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Scott J. Weissman, MD

Scott J. Weissman, MD

Infectious Disease

On staff since November 2003

Academic Title: Assistant Professor

Research Center: Center for Global Infectious Disease Research


Board Certification(s)
Pediatric Infectious Diseases
Medical/Professional School
University of California, California College of Medicine, Irvine
Pediatrics, Kaiser Permanente Health Care, Los Angeles
Pediatric Infectious Disease, Seattle Children's Hospital, Seattle
Research Description

Despite being one of the most exhaustively studied free-living organisms in biology, Escherichia coli continues to produce a massive burden of disease, including extraintestinal syndromes such as urinary tract infections (UTI) and bloodstream infections. Since 2000, we have witnessed the worldwide emergence of Gram-negative "superbugs," such as E. coli ST131 and Klebsiella pneumoniae ST258 - which not only encode multiple virulence factors associated with extraintestinal disease, but also Class A enzymes that hydrolyze third-generation cephalosporins and carbapenem antibiotics (CTX-M-15 and KPC, respectively). The subsequent appearance of the New Delhi Metallo-beta-lactamase (NDM) enzyme has accentuated the highly dynamic nature of spreading antibiotic resistance, as travelers abroad have become colonized with pan-resistant bacteria and brought them back to their countries of origin and then experienced virtually untreatable infections. Through collaborations with other free-standing children's hospitals and the Washington State Department of Health, Dr. Weissman's lab uses molecular and sequence-based techniques to characterize the spread of plasmid-borne extended-spectrum beta-lactamase (ESBL) and carbapenemase enzymes among Enterobacteriaceae. Their molecular typing methods characterize the molecular dynamics of antibiotic resistance, distinguishing epidemics of resistance genes that spread between plasmids, plasmids that spread between strains, and strains that spread across continents.


Research Focus Area

Infectious Disease

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Seattle Magazine Top Doctor - 2012Seattle Magazine Top Doctor - 2012Seattle Magazine 2012
U.S. News Top DoctorU.S. News and World Report 2012


Pediatric Infection and Intestinal Carriage Due to Extended-Spectrum-Cephalosporin-Resistant Enterobacteriaceae.
Antimicrobial agents and chemotherapy , July 2014: 58(7)3997-4004
Intestinal decontamination of multidrug-resistant Klebsiella pneumoniae after recurrent infections in an immunocompromised host.
Diagnostic microbiology and infectious disease , June 2014
Empiric Combination Therapy for Gram-Negative Bacteremia.
Pediatrics , April 2014
Challenges in the management of infections due to carbapenem-resistant Enterobacteriaceae.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America , April 2014: 35(4)437-9
Molecular epidemiology of colonizing and disease-causing Klebsiella pneumoniae in paediatric patients.
Journal of medical microbiology , April 2014: 63(Pt 4)610-6
Prevalence and characteristics of antimicrobial stewardship programs at freestanding children's hospitals in the United States.
Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America , March 2014: 35(3)265-71
Predictive diagnostics for Escherichia coli infections based on the clonal association of antimicrobial resistance and clinical outcome.
Journal of clinical microbiology , Sept. 2013: 51(9)2991-9
Microbial variome database: point mutations, adaptive or not, in bacterial core genomes.
Molecular biology and evolution , June 2013: 30(6)1465-70
Emergence of extended-spectrum -lactam resistance among Escherichia coli at a US academic children's hospital is clonal at the sequence type level for CTX-M-15, but not for CMY-2.
International journal of antimicrobial agents , May 2013: 41(5)414-20
Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.
The Journal of infectious diseases , March 2013: 207(6)919-28
Evolutionary analysis points to divergent physiological roles of type 1 fimbriae in Salmonella and Escherichia coli.
mBio , March 2013: 4(2)
The use of intravenous colistin among children in the United States: results from a multicenter, case series.
The Pediatric infectious disease journal , Jan. 2013: 32(1)17-22
Antimicrobial stewardship in pediatric care: strategies and future directions.
Pharmacotherapy , Aug. 2012: 32(8)735-43
Molecular epidemiological analysis of Escherichia coli sequence type ST131 (O25:H4) and blaCTX-M-15 among extended-spectrum--lactamase-producing E. coli from the United States, 2000 to 2009.
Antimicrobial agents and chemotherapy , May 2012: 56(5)2364-70
Comparison of Escherichia coli ST131 pulsotypes, by epidemiologic traits, 1967-2009.
Emerging infectious diseases , April 2012: 18(4)598-607
High-resolution two-locus clonal typing of extraintestinal pathogenic Escherichia coli.
Applied and environmental microbiology , March 2012: 78(5)1353-60
Molecular diversity in mechanisms of carbapenem resistance in paediatric Enterobacteriaceae.
International journal of antimicrobial agents , Jan. 2012: 39(1)52-7
Antibiotic options for treatment of pediatric infections with Enterobacteriaceae producing broad spectrum beta-lactamases
Anti-Infective Agents , 2012: 10(2)130-135
Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
The Pediatric infectious disease journal , April 2010: 379-81
Comparative structure-function analysis of mannose-specific FimH adhesins from Klebsiella pneumoniae and Escherichia coli.
Journal of bacteriology , Nov. 2009: 6592-601
High frequency of hotspot mutations in core genes of Escherichia coli due to short-term positive selection.
Proceedings of the National Academy of Sciences of the United States of America , July 2009: 12412-7
Population variability of the FimH type 1 fimbrial adhesin in Klebsiella pneumoniae.
Journal of bacteriology , March 2009: 1941-50
Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experience.
Antimicrobial agents and chemotherapy , Nov. 2008: 3909-14
Genetic diversity of the gene cluster encoding longus, a type IV pilus of enterotoxigenic Escherichia coli.
Journal of bacteriology , Dec. 2007: 9145-9
Differential stability and trade-off effects of pathoadaptive mutations in the Escherichia coli FimH adhesin.
Infection and immunity , July 2007: 3548-55
Haplotype diversity in "source-sink" dynamics of Escherichia coli urovirulence.
Journal of molecular evolution , Feb. 2007: 204-14
Phylogenetic relationships among clonal groups of extraintestinal pathogenic Escherichia coli as assessed by multi-locus sequence analysis.
Microbes and infection / Institut Pasteur , June 2006: 1702-13
Clonal analysis reveals high rate of structural mutations in fimbrial adhesins of extraintestinal pathogenic Escherichia coli.
Molecular microbiology , Feb. 2006: 975-88
Kirby-Bauer disc approximation to detect inducible third-generation cephalosporin resistance in Enterobacteriaceae.
Annals of clinical microbiology and antimicrobials , July 2004: 13
Selection footprint in the FimH adhesin shows pathoadaptive niche differentiation in Escherichia coli.
Molecular biology and evolution , July 2004: 1373-83
Enterobacterial adhesins and the case for studying SNPs in bacteria.
Trends in microbiology , March 2003: 115-7
Extrapulmonary Legionella micdadei infection in a previously healthy child.
The Pediatric infectious disease journal , Dec. 2002: 1174-6

Research Funding

Grant TitleGrantorAmountAward Date
Differences in infecting and colonizing Enterobacteriaceae from short-course vs standard therapy of pediatric UTI - R21AI099930NIH/NIAID $125,000 annual DCApril 1, 2012 - Feb. 28, 2015
Resistance and relatedness: Molecular features of Klebsiella pneumoniae as a colonizer and pathogen in pediatric patients in Seattle, WAInstitute of Translational Health Sciences/UWJune 3, 2010 - April 30, 2012
National surveillance of emerging MDR in pediatric Enterobacteriaceae infections - R01 AI083413 (Co-PI with Zerr)NIH/NIAID $420,236 annual DCJune 1, 2010 - May 31, 2015
Multi-drug resistance and virulence patterns in canine and feline urinary E. coliAmerican College of Veterinary MedicineJan. 1, 2008 - March 31, 2011

Primary Office

Seattle Children's
MA.7.226 - Infectious Disease Clinic
4800 Sand Point Way NE
Seattle, WA 98105

Additional Offices

Seattle Children's Research Institute
JMB - 8 - Infectious Disease
1900 - 9th Ave
Seattle, WA 98101

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