Profile

Michael L. Cunningham, MD, PhD

Michael L. Cunningham, MD, PhD

Craniofacial, Pediatrics-Inpatient

On staff since October 1991

Children's Title: Division Chief, Craniofacial Medicine; Medical Director, Craniofacial Center; Jean Renny Endowed Chair in Pediatric Craniofacial Medicine

Academic Title: Professor

Research Center: Center for Developmental Biology and Regenerative Medicine

"The care of a single patient during residency made me realize that I enjoyed helping families work through the difficult time after the birth of a child with complex cleft and craniofacial disorders. After residency, I was given the unique opportunity to train in the longitudinal care of these patients and their families. Encouraged by my mentors, Drs. Ron Lemire and Sterling Clarren, I returned to graduate school to obtain a PhD in Anatomy and Embryology. Now, after this 20-year journey as a physician-scientist, I recognize that it is my patients, their families and my trainees who serve as my teachers. I am dedicated to the advancement of craniofacial research and our unique model of pediatric care for children born with these conditions."

Michael L. Cunningham, MD, PhD, is chief of the Division of Craniofacial Medicine and Professor of Pediatrics in the Department of Pediatrics at the University of Washington School of Medicine. He is medical director of Seattle Children’s Craniofacial Center and holds the Jean Renny Endowed Chair in Craniofacial Medicine. He is also adjunct Professor in the Departments of Biological Structures, Oral Biology and Pediatric Dentistry at the University of Washington.

Dr. Cunningham balances responsibilities in administration, patient care and research. He does bedside teaching of medical students, pediatrics residents and dental students. His clinical interests focus on the diagnosis and long-term interdisciplinary care of children with craniofacial malformations, with a particular interest in craniosynostosis. He is co-investigator on several clinical research projects, ranging from the epidemiology of positional plagiocephaly to computer modeling of craniofacial conditions.

Funded through the National Institute of Dental and Craniofacial Research, Cunningham’s basic molecular and developmental biology lab has been open since 1993 and is using human and mouse models to investigate the molecular causes of craniosynostosis and developmental pathogenesis of midface hypoplasia associated with syndromic craniosynostosis.

Recommendations

  • Cindy Chehalis, Wa 98532 03.06.13

    Dr. Cunningham has been and is one of my son's all time favorite doctors of all time. He truly is one of a kind. Brilliant with the best bedside side manners. He truly loves his kids! Parker T. Walsh son and long time patient. Thanks from most grateful mother, Cindy Walsh

  • Angelica Granger Washington 08.15.11

    Dr. Cunningham is one of my best doctors. He has helped me alot through my appointments. And I could always count on him whenever I have a problem.

  • Carla Shoreline, WA 05.03.11

    Dr. Cunningham is very personable and relates to our child where he is in this journey. A compassionate, caring physician who treats our family with the utmost respect and allows us to make this journey at our pace and understands our hesitencies about the care and surgery of our child. My son said after one of the clinics "Mom, that was one of the very best clinics ever. Dr. Cunningham talked to me and not to you. I am in charge and I like it." From that point on, my son has taken charge in his healthcare and when providers begin to ask me questions, he jumps to answer them. Dr. Cunninhgam has helped my son realize his potential for controlling his healthcare course and making decisions, to ask more questions or to look at me and ask for help. Thank you Dr. Cunningham you are a great, caring and wonderful person!

  • Nancy Seattle, Wa 12.01.10

    Dr. Cunningham is the best! My daughter has been a patient at the Cranifacial center for almost 14 years. The care that we have received from Dr. Cunningham and the entire crew is outstanding.

Overview

Board Certification(s)

Pediatrics

Medical/Professional School

University of Washington, Seattle
University of Vermont College of Medicine, Burlington

Residency

Pediatrics, University of Washington School of Medicine, Seattle

Fellowship

Neurodevelopmental Disabilities, Seattle Children's Hospital, Seattle

Clinical Interests

Diagnosis and management of craniofacial malformation syndromes, Molecular developmental biology of craniosynostosis and other craniofacial conditions

Research Description

Craniosynostosis Research Program

Isolated craniosynostosis (premature fusion of the skull bones) occurs in approximately 1 out of 2500 births. The sutures of the skull are the areas of expansion during normal brain growth. Premature suture fusion results in abnormalities in head shape due to restriction of growth in the region of a fused suture. These changes of head shape can be associated with increased intracranial pressure (pressure within the skull) that can result in permanent brain injury.

In addition to the risks of brain injury, craniosynostosis is often associated with alteration of craniofacial growth leading to mid-facial hypoplasia, dental malocclusion, and orbital deformation. The combination of craniosynostosis and its associated facial malformations leads to significant health problems. Patients with craniosynostosis require one or more reconstructive surgeries to correct the functional deficits associated with their malformations.

Craniosynostosis remains a significant medical and dental health issue deserving of aggressive scientific investigation. The Cunningham Laboratory and members of the Children's Craniofacial Center use both basic science and clinical science to answer important questions about the etiology, diagnosis, treatment, and prevention of craniosynostosis.

Dr. Cunningham and his lab group use bone cell lines and animal models to study the molecular and developmental causes of human malformations. Their primary interest is a condition called craniosynostosis. Their research is focused on the molecular and developmental causes of several hereditary craniosynostosis syndromes including Apert, Crouzon, Saethre-Chotzen, and Muenke syndromes. These conditions are caused by mutations in members of the fibroblast growth factor receptor family (FGFRs) or TWIST.

In addition to these relatively rare forms of synostosis, the Cunningham lab investigates the molecular and developmental causes of isolated single suture craniosynostosis. Through the use of modern techniques of molecular biology, mutational analysis, expression analysis, and cell biology the Cunningham lab investigates the normal development of the human skull and pathogenesis of craniosynostosis as a mechanism to identify alternative treatment and prevention strategies.

Lab URL

http://www.seattlechildrens.org/research/developmental-biology-regenerative-medicine/cunningham-lab/

Research Focus Area

Craniofacial

Awards and Honors

Award Name Award Description Awarded By Award Date
Inaugural Holder, Jean Renny Endowed Chair for Craniofacial Medicine University of Washington 2007
Parent Choice Award Children’s Hospital and Regional Medical Center 2005
Outstanding Teacher Award University of Washington Pediatric Residency Program 2001
F. Clarke Fraser New Investigator Award The Teratology Society 2001
Member Society for Pediatric Research 1999
Child Heath Research Center Award University of Washington, Department of Pediatrics 1993
Physician Scientist Research Training Award National Institute of Child Health & Human Development, NIH 1993
James G. Wilson Award for Excellence in Research The Teratology Society 1993

Publications

  • Keppler-Noreuil KM, Sapp JC, Lindhurst MJ, Parker VE, Blumhorst C, Darling T, Tosi LL, Huson SM, Whitehouse RW, Jakkula E, Grant I, Balasubramanian M, Chandler KE, Fraser JL, Gucev Z, Crow YJ, Brennan LM, Clark R, Sellars EA, Pena LD, Krishnamurty V, Shuen A, Braverman N, Cunningham ML, Sutton VR, Tasic V, Graham JM Jr, Geer J Jr, Henderson A, Semple RK, Biesecker LG
    Clinical delineation and natural history of the PIK3CA-related overgrowth spectrum.
    American journal of medical genetics. Part A , 2014 July : 164(7)1713-33
  • Gordon CT, Cunniff CM, Green GE, Zechi-Ceide RM, Johnson JM, Henderson A, Petit F, Kokitsu-Nakata NM, Guion-Almeida ML, Munnich A, Cunningham ML, Lyonnet S, Amiel J
    Clinical evidence for a mandibular to maxillary transformation in Auriculocondylar syndrome.
    American journal of medical genetics. Part A , 2014 Mar. 26
  • Kim SD, Yagnik G, Cunningham ML, Kim J, Boyadjiev SA
    MAPK/ERK Signaling Pathway Analysis in Primary Osteoblasts From Patients With Nonsyndromic Sagittal Craniosynostosis.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2014 Jan. : 51(1)115-9
  • Cox TC, Luquetti DV, Cunningham ML
    Perspectives and challenges in advancing research into craniofacial anomalies.
    American journal of medical genetics. Part C, Seminars in medical genetics , 2013 Nov. : 163(4)213-7
  • Kido Y, Gordon CT, Sakazume S, Ben Bdira E, Dattani M, Wilson LC, Lyonnet S, Murakami N, Cunningham ML, Amiel J, Nagai T
    Further characterization of atypical features in auriculocondylar syndrome caused by recessive PLCB4 mutations.
    American journal of medical genetics. Part A , 2013 Sept. : 161(9)2339-46
  • Collett BR, Gray KE, Kapp-Simon KA, Birgfeld C, Cunningham M, Rudo-Stern J, Ung D, Buono L, Speltz ML
    Laypersons' ratings of appearance in children with and without single-suture craniosynostosis.
    The Journal of craniofacial surgery , 2013 July : 24(4)1331-5
  • Evans KN, Gruss JS, Khanna PC, Cunningham ML, Cox TC, Hing AV
    Oculoauriculofrontonasal syndrome: case series revealing new bony nasal anomalies in an old syndrome.
    American journal of medical genetics. Part A , 2013 June : 161A(6)1345-53
  • Luquetti DV, Cox TC, Lopez-Camelo J, Dutra Mda G, Cunningham ML, Castilla EE
    Preferential associated anomalies in 818 cases of microtia in South America.
    American journal of medical genetics. Part A , 2013 May : 161A(5)1051-7
  • Gordon CT, Vuillot A, Marlin S, Gerkes E, Henderson A, AlKindy A, Holder-Espinasse M, Park SS, Omarjee A, Sanchis-Borja M, Bdira EB, Oufadem M, Sikkema-Raddatz B, Stewart A, Palmer R, McGowan R, Petit F, Delobel B, Speicher MR, Aurora P, Kilner D, Pellerin P, Simon M, Bonnefont JP, Tobias ES, García-Miñaúr S, Bitner-Glindzicz M, Lindholm P, Meijer BA, Abadie V, Denoyelle F, Vazquez MP, Rotky-Fast C, Couloigner V, Pierrot S, Manach Y, Breton S, Hendriks YM, Munnich A, Jakobsen L, Kroisel P, Lin A, Kaban LB, Basel-Vanagaite L, Wilson L, Cunningham ML, Lyonnet S, Amiel J
    Heterogeneity of mutational mechanisms and modes of inheritance in auriculocondylar syndrome.
    Journal of medical genetics , 2013 Mar. : 50(3)174-86
  • Menendez L, Kulik MJ, Page AT, Park SS, Lauderdale JD, Cunningham ML, Dalton S
    Directed differentiation of human pluripotent cells to neural crest stem cells.
    Nature protocols , 2013 Jan. 3 : 8(1)203-12
  • Luquetti DV, Hing AV, Rieder MJ, Nickerson DA, Turner EH, Smith J, Park S, Cunningham ML
    "Mandibulofacial dysostosis with microcephaly" caused by EFTUD2 mutations: expanding the phenotype.
    American journal of medical genetics. Part A , 2013 Jan. : 161A(1)108-13
  • Collett BR, Gray KE, Starr JR, Heike CL, Cunningham ML, Speltz ML
    Development at age 36 months in children with deformational plagiocephaly.
    Pediatrics , 2013 Jan. : 131(1)e109-15
  • Gallagher ER, Evans KN, Hing AV, Cunningham ML
    Bathrocephaly: a head shape associated with a persistent mendosal suture.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2013 Jan. : 50(1)104-8
  • Justice CM, Yagnik G, Kim Y, Peter I, Jabs EW, Erazo M, Ye X, Ainehsazan E, Shi L, Cunningham ML, Kimonis V, Roscioli T, Wall SA, Wilkie AO, Stoler J, Richtsmeier JT, Heuzé Y, Sanchez-Lara PA, Buckley MF, Druschel CM, Mills JL, Caggana M, Romitti PA, Kay DM, Senders C, Taub PJ, Klein OD, Boggan J, Zwienenberg-Lee M, Naydenov C, Kim J, Wilson AF, Boyadjiev SA
    A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9.
    Nature genetics , 2012 Dec. : 44(12)1360-4
  • Yagnik G, Ghuman A, Kim S, Stevens CG, Kimonis V, Stoler J, Sanchez-Lara PA, Bernstein JA, Naydenov C, Drissi H, Cunningham ML, Kim J, Boyadjiev SA
    ALX4 gain-of-function mutations in nonsyndromic craniosynostosis.
    Human mutation , 2012 Dec. : 33(12)1626-9
  • Collett BR, Aylward EH, Berg J, Davidoff C, Norden J, Cunningham ML, Speltz ML
    Brain volume and shape in infants with deformational plagiocephaly.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery , 2012 July : 28(7)1083-90
  • Lindhurst MJ, Parker VE, Payne F, Sapp JC, Rudge S, Harris J, Witkowski AM, Zhang Q, Groeneveld MP, Scott CE, Daly A, Huson SM, Tosi LL, Cunningham ML, Darling TN, Geer J, Gucev Z, Sutton VR, Tziotzios C, Dixon AK, Helliwell T, O'Rahilly S, Savage DB, Wakelam MJ, Barroso I, Biesecker LG, Semple RK
    Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.
    Nature genetics , 2012 June 24 : 44(8)928-33
  • Starr JR, Collett BR, Gaither R, Kapp-Simon KA, Cradock MM, Cunningham ML, Speltz ML
    Multicenter study of neurodevelopment in 3-year-old children with and without single-suture craniosynostosis.
    Archives of pediatrics & adolescent medicine , 2012 June 1 : 166(6)536-42
  • Collett BR, Heike CL, Atmosukarto I, Starr JR, Cunningham ML, Speltz ML
    Longitudinal, three-dimensional analysis of head shape in children with and without deformational plagiocephaly or brachycephaly.
    The Journal of pediatrics , 2012 Apr, : 160(4)673-678.e1
  • Hing AV, Mefford HC, Cunningham ML
    New developments in genetic diagnosis: implications for the craniofacial surgeon.
    The Journal of craniofacial surgery , 2012 Jan. : 23(1)212-6
  • Nelsen LM, Shields KE, Cunningham ML, Stoler JM, Bamshad MJ, Eng PM, Smugar SS, Gould AL, Philip G
    Congenital malformations among infants born to women receiving montelukast, inhaled corticosteroids, and other asthma medications.
    The Journal of allergy and clinical immunology , 2012 Jan. : 129(1)251-4.e1-6
  • Stamper BD, Park SS, Beyer RP, Bammler TK, Cunningham ML
    Unique sex-based approach identifies transcriptomic biomarkers associated with non-syndromic craniosynostosis.
    Gene regulation and systems biology , 2012 : 681-92
  • McCarthy JG, Warren SM, Bernstein J, Burnett W, Cunningham ML, Edmond JC, Figueroa AA, Kapp-Simon KA, Labow BI, Peterson-Falzone SJ, Proctor MR, Rubin MS, Sze RW, Yemen TA, Craniosynostosis Working Group
    Parameters of care for craniosynostosis.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2012 Jan. : 49 Suppl1S-24S
  • Luquetti DV, Heike CL, Hing AV, Cunningham ML, Cox TC
    Microtia: Epidemiology and genetics.
    American journal of medical genetics. Part A , 2011 Nov.
  • Fairfield H, Gilbert GJ, Barter M, Corrigan RR, Curtain M, Ding Y, D'Ascenzo M, Gerhardt DJ, He C, Huang W, Richmond T, Rowe L, Probst FJ, Bergstrom DE, Murray SA, Bult C, Richardson J, Kile BT, Gut I, Hager J, Sigurdsson S, Mauceli E, Di Palma F, Lindblad-Toh K, Cunningham ML, Cox TC, Justice MJ, Spector MS, Lowe SW, Albert T, Donahue LR, Jeddeloh J, Shendure J, Reinholdt LG
    Mutation discovery in mice by whole exome sequencing.
    Genome biology , 2011 Sept. 14 : R86
  • Vissers LE, Cox TC, Maga AM, Short KM, Wiradjaja F, Janssen IM, Jehee F, Bertola D, Liu J, Yagnik G, Sekiguchi K, Kiyozumi D, van Bokhoven H, Marcelis C, Cunningham ML, Anderson PJ, Boyadjiev SA, Passos-Bueno MR, Veltman JA, Smyth I, Buckley MF, Roscioli T
    Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice.
    PLoS genetics , 2011 Sept. : e1002278
  • Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA
    The FaceBase Consortium: a comprehensive program to facilitate craniofacial research.
    Developmental biology , 2011 July 15 : 175-82
  • Parhizkar N, Saltzman B, Grote K, Starr J, Cunningham M, Perkins J, Sie K
    Nasopharyngeal airway for management of airway obstruction in infants with micrognathia.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2011 July : 478-82
  • Purushothaman R, Cox TC, Muga AM, Cunningham ML
    Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes.
    Birth defects research. Part A, Clinical and molecular teratology , 2011 July : 603-9
  • Collett BR, Starr JR, Kartin D, Heike CL, Berg J, Cunningham ML, Speltz ML
    Development in toddlers with and without deformational plagiocephaly.
    Archives of pediatrics & adolescent medicine , 2011 July : 653-8
  • Evans KN, Sie KC, Hopper RA, Glass RP, Hing AV, Cunningham ML
    Robin sequence: from diagnosis to development of an effective management plan.
    Pediatrics , 2011 May : 936-48
  • Milunsky JM, Maher TM, Zhao G, Wang Z, Mulliken JB, Chitayat D, Clemens M, Stalker HJ, Bauer M, Burch M, Chénier S, Cunningham ML, Drack AV, Janssens S, Karlea A, Klatt R, Kini U, Klein O, Lachmeijer AM, Megarbane A, Mendelsohn NJ, Meschino WS, Mortier GR, Parkash S, Ray CR, Roberts A, Roberts A, Reardon W, Schnur RE, Smith R, Splitt M, Tezcan K, Whiteford ML, Wong DA, Zori R, Lin AE
    Genotype-phenotype analysis of the branchio-oculo-facial syndrome.
    American journal of medical genetics. Part A , 2011 Jan. : 22-32
  • Cunningham ML, Horst JA, Rieder MJ, Hing AV, Stanaway IB, Park SS, Samudrala R, Speltz ML
    IGF1R variants associated with isolated single suture craniosynostosis.
    American journal of medical genetics. Part A , 2011 Jan. : 91-7
  • Stamper BD, Park SS, Beyer RP, Bammler TK, Farin FM, Mecham B, Cunningham ML
    Differential expression of extracellular matrix-mediated pathways in single-suture craniosynostosis.
    PloS one , 2011 : e26557
  • Horst JA, Wang K, Horst OV, Cunningham ML, Samudrala R
    Disease Risk of Missense Mutations using Structural Inference from Predicted Function.
    Current protein & peptide science , 2010 Nov. 4
  • Lam DJ, Jensen CC, Mueller BA, Starr JR, Cunningham ML, Weaver EM
    Pediatric sleep apnea and craniofacial anomalies: a population-based case-control study.
    The Laryngoscope , 2010 Oct. : 2098-105
  • Mefford HC, Shafer N, Antonacci F, Tsai JM, Park SS, Hing AV, Rieder MJ, Smyth MD, Speltz ML, Eichler EE, Cunningham ML
    Copy number variation analysis in single-suture craniosynostosis: multiple rare variants including RUNX2 duplication in two cousins with metopic craniosynostosis.
    American journal of medical genetics. Part A , 2010 Sept. : 2203-10
  • Starr JR, Lin HJ, Ruiz-Correa S, Cunningham ML, Ellenbogen RG, Collett BR, Kapp-Simon KA, Speltz ML
    Little evidence of association between severity of trigonocephaly and cognitive development in infants with single-suture metopic synostosis.
    Neurosurgery , 2010 Aug. : 408-15; discussion 415-6
  • Perkins JA, Manning SC, Tempero RM, Cunningham MJ, Edmonds JL Jr, Hoffer FA, Egbert MA
    Lymphatic malformations: review of current treatment.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery , 2010 June : 795-803, 803.e1
  • Collett BR, Stott-Miller M, Kapp-Simon KA, Cunningham ML, Speltz ML
    Reading in children with orofacial clefts versus controls.
    Journal of pediatric psychology , 2010 Mar. : 199-208
  • Speltz ML, Collett BR, Stott-Miller M, Starr JR, Heike C, Wolfram-Aduan AM, King D, Cunningham ML
    Case-control study of neurodevelopment in deformational plagiocephaly.
    Pediatrics , 2010 Mar. : e537-42
  • Heike CL, Starr JR, Rieder MJ, Cunningham ML, Edwards KL, Stanaway IB, Crawford DC
    Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome.
    Birth defects research. Part A, Clinical and molecular teratology , 2010 Jan. : 54-63
  • Dana A, Buchanan KM, Goss MA, Seminack MM, Shields KE, Korn S, Cunningham ML, Haupt RM
    Pregnancy outcomes from the pregnancy registry of a human papillomavirus type 6/11/16/18 vaccine.
    Obstetrics and gynecology , 2009 Dec. : 1170-8
  • Heike CL, Cunningham ML, Hing AV, Stuhaug E, Starr JR
    Picture perfect? Reliability of craniofacial anthropometry using three-dimensional digital stereophotogrammetry.
    Plastic and reconstructive surgery , 2009 Oct. : 1261-72
  • McKinney CM, Cunningham ML, Holt VL, Leroux B, Starr JR
    A case-control study of infant, maternal and perinatal characteristics associated with deformational plagiocephaly.
    Paediatric and perinatal epidemiology , 2009 July : 332-45
  • Hing AV, Click ES, Holder U, Seto ML, Vessey K, Gruss J, Hopper R, Cunningham ML
    Bilateral lambdoid and sagittal synostosis (BLSS): a unique craniosynostosis syndrome or predictable craniofacial phenotype?
    American journal of medical genetics. Part A , 2009 May : 1024-32
  • Atmosukarto I, Shapiro LG, Cunningham ML, Speltz M
    Automatic 3D Shape Severity Quantification and Localization for Deformational Plagiocephaly.
    Proceedings of SPIE , 2009 Jan. 1
  • Ploplys EA, Hopper RA, Muzaffar AR, Starr JR, Avellino AM, Cunningham ML, Ellenbogen RG, Gruss JS
    Comparison of computed tomographic imaging measurements with clinical findings in children with unilateral lambdoid synostosis.
    Plastic and reconstructive surgery , 2009 Jan. : 300-9
  • Ruiz-Correa S, Starr JR, Lin HJ, Kapp-Simon KA, Sze RW, Ellenbogen RG, Speltz ML, Cunningham ML
    New severity indices for quantifying single-suture metopic craniosynostosis.
    Neurosurgery , 2008 Aug. : 318-24; discussion 324-5
  • McKinney CM, Holt VL, Cunningham ML, Leroux BG, Starr JR
    Maternal and infant characteristics associated with prone and lateral infant sleep positioning in Washington state, 1996-2002.
    The Journal of pediatrics , 2008 Aug. : 194-8, 198.e1-3
  • Ruiz-Correa S, Starr JR, Lin HJ, Kapp-Simon KA, Sze RW, Ellenbogen RG, Speltz ML, Cunningham ML
    New severity indices for quantifying single-suture metopic craniosynostosis.
    Neurosurgery , 2008 Aug. : 318-24; discussion 324-5
  • McKinney CM, Cunningham ML, Holt VL, Leroux B, Starr JR
    Characteristics of 2733 cases diagnosed with deformational plagiocephaly and changes in risk factors over time.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2008 Mar. : 208-16
  • Sanchez-Lara PA, Graham JM Jr, Hing AV, Lee J, Cunningham M
    The morphogenesis of wormian bones: a study of craniosynostosis and purposeful cranial deformation.
    American journal of medical genetics. Part A , 2007 Dec. 15 : 3243-51
  • Cunningham ML, Heike CL
    Evaluation of the infant with an abnormal skull shape.
    Current opinion in pediatrics , 2007 Dec. : 645-51
  • Toth K, Collett B, Kapp-Simon KA, Cloonan YK, Gaither R, Cradock MM, Buono L, Cunningham ML, Dawson G, Starr J, Speltz ML
    Memory and Response Inhibition in Young Children with Single-Suture Craniosynostosis.
    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence , 2007 Sept. 26 : 1-14
  • Zhang H, Somerman MJ, Berg J, Cunningham ML, Williams B
    Dental anomalies in a child with craniometaphysial dysplasia.
    Pediatric dentistry , 2007 Sept. : 415-9
  • Ruiz-Correa S, Starr JR, Lin HJ, Kapp-Simon KA, Cunningham ML, Speltz ML
    Severity of skull malformation is unrelated to presurgery neurobehavioral status of infants with sagittal synostosis.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2007 Sept. : 548-54
  • Zhang H, Somerman MJ, Berg J, Cunningham ML, Williams B
    Dental anomalies in a child with craniometaphysial dysplasia.
    Pediatric dentistry , 2007 Sept. : 415-9
  • Starr JR, Kapp-Simon KA, Cloonan YK, Collett BR, Cradock MM, Buono L, Cunningham ML, Speltz ML
    Presurgical and postsurgical assessment of the neurodevelopment of infants with single-suture craniosynostosis: comparison with controls.
    Journal of neurosurgery , 2007 Aug. : 103-10
  • Cunningham ML
    Is cleft lip and palate ever isolated? Phenotype is in the eye of the beholder.
    Archives of pediatrics & adolescent medicine , 2007 Aug. : 811-2
  • Starr JR, Kapp-Simon KA, Cloonan YK, Collett BR, Cradock MM, Buono L, Cunningham ML, Speltz ML
    Presurgical and postsurgical assessment of the neurodevelopment of infants with single-suture craniosynostosis: comparison with controls.
    Journal of neurosurgery , 2007 Aug. : 103-10
  • Speltz ML, Kapp-Simon K, Collett B, Keich Y, Gaither R, Cradock MM, Buono L, Cunningham ML
    Neurodevelopment of infants with single-suture craniosynostosis: presurgery comparisons with case-matched controls.
    Plastic and reconstructive surgery , 2007 May : 1874-81
  • Seto ML, Hing AV, Chang J, Hu M, Kapp-Simon KA, Patel PK, Burton BK, Kane AA, Smyth MD, Hopper R, Ellenbogen RG, Stevenson K, Speltz ML, Cunningham ML
    Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations.
    American journal of medical genetics. Part A , 2007 Apr, 1 : 678-86
  • Kapp-Simon KA, Speltz ML, Cunningham ML, Patel PK, Tomita T
    Neurodevelopment of children with single suture craniosynostosis: a review.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery , 2007 Mar. : 269-81
  • Cunningham ML
    Three-dimensional ultrasonography is superior to 2-dimensional ultrasonography in the detection of orofacial clefts during the second trimester of pregnancy.
    The journal of evidence-based dental practice , 2006 Dec. : 278-9
  • Hatch NE, Hudson M, Seto ML, Cunningham ML, Bothwell M
    Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F.
    The Journal of biological chemistry , 2006 Sept. 15 : 27292-305
  • Ruiz-Correa S, Sze RW, Starr JR, Lin HT, Speltz ML, Cunningham ML, Hing AV
    New scaphocephaly severity indices of sagittal craniosynostosis: a comparative study with cranial index quantifications.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2006 Mar. : 211-21
  • Cunningham ML, Seto ML, Hing AV, Bull MJ, Hopkin RJ, Leppig KA
    Cleidocranial dysplasia with severe parietal bone dysplasia: C-terminal RUNX2 mutations.
    Birth defects research. Part A, Clinical and molecular teratology , 2006 Feb. : 78-85
  • Ruiz-Correa S, Shapiro LG, Meila M, Berson G, Cunningham ML, Sze RW
    Symbolic signatures for deformable shapes.
    IEEE transactions on pattern analysis and machine intelligence , 2006 Jan. : 75-90
  • Tempero RM, Hannibal M, Finn LS, Manning SC, Cunningham ML, Perkins JA
    Lymphocytopenia in children with lymphatic malformation.
    Archives of otolaryngology--head & neck surgery , 2006 Jan. : 93-7
  • Heike CL, Cunningham ML, Steiner RD, Wenkert D, Hornung RL, Gruss JS, Gannon FH, McAlister WH, Mumm S, Whyte MP
    Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis?
    American journal of medical genetics. Part A , 2005 Dec. 1 : 67-77
  • Pollack PS, Shields KE, Burnett DM, Osborne MJ, Cunningham ML, Stepanavage ME
    Pregnancy outcomes after maternal exposure to simvastatin and lovastatin.
    Birth defects research. Part A, Clinical and molecular teratology , 2005 Nov. : 888-96
  • Sze RW, Hopper RA, Ghioni V, Gruss JS, Ellenbogen RG, King D, Hing AV, Cunningham ML
    MDCT diagnosis of the child with posterior plagiocephaly.
    AJR. American journal of roentgenology , 2005 Nov. : 1342-6
  • Collett B, Breiger D, King D, Cunningham M, Speltz M
    Neurodevelopmental implications of "deformational" plagiocephaly.
    Journal of developmental and behavioral pediatrics : JDBP , 2005 Oct. : 379-89
  • Kapp-Simon KA, Leroux B, Cunningham M, Speltz ML
    Multisite study of infants with single-suture craniosynostosis: preliminary report of presurgery development.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2005 July : 377-84
  • Ratisoontorn C, Seto ML, Broughton KM, Cunningham ML
    In vitro differentiation profile of osteoblasts derived from patients with Saethre-Chotzen syndrome.
    Bone , 2005 Apr, : 627-34
  • Yeung LC, Cunningham ML, Allpress AL, Gruss JS, Ellenbogen RG, Zerr DM
    Surgical site infections after pediatric intracranial surgery for craniofacial malformations: frequency and risk factors.
    Neurosurgery , 2005 Apr, : 733-9; discussion 733-9
  • Lin HJ, Ruiz-Correa S, Shapiro LG, Cunningham ML, Sze RW
    A symbolic shaped-based retrieval of skull images.
    AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium , 2005 : 1030
  • Speltz ML, Kapp-Simon KA, Cunningham M, Marsh J, Dawson G
    Single-suture craniosynostosis: a review of neurobehavioral research and theory.
    Journal of pediatric psychology , 2004 Dec. : 651-68
  • Hing AV, Syed N, Cunningham ML
    Familial acromelic frontonasal dysostosis: autosomal dominant inheritance with reduced penetrance.
    American journal of medical genetics. Part A , 2004 Aug. 1 : 374-82
  • Hu S, Michels DA, Fazal MA, Ratisoontorn C, Cunningham ML, Dovichi NJ
    Capillary sieving electrophoresis/micellar electrokinetic capillary chromatography for two-dimensional protein fingerprinting of single mammalian cells.
    Analytical chemistry , 2004 July 15 : 4044-9
  • Ngo AV, Sze RW, Parisi MT, Sidhu M, Paladin AM, Weinberger E, Seidel KD, Cunningham ML
    Cranial suture simulator for ultrasound diagnosis of craniosynostosis.
    Pediatric radiology , 2004 July : 535-40
  • Heinloth AN, Irwin RD, Boorman GA, Nettesheim P, Fannin RD, Sieber SO, Snell ML, Tucker CJ, Li L, Travlos GS, Vansant G, Blackshear PE, Tennant RW, Cunningham ML, Paules RS
    Gene expression profiling of rat livers reveals indicators of potential adverse effects.
    Toxicological sciences : an official journal of the Society of Toxicology , 2004 July : 193-202
  • Ngo AV, Sze RW, Parisi MT, Sidhu M, Paladin AM, Weinberger E, Seidel KD, Cunningham ML
    Cranial suture simulator for ultrasound diagnosis of craniosynostosis.
    Pediatric radiology , 2004 July : 535-40
  • Schecter A, Lucier GW, Cunningham ML, Abdo KM, Blumenthal G, Silver AG, Melnick R, Portier C, Barr DB, Barr JR, Stanfill SB, Patterson DG Jr, Needham LL, Stopford W, Masten S, Mignogna J, Tung KC
    Human consumption of methyleugenol and its elimination from serum.
    Environmental health perspectives , 2004 May : 678-80
  • Connolly JP, Gruss J, Seto ML, Whelan MF, Ellenbogen R, Weiss A, Buchman SR, Cunningham ML
    Progressive postnatal craniosynostosis and increased intracranial pressure.
    Plastic and reconstructive surgery , 2004 Apr, 15 : 1313-23
  • Ehret FW, Whelan MF, Ellenbogen RG, Cunningham ML, Gruss JS
    Differential diagnosis of the trapezoid-shaped head.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association , 2004 Jan. : 13-9
  • Cai J, Goodman BK, Patel AS, Mulliken JB, Van Maldergem L, Hoganson GE, Paznekas WA, Ben-Neriah Z, Sheffer R, Cunningham ML, Daentl DL, Jabs EW
    Increased risk for developmental delay in Saethre-Chotzen syndrome is associated with TWIST deletions: an improved strategy for TWIST mutation screening.
    Human genetics , 2003 Dec. : 68-76
  • Sze RW, Parisi MT, Sidhu M, Paladin AM, Ngo AV, Seidel KD, Weinberger E, Ellenbogen RG, Gruss JS, Cunningham ML
    Ultrasound screening of the lambdoid suture in the child with posterior plagiocephaly.
    Pediatric radiology , 2003 Sept. : 630-6
  • Cunningham ML, Perry RJ, Eby PR, Gibson RL, Opheim KE, Manning SC
    Primary pulmonary dysgenesis in velocardiofacial syndrome: a second patient.
    American journal of medical genetics. Part A , 2003 Aug. 30 : 177-9
  • Jaeger A, Kapur R, Whelan M, Leung E, Cunningham M
    Cleft-palate lateral synechia syndrome: insight into the phenotypic spectrum of Fryns syndrome?
    Birth defects research. Part A, Clinical and molecular teratology , 2003 June : 460-6
  • Simon GE, Cunningham ML, Davis RL
    Outcomes of prenatal antidepressant exposure.
    The American journal of psychiatry , 2002 Dec. : 2055-61
  • Conway K, Gibson R, Perkins J, Cunningham ML
    Pulmonary agenesis: expansion of the VCFS phenotype.
    American journal of medical genetics , 2002 Nov. 15 : 89-92
  • Sze RW, Paladin AM, Lee S, Cunningham ML
    Hemifacial microsomia in pediatric patients: asymmetric abnormal development of the first and second branchial arches.
    AJR. American journal of roentgenology , 2002 June : 1523-30
  • Bonadio J, Cunningham ML
    Genetic approaches to craniofacial tissue repair.
    Annals of the New York Academy of Sciences , 2002 June : 48-57

Research Funding

Grant Title Grantor Amount Award Date
Ontology-Based Integration, Visualization and Exploration of Craniofacial Data NIH NIDCR $375,507 Subcontract 2014 - 2019
Genetic and Developmental Pathways Causing Midfacial Hypoplasia NIH NIDCR $2,278,095 2012 - 2017
Single Suture Craniosynostosis Gene Expression and Discovery NIH NIDCR $2,173,288 2008 - 2018
Neurobehavioral Correlates of Craniosynostosis NIH NIDCR $2,206,263 2001 - 2014