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Kai Yu, PhD

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"As a developmental biologist, my goal is to translate knowledge gained from animal model studies into clinical treatments of human birth defects. I am particularly interested in cleft palate, one of the most common birth defects. Although cleft palate can be corrected by surgical treatments after birth, patients with cleft palate need multidisciplinary care and follow-up treatment of complications from birth to adulthood. At Seattle Children's, I combine mouse genetics and state-of-the-art three-dimensional imaging technologies to undersatnd palate morphogenesis during embryonic development and to investigate how various genetic and environmental risk factors disturb normal development to cause cleft palate formation. I hope that one day my research will aid in developing new strategies for prevention, diagnosis and treatment of cleft palate disorders."

Overview

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
T32 National Research Service AwardNational Institutes of Health 2002 - 2005

Publications

Histomorphological study of palatal shelf elevation during murine secondary palate formation.
Developmental dynamics : an official publication of the American Association of Anatomists , 2011 Jul: 240(7)1737-44
Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate.
Proceedings of the National Academy of Sciences of the United States of America , 2010 Feb 9: 107(6)2515-20
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.
Developmental biology , 2008 Jun 15: 318(2)276-88
FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.
Development (Cambridge, England) , 2008 Feb: 135(3)483-91
Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2007 Aug 8: 27(32)8581-92
FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod.
Developmental biology , 2007 Jul 15: 307(2)300-13
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis.
Development (Cambridge, England) , 2007 Feb: 134(4)723-34
Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience , 2006 Nov 22: 26(47)12339-50
FGF signalling generates ventral telencephalic cells independently of SHH.
Development (Cambridge, England) , 2006 Aug: 133(15)2937-46
Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans.
The Journal of biological chemistry , 2006 Mar 17: 281(11)6924-30
Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse.
Development (Cambridge, England) , 2005 Aug: 132(15)3537-48
Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation.
Developmental dynamics : an official publication of the American Association of Anatomists , 2005 Jun: 233(2)516-27
Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation.
American journal of human genetics , 2005 Feb: 76(2)361-7
Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo.
Developmental cell , 2005 Jan: 8(1)85-95
Sequential roles of Hedgehog and Wnt signaling in osteoblast development.
Development (Cambridge, England) , 2005 Jan: 132(1)49-60
A twist code determines the onset of osteoblast differentiation.
Developmental cell , 2004 Mar: 6(3)423-35
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth.
Development (Cambridge, England) , 2003 Jul: 130(13)3063-74
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.
Cell , 2003 Jan 24: 112(2)169-80
Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome.
Proceedings of the National Academy of Sciences of the United States of America , 2001 Jun 19: 98(13)7182-7
Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to Apert syndrome-like phenotypes.
Proceedings of the National Academy of Sciences of the United States of America , 2001 Mar 27: 98(7)3641-3
Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.
Proceedings of the National Academy of Sciences of the United States of America , 2000 Dec 19: 97(26)14536-41

Primary Office

Seattle Children's Research Institute
JMB - 5 - Center for Developmental Biology and Regenerative Medicine
1900 - 9th Ave
Seattle, WA 98101
206-884-1136

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