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Daniel Guthrie Miller, MD, PhD

Daniel Guthrie Miller, MD, PhD


On staff since October 2003

Academic Title: Associate Professor

Research Center: Center for Immunity and Immunotherapies

"A patient’s father who is a retired Boeing engineer likens my work to his in that we both bring intelligent people together to tackle big problems. He calls the solutions "planned inventions." Whether it’s gene therapy or a new breed of aircraft, it’s something that hasn’t previously existed. But when we saw we needed it, we brought together the right people to make it a reality."

Making a Difference

  • Mentoring Talented Junior Faculty

    An academic medical center and research institute, Seattle Children’s is dedicated to helping junior faculty establish research careers. Recently, several of our emerging genetics researchers have made significant contributions to their field.... cont.


KateBellevue, WA06.05.12
We only saw Dr. Miller one time and got a good impression for him. He is very attentive, smart and spent a LOT of time with our family explaining all the issues/concerns that we had, offering tests that other doctors failed to mention, and answering all of our questions. He was easy to talk to. He doesn't make you feel like you are a lesser person an he is THE doctor.. like a lot of doctors of his level tend to do. He also paid attention to our kid, which was nice, most doctors tend to ignore the little ones and treat them as subjects that they are "treating".
Recommend Dr. Daniel Miller


Board Certification(s)
Clinical Genetics (MD)
Medical/Professional School
University of Washington School of Medicine, Seattle
Pediatrics, University of Washington School of Medicine, Seattle
Medical Genetics, University of Washington School of Medicine, Seattle
Clinical Interests

Gene therapy, cellular mechanisms of chromosomal translocation and deletion

Research Focus Area

Genetics and Developmental Biology


Antibiotic-induced serotonin syndrome.
The Journal of emergency medicine , 2011 Jan: 25-7
Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene.
PLoS genetics , 2010 Oct 28: e1001181
A unifying genetic model for facioscapulohumeral muscular dystrophy.
Science (New York, N.Y.) , 2010 Sep 24: 1650-3
Efficient KRT14 targeting and functional characterization of transplanted human keratinocytes for the treatment of epidermolysis bullosa simplex.
Molecular therapy : the journal of the American Society of Gene Therapy , 2010 Sep: 1624-32
Characterization of microRNAs involved in embryonic stem cell states.
Stem cells and development , 2010 Jul: 935-50
Frequent endonuclease cleavage at off-target locations in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy , 2010 May: 983-6
RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.
Human molecular genetics , 2009 Jul 1: 2414-30
AAV vector integration sites in mouse hepatocellular carcinoma.
Science (New York, N.Y.) , 2007 Jul 27: 477
Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells.
Molecular therapy : the journal of the American Society of Gene Therapy , 2007 Jul: 1356-65
Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus.
Human gene therapy , 2007 May: 423-34
Gene targeting in vivo by adeno-associated virus vectors.
Nature biotechnology , 2006 Aug: 1022-6
Integration bias of gammaretrovirus vectors following transduction and growth of primary mouse hematopoietic progenitor cells with and without selection.
Molecular therapy : the journal of the American Society of Gene Therapy , 2006 Aug: 226-35
Foamy virus vector integration sites in normal human cells.
Proceedings of the National Academy of Sciences of the United States of America , 2006 Jan 31: 1498-503
Large-scale analysis of adeno-associated virus vector integration sites in normal human cells.
Journal of virology , 2005 Sep: 11434-42
Systemic delivery of genes to striated muscles using adeno-associated viral vectors.
Nature medicine , 2004 Aug: 828-34
Adeno-associated virus vectors integrate at chromosome breakage sites.
Nature genetics , 2004 Jul: 767-73
Efficient PRNP gene targeting in bovine fibroblasts by adeno-associated virus vectors.
Cloning and stem cells , 2004: 31-6
Human gene targeting by adeno-associated virus vectors is enhanced by DNA double-strand breaks.
Molecular and cellular biology , 2003 May: 3550-7
Chromosomal effects of adeno-associated virus vector integration.
Nature genetics , 2002 Feb: 147-8

Primary Office

Seattle Children's
OC.9.850 - Medical Genetics
4800 Sand Point Way NE
Seattle, WA 98105

Additional Offices

University of Washington
UW Box 358056 - ISCRM
815 Mercer St N416
Seattle, WA 98195

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