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John K. McGuire, MD

John K. McGuire, MD

Critical Care, PICU

On staff since November 2004

Children's Title: Chief, Division of Pediatrics Critical Care Medicine

Academic Title: Associate Professor

Research Center: Center for Clinical and Translational Research

"Every day, I am reminded of the special privilege and honor that it is to participate in the care of the children and families in the Pediatric ICU. This inspires me to do my very best to provide outstanding patient care and education in pediatric critical care."


Board Certification(s)
Pediatric Critical Care Medicine
Medical/Professional School
Northwestern University Medical School, Chicago
Pediatrics, Children's Memorial Hospital, Chicago
Pediatric Critical Care Medicine, Children's Memorial Hospital, Chicago

Awards and Honors

Award NameAward DescriptionAwarded ByAward Date
Pediatric Critical Care Medicine Fellowship Outstanding Teacher AwardSeattle Children's HospitalMay 2067
Pediatric Critical Care Medicine Fellowship Outstanding Mentor AwardSeattle Children's HospitalJuly 1, 2011


Submersion Injury in Children
Perinatal and Pediatric Respiratory Care. 3rd Edition. Saint Louis: Saunders-Elsevier , 2010
Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin).
The American journal of pathology , 2009 Dec: 2319-31
Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients.
Journal of leukocyte biology , 2008 Jun: 1404-12
Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.
The American journal of pathology , 2008 May: 1256-70
Matrix metalloproteinases as modulators of inflammation.
Seminars in cell & developmental biology , 2008 Feb: 34-41
Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
Infection and immunity , 2007 Dec: 5640-50
Noninvasive positive-pressure ventilation in children with lower airway obstruction.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2004 Jul: 337-42
Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4.
Kidney international , 2004 Jun: 2212-22
Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.
The American journal of pathology , 2003 Jun: 1831-43
Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
The Pediatric infectious disease journal , 1900: : 379-81


Presentations TitleEventLocationDate
ICU Infections/Viral Pneumonias in the PICU/Management of Acute Hypoxemic Respiratory Failure in the Pediatric Patient2010 Ain-Shams Medical School International Pediatric Critical Care ConferenceCairo, Egypt 2010
Resolution of acute lung injury: Putting out the fireSeattle Children's Grand RoundsSeattle, WA2009
Resolving acute lung injury: Getting the horse back in the barn2008 First Annual Ron Lemire Northwest Pediatric Critical Care SymposiumSeattle, WA 2008
Shed E-cadherin controls influx of CD103+ dendritic cellsAmerican Society of Matrix BiologyNashville, TN 2006
Matrix metalloproteinases in epithelial injury: A role for MMP-7 in inflammation and re-epithelializationEuropean Tissue Repair SocietyStuttgart, Germany 2005
Proteinase function in epithelial repair and fibrosisSecond World Union of Wound Healing SocietiesParis, France 2004

Research Funding

Grant TitleGrantorAmountAward Date
Proteomic Analysis of Exhaled Breath Condensates (EBC) in Pediatric Acute Lung InjuryNIH/NCRR-UW Institute for Translational Health Sciences $$10,000 2011 - 2012
Proteomic Analysis of Exhaled Breath Condensates (EBC) in Pediatric Acute Lung InjuryNIH/NCRR-UW Institute of Translational Health Sciences $$10,000 2011 - 2012
E-cadherin shedding in chronic lung injuryNIH-NHLBI $1,250,000.00Dec. 1, 2009
Epithelial-leukocyte interactions in regulation of pulmonary inflammation in cystic fibrosisCystic Fibrosis Foundation-Research Development Program $36,000.00Oct. 1, 2009
Mechanisms in the Remodeling of Lung StructureNIH-NHLBI $1,350,000.00Sept. 1, 2008
Function in Pulmonary FibrosisAmerican Heart Association $120,000.00July 1, 2008
Cystic Fibrosis Research Center: Epithelial biology coreCystic Fibrosis Foundation $180,000.00Oct. 1, 2007
Arnold Lee Smith Endowed Professorship for Research Faculty DevelopmentArnold Lee Smith Endowement $140,000.00Sept. 1, 2006

Primary Office

Seattle Children's
MB.10.620 - Critical Care
4800 Sand Point Way NE
Seattle, WA 98105

Additional Offices

850 Republican Street
Box 358052
Seattle, WA 98105

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