Current Research Studies

Cancer – ADVL1513: Phase 1 Study of Entinostat, an Oral Histone Deacetylase Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Condition or Therapy:

Recurrent solid tumors, refractory solid tumors


Cancer and Blood Disorders

What is the goal of this study?

This phase 1 trial studies the side effects and best dose of entinostat in treating pediatric patients with solid tumors that have come back or have not responded to treatment.

Who can join the study?

This study might be a good fit for children and young adults who:

  • Are between 21 months and 21 years old
  • Have recurrent or refractory solid tumors including CNS tumors or lymphoma, intrinsic brain stem tumors, optic pathway gliomas, pineal tumors, or elevations of cerebrospinal fluid (CSF) or serum tumors

What will happen if my child takes part in this study?

You can read more about this study on

Who can I contact for more information?

To learn more, call 206-987-2106 or send us an email.

Study Location(s):

Seattle Children's Main Hospital Campus

Principal Investigator:

Dr. Julie Park