AJA01 - USING THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY TO TREAT JUVENILE IDIOPATHIC ARTHRITIS
AJA01 tcVNS in JIA
What is the goal of the study?
The primary objective of this study is to determine the effect of tcVNS on disease activity in participants with active JIA as assessed by the JIA ACR 50 response. The secondary objectives of this study are to determine the effect of tcVNS on disease activity in participants with active JIA assessed by the JIA ACR 30 response, JIA ACR 70 response, and Juvenile Arthritis Disease Activity Score in 27 Joints (JADAS-27) response. The clinical exploratory objectives of this study are to determine the effect of tcVNS on the following aspects of JIA in participants with active JIA: • Pain • Functional status • Overall health and health-related quality of life • Arthritis The mechanistic objectives of this study seek to understand the mechanisms by which tcVNS may reduce inflammation and decrease musculoskeletal pain in participants with active JIA by examining serum, cellular and transcriptomic biomarkers of clinical response.
Who can participate in the study?
Please contact the study team listed below to learn more.