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A Murat Maga, PhD

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A. Murat Maga, PhD

Craniofacial

Academic Title: Assistant Professor

Research Center: Center for Developmental Biology and Regenerative Medicine

"I find it rather surprising (and also quite alarming) to see how quickly the genetic programming for the normal development can be altered during pregnancy by the man-made environmental factors. And yet alcohol consumption during pregnancy remains a major issue and causes a significant emotional and financial burden on families and also on the society. I am currently studying how alcohol consumption prior and during pregnancy affects the normal craniofacial development in mice. In the future, this study will provide the mechanism(s) by which genes are modified through alcohol exposure and can be translated into clinical research. It will also offer the potential to find ways to better diagnose or even prevent or circumvent the negative effects of alcohol on fetal development."

Publications

Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
PLoS genetics , 2011 Sep: 7(9)e1002278
Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes.
Birth defects research. Part A, Clinical and molecular teratology , July 2011: 91(7)603-9
Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1.
Journal of medical genetics , 2011 Jun: 48(6)375-82
A landmark-free framework for the detection and description of shape differences in embryos.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference , 2011: 20115153-6
Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model.
PLoS genetics , 2010 Jan 15: 6(1)e1000811

Research Funding

Grant TitleGrantorAmountAward Date
Maternal alcohol exposure: impact on genetic control of craniofacial phenotypeNIH / National Institute of Dental and Craniofacial ResearchJuly 1, 2011 - June 30, 2016

Additional Offices

Seattle Children's
OB.9.520 - Craniofacial
4800 Sand Point Way NE
Seattle, WA 98105
206-987-2208

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