Profile

A Murat Maga, PhD

A Murat Maga, PhD

Craniofacial

Academic Title: Assistant Professor

Research Center: Center for Developmental Biology and Regenerative Medicine

"I find it rather surprising (and also quite alarming) to see how quickly the genetic programming for the normal development can be altered during pregnancy by the man-made environmental factors. And yet alcohol consumption during pregnancy remains a major issue and causes a significant emotional and financial burden on families and also on the society. I am currently studying how alcohol consumption prior and during pregnancy affects the normal craniofacial development in mice. In the future, this study will provide the mechanism(s) by which genes are modified through alcohol exposure and can be translated into clinical research. It will also offer the potential to find ways to better diagnose or even prevent or circumvent the negative effects of alcohol on fetal development."

Murat Maga, PhD, is an assistant professor in the Department of Pediatrics at the University of Washington School of Medicine and a member of the Seattle Children's Research Institute's Center for Developmental Biology and Regenerative Medicine. Dr. Maga is investigating the role of environmental (epigenetic) programming in the presentation of alcohol-related malformations, specifically in the development of face and head. He is also researching how genomic differences correlate with these features to find epigenetically modified genes responsible for the differences.

Publications

  • Vissers LE, Cox TC, Maga AM, Short KM, Wiradjaja F, Janssen IM, Jehee F, Bertola D, Liu J, Yagnik G, Sekiguchi K, Kiyozumi D, van Bokhoven H, Marcelis C, Cunningham ML, Anderson PJ, Boyadjiev SA, Passos-Bueno MR, Veltman JA, Smyth I, Buckley MF, Roscioli T
    Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
    21931569 PLoS genetics , 2011 Sept. : 7(9)e1002278 PMCID: PMC3169541
  • Purushothaman R, Cox TC, Muga AM, Cunningham ML
    Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes.
    21538817 Birth defects research. Part A, Clinical and molecular teratology , 2011 July : 91(7)603-9
  • Slavotinek AM, Baranzini SE, Schanze D, Labelle-Dumais C, Short KM, Chao R, Yahyavi M, Bijlsma EK, Chu C, Musone S, Wheatley A, Kwok PY, Marles S, Fryns JP, Maga AM, Hassan MG, Gould DB, Madireddy L, Li C, Cox TC, Smyth I, Chudley AE, Zenker M
    Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1.
    21507892 Journal of medical genetics , 2011 June : 48(6)375-82
  • Rolfe SM, Shapiro LG, Cox TC, Maga AM, Cox LL
    A landmark-free framework for the detection and description of shape differences in embryos.
    22255499 Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference , 2011 : 20115153-6 PMCID: PMC3261520
  • Kaminen-Ahola N, Ahola A, Maga M, Mallitt KA, Fahey P, Cox TC, Whitelaw E, Chong S
    Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model.
    20084100 PLoS genetics , 2010 Jan. 15 : 6(1)e1000811 PMCID: PMC2797299

Research Funding

Grant Title Grantor Amount Award Date
Maternal alcohol exposure: impact on genetic control of craniofacial phenotype NIH NIDCR 2011 - 2016