Profile

Jerry J. Zimmerman, MD, PhD

Jerry J. Zimmerman, MD, PhD

Critical Care, PICU

On staff since October 1998

Children's Title: Director, Continuous Quality Improvement (CPI)

Academic Title: Professor

Research Center: Center for Clinical and Translational Research

Jerry J. Zimmerman, MD, PhD, is an attending physician in the Pediatric Intensive Care Unit at Seattle Children's Hospital. He is Professor of Pediatrics and Anesthesiology at the University of Washington School of Medicine. Zimmerman has been chair of the Scientific Advisory Committee for Children's Hospital Clinical Research Center since its inception and is a member of the Steering Committee for the Center for Clinical and Translational Research. He is a charter member of the American College of Critical Care Medicine and is Treasurer of the Society of Critical Care Medicine and is a member of the Executive Committee.

With Bradley Fuhrman, Zimmerman is co-editor of the current premier textbook for the field, Pediatric Critical Care, now in its 4th edition. Additionally, Zimmerman serves on the editorial boards for Critical Care Medicine and Pediatric Critical Care Medicine, and is book review editor for both journals. He also provides ad hoc review for a number of other journals. Zimmerman is interested in the disequilibrium between the systemic inammatory response syndrome and compensatory anti-inammatory response syndrome that occurs as an important aspect of pathophysiology in critical illness. He is interested in the integrated role of neurological, endocrinologic and inammatory cross-talk, particularly involving reactive oxygen species and fatty acidderived mediators and their effect on metabolism. Zimmerman was chosen as a charter principal investigator for the recently established Collaborative Pediatric Critical Care Research Network.

Overview

Board Certification(s)

Pediatric Critical Care Medicine
Pediatrics

Medical/Professional School

University of Wisconsin School of Medicine and Public Health, Madison

Residency

Pediatrics, University of Wisconsin Hospital and Clinics, Madison

Clinical Interests

Neurologic-Endocrinologic-Inflammatory stress response

Research Focus Area

Translational Research

Awards and Honors

Award Name Award Description Awarded By Award Date
Executive Committee and Treasurer Society of Critical Care Medicine 2015
SEATTLE'S TOP DOCTOR - 2015 Seattle Met Magazine 2015
SEATTLE'S TOP DOCTOR - 2014 Seattle Metropolitan Magazine 2014
Seattle's Top Doc Seattle Met Magazine 2013
U.S. News and World Report Top Doctor- 2012 U.S. News and World Report Top Doctor- 2012 U.S. News and World Report 2012
Seattle Magazine Top Doctor - 2012 Seattle Magazine Top Doctor - 2012 Seattle Magazine 2012
Distinguished Career Award Distinguished Career Award American Academy of Pediatrics, Critical Care Section 2010
Distinguished Career Award Distinguished Career Award American Academy of Pediatrics 2010

Publications

  • The Pediatric Acute Lung Injury Consensus Conference Group
    Pediatric Acute Respiratory Distress Syndrome: Consensus Recommendations From the Pediatric Acute Lung Injury Consensus Conference.
    25647235 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2015 Feb. 2
  • Whalen LD, Di Gennaro JL, Irby GA, Yanay O, Zimmerman JJ
    Long-term dexmedetomidine use and safety profile among critically ill children and neonates.
    25068249 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2014 Oct. : 15(8)706-14
  • Wong HR, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Weiss SL, Shanley TP, Bigham MT, Banschbach S, Beckman E, Harmon K, Zimmerman JJ
    Corticosteroids are associated with repression of adaptive immunity gene programs in pediatric septic shock.
    24650276 American journal of respiratory and critical care medicine , 2014 Apr, 15 : 189(8)940-6 PMCID: PMC4098101
  • Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR, Multiple Medical Therapies for Pediatric Traumatic Brain Injury Workgroup
    Differences in medical therapy goals for children with severe traumatic brain injury-an international study.
    23863819 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2013 Oct. : 14(8)811-8
  • Holubkov R, Casper TC, Dean JM, Anand KJ, Zimmerman J, Meert KL, Newth CJ, Berger J, Harrison R, Willson DF, Nicholson C, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN)
    The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study.
    23392377 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2013 May : 14(4)374-83 PMCID: PMC3648617
  • Anand KJ, Clark AE, Willson DF, Berger J, Meert KL, Zimmerman JJ, Harrison R, Carcillo JA, Newth CJ, Bisping S, Holubkov R, Dean JM, Nicholson CE, Eunice Kennedy Shriver National Institute of Child Health, Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN)
    Opioid analgesia in mechanically ventilated children: results from the multicenter Measuring Opioid Tolerance Induced by Fentanyl study.
    23132396 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2013 Jan. : 14(1)27-36 PMCID: PMC3581608
  • Randolph AG, Vaughn F, Sullivan R, Rubinson L, Thompson BT, Yoon G, Smoot E, Rice TW, Loftis LL, Helfaer M, Doctor A, Paden M, Flori H, Babbitt C, Graciano AL, Gedeit R, Sanders RC, Giuliano JS, Zimmerman J, Uyeki TM, Pediatric Acute Lung Injury and Sepsis Investigator's Network and the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network
    Critically ill children during the 2009-2010 influenza pandemic in the United States.
    22065262 Pediatrics , 2011 Dec. : 128(6)e1450-8 PMCID: PMC3387899
  • Schwartz SM, Anand KJ, Portman MA, Crow S, Nelson DP, Zimmerman JJ
    Endocrinopathies in the cardiac ICU.
    23803992 World journal for pediatric & congenital heart surgery , 2011 July 1 : 2(3)400-10
  • Meert KL, Shear K, Newth CJ, Harrison R, Berger J, Zimmerman J, Anand KJ, Carcillo J, Donaldson AE, Dean JM, Willson DF, Nicholson C, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network
    Follow-up study of complicated grief among parents eighteen months after a child's death in the pediatric intensive care unit.
    21281122 Journal of palliative medicine , 2011 Feb. : 14(2)207-14 PMCID: PMC3037801
  • Meert KL, Donaldson AE, Newth CJ, Harrison R, Berger J, Zimmerman J, Anand KJ, Carcillo J, Dean JM, Willson DF, Nicholson C, Shear K, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network
    Complicated grief and associated risk factors among parents following a child's death in the pediatric intensive care unit.
    21041597 Archives of pediatrics & adolescent medicine , 2010 Nov. : 164(11)1045-51 PMCID: PMC3279721
  • Varni JW, Limbers CA, Neighbors K, Schulz K, Lieu JE, Heffer RW, Tuzinkiewicz K, Mangione-Smith R, Zimmerman JJ, Alonso EM
    The PedsQL Infant Scales: feasibility, internal consistency reliability, and validity in healthy and ill infants.
    20730626 Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation , 2010 Aug. 22
  • Zimmerman JJ, Barker RM, Jack R
    Initial observations regarding free cortisol quantification logistics among critically ill children.
    20721535 Intensive care medicine , 2010 Aug. 19
  • Varni JW, Limbers CA, Neighbors K, Schulz K, Lieu JE, Heffer RW, Tuzinkiewicz K, Mangione-Smith R, Zimmerman JJ, Alonso EM
    The PedsQL Infant Scales: feasibility, internal consistency reliability, and validity in healthy and ill infants.
    20730626 Quality of life research , 2010 Aug.
  • Zimmerman JJ, Williams MD
    Adjunctive corticosteroid therapy in pediatric severe sepsis: Observations from the RESOLVE study*
    20228689 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2010 Mar. 11 : .
  • Zimmerman JJ, Williams MD
    Adjunctive corticosteroid therapy in pediatric severe sepsis: Observations from the RESOLVE study*
    20228689 Pediatric Critical Care Medicine , 2010 Mar.
  • Di Gennaro JL, Mack CD, Malakouti A, Zimmerman JJ, Armstead W, Vavilala MS
    Use and effect of vasopressors after pediatric traumatic brain injury.
    21124016 Developmental neuroscience , 2010 : 420-30
  • Philip S, Chaiwat O, Udomphorn Y, Moore A, Zimmerman JJ, Armstead W, Vavilala MS
    Variation in cerebral blood flow velocity with cerebral perfusion pressure >40 mm Hg in 42 children with severe traumatic brain injury.
    19770734 Critical care medicine , 2009 Nov. : 2973-8
  • Zimmerman JJ, Akhtar SR, Caldwell E, Rubenfeld GD
    Incidence and outcomes of pediatric acute lung injury.
    19564287 Pediatrics , 2009 July : 87-95
  • Czaja AS, Zimmerman JJ
    The use of dexmedetomidine in critically ill children.
    19325505 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2009 May : 381-6
  • Zimmerman JJ
    Development of reliable methods supporting adjunctive therapy for congenital heart surgery.
    19433949 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2009 May : 410-2
  • Czaja AS, Zimmerman JJ, Nathens AB
    Readmission and late mortality after pediatric severe sepsis.
    19255013 Pediatrics , 2009 Mar. : 849-57
  • Cengiz P, Zemlan F, Ellenbogen R, Hawkins D, Zimmerman JJ
    Cerebrospinal fluid cleaved-tau protein and 9-hydroxyoctadecadienoic acid concentrations in pediatric patients with hydrocephalus.
    18679140 Pediatric Critical Care Medicine : , 2008 Sept. : 524-9
  • King MA, Garrison MM, Vavilala MS, Zimmerman JJ, Rivara FP
    Complications associated with arterial catheterization in children.
    18496411 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2008 July : 367-71
  • Vavilala MS, Tontisirin N, Udomphorn Y, Armstead W, Zimmerman JJ, Chesnut R, Lam AM
    Hemispheric differences in cerebral autoregulation in children with moderate and severe traumatic brain injury.
    18084727 Neurocritical care , 2008 : 45-54
  • Zimmerman JJ
    A history of adjunctive glucocorticoid treatment for pediatric sepsis: moving beyond steroid pulp fiction toward evidence-based medicine.
    17914311 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2007 Nov. : 530-9
  • Tontisirin N, Armstead W, Waitayawinyu P, Moore A, Udomphorn Y, Zimmerman JJ, Chesnut R, Vavilala MS
    Change in cerebral autoregulation as a function of time in children after severe traumatic brain injury: a case series.
    17429655 Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery , 2007 Oct. : 1163-9
  • Li JT, Bonneau LA, Zimmerman JJ, Weiss DJ
    Perfluorochemical (PFC) liquid enhances recombinant adenovirus vector-mediated viral interleukin-10 (AdvIL-10) expression in rodent lung.
    17472748 Journal of inflammation (London, England) , 2007 May 1 : 9
  • Zimmerman JJ
    Testing the waters.
    17496522 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2007 May : 305-7
  • Zimmerman JJ
    Understanding another acute respiratory distress syndrome.
    17421102 Critical care medicine , 2007 Mar. : 974-5
  • Zimmerman JJ
    Moving beyond Babel.
    17251889 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2007 Jan. : 73-5
  • Vavilala MS, Muangman S, Waitayawinyu P, Roscigno C, Jaffe K, Mitchell P, Kirkness C, Zimmerman JJ, Ellenbogen R, Lam AM
    Neurointensive care; impaired cerebral autoregulation in infants and young children early after inflicted traumatic brain injury: a preliminary report.
    17263672 Journal of neurotrauma , 2007 Jan. : 87-96
  • Baden HP, Berger J, Brilli RI, Burns JP, Checchia PA, Dalton HJ, Nadkarni V, Pollack M, Wetzel RC, Zimmerman JJ
    Pediatric cardiac critical care patients should be cared for by intensivists.
    16814678 Journal of the American College of Cardiology , 2006 July 4 : 221-2; author reply 222-3
  • Baden HP, Zimmerman JJ, Brilli RJ, Wong H, Wetzel RC, Burns JP, Nadkarni V, Checchia PA, Dalton HJ, Berger J, Pollack M, Notterman D, Green TP, Blumer J, Dean M
    Intensivist-led team approach to critical care of children with heart disease.
    16651353 Pediatrics , 2006 May : 1854-6; author reply 1856-7
  • Curley MA, Zimmerman JJ
    Alternative outcome measures for pediatric clinical sepsis trials.
    15857550 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2005 May : S150-6
  • Vavilala MS, Lee LA, Boddu K, Visco E, Newell DW, Zimmerman JJ, Lam AM
    Cerebral autoregulation in pediatric traumatic brain injury.
    15115564 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2004 May : 257-63
  • Curley MA, Zimmerman JJ
    Highlights of the Fourth World Congress on Pediatric Intensive Care.
    14525633 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2003 Oct. : 409-11
  • Nicholson CE, Gans BM, Chang AC, Pollack MM, Blackman J, Giroir BP, Wilson D, Zimmerman JJ, Whyte J, Dalton HJ, Carcillo JA, Randolph AG, Kochanek PM
    Pediatric critical care medicine: planning for our research future.
    12749652 Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies , 2003 Apr, : 196-202
  • Meyer KC, Zimmerman JJ
    Inflammation and surfactant.
    12457601 Paediatric respiratory reviews , 2002 Dec. : 308-14

Presentations

Presentations Title Event Location Date
"Life After Pediatric Sepsis", "Steroid Therapy for Sepsis MODS" Pediatric Multiple Organ Dysfunction Syndrome, State of the Science Conference Eunice Kennedy Shriver National Institute Of Child Health and Human Development,Rockville, MD March 26, 2015 - March 27, 2015
"Contemporary Treatment of Pediatric Sepsis" New PICU Nursing Education Day Seattle Childrens Hospital, Seattle, WA March 10, 2015
"Monitoring Intravascular Volume Adequacy", "Corticosteroid Use in the PICU", "Long Term Outcomes Following Pediatric Critical Illness" 16th National Conference Of Pediatric Critical Care Delhi, India Nov. 6, 2014 - Nov. 9, 2014
"Contemporary Treatment of Pediatric Sepsis" 7th Ron Lemire Northwest Symposium on Contemporary Pediatric Critical Care Medicine Seattle Childrens Hospital, Seattle, WA Oct. 24, 2014
"Critical Salt and Water Issues" Seattle Childrens Hospital Endocrinology Division Seattle Childrens Hospital, Seattle, WA Sept. 17, 2014
"Pediatric Endocrinopathies"; "Pediatric Endocrine Emergencies" Pediatric Multiprofessional Critical Care Board Review Course Society of Critical Care Medicine, Chicago, IL Aug. 12, 2014 - Aug. 16, 2014
"Cellular Pathophysiology of ARDS" Critical Care in the PICU and NICU Arena Seattle Childrens Research Institute, Seattle, WA Aug. 7, 2014 - Aug. 8, 2014
"Catabolism and the Stress Response"; "Critical Illness Cortisol Metabolism"; "Long Term Outcomes Following Pediatric Sepsis"; "Microcirculation in Critical Illness" 13 Congresso Brasileiro De Medicina Intensiva Peditrica Florianpolis, Brazil July 30, 2014 - Aug. 2, 2014
SteroidsWhat is Their Place in the PICU? Can We Learn to Use Biomarkers to Guide Therapy in the PICU? 7th World Congress on Pediatric Intensive and Critical Care Istanbul, Turkey May 3, 2014 - May 7, 2014
"Pathophysiology of Sepsis" Regional Sepsis Conference Harborview Medical Center. Seattle, WA Feb. 7, 2014
"Food For Thought (Or Not)? Hypoglycemia During DKA Management" Patient Safety Conference Seattle Childrens Hospital. Seattle, WA Feb. 5, 2014

Research Funding

Grant Title Grantor Amount Award Date
Genotype and Phenotypes in Pediatric SIRS and Sepsis, GAPPSS Seattle Childrens Research Institute and ImmuneXpress $55,083 2013 - 2015
Genotype and Phenotypes in Pediatric SIRS and Sepsis, GAPPSS Seattle Childrens Research Institute and ImmuneXpress $55,083 2013 - 2015
Approaches and Decisions for Acute Pediatric TBI, ADAPT NIH/NINDS $4600 per subject (Contract). 2013 - 2018
Life After Pediatric Sepsis, LAPSE NIH/NICHD $2,629,156, direct costs 2013 - 2018
Age of Blood in Children in Pediatric Intensive Care Units, ABC-PICU NIH/NHLBI $3850 per subject (Contract) 2013 - 2017
Catabolism and Morbidity After Pediatric Sepsis, CAMPS Center for Clinical and Translational Research Pilot Award $20,000 2012 - 2014
Extended Cortisol Quantification Investigation ARRA $270,169 2010 - 2012
Therapeutic Hypothermia After Pediatric Cardiac Arrest NIH/NHLBI $10,475, per subject enrolled 2009 - 2015
Critical Pertussis in the USA Centers for Disease Control $53,000 2006 - 2014
Collaborative Pediatric Critical Care Research Network, Charter Member NIH/NICHD $1,376,439 2004 - 2010
"Investigation of the Efficacy and Safety of Drotrecogin Alfa (Activated) in Pediatric Severe Sepsis" Eli Lilly $18,372 2001 - 2005
2001-2003 "Stress Dose Hydrocortisone in Pediatric Septic Shock" Pharmacia $27,000 2001 - 2003