Profile

Sara Jane Webb, PhD

Sara Jane Webb, PhD

Academic Title: Associate Professor of Psychiatry and Behavioral Sciences and the Center on Child Health, Behavior and Development, Seattle Childrens Research Institute

Research Center: Center for Child Health, Behavior and Development

  • Dr. Sara Jane Webb studies development in individuals with autism spectrum disorders and other neurodevelopmental disorders. Her work is focused on developing biomarkers of nervous system functioning across the lifespan, using methodologies such as electroencephalography (EEG), event-related potentials (ERP), eye tracking, cardiophysiology (EKG), functional magnetic resonance imaging and behavioral measures. She is the director of research for Seattle Children's Autism Center, director of data acquisition and analytics for the Autism Biomarkers Consortium, director of the Seattle site for the GENDAAR study of girls with ASD and a co-investigator on projects investigating the relation between genetics and brain functioning. She is the recipient of the Mary Gates Undergraduate Research Monitorship Award and takes an active role in local, national and international mentorship and training.

  • Award Name Award Description Awarded By Award Date
    UW Medicine Excellence in Mentoring Award, Recognized Nominee UW School of Medicine 2017
    Summary of Advances, Nominated Article Early sex differences are not autism-specific: A baby siblings research consortium study. Molecular Autism Interagency Autism Coordinating Council 2016
    Summary of Advances, Selected Article Reduced engagement with social stimuli in 6-month old infants with later ASD. Journal of Neurodevelopmental Disorders. Interagency Autism Coordinating Council 2016
    UW Undergraduate Research Mentor Award University of Washington 2015
    UW Medicine Excellence in Mentoring Award, Recognized Nominee UW School of Medicine 2014
    Top 10 Medical Breakthroughs Early behavioral intervention is associated with normalized brain activity in young children with autism. Journal of the Academy of Child and Adolescent Psychiatry. Time Magazine 2012
    Women in Psychology Leadership Fellow American Psychological Association 2011 - 2012
    • Webb SJ, Neuhaus E, Faja S
      Face perception and learning in autism spectrum disorders.
      26886246 Quarterly journal of experimental psychology (2006) , 2017 May : 70(5)970-986 PMCID: PMC5026554
    • Jones EJ, Venema K, Earl RK, Lowy R, Webb SJ
      Infant social attention: an endophenotype of ASD-related traits?
      27861851 Journal of child psychology and psychiatry, and allied disciplines , 2017 Mar. : 58(3)270-281
    • Webb SJ, Garrison MM, Bernier R, McClintic AM, King BH, Mourad PD
      Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound.
      27582229 Autism research : official journal of the International Society for Autism Research , 2017 Mar. : 10(3)472-484 PMCID: PMC5332517
    • Charman T, Young GS, Brian J, Carter A, Carver LJ, Chawarska K, Curtin S, Dobkins K, Elsabbagh M, Georgiades S, Hertz-Picciotto I, Hutman T, Iverson JM, Jones EJ, Landa R, Macari S, Messinger DS, Nelson CA, Ozonoff S, Saulnier C, Stone WL, Tager-Flusberg H, Webb SJ, Yirmiya N, Zwaigenbaum L
      Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study.
      27417857 Autism research : official journal of the International Society for Autism Research , 2017 Jan. : 10(1)169-178
    • Faja S, Clarkson T, Webb SJ
      Neural and behavioral suppression of interfering flankers by children with and without autism spectrum disorder.
      27825750 Neuropsychologia , 2016 Dec. : 93(Pt A)251-261 PMCID: PMC5154614
    • Garman HD, Spaulding CJ, Webb SJ, Mikami AY, Morris JP, Lerner MD
      Wanting it Too Much: An Inverse Relation Between Social Motivation and Facial Emotion Recognition in Autism Spectrum Disorder.
      26743637 Child psychiatry and human development , 2016 Dec. : 47(6)890-902 PMCID: PMC4936965
    • Neuhaus E, Jones EJ, Barnes K, Sterling L, Estes A, Munson J, Dawson G, Webb SJ
      The Relationship Between Early Neural Responses to Emotional Faces at Age 3 and Later Autism and Anxiety Symptoms in Adolescents with Autism.
      27055415 Journal of autism and developmental disorders , 2016 July : 46(7)2450-63 PMCID: PMC5305034
    • Navot N, Jorgenson AG, Vander Stoep A, Toth K, Webb SJ
      Family planning and family vision in mothers after diagnosis of a child with autism spectrum disorder.
      26395237 Autism : the international journal of research and practice , 2016 July : 20(5)605-15 PMCID: PMC4981328
    • Faja S, Dawson G, Aylward E, Wijsman EM, Webb SJ
      Early event-related potentials to emotional faces differ for adults with autism spectrum disorder and by serotonin transporter genotype.
      27178863 Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology , 2016 June : 127(6)2436-47 PMCID: PMC5279301
    • Messinger DS, Young GS, Webb SJ, Ozonoff S, Bryson SE, Carter A, Carver L, Charman T, Chawarska K, Curtin S, Dobkins K, Hertz-Picciotto I, Hutman T, Iverson JM, Landa R, Nelson CA, Stone WL, Tager-Flusberg H, Zwaigenbaum L
      Commentary: sex difference differences? A reply to Constantino.
      27358719 Molecular autism , 2016 : 731 PMCID: PMC4926305
    • Neuhaus E, Kresse A, Faja S, Bernier RA, Webb SJ
      Face processing among twins with and without autism: social correlates and twin concordance.
      26137974 Social cognitive and affective neuroscience , 2016 Jan. : 11(1)44-54 PMCID: PMC4692310
    • Jones EJ, Venema K, Lowy R, Earl RK, Webb SJ
      Developmental changes in infant brain activity during naturalistic social experiences.
      26219834 Developmental psychobiology , 2015 Nov. : 57(7)842-53 PMCID: PMC4615531
    • Chapman NH, Nato AQ Jr, Bernier R, Ankenman K, Sohi H, Munson J, Patowary A, Archer M, Blue EM, Webb SJ, Coon H, Raskind WH, Brkanac Z, Wijsman EM
      Whole exome sequencing in extended families with autism spectrum disorder implicates four candidate genes.
      26204995 Human genetics , 2015 Oct. : 134(10)1055-68 PMCID: PMC4578871
    • Baldarçara L, Currie S, Hadjivassiliou M, Hoggard N, Jack A, Jackowski AP, Mascalchi M, Parazzini C, Reetz K, Righini A, Schulz JB, Vella A, Webb SJ, Habas C
      Consensus paper: radiological biomarkers of cerebellar diseases.
      25382714 Cerebellum (London, England) , 2015 Apr, : 14(2)175-96 PMCID: PMC4929983
    • Webb SJ, Bernier R, Henderson HA, Johnson MH, Jones EJ, Lerner MD, McPartland JC, Nelson CA, Rojas DC, Townsend J, Westerfield M
      Guidelines and best practices for electrophysiological data collection, analysis and reporting in autism.
      23975145 Journal of autism and developmental disorders , 2015 Feb. : 45(2)425-43 PMCID: PMC4141903
    • Hudac CM, Kresse A, Aaronson B, DesChamps TD, Webb SJ, Bernier RA
      Modulation of mu attenuation to social stimuli in children and adults with 16p11.2 deletions and duplications.
      26213586 Journal of neurodevelopmental disorders , 2015 : 7(1)25 PMCID: PMC4514956
    • Messinger DS, Young GS, Webb SJ, Ozonoff S, Bryson SE, Carter A, Carver L, Charman T, Chawarska K, Curtin S, Dobkins K, Hertz-Picciotto I, Hutman T, Iverson JM, Landa R, Nelson CA, Stone WL, Tager-Flusberg H, Zwaigenbaum L
      Early sex differences are not autism-specific: A Baby Siblings Research Consortium (BSRC) study.
      26045943 Molecular autism , 2015 : 632 PMCID: PMC4455973
    • McClintic AM, King BH, Webb SJ, Mourad PD
      Mice exposed to diagnostic ultrasound in utero are less social and more active in social situations relative to controls.
      24249575 Autism research : official journal of the International Society for Autism Research , 2014 June : 7(3)295-304 PMCID: PMC4025980
    • King BH, Navot N, Bernier R, Webb SJ
      Update on diagnostic classification in autism.
      24441420 Current opinion in psychiatry , 2014 Mar. : 27(2)105-9 PMCID: PMC4929984
    • Webb SJ, Jones EJ, Kelly J, Dawson G
      The motivation for very early intervention for infants at high risk for autism spectrum disorders.
      24410019 International journal of speech-language pathology , 2014 Feb. : 16(1)36-42 PMCID: PMC4141560
    • Kodish I, Rockhill CM, Webb SJ
      ASD: Psychopharmacologic Treatments and Neurophysiologic Underpinnings.
      24683058 Current topics in behavioral neurosciences , 2014 : 21257-75 PMCID: PMC4180816
    • Dawson G, Jones EJ, Merkle K, Venema K, Lowy R, Faja S, Kamara D, Murias M, Greenson J, Winter J, Smith M, Rogers SJ, Webb SJ
      Early behavioral intervention is associated with normalized brain activity in young children with autism.
      23101741 Journal of the American Academy of Child and Adolescent Psychiatry , 2012 Nov. : 51(11)1150-9
    • Webb SJ, Merkle K, Murias M, Richards T, Aylward E, Dawson G
      ERP responses differentiate inverted but not upright face processing in adults with ASD.
      19454620 Social cognitive and affective neuroscience , 2012 June : 7(5)578-87 PMCID: PMC3375882
    • Faja S, Webb SJ, Jones E, Merkle K, Kamara D, Bavaro J, Aylward E, Dawson G
      The effects of face expertise training on the behavioral performance and brain activity of adults with high functioning autism spectrum disorders.
      21484517 Journal of autism and developmental disorders , 2012 Feb. : 42(2)278-93
    • Webb SJ, Jones EJ, Merkle K, Venema K, Greenson J, Murias M, Dawson G
      Developmental change in the ERP responses to familiar faces in toddlers with autism spectrum disorders versus typical development.
      22004249 Child development , 2011 Nov. : 82(6)1868-86
    • Webb SJ, Nalty T, Munson J, Brock C, Abbott R, Dawson G
      Rate of head circumference growth as a function of autism diagnosis and history of autistic regression.
      17940244 Journal of child neurology , 2007 Oct. : 1182-90
    • Dawson G, Munson J, Webb SJ, Nalty T, Abbott R, Toth K
      Rate of head growth decelerates and symptoms worsen in the second year of life in autism.
      17137564 Biological psychiatry , 2007 Feb. 15 : 458-64
    • Munson J, Dawson G, Abbott R, Faja S, Webb SJ, Friedman SD, Shaw D, Artru A, Dager SR
      Amygdalar volume and behavioral development in autism.
      16754842 Archives of general psychiatry , 2006 June : 686-93
    • Dawson G, Webb SJ, McPartland J
      Understanding the nature of face processing impairment in autism: insights from behavioral and electrophysiological studies.
      15843104 Developmental neuropsychology , 2005 : 403-24
    • Dawson G, Webb SJ, Wijsman E, Schellenberg G, Estes A, Munson J, Faja S
      Neurocognitive and electrophysiological evidence of altered face processing in parents of children with autism: implications for a model of abnormal development of social brain circuitry in autism.
      16262987 Development and psychopathology , 2005 : 679-97

  • Grant Title Grantor Amount Award Date
    U19 Consortium on biomarker and outcome measures of social impariment for use in clinical trials in autism spectrum disorders NIMH 2015 - 2019
    R01 Phenotypic characterization of gene disrupting mutations in ASD NIMH 2014 - 2019
    Investigating the role of somatic mutations in autism spectrum disorders SFARI 2014 - 2017
    Mechanisms of face understanding in children in Seoul Korea and Seattle WA USA Korean Research Foundation 2013 - 2016
    ACE Multimodal developmental Neurogenetics of females with ASD NIMH 2012 - 2017

Overview

Medical/Professional School

University of Washington, Seattle
Yale University, New Haven
University of Minnesota - Institute of Child Development, Minneapolis

Research Description

My research program focuses on brain development in individuals with autism spectrum disorders and other neurodevelopment disorders. My work is focused on developing biomarkers of nervous system functioning across the lifespan, using methodologies such as electroencephalography (EEG), event-related potentials (ERP), eye tracking, cardiophysiology (EKG), functional magnetic resonance imaging (fMRI), and behavioral measures. My current work covers several conceptual areas including: (1) attention, perceptual and cognitive performance and the relation to social ability and disability; (2) early attention, perceptual, and cognitive risk markers for autism in infants at high risk; (3) objective measures of behavior and psychophysiology as prediction of response to intervention; and (4) electrophysiological markers of neural activity and event related temporal processing in children with neurodevelopmental disability.

About My Work

http://depts.washington.edu/pbslab/Home.html

Research Focus Area

Neuroscience / Neurodevelopment