Profile

Daryl M. Okamura, MD

On staff since October 2002

Academic Title: Assistant Professor of Pediatrics

Research Center: Center for Developmental Biology and Regenerative Medicine

Daryl M. Okamura, MD, is an attending physician at Seattle Children’s and an Assistant Professor of Pediatrics at the University of Washington School of Medicine. He earned his MD and completed his pediatric residency training at the University of Hawaii, after which he completed his pediatric nephrology fellowship at Seattle Children’s.

Dr. Okamura has an active, NIH-funded, basic science research program that is focused on halting and potentially reversing progressive kidney failure through further elucidation of the pathogenic mechanisms involved in renal fibrosis. Currently, his lab is investigating the role of macrophages in mediating both inflammatory and oxidative pathways and their role in cellular crosstalk with interstitial fibroblasts during chronic kidney injury. His clinical interests include the diagnosis and management of infants, children and adolescents with renal disease, particularly renal vasculitis, hypertension and chronic kidney disease.

Recommendations

MilisaEdgemont, SD11.04.12

Dr. Okamura was very up front and compassionate in our diagnosis with HSP and IgA Nephropothy. I wholeheartedly recommend Dr. Okamura and his team.

Recommend Dr. Daryl Okamura

Overview
Publications
Presentations
Research Funding

Overview

Board Certification(s): Pediatric Nephrology
Medical/Professional School: University of Hawaii John A Burns School of Medicine, Honolulu
Residency: Pediatrics, University of Hawaii John A Burns School of Medicine, Honolulu
Fellowship: Pediatric Nephrology, Seattle Children's Hospital, Seattle
Clinical Interests: Diagnosis and management of infants, children and adolescents with renal disease, particularly renal vasculitis, glomerulonephritis, and chronic kidney disease.
Research Focus Area: Tissue Response to Injury

Publications

Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease.
Pediatric nephrology (Berlin, Germany) , 2009 Dec: 2309-19

CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD.
Journal of the American Society of Nephrology : JASN , 2009 Mar: 495-505

Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury.
American journal of physiology. Renal physiology , 2007 Aug: F575-85

Endogenous urokinase lacks antifibrotic activity during progressive renal injury.
American journal of physiology. Renal physiology , 2007 Jul: F12-9

Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice.
Nephron. Experimental nephrology , 2006: e23-34

Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.
Kidney international , 2005 Jun: 2221-38

Presentations

Presentations Title	Event	Location	Date
Role of oxidized lipids in progression of chronic kidney disease	8. American Society of Pediatric Nephrology Annual Meeting	Baltimore, Maryland	May 3, 2009

Research Funding

Grant Title	Grantor	Amount	Award Date
Uncovering CD36-mediated oxidative and inflammatory pathways in progressive renal fibrosis	unknown	$50,000.00	April 1, 2009
Cysteamine effects on extracellular matrix accumulation in chronic kidney disease	Cystinosis Research Foundation Award	$89,069.00	July 1, 2008
Role of CD36 in oxidative and inflammatory pathways in renal fibrosis	National Kidney Foundation	$50,000.00	July 1, 2007
Multifunctional role of CD36 in progressive renal fibrosis	unknown	$128,250.00	July 1, 2006
Multifunctional role of CD36 in progressive renal fibrosis	NIH	$35,000.00	July 1, 2004

Primary Office

Seattle Children's

OC.9.820 - Nephrology
4800 Sand Point Way NE

Seattle, WA 98105

206-987-2524

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Daryl M. Okamura, MD

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