevic S, Filbrun AG, Subbarao P
      Bronchodilator responsiveness in wheezy infants and toddlers is not associated with asthma risk factors.
      22006677 Pediatric pulmonology, 2012 May : 47(5)421-8 PMCID:PMC3325342
    • Lopez-Guisa JM, Powers C, File D, Cochrane E, Jimenez N, Debley JS
      Airway epithelial cells from asthmatic children differentially express proremodeling factors.
      22227417 The Journal of allergy and clinical immunology, 2012 April : 129(4)990-7.e6 PMCID:PMC3604976
    • Debley JS, Ohanian AS, Spiekerman CF, Aitken ML, Hallstrand TS
      Effects of bronchoconstriction, minute ventilation, and deep inspiration on the composition of exhaled breath condensate.
      20382713 Chest, 2011 Jan. : 139(1)16-22 PMCID:PMC3014689
    • Ohanian AS, Zimmerman J, Debley JS
      Effects of sample processing, time and storage condition on cysteinyl leukotrienes in exhaled breath condensate.
      21383485 Journal of breath research, 2010 Dec. : 4(4)046002
    • Debley JS, Stamey DC, Cochrane ES, Gama KL, Redding GJ
      Exhaled nitric oxide, lung function, and exacerbations in wheezy infants and toddlers.
      20462633 The Journal of allergy and clinical immunology, 2010 June : 125(6)1228-1234.e13 PMCID:PMC2879468
    • Hsia D, DiBlasi RM, Richardson P, Crotwell D, Debley J, Carter E
      The effects of flexible bronchoscopy on mechanical ventilation in a pediatric lung model.
      18812449 Chest, 2009 Jan. : 135(1)33-40
    • Debley JS, Hallstrand TS, Monge T, Ohanian A, Redding GJ, Zimmerman J
      Methods to improve measurement of cysteinyl leukotrienes in exhaled breath condensate from subjects with asthma and healthy controls.
      17655919 The Journal of allergy and clinical immunology, 2007 Nov. : 120(5)1216-7
    • Hallstrand TS, Debley JS, Farin FM, Henderson WR Jr
      Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction.
      17321575 The Journal of allergy and clinical immunology, 2007 May : 119(5)1092-8 PMCID:PMC2049009
    • Carter ER, Debley JS, Redding GR
      Chronic productive cough in school children: prevalence and associations with asthma and environmental tobacco smoke exposure.
      17192188 Cough (London, England), 2006 Dec 27 : 211 PMCID:PMC1770929
    • Debley JS, Carter ER, Redding GJ
      Prevalence and impact of gastroesophageal reflux in adolescents with asthma: a population-based study.
      16547933 Pediatric pulmonology, 2006 May : 41(5)475-81
    • Debley JS, Carter ER, Gibson RL, Rosenfeld M, Redding GJ
      The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study.
      16126056 The Journal of pediatrics, 2005 Aug. : 147(2)233-8
    • Carter ER, Debley JS, Redding GJ
      Changes in asthma prevalence and impact on health and function in Seattle middle-school children: 1995 vs 2003.
      15984594 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005 June : 94(6)634-9
    • Debley JS, Smith JM, Redding GJ, Critchlow CW
      Childhood asthma hospitalization risk after cesarean delivery in former term and premature infants.
      15765737 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005 Feb. : 94(2)228-33
    • Marshall SG, Debley JS
      The Respiratory System
      Nelson Essential Pediatrics, 5th Edition, 2005 : 133-138
    • Debley JS, Redding GJ, Critchlow CW
      Impact of adolescence and gender on asthma hospitalization: a population-based birth cohort study.
      15690559 Pediatric pulmonology, 2004 Dec. : 38(6)443-50
    • Harding CO, Pillers DA, Steiner RD, Bottiglieri T, Rosenblatt DS, Debley J, Michael Gibson K
      Potential for misdiagnosis due to lack of metabolic derangement in combined methylmalonic aciduria/hyperhomocysteinemia (cblC) in the neonate.
      12847533 Journal of perinatology : official journal of the California Perinatal Association, 2003 July : 23(5)384-6

Overview

Board Certification(s)

Pediatric Pulmonology

Medical/Professional School

Northwestern University, Chicago, IL
University of Washington School of Public Health, Seattle, WA

Residency

Children's Memorial Hospital, Chicago, IL
Legacy Emanuel Hospital and Health Center, Portland, OR

Fellowship

Seattle Children's Hospital, Seattle, WA

Clinical Interests

Recurrent wheezing of early childhood, Non-invasive measures of airway inflammation, Asthma epidemiology

Research Focus Area

Therapeutic Trials, Translational research, observational studies, investigator-initiated interventional studies