Profile

Mark A. Stein, PhD, ABPP

Mark A. Stein, PhD, ABPP

Psychiatry and Behavioral Health, Pediatrics-Inpatient

On staff since April 2013

Research Center: Center for Child Health, Behavior and Development

"I first became interested in ADHD and stimulant medications when I was a camp counselor of 12, 7-year old boys. One of my exuberant campers, would chase butterflies but would not play kickball or follow directions. One day, he seemed very different. That day, he followed the rules of the game, and even scored a run. His personality was different also, more serious and quiet , and he had no appetite for lunch. Having spent the last 30 years studying ADHD treatment effects, both positive and negative, I want to spend the next 10 learning how to sequence and deliver individualized treatments for the impairments related to ADHD and to train others who see children, adolescents, and adults in managing this commonly misunderstood disorder."

Recommendations

  • Anna Chicago, Il 04.29.13

    Dr. Stein is equal parts compassionate and knowledgeable. He is very comfortable chatting with children in an age appropriate manner, and he is equally adroit in communicating with parents. There is the old saying, about loss and gain. When Dr. Stein (understandably went to Seattle Children's) Chicago's loss, Seattle's gain.

Overview

Board Certification(s)

Clinical Psychology

Medical/Professional School

Southern Illinois University - Carbondale, Carbondale

Fellowship

MacLean Center for Clinical Medical Ethics, Chicago

Lab URL

http://www.seattlechildrens.org/about/stories/improving-treatment-for-ADHD/

Awards and Honors

Award Name Award Description Awarded By Award Date
Fellow Society of Clinical Child and Adolescent Psychology 2001
Fellow in recognition of outstanding and unusual contributions to the science and profession of psychology American Psychological Association 2000

Publications

  • Bédard AC, Stein MA, Halperin JM, Krone B, Rajwan E, Newcorn JH
    Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder.
    Journal of child psychology and psychiatry, and allied disciplines , 2014 June 19
  • Stein MA, Waldman I, Newcorn J, Bishop J, Kittles R, Cook EH Jr
    Dopamine transporter genotype and stimulant dose-response in youth with attention-deficit/hyperactivity disorder.
    Journal of child and adolescent psychopharmacology , 2014 June : 24(5)238-44
  • Owens J, Gruber R, Brown T, Corkum P, Cortese S, O'Brien L, Stein M, Weiss M
    Future research directions in sleep and ADHD: report of a consensus working group.
    Journal of attention disorders , 2013 Oct. : 17(7)550-64
  • Newcorn JH, Stein MA, Childress AC, Youcha S, White C, Enright G, Rubin J
    Randomized, double-blind trial of guanfacine extended release in children with attention-deficit/hyperactivity disorder: morning or evening administration.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2013 Sept. : 52(9)921-30
  • Cortese S, Brown TE, Corkum P, Gruber R, O'Brien LM, Stein M, Weiss M, Owens J
    Assessment and management of sleep problems in youths with attention-deficit/hyperactivity disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2013 Aug. : 52(8)784-96
  • Mark A. Stein, PhD, ABPP
    Sleep problems and interventions in preschoolers with ADHD
    ADHD in Preschool Children:Assessment and Treatment , 2013
  • Mark A. Stein, PhD, ABPP
    The War on ADHD
    Nature Medicine , 2013 : 19(12)1366
  • Adler LA, Kroon RA, Stein M, Shahid M, Tarazi FI, Szegedi A, Schipper J, Cazorla P
    A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder.
    Biological psychiatry , 2012 Dec. 1 : 72(11)971-7
  • Conrad KJ, Conrad KM, Mazza J, Riley BB, Funk R, Stein MA, Dennis ML
    Dimensionality, hierarchical structure, age generalizability, and criterion validity of the GAIN's Behavioral Complexity Scale.
    Psychological assessment , 2012 Dec. : 24(4)913-24
  • Chronis-Tuscano A, Stein MA
    Pharmacotherapy for parents with attention-deficit hyperactivity disorder (ADHD): impact on maternal ADHD and parenting.
    CNS drugs , 2012 Sept. 1 : 26(9)725-32
  • Spruyt K, Raubuck DL, Grogan K, Gozal D, Stein MA
    Variable sleep schedules and outcomes in children with psychopathological problems: preliminary observations.
    Nature and science of sleep , 2012 : 49-17
  • Mark A. Stein, PhD, ABPP
    ADHD Treatments, Sleep, and Sleep Problems: Complex Associations
    Neurotherapeutics , 2012 : 9509-517
  • Stein MA, Waldman ID, Charney E, Aryal S, Sable C, Gruber R, Newcorn JH
    Dose effects and comparative effectiveness of extended release dexmethylphenidate and mixed amphetamine salts.
    Journal of child and adolescent psychopharmacology , 2011 Dec. : 21(6)581-8
  • Froehlich TE, Epstein JN, Nick TG, Melguizo Castro MS, Stein MA, Brinkman WB, Graham AJ, Langberg JM, Kahn RS
    Pharmacogenetic predictors of methylphenidate dose-response in attention-deficit/hyperactivity disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2011 Nov. : 50(11)1129-1139.e2
  • Shook D, Brady C, Lee PS, Kenealy L, Murphy ER, Gaillard WD, VanMeter JW, Cook EH Jr, Stein M, Vaidya CJ
    Effect of dopamine transporter genotype on caudate volume in childhood ADHD and controls.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics , 2011 Jan. : 156B(1)28-35
  • Stollstorff M, Foss-Feig J, Cook EH Jr, Stein MA, Gaillard WD, Vaidya CJ
    Neural response to working memory load varies by dopamine transporter genotype in children.
    NeuroImage , 2010 Nov. 15 : 53(3)970-7
  • Newcorn JH, Stein MA, Cooper KM
    Dose-response characteristics in adolescents with attention-deficit/hyperactivity disorder treated with OROS methylphenidate in a 4-week, open-label, dose-titration study.
    Journal of child and adolescent psychopharmacology , 2010 June : 20(3)187-96
  • Lee SH, Shin DW, Stein MA
    Increased cortisol after stress is associated with variability in response time in ADHD children.
    Yonsei medical journal , 2010 Mar. : 51(2)206-11
  • Froehlich TE, McGough JJ, Stein MA
    Progress and promise of attention-deficit hyperactivity disorder pharmacogenetics.
    CNS drugs , 2010 Feb. : 24(2)99-117
  • Froehlich TE, McGough JJ, Stein MA
    Progress and promise of attention-deficit hyperactivity disorder pharmacogenetics.
    CNS drugs , 2010 Feb. : 24(2)99-117
  • Chronis-Tuscano A, Rooney M, Seymour KE, Lavin HJ, Pian J, Robb A, Efron L, Conlon C, Stein MA
    Effects of maternal stimulant medication on observed parenting in mother-child dyads with attention-deficit/hyperactivity disorder.
    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 , 2010 : 39(4)581-7
  • Chronis-Tuscano A, Rooney M, Seymour KE, Lavin HJ, Pian J, Robb A, Efron L, Conlon C, Stein MA
    Effects of maternal stimulant medication on observed parenting in mother-child dyads with attention-deficit/hyperactivity disorder.
    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 , 2010 : 39(4)581-7
  • Hahn MK, Steele A, Couch RS, Stein MA, Krueger JJ
    Novel and functional norepinephrine transporter protein variants identified in attention-deficit hyperactivity disorder.
    Neuropharmacology , 2009 Dec. : 57(7-8)694-701
  • English BA, Hahn MK, Gizer IR, Mazei-Robison M, Steele A, Kurnik DM, Stein MA, Waldman ID, Blakely RD
    Choline transporter gene variation is associated with attention-deficit hyperactivity disorder.
    Journal of neurodevelopmental disorders , 2009 Dec. : 1(4)252-63
  • Hahn MK, Steele A, Couch RS, Stein MA, Krueger JJ
    Novel and functional norepinephrine transporter protein variants identified in attention-deficit hyperactivity disorder.
    Neuropharmacology , 2009 Dec. : 57(7-8)694-701
  • Gruber R, Joober R, Grizenko N, Leventhal BL, Cook EH Jr, Stein MA
    Dopamine transporter genotype and stimulant side effect factors in youth diagnosed with attention-deficit/hyperactivity disorder.
    Journal of child and adolescent psychopharmacology , 2009 June : 19(3)233-9
  • Gruber R, Joober R, Grizenko N, Leventhal BL, Cook EH Jr, Stein MA
    Dopamine transporter genotype and stimulant side effect factors in youth diagnosed with attention-deficit/hyperactivity disorder.
    Journal of child and adolescent psychopharmacology , 2009 June : 19(3)233-9
  • Polanczyk G, Faraone SV, Bau CH, Victor MM, Becker K, Pelz R, Buitelaar JK, Franke B, Kooij S, van der Meulen E, Cheon KA, Mick E, Purper-Ouakil D, Gorwood P, Stein MA, Cook EH Jr, Rohde LA
    The impact of individual and methodological factors in the variability of response to methylphenidate in ADHD pharmacogenetic studies from four different continents.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics , 2008 Dec. 5 : 147B(8)1419-24
  • Chronis-Tuscano A, Seymour KE, Stein MA, Jones HA, Jiles CD, Rooney ME, Conlon CJ, Efron LA, Wagner SA, Pian J, Robb AS
    Efficacy of osmotic-release oral system (OROS) methylphenidate for mothers with attention-deficit/hyperactivity disorder (ADHD): preliminary report of effects on ADHD symptoms and parenting.
    The Journal of clinical psychiatry , 2008 Dec. : 69(12)1938-47
  • Stein MA
    Medical mimics and differential diagnosis in adult ADHD.
    CNS spectrums , 2008 Oct. : 13(10 Suppl 15)14-6
  • Stein MA
    Treating adult ADHD with stimulants.
    CNS spectrums , 2008 Sept. : 13(9 Suppl 13)8-11
  • Phan L, Kasza K, Jalbrzikowski J, Noble AG, Latkany P, Kuo A, Mieler W, Meyers S, Rabiah P, Boyer K, Swisher C, Mets M, Roizen N, Cezar S, Sautter M, Remington J, Meier P, McLeod R, Toxoplasmosis Study Group
    Longitudinal study of new eye lesions in children with toxoplasmosis who were not treated during the first year of life.
    American journal of ophthalmology , 2008 Sept. : 146(3)375-384
  • Shin DW, Stein MA
    Maternal depression predicts maternal use of corporal punishment in children with attention-deficit/hyperactivity disorder.
    Yonsei medical journal , 2008 Aug. 30 : 49(4)573-80
  • Stein MA
    Impairment associated with adult ADHD.
    CNS spectrums , 2008 Aug. : 13(8 Suppl 12)9-11
  • Benevento JD, Jager RD, Noble AG, Latkany P, Mieler WF, Sautter M, Meyers S, Mets M, Grassi MA, Rabiah P, Boyer K, Swisher C, McLeod R, Toxoplasmosis Study Group
    Toxoplasmosis-associated neovascular lesions treated successfully with ranibizumab and antiparasitic therapy.
    Archives of ophthalmology , 2008 Aug. : 126(8)1152-6
  • Stein MA, McGough JJ
    The pharmacogenomic era: promise for personalizing attention deficit hyperactivity disorder therapy.
    Child and adolescent psychiatric clinics of North America , 2008 Apr, : 17(2)475-90, xi-xii
  • Yang SJ, Shin DW, Noh KS, Stein MA
    Cortisol is inversely correlated with aggression for those boys with attention deficit hyperactivity disorder who retain their reactivity to stress.
    Psychiatry research , 2007 Sept. 30 : 153(1)55-60
  • Newcorn JH, Weiss M, Stein MA
    The complexity of ADHD: diagnosis and treatment of the adult patient with comorbidities.
    CNS spectrums , 2007 Aug. : 12(8 Suppl 12)1-14; quiz 15-6
  • Newcorn JH, Weiss M, Stein MA
    The complexity of ADHD: diagnosis and treatment of the adult patient with comorbidities.
    CNS spectrums , 2007 Aug. : 12(8 Suppl 12)1-14; quiz 15-6
  • Coccaro EF, Hirsch SL, Stein MA
    Plasma homovanillic acid correlates inversely with history of learning problems in healthy volunteer and personality disordered subjects.
    Psychiatry research , 2007 Jan. 15 : 149(1-3)297-302
  • Coccaro EF, Hirsch SL, Stein MA
    Plasma homovanillic acid correlates inversely with history of learning problems in healthy volunteer and personality disordered subjects.
    Psychiatry research , 2007 Jan. 15 : 149(1-3)297-302
  • Roizen N, Kasza K, Karrison T, Mets M, Noble AG, Boyer K, Swisher C, Meier P, Remington J, Jalbrzikowski J, McLeod R, Kipp M, Rabiah P, Chamot D, Estes R, Cezar S, Mack D, Pfiffner L, Stein M, Danis B, Patel D, Hopkins J, Holfels E, Stein L, Withers S, Cameron A, Perkins J, Heydemann P
    Impact of visual impairment on measures of cognitive function for children with congenital toxoplasmosis: implications for compensatory intervention strategies.
    Pediatrics , 2006 Aug. : 118(2)e379-90
  • Roizen N, Kasza K, Karrison T, Mets M, Noble AG, Boyer K, Swisher C, Meier P, Remington J, Jalbrzikowski J, McLeod R, Kipp M, Rabiah P, Chamot D, Estes R, Cezar S, Mack D, Pfiffner L, Stein M, Danis B, Patel D, Hopkins J, Holfels E, Stein L, Withers S, Cameron A, Perkins J, Heydemann P
    Impact of visual impairment on measures of cognitive function for children with congenital toxoplasmosis: implications for compensatory intervention strategies.
    Pediatrics , 2006 Aug. : 118(2)e379-90
  • McGough JJ, McBurnett K, Bukstein O, Wilens TE, Greenhill L, Lerner M, Stein M
    Once-daily OROS methylphenidate is safe and well tolerated in adolescents with attention-deficit/hyperactivity disorder.
    Journal of child and adolescent psychopharmacology , 2006 June : 16(3)351-6
  • Wilens TE, McBurnett K, Bukstein O, McGough J, Greenhill L, Lerner M, Stein MA, Conners CK, Duby J, Newcorn J, Bailey CE, Kratochvil CJ, Coury D, Casat C, Denisco MJ, Halstead P, Bloom L, Zimmerman BA, Gu J, Cooper KM, Lynch JM
    Multisite controlled study of OROS methylphenidate in the treatment of adolescents with attention-deficit/hyperactivity disorder.
    Archives of pediatrics & adolescent medicine , 2006 Jan. : 160(1)82-90
  • Mazei-Robison MS, Couch RS, Shelton RC, Stein MA, Blakely RD
    Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder.
    Neuropharmacology , 2005 Nov. : 49(6)724-36
  • Wilens T, McBurnett K, Stein M, Lerner M, Spencer T, Wolraich M
    ADHD treatment with once-daily OROS methylphenidate: final results from a long-term open-label study.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2005 Oct. : 44(10)1015-23
  • Stein MA, Waldman ID, Sarampote CS, Seymour KE, Robb AS, Conlon C, Kim SJ, Cook EH
    Dopamine transporter genotype and methylphenidate dose response in children with ADHD.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology , 2005 July : 30(7)1374-82
  • Stein MA
    Innovations in attention-deficit/hyperactivity disorder pharmacotherapy: long-acting stimulant and nonstimulant treatments.
    The American journal of managed care , 2004 July : 10(4 Suppl)S89-98
  • Stein MA, Sarampote CS, Waldman ID, Robb AS, Conlon C, Pearl PL, Black DO, Seymour KE, Newcorn JH
    A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorder.
    Pediatrics , 2003 Nov. : 112(5)e404
  • Stein MA, Sarampote CS, Waldman ID, Robb AS, Conlon C, Pearl PL, Black DO, Seymour KE, Newcorn JH
    A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorder.
    Pediatrics , 2003 Nov. : 112(5)e404
  • Stein MA, Weiss RE
    Thyroid function tests and neurocognitive functioning in children referred for attention deficit/hyperactivity disorder.
    Psychoneuroendocrinology , 2003 Apr, : 28(3)304-16
  • Wilens T, Pelham W, Stein M, Conners CK, Abikoff H, Atkins M, August G, Greenhill L, McBurnett K, Palumbo D, Swanson J, Wolraich M
    ADHD treatment with once-daily OROS methylphenidate: interim 12-month results from a long-term open-label study.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2003 Apr, : 42(4)424-33
  • Stein MA, Weiss RE
    Thyroid function tests and neurocognitive functioning in children referred for attention deficit/hyperactivity disorder.
    Psychoneuroendocrinology , 2003 Apr, : 28(3)304-16
  • Wilens T, Pelham W, Stein M, Conners CK, Abikoff H, Atkins M, August G, Greenhill L, McBurnett K, Palumbo D, Swanson J, Wolraich M
    ADHD treatment with once-daily OROS methylphenidate: interim 12-month results from a long-term open-label study.
    Journal of the American Academy of Child and Adolescent Psychiatry , 2003 Apr, : 42(4)424-33
  • Hartung CM, Willcutt EG, Lahey BB, Pelham WE, Loney J, Stein MA, Keenan K
    Sex differences in young children who meet criteria for attention deficit hyperactivity disorder.
    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 , 2002 Dec. : 31(4)453-64
  • Hartung CM, Willcutt EG, Lahey BB, Pelham WE, Loney J, Stein MA, Keenan K
    Sex differences in young children who meet criteria for attention deficit hyperactivity disorder.
    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 , 2002 Dec. : 31(4)453-64
  • Sarampote CS, Efron LA, Robb AS, Pearl PL, Stein MA
    Can stimulant rebound mimic pediatric bipolar disorder?
    Journal of child and adolescent psychopharmacology , 2002 : 12(1)63-7
  • Sarampote CS, Efron LA, Robb AS, Pearl PL, Stein MA
    Can stimulant rebound mimic pediatric bipolar disorder?
    Journal of child and adolescent psychopharmacology , 2002 : 12(1)63-7
  • Mark A. Stein, PhD, ABPP
    Attention Deficit Disorder and Hyperactivity in Children and Adults ( 2nd Edition). Marcel Dekker: New York. 736pp.
  • Mark A. Stein, PhD, ABPP
    Adaptive skills dysfunction in ADD and ADHD Children.
    Journal of Child Psychology and Psychiatry , 1995 : 36663-70
  • Mark A. Stein, PhD, ABPP
    Mimics of ADHD: Medical and Neurological.
    ADHD in Children, Adolescents and Adults.

Presentations

Presentations Title Event Location Date
Evaluating Research Start (Study and Trial Accelerator for Research Teams) NIH Workshop on Enrollment and Retention of Participants in Clinical TriaLS Bethesda,Maryland 2014
Effects of Dosage on Sleep Duration during Stimulant Treatmenbt for ADHD Canadian Paediatric Society Montreal 2014
Making Sense of ADHD Pharmacogenetics: DAT1, Ancestral Markers, Dose, and Study Methodology. SOciety of Biological Psychiatry San Francisco, Ca May 2013
How new ADHD treatment studies can inform practice? WOrld Congress on ADHD Tel Aviv, Israel April 2013
Stein M, White C, Enright G, Dammerman R. Morning or Evening Dosing of Guanfacine Extended Release: Remission of Pediatric ADHD as Assessed by Clinical Global Impressions. Pediatric Academic Society (Society for Pediatric Research Boston, MA. May 2012
Pharmacogenomics and Personalized ADHD Treatment: Are we there yet? Johns Hoplins Spectrum Conference on ADHD Baltimore, MD April 2012