John K. McGuire, MD

John K. McGuire, MD

Critical Care, PICU

On staff since November 2004

Children's Title: Chief, Division of Pediatrics Critical Care Medicine

Academic Title: Associate Professor

Research Center: Center for Clinical and Translational Research

"Every day, I am reminded of the special privilege and honor that it is to participate in the care of the children and families in the Pediatric ICU at Seattle Children's Hospital. This inspires me to do my very best to provide outstanding patient care and education in pediatric critical care."

John K. McGuire, MD, is the Chief of the Division of Pediatric Critical Care Medicine at Seattle Children's Hospital and Associate Professor of Pediatrics at the University of Washington School of Medicine. Dr. McGuire earned his MD from Northwestern University and trained in general pediatrics and pediatric critical care medicine at Childrens Memorial Hospital and Northwestern University in Chicago. Prior to joining the group in Seattle, he worked at Washington University in St. Louis.

He is board certified in general pediatrics and pediatric critical care medicine and is a member of several academic societies including the American Thoracic Society, Society for Critical Care Medicine, and the American Society for Matrix Biology. Dr. McGuire is a member of the University of Washington Center for Lung Biology. His laboratory work is directed at understanding how epithelial responses to acute injury and infection regulate repair and resolution of inflammation. Related projects are focused on elucidating the role of matrix metalloproteinases in viral and bacterial lung infections. These studies receive funding from the National Institutes of Health and the Cystic Fibrosis Foundation. Dr. McGuire serves as a member of the Accreditation Council for Graduate Medical Education Board of Appeals Panel for Pediatrics and as a reviewer for the National Institutes of Health, the American Heart Association Research Program and several journals.


Board Certification(s)

Pediatric Critical Care Medicine

Medical/Professional School

Northwestern University Medical School, Chicago


Pediatrics, Children's Memorial Hospital, Chicago


Pediatric Critical Care Medicine, Children's Memorial Hospital, Chicago

Awards and Honors

Award Name Award Description Awarded By Award Date
Pediatric Critical Care Medicine Fellowship Outstanding Mentor Award Seattle Children's Hospital July 1, 2011
Pediatric Critical Care Medicine Fellowship Outstanding Teacher Award Seattle Children's Hospital 2009
Elected to membership Society for Pediatric Research 2008
Outstanding Subspecialty Teacher Saint Louis Childrens Hospital 2003
Resident Teaching Award Northwestern University Medical School 1995
Outstanding PL-2 Resident Teacher 1995 Childrens Memorial Hospital 1995
Outstanding PL-1 Resident Teacher Childrens Memorial Hospital 1994
United States Public Health Service Citation 1990


  • John K. McGuire, MD
    Submersion Injury in Children
    Perinatal and Pediatric Respiratory Care. 3rd Edition. Saint Louis: Saunders-Elsevier , 2010
  • Manicone AM, Huizar I, McGuire JK
    Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin).
    The American journal of pathology , 2009 Dec. : 2319-31
  • Swee M, Wilson CL, Wang Y, McGuire JK, Parks WC
    Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients.
    Journal of leukocyte biology , 2008 June : 1404-12
  • Chen P, McGuire JK, Hackman RC, Kim KH, Black RA, Poindexter K, Yan W, Liu P, Chen AJ, Parks WC, Madtes DK
    Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.
    The American journal of pathology , 2008 May : 1256-70
  • Manicone AM, McGuire JK
    Matrix metalloproteinases as modulators of inflammation.
    Seminars in cell & developmental biology , 2008 Feb. : 34-41
  • Kassim SY, Gharib SA, Mecham BH, Birkland TP, Parks WC, McGuire JK
    Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
    Infection and immunity , 2007 Dec. : 5640-50
  • Thill PJ, McGuire JK, Baden HP, Green TP, Checchia PA
    Noninvasive positive-pressure ventilation in children with lower airway obstruction.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2004 July : 337-42
  • Surendran K, Simon TC, Liapis H, McGuire JK
    Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4.
    Kidney international , 2004 June : 2212-22
  • McGuire JK, Li Q, Parks WC
    Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.
    The American journal of pathology , 2003 June : 1831-43
  • Jaspan HB, Brothers AW, Campbell AJ, McGuire JK, Browd SR, Manley TJ, Pak D, Weissman SJ
    Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
    The Pediatric infectious disease journal : : 379-81


Presentations Title Event Location Date
ICU Infections/Viral Pneumonias in the PICU/Management of Acute Hypoxemic Respiratory Failure in the Pediatric Patient 2010 Ain-Shams Medical School International Pediatric Critical Care Conference Cairo, Egypt 2010
Resolving acute lung injury: Getting the horse back in the barn 2008 First Annual Ron Lemire Northwest Pediatric Critical Care Symposium Seattle, WA 2008
Shed E-cadherin controls influx of CD103+ dendritic cells American Society of Matrix Biology Nashville, TN 2006
Matrix metalloproteinases in epithelial injury: A role for MMP-7 in inflammation and re-epithelialization European Tissue Repair Society Stuttgart, Germany 2005
Proteinase function in epithelial repair and fibrosis Second World Union of Wound Healing Societies Paris, France 2004
Resolution of acute lung injury: Putting out the fire Seattle Children's Grand Rounds , Seattle, WA

Research Funding

Grant Title Grantor Amount Award Date
Regulatory T cell function in cystic fibrosis lung disease Cystic Fibrosis Foundation $Annual Direct Costs: $90,000 April 2013 - March 2015
Proteomic Analysis of Exhaled Breath Condensates (EBC) in Pediatric Acute Lung Injury NIH/NCRR-UW Institute of Translational Health Sciences $10,000 2011 - 2012
Proteomic Analysis of Exhaled Breath Condensates (EBC) in Pediatric Acute Lung Injury NIH/NCRR-UW Institute for Translational Health Sciences $10,000 2011 - 2012
E-cadherin shedding in chronic lung injury NIH-NHLBI $Annual direct costs: $250,000 Jan. 2010 - Feb. 2015
E-cadherin shedding in chronic lung injury NIH-NHLBI $1,250,000.00 Dec. 1, 2009
Epithelial-leukocyte interactions in regulation of pulmonary inflammation in cystic fibrosis Cystic Fibrosis Foundation-Research Development Program $36,000.00 Oct. 1, 2009
Mechanisms in the Remodeling of Lung Structure NIH-NHLBI $1,350,000.00 Sept. 1, 2008
Function in Pulmonary Fibrosis American Heart Association $120,000.00 July 1, 2008
Cystic Fibrosis Research Center: Epithelial biology core Cystic Fibrosis Foundation $180,000.00 Oct. 1, 2007
Arnold Lee Smith Endowed Professorship for Research Faculty Development Arnold Lee Smith Endowement $140,000.00 Sept. 1, 2006