Current Research Studies

Cancer – NANT 2004-05: Neuroblastoma Biology Study

Condition or Therapy:



Cancer and Blood Disorders
Study Number: NANT 2004-05

What is the goal of this study?

Medical scientists want to find better ways to treat neuroblastoma and to find ways to prevent the tumor from growing back. To do this, they need more information about the characteristics of neuroblastoma cells. Therefore, they want to study samples of neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that may be related to the growth of neuroblastoma cells. Doctors and other medical scientists also want to find better ways to detect and measure neuroblastoma to improve the ability to follow the response of tumor cells to therapy.

The purposes of this study are:

  • To establish a storage place or bank of samples of blood, bone marrow, and/or tumor, and molecular components isolated from these samples from children with neuroblastoma. The stored specimens will be shared with laboratory researchers studying high-risk neuroblastoma.
  • To evaluate a new test of blood and bone marrow specimens to find tumor cells. The results of this new test, called 5-gene TaqMan® Low Density Array or TLDA, will be compared between blood and bone marrow and imaging (radiology) studies. Radiology studies (CT scans, MRI scans, and MIBG scans) and the TLDA test will be compared for their ability to measure the amount of tumor present and how this changes with therapy.
  • To collect clinical data (such as treatments received, date of diagnosis, tumor stage, etc) and radiology scans to provide this information as needed for the laboratory studies to be done on the specimens.
  • To obtain neuroblastoma tumor cells from tumor tissue, bone marrow, and/or blood to use to start cell lines, or tumor cells that will keep growing in the laboratory. These cell lines will be shared with laboratory researchers studying high risk neuroblastoma.

Who can join the study?

This study may be a good fit for children and young adults who:

  • Are older than 31 days of age, and
  • Have had a diagnosis of high-risk neuroblastoma either by histological verification of neuroblastoma and/or demonstration of tumor cells in the bone marrow with increased urinary catecholamines
  • Undergo a disease evaluation and submit appropriate samples if they have been diagnosd with refractory or recurrent high-risk neuroblastoma at NANT institutions, regardless of disease status (including no measurable or evaluable tumor) 
  • Are patients with high-risk neuroblastoma without relapse treated at a NANT institution, if undergoing a disease evaluation, as long as Children's Oncology Group specimens are prioritized

What will happen if my child takes part in this study?

You can read more about this study on

Who can I contact for more information?

To learn more, call 206-987-2106 or email the study coordinator.

Study Location(s):

Seattle Children's Main Hospital Campus

Principal Investigator:

Dr. Julie Park
Research Center: Center for Clinical and Translational Research