Condition or Therapy:

Central nervous system (CNS) tumors; tumor paint; Canvas Imaging System

Category:

Cancer and Blood Disorders
Study Number: PNOC012

What is the goal of this study?

Many types of cancer are primarily treated with surgery and patient survival is directly related to the extent to which the tumor is able to be removed. It is often difficult for surgeons to distinguish tumor tissue from normal tissue or to detect tumor cells that have spread from the original tumor site, resulting in incomplete removal of the tumor and reduced patient survival. In some areas, such as the brain, it is critical to avoid damage to normal tissue around the tumor to prevent adverse effects of surgery on function.

Tozuleristide is a drug that is thought to attach to tumor tissue and then fluoresces (glows) when a special light (called the “Canvas System”) is shined on it. It is hypothesized that tozuleristide, when imaged with the Canvas System, will improve surgical outcomes by allowing surgeons to visualize the edges of the tumor or other ambiguous tissue in real-time as they operate.

The purpose of this study is to evaluate how well tozuleristide imaged with Canvas work at helping to distinguish between tumor and normal tissue during surgery in pediatric primary central nervous system (CNS) tumors.

Who can join the study?

This study might be a good fit for children and young adults who:

  • Are between 1 month to 30 years
  • Have been diganosed with a primary CNS tumor

You can read about the eligibility requirements for this study on clinicaltrials.gov.

Researchers use many other factors to decide whether a patient can take part in a study (inclusion criteria) or cannot take part (exclusion criteria). The study team at Seattle Children’s can explain what these factors mean for you or your child.

What will happen if my child takes part in this study?

You can read more about this study on clinicaltrials.gov.

Who can I contact for more information?

Please call us at 206-987-2106 or send us an email.


Study Location(s):

Seattle Children's Hospital main campus

Principal Investigator:

Dr. Sarah Leary