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John K. McGuire, MD

On staff since November 2004

Children's Title: Program Director, Critical Care Medicine Fellowship

Academic Title: Associate Professor

"Every day, I am reminded of the special privilege and honor that it is to participate in the care of the children and families in the Pediatric ICU. This inspires me to do my very best to provide outstanding patient care and education in pediatric critical care."

John K. McGuire, MD, is attending physician in the PICUs at Seattle Children’s Hospital and Harborview Medical Center and Associate Professor of pediatrics at the University of Washington School of Medicine. He is also Associate Division Chief for Pediatric Critical Care Education and Research and director of the Pediatric Critical Care Medicine fellowship program. Dr. McGuire earned his MD from Northwestern University and trained in general pediatrics and pediatric critical care medicine at Children’s Memorial Hospital and Northwestern University in Chicago. Prior to joining the group in Seattle, he worked at Washington University in St. Louis.

He is board certified in general pediatrics and pediatric critical care medicine and is a member of several academic societies including the American Thoracic Society, Society for Critical Care Medicine,f and the American Society for Matrix Biology. Dr. McGuire is a member of the University of Washington Center for Lung Biology. His laboratory work is directed at understanding how epithelial responses to acute injury and infection regulate repair and resolution of inflammation. Related projects are focused on elucidating the role of matrix metalloproteinases in viral and bacterial lung infections. These studies receive funding from the National Institutes of Health, The American Heart Association, and the Cystic Fibrosis Foundation. Dr. McGuire serves as a member of the Accreditation Council for Graduate Medical Education Board of Appeals Panel for Pediatrics and as a reviewer for the American Heart Association Research Program and several journals.

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Overview
Awards and Honors
Publications
Presentations
Research Funding

Overview

Board Certification(s): Pediatrics
Pediatric Critical Care Medicine
Medical/Professional School: Northwestern University Medical School, Chicago
Residency: Pediatrics, Children's Memorial Hospital, Chicago
Fellowship: Pediatric Critical Care Medicine, Children's Memorial Hospital, Chicago

Awards and Honors

Award Name	Award Description	Awarded By	Award Date
	Pediatric Critical Care Medicine Fellowship Outstanding Teacher Award	Seattle Children's Hospital	May 2067
	Pediatric Critical Care Medicine Fellowship Outstanding Mentor Award	Seattle Children's Hospital	July 1, 2011

Publications

Submersion Injury in Children
Perinatal and Pediatric Respiratory Care. 3rd Edition. Saint Louis: Saunders-Elsevier , 2010

Matrilysin (Matrix Metalloproteinase-7) regulates anti-inflammatory and antifibrotic pulmonary dendritic cells that express CD103 (alpha(E)beta(7)-integrin).
The American journal of pathology , 2009 Dec: 2319-31

Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients.
Journal of leukocyte biology , 2008 Jun: 1404-12

Tissue inhibitor of metalloproteinase-1 moderates airway re-epithelialization by regulating matrilysin activity.
The American journal of pathology , 2008 May: 1256-70

Matrix metalloproteinases as modulators of inflammation.
Seminars in cell & developmental biology , 2008 Feb: 34-41

Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
Infection and immunity , 2007 Dec: 5640-50

Noninvasive positive-pressure ventilation in children with lower airway obstruction.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2004 Jul: 337-42

Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4.
Kidney international , 2004 Jun: 2212-22

Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epithelium.
The American journal of pathology , 2003 Jun: 1831-43

Multidrug-resistant Enterococcus faecium meningitis in a toddler: characterization of the organism and successful treatment with intraventricular daptomycin and intravenous tigecycline.
The Pediatric infectious disease journal , 1900: : 379-81

Presentations

Presentations Title	Event	Location	Date
ICU Infections/Viral Pneumonias in the PICU/Management of Acute Hypoxemic Respiratory Failure in the Pediatric Patient	2010 Ain-Shams Medical School International Pediatric Critical Care Conference	Cairo, Egypt	2010
Resolution of acute lung injury: Putting out the fire	Seattle Children's Grand Rounds	Seattle, WA	2009
Resolving acute lung injury: Getting the horse back in the barn	2008 First Annual Ron Lemire Northwest Pediatric Critical Care Symposium	Seattle, WA	2008
Shed E-cadherin controls influx of CD103+ dendritic cells	American Society of Matrix Biology	Nashville, TN	2006
Matrix metalloproteinases in epithelial injury: A role for MMP-7 in inflammation and re-epithelialization	European Tissue Repair Society	Stuttgart, Germany	2005
Proteinase function in epithelial repair and fibrosis	Second World Union of Wound Healing Societies	Paris, France	2004

Research Funding

Grant Title	Grantor	Amount	Award Date
Proteomic Analysis of Exhaled Breath Condensates (EBC) in Pediatric Acute Lung Injury	NIH/NCRR-UW Institute of Translational Health Sciences	$$10,000	2011 - 2012
Proteomic Analysis of Exhaled Breath Condensates (EBC) in Pediatric Acute Lung Injury	NIH/NCRR-UW Institute for Translational Health Sciences	$$10,000	2011 - 2012
E-cadherin shedding in chronic lung injury	NIH-NHLBI	$1,250,000.00	Dec. 1, 2009
Epithelial-leukocyte interactions in regulation of pulmonary inflammation in cystic fibrosis	Cystic Fibrosis Foundation-Research Development Program	$36,000.00	Oct. 1, 2009
Mechanisms in the Remodeling of Lung Structure	NIH-NHLBI	$1,350,000.00	Sept. 1, 2008
Function in Pulmonary Fibrosis	American Heart Association	$120,000.00	July 1, 2008
Cystic Fibrosis Research Center: Epithelial biology core	Cystic Fibrosis Foundation	$180,000.00	Oct. 1, 2007
Arnold Lee Smith Endowed Professorship for Research Faculty Development	Arnold Lee Smith Endowement	$140,000.00	Sept. 1, 2006

Primary Office

Seattle Children's

OB.10.625 - Critical Care
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2170

Additional Offices

850 Republican Street
Box 358052

Seattle, WA 98105

206-987-2170

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John K. McGuire, MD

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